Ignite Creation Date:
2025-12-25 @ 3:27 AM
Ignite Modification Date:
2025-12-26 @ 2:07 AM
Study NCT ID:
NCT04135105
Status:
COMPLETED
Last Update Posted:
2020-01-27
First Post:
2019-10-19
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Lexical Tone Perception in Tone language--a fMRI Study
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'OTHER', 'observationalModel': 'OTHER'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 29}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2017-02-12', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2020-01', 'completionDateStruct': {'date': '2019-09-30', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2020-01-24', 'studyFirstSubmitDate': '2019-10-19', 'studyFirstSubmitQcDate': '2019-10-19', 'lastUpdatePostDateStruct': {'date': '2020-01-27', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2019-10-22', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2018-02-25', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Activation areas in the brain that are responsible for lexical tone perception', 'timeFrame': '2015-2019', 'description': 'To identify the activation area(s) in the brain that are responsible for lexical tone perception in normal hearing participants'}], 'secondaryOutcomes': [{'measure': 'Accuracy rate', 'timeFrame': '2015-2019', 'description': 'Accuracy rate of passive listening task'}, {'measure': 'Reaction Time', 'timeFrame': '2015-2019', 'description': 'reaction time of passive listening task'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Speech Perception', 'Neuroimaging', 'Lexical Tone', 'Chinese'], 'conditions': ['Lexical Tone', 'Neuroimaging', 'Chinese', 'Speech Perception']}, 'descriptionModule': {'briefSummary': 'Tone language refers to a language that uses fixed pitch pattern to distinguish words (Yip, 2002). Understanding the functional anatomy of the brain during lexical tone processing will provide useful hints for an effective intervention strategy such as brain stimulation. The present study investigate the cortical organisation of the brain in lexical tone perception of Cantonese speakers by the use of functional magnetic resonance imaging (fMRI).', 'detailedDescription': 'Tone language refers to a language that uses fixed pitch pattern to distinguish words (Yip, 2002). Cantonese is one of the main tone languages spoken by over 70 million around the world (Li et al.,1995; Adolfsson, 2010). Individuals with significant hearing impairment often present great difficulty in tone perception, affecting their understanding of words and hence, hamper their overall communication. The poor tone perception persists even with intensive auditory training coupled with advanced hearing technology such as cochlear implants.\n\nUnderstanding the functional anatomy of the brain during lexical tone processing will provide useful hints for an effective intervention strategy such as brain stimulation. Researchers have been investigating the neural basis for tone perception in the past decades but failing to come to a consensus on the location of the brain that is responsible for lexical tone processing. The discrepant results may be due to the fact of the differences in subject selection (animals, healthy adults, brain-injured patients, tonal-language and non-tonal language speakers), testing materials and tasks employed (linguistic versus non-linguistic stimuli; dichotic listening versus discrimination and identification tasks) and outcome measurements (performance score, reaction time, accuracy rate, PET scan and fMRI).\n\nCortical organization, or brain mapping, refers to functional anatomy of the brain. The present study is the first study to systematically investigate the cortical organization of the brain in lexical tone perception of Cantonese speakers by the use of functional magnetic resonance imaging (fMRI). A comprehensive set of auditory stimuli specifically for investigating the different levels of lexical tone processing will be constructed. Native Cantonese speakers with normal hearing were recruited. They underwent fMRI while listening to the carefully designed auditory stimuli.\n\nOnce the cortical organization of lexical tone processing in Cantonese is identified, the valuable findings could be applied in further brain intervention procedures to tackle the long lasting, unresolved tone perception difficulty encountered by people with hearing impairment or other related disorders.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT'], 'maximumAge': '60 Years', 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Recruitment via University mass mail They were paid for their participations.', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* native Cantonese speaker\n* right-handed\n* normal hearing\n* no reported of neurological disorder\n\nExclusion Criteria:\n\n* neurological disorder\n* left-handed\n* hearing impairment'}, 'identificationModule': {'nctId': 'NCT04135105', 'briefTitle': 'Lexical Tone Perception in Tone language--a fMRI Study', 'organization': {'class': 'OTHER', 'fullName': 'Chinese University of Hong Kong'}, 'officialTitle': 'Lexical Tone Perception in Tone Language speakers--a fMRI Study', 'orgStudyIdInfo': {'id': 'Lexical tone perception(fMRI)'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Normal hearing group', 'description': 'Right-handed, normal hearing, no reported neurological disorders', 'interventionNames': ['Other: Normal hearing group']}], 'interventions': [{'name': 'Normal hearing group', 'type': 'OTHER', 'description': 'Observational', 'armGroupLabels': ['Normal hearing group']}]}, 'contactsLocationsModule': {'locations': [{'city': 'Hong Kong', 'state': 'Hong Kong', 'country': 'China', 'facility': 'Prince of Wales Hospital', 'geoPoint': {'lat': 22.27832, 'lon': 114.17469}}], 'overallOfficials': [{'name': 'Yuet Sheung Lee, Professor', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Chinese University of Hong Kong'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'UNDECIDED'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Chinese University of Hong Kong', 'class': 'OTHER'}, 'collaborators': [{'name': 'Prince of Wales Hospital, Shatin, Hong Kong', 'class': 'OTHER'}], 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Chief of Division of Speech Therapy', 'investigatorFullName': 'Kathy Y.S. LEE', 'investigatorAffiliation': 'Chinese University of Hong Kong'}}}}