Ignite Creation Date:
2025-12-24 @ 2:38 PM
Ignite Modification Date:
2025-12-29 @ 6:53 AM
Study NCT ID:
NCT01645059
Status:
COMPLETED
Last Update Posted:
2014-01-08
First Post:
2012-07-13
Is Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Multicenter Descriptive Study of the Patient Clinical Profile That Begins With Disseminated Her 2 + Breast Cancer or Develops a Metastasis After or During the Adjuvant Therapy
Sponsor:
Organization:
Raw JSON
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Cancer'}], 'classes': [{'title': 'Perfomance Status (ECOG) 0', 'categories': [{'measurements': [{'value': '63.5', 'groupId': 'OG000', 'lowerLimit': '54.4', 'upperLimit': '71.8'}]}]}, {'title': 'Metastasic Breast Cancer', 'categories': [{'measurements': [{'value': '48.8', 'groupId': 'OG000', 'lowerLimit': '40.0', 'upperLimit': '57.7'}]}]}, {'title': 'Ductal Carcinoma', 'categories': [{'measurements': [{'value': '84.1', 'groupId': 'OG000', 'lowerLimit': '76.3', 'upperLimit': '89.8'}]}]}, {'title': 'Histological Grade III', 'categories': [{'measurements': [{'value': '41.1', 'groupId': 'OG000', 'lowerLimit': '32.6', 'upperLimit': '50.1'}]}]}, {'title': 'Node involvement', 'categories': [{'measurements': [{'value': '78.0', 'groupId': 'OG000', 'lowerLimit': '69.3', 'upperLimit': '84.9'}]}]}, {'title': 'Positive Estrogen Receptor', 'categories': [{'measurements': [{'value': '57.5', 'groupId': 'OG000', 'lowerLimit': '48.4', 'upperLimit': '66.1'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '1 day (there is no follow-up, it is a cross-sectional study)', 'description': 'General clinical data: age, weigh, height, Perfomance Status (ECOG Eastern Cooperative Oncology Group, runs from 0 to 5, with 0 denoting perfect health and 5 death), Breast cancer characteristics: familiar history of breast cancer, initial diagnostic (localized or disseminated), age at diagnostic, TNM (tumor node metástasis), tumor size, node involvement, primary tumor surgery, HER2 overexpression, histological Classification (grades I, II and III,determines the urgency and aggressiveness of treatment, as the higher grades do tend to correspond to poorer survival rates and prognosis), time from the primary breast cancer to distant relapse, description and localization of metastasis', 'unitOfMeasure': 'percentage of participants', 'dispersionType': '95% Confidence Interval', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Adjuvant Treatment in Primary Breast Cancer: Chemotherapy (Treatment With TAC-Docetaxel, Adriamicine and Cyclophosphamide), Hormonal Therapy Anti-HER Biological Therapy', 'denoms': [{'units': 'Participants', 'counts': [{'value': '66', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Disseminated Her 2+ Breast Cancer'}], 'classes': [{'title': 'Adjuvant treatment (Chemotherapy with TAC)', 'categories': [{'measurements': [{'value': '22.0', 'groupId': 'OG000', 'lowerLimit': '12', 'upperLimit': '36.3'}]}]}, {'title': 'Adjuvant treatment (Hormonal therapy tamoxifen)', 'categories': [{'measurements': [{'value': '41.7', 'groupId': 'OG000', 'lowerLimit': '26.0', 'upperLimit': '59.2'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'one day (there is no follow-up, it is a cross-sectional study)', 'unitOfMeasure': 'percentage of participants', 'dispersionType': '95% Confidence Interval', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'The Pattern of Treatment in Metastatic Breast Cancer: Chemotherapy, Hormonal Therapy Anti-HER Biological Therapy', 'denoms': [{'units': 'Participants', 'counts': [{'value': '129', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Disseminated HER 2 + Breast Cancer'}], 'classes': [{'title': 'First line-Chemotherapy', 'categories': [{'measurements': [{'value': '86.8', 'groupId': 'OG000'}]}]}, {'title': 'Chemotherapy with Taxanes', 'categories': [{'measurements': [{'value': '37.5', 'groupId': 'OG000'}]}]}, {'title': 'Chemotherapy with Taxanes-Anthraciclines', 'categories': [{'measurements': [{'value': '20.5', 'groupId': 'OG000'}]}]}, {'title': 'Chemotherapy Vinorelbine', 'categories': [{'measurements': [{'value': '17.0', 'groupId': 'OG000'}]}]}, {'title': 'Hormonotherapy+ trastuzumab', 'categories': [{'measurements': [{'value': '8.5', 'groupId': 'OG000'}]}]}, {'title': 'Chemotherapy+ trastuzumab', 'categories': [{'measurements': [{'value': '86.8', 'groupId': 'OG000'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'one day (there is no follow-up, it si a cross-sectional study)', 'unitOfMeasure': 'percentage of participants', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Adjuvant Treatment and Age', 'denoms': [{'units': 'Participants', 'counts': [{'value': '33', 'groupId': 'OG000'}, {'value': '33', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Trastuzumab Adjuvant Treatment'}, {'id': 'OG001', 'title': 'No Trastuzumab Adjuvant Treatment'}], 'classes': [{'categories': [{'measurements': [{'value': '55.3', 'spread': '10.4', 'groupId': 'OG000'}, {'value': '61.8', 'spread': '13.4', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'one day (there is no follow-up, it is a cross-sectional study)', 'description': 'Adjuvant treatment and clinical profile (age)\n\nThe patients analysed in this outcome are patients initially diagnosed with localized breast cáncer (N=66)', 'unitOfMeasure': 'years', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Adjuvant Treatment-Physical Activity', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '28', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Trastuzumab Adjuvant Treatment'}, {'id': 'OG001', 'title': 'No Trastuzumab Adjuvant Treatment'}], 'classes': [{'categories': [{'measurements': [{'value': '56.3', 'groupId': 'OG000'}, {'value': '17.9', 'groupId': 'OG001'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'one day (there is no follow-up, it is a cross-sectional study)', 'description': 'Adjuvant treatment and clinical profile (Physical activity)\n\nThe patients analysed in this outcome are patients initially diagnosed with localized breast cáncer (N=66)', 'unitOfMeasure': 'percentage of patients physical activity', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Adjuvant Treatment-Node Affectation', 'denoms': [{'units': 'Participants', 'counts': [{'value': '27', 'groupId': 'OG000'}, {'value': '18', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Trastuzumab Adjuvant Treatment'}, {'id': 'OG001', 'title': 'No Trastuzumab Adjuvant Treatment'}], 'classes': [{'categories': [{'measurements': [{'value': '84.4', 'groupId': 'OG000'}, {'value': '54.5', 'groupId': 'OG001'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'one day (there is no follow-up, it is a cross-sectional study)', 'description': 'Adjuvant treatment and clinical profile (Node affectation)\n\nThe patients analysed in this outcome are patients initially diagnosed with localized breast cáncer (N=66)', 'unitOfMeasure': 'percentage of patients node affectation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Disseminated Breast Cancer Treatment-Age', 'denoms': [{'units': 'Participants', 'counts': [{'value': '79', 'groupId': 'OG000'}, {'value': '50', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Taxanes First Line Treatment'}, {'id': 'OG001', 'title': 'No Taxanes First Line Treatment'}], 'classes': [{'categories': [{'measurements': [{'value': '56.1', 'spread': '13.5', 'groupId': 'OG000'}, {'value': '61.3', 'spread': '14.1', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'one day (there is no follow-up, it is a cross-sectional study)', 'description': 'Analyse disseminated Breast Cancer treatment and clinical profile (age)', 'unitOfMeasure': 'years', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Disseminated Breast Cancer Treatment-physical Activity', 'denoms': [{'units': 'Participants', 'counts': [{'value': '75', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Taxanes First Line Treatment'}, {'id': 'OG001', 'title': 'No Taxanes First Line Treatment'}], 'classes': [{'categories': [{'measurements': [{'value': '24', 'groupId': 'OG000'}, {'value': '43.2', 'groupId': 'OG001'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'one day (there is no follow-up, it is a cross-sectional study)', 'description': 'Analyse disseminated Breast Cancer treatment and clinical profile (physical activity)', 'unitOfMeasure': 'percentage of patients physical activity', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Disseminated Breast Cancer Treatment-Smoking', 'denoms': [{'units': 'Participants', 'counts': [{'value': '76', 'groupId': 'OG000'}, {'value': '47', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Taxanes First Line Treatment'}, {'id': 'OG001', 'title': 'No Taxanes First Line Treatment'}], 'classes': [{'categories': [{'measurements': [{'value': '25', 'groupId': 'OG000'}, {'value': '6.4', 'groupId': 'OG001'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'one day (there is no follow-up, it is a cross-sectional study)', 'description': 'Analyse disseminated Breast Cancer treatment and clinical profile (Smoking)', 'unitOfMeasure': 'percentage of smoking participants', 'reportingStatus': 'POSTED'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Disseminated Her 2+ Breast Cancer'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '129'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '129'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}]}]}], 'recruitmentDetails': 'First Patient included: 28th july 2011 Last Patient included: 27 th march 2013 Location: outpatient department'}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '129', 'groupId': 'BG000'}]}], 'groups': [{'id': 'BG000', 'title': 'Disseminated Her 2+ Breast Cancer'}], 'measures': [{'title': 'Age, Categorical', 'classes': [{'categories': [{'title': '<=18 years', 'measurements': [{'value': '0', 'groupId': 'BG000'}]}, {'title': 'Between 18 and 65 years', 'measurements': [{'value': '91', 'groupId': 'BG000'}]}, {'title': '>=65 years', 'measurements': [{'value': '38', 'groupId': 'BG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '58.1', 'spread': '13.9', 'groupId': 'BG000'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '129', 'groupId': 'BG000'}]}, {'title': 'Male', 'measurements': [{'value': '0', 'groupId': 'BG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Region of Enrollment', 'classes': [{'title': 'Spain', 'categories': [{'measurements': [{'value': '129', 'groupId': 'BG000'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'participants'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'CROSS_SECTIONAL', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 129}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2011-07'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2013-11', 'completionDateStruct': {'date': '2013-03', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2013-11-20', 'studyFirstSubmitDate': '2012-07-13', 'resultsFirstSubmitDate': '2013-07-09', 'studyFirstSubmitQcDate': '2012-07-19', 'lastUpdatePostDateStruct': {'date': '2014-01-08', 'type': 'ESTIMATED'}, 'resultsFirstSubmitQcDate': '2013-11-20', 'studyFirstPostDateStruct': {'date': '2012-07-20', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2014-01-08', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2013-03', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'The Patient Clinical Profile (General Clinical Data and Breast Cancer Characteristics)', 'timeFrame': '1 day (there is no follow-up, it is a cross-sectional study)', 'description': 'General clinical data: age, weigh, height, Perfomance Status (ECOG Eastern Cooperative Oncology Group, runs from 0 to 5, with 0 denoting perfect health and 5 death), Breast cancer characteristics: familiar history of breast cancer, initial diagnostic (localized or disseminated), age at diagnostic, TNM (tumor node metástasis), tumor size, node involvement, primary tumor surgery, HER2 overexpression, histological Classification (grades I, II and III,determines the urgency and aggressiveness of treatment, as the higher grades do tend to correspond to poorer survival rates and prognosis), time from the primary breast cancer to distant relapse, description and localization of metastasis'}], 'secondaryOutcomes': [{'measure': 'Adjuvant Treatment in Primary Breast Cancer: Chemotherapy (Treatment With TAC-Docetaxel, Adriamicine and Cyclophosphamide), Hormonal Therapy Anti-HER Biological Therapy', 'timeFrame': 'one day (there is no follow-up, it is a cross-sectional study)'}, {'measure': 'The Pattern of Treatment in Metastatic Breast Cancer: Chemotherapy, Hormonal Therapy Anti-HER Biological Therapy', 'timeFrame': 'one day (there is no follow-up, it si a cross-sectional study)'}, {'measure': 'Adjuvant Treatment and Age', 'timeFrame': 'one day (there is no follow-up, it is a cross-sectional study)', 'description': 'Adjuvant treatment and clinical profile (age)\n\nThe patients analysed in this outcome are patients initially diagnosed with localized breast cáncer (N=66)'}, {'measure': 'Adjuvant Treatment-Physical Activity', 'timeFrame': 'one day (there is no follow-up, it is a cross-sectional study)', 'description': 'Adjuvant treatment and clinical profile (Physical activity)\n\nThe patients analysed in this outcome are patients initially diagnosed with localized breast cáncer (N=66)'}, {'measure': 'Adjuvant Treatment-Node Affectation', 'timeFrame': 'one day (there is no follow-up, it is a cross-sectional study)', 'description': 'Adjuvant treatment and clinical profile (Node affectation)\n\nThe patients analysed in this outcome are patients initially diagnosed with localized breast cáncer (N=66)'}, {'measure': 'Disseminated Breast Cancer Treatment-Age', 'timeFrame': 'one day (there is no follow-up, it is a cross-sectional study)', 'description': 'Analyse disseminated Breast Cancer treatment and clinical profile (age)'}, {'measure': 'Disseminated Breast Cancer Treatment-physical Activity', 'timeFrame': 'one day (there is no follow-up, it is a cross-sectional study)', 'description': 'Analyse disseminated Breast Cancer treatment and clinical profile (physical activity)'}, {'measure': 'Disseminated Breast Cancer Treatment-Smoking', 'timeFrame': 'one day (there is no follow-up, it is a cross-sectional study)', 'description': 'Analyse disseminated Breast Cancer treatment and clinical profile (Smoking)'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'conditions': ['Disseminated HER2+ Breast Cancer']}, 'descriptionModule': {'briefSummary': 'This is an observational, cross-sectional study that the main objective is to describe the patient clinical profile that begins with disseminated Her 2+ Breast Cancer or develops a metastasis after or during the adjuvant treatment.'}, 'eligibilityModule': {'sex': 'FEMALE', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Female patients with disseminated HER2+ breast cancer in first line treatment', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Women with 18 years or over\n* Patients with disseminated breast cancer histologically or cytological confirmed, who begins with Her 2+ metastatic breast cancer or develops a metastasis after or during the adjuvant therapy\n* Patients treated in first line treatment in metastatic disease.\n* Patients who have positive Her 2 receptor test\n* Patients who have given their written informed consent\n\nExclusion Criteria:\n\n* Patients who are participating in other studies'}, 'identificationModule': {'nctId': 'NCT01645059', 'acronym': 'PRIMHER', 'briefTitle': 'Multicenter Descriptive Study of the Patient Clinical Profile That Begins With Disseminated Her 2 + Breast Cancer or Develops a Metastasis After or During the Adjuvant Therapy', 'organization': {'class': 'NETWORK', 'fullName': 'Asociación Cacereña para la Investigación y el Desarrollo en Oncología Médica'}, 'officialTitle': 'Observational, Cross-sectional, Multicenter Descriptive Study of the Patient Clinical Profile That Begins With Disseminated Her 2 + Breast Cancer or Develops a Metastasis After or During the Adjuvant Therapy (PRIMHER)', 'orgStudyIdInfo': {'id': 'ACI-CMM-2010-01'}}, 'contactsLocationsModule': {'locations': [{'zip': '03700', 'city': 'Denia', 'state': 'Alicante', 'country': 'Spain', 'facility': 'Hospital de Denia', 'geoPoint': {'lat': 38.84078, 'lon': 0.10574}}, {'zip': '03600', 'city': 'Elda', 'state': 'Alicante', 'country': 'Spain', 'facility': 'Hospital General de Elda', 'geoPoint': {'lat': 38.47783, 'lon': -0.79157}}, {'zip': '04009', 'city': 'Almería', 'state': 'Almería', 'country': 'Spain', 'facility': 'Hospital de Torrecárdenas', 'geoPoint': {'lat': 36.83814, 'lon': -2.45974}}, {'zip': '06008', 'city': 'Badajoz', 'state': 'Badajoz', 'country': 'Spain', 'facility': 'Hospital Infanta Cristina de Badajoz', 'geoPoint': {'lat': 38.87789, 'lon': -6.97061}}, {'zip': '06400', 'city': 'Don Benito', 'state': 'Badajoz', 'country': 'Spain', 'facility': 'Hospital don Benito', 'geoPoint': {'lat': 38.95627, 'lon': -5.86162}}, {'zip': '06900', 'city': 'Llerena', 'state': 'Badajoz', 'country': 'Spain', 'facility': 'Hospital de Llerena', 'geoPoint': {'lat': 38.23333, 'lon': -6.01667}}, {'zip': '06800', 'city': 'Mérida', 'state': 'Badajoz', 'country': 'Spain', 'facility': 'Hospital de Mérida', 'geoPoint': {'lat': 38.91802, 'lon': -6.34292}}, {'zip': '07198', 'city': 'Palma de Mallorca', 'state': 'Balearic Islands', 'country': 'Spain', 'facility': 'Hospital Son Llàtzer', 'geoPoint': {'lat': 39.56939, 'lon': 2.65024}}, {'zip': '08916', 'city': 'Badalona', 'state': 'Barcelona', 'country': 'Spain', 'facility': 'ICO Badalona', 'geoPoint': {'lat': 41.45004, 'lon': 2.24741}}, {'zip': '08017', 'city': 'Barcelona', 'state': 'Barcelona', 'country': 'Spain', 'facility': 'Clínica Corachan', 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'zip': '08906', 'city': "L'Hospitalet de Llobregat", 'state': 'Barcelona', 'country': 'Spain', 'facility': "Hospital General de l'Hospitalet", 'geoPoint': {'lat': 41.35967, 'lon': 2.10028}}, {'zip': '13005', 'city': 'Ciudad Real', 'state': 'Ciudad Real', 'country': 'Spain', 'facility': 'Complejo Hospitalario Ciudad Real', 'geoPoint': {'lat': 38.98626, 'lon': -3.92907}}, {'zip': '10003', 'city': 'Cáceres', 'state': 'Cáceres', 'country': 'Spain', 'facility': 'Hospital San Pedro Alcántara', 'geoPoint': {'lat': 39.47649, 'lon': -6.37224}}, {'zip': '10600', 'city': 'Plasencia', 'state': 'Cáceres', 'country': 'Spain', 'facility': 'Hospital Virgen del Puerto', 'geoPoint': {'lat': 40.03116, 'lon': -6.08845}}, {'zip': '11404', 'city': 'Jerez de la Frontera', 'state': 'Cádiz', 'country': 'Spain', 'facility': 'Hospital de Jerez', 'geoPoint': {'lat': 36.68645, 'lon': -6.13606}}, {'zip': '24008', 'city': 'León', 'state': 'León', 'country': 'Spain', 'facility': 'Hospital de León', 'geoPoint': {'lat': 42.60003, 'lon': -5.57032}}, {'zip': '25198', 'city': 'Lleida', 'state': 'Lleida', 'country': 'Spain', 'facility': 'Hospital Universitario Arnau de Vilanova', 'geoPoint': {'lat': 41.61674, 'lon': 0.62218}}, {'zip': '27003', 'city': 'Lugo', 'state': 'Lugo', 'country': 'Spain', 'facility': 'Hospital Lucus Augusti', 'geoPoint': {'lat': 43.00992, 'lon': -7.55602}}, {'zip': '28901', 'city': 'Getafe', 'state': 'Madrid', 'country': 'Spain', 'facility': 'Hospital de Getafe', 'geoPoint': {'lat': 40.30571, 'lon': -3.73295}}, {'zip': '28911', 'city': 'Leganés', 'state': 'Madrid', 'country': 'Spain', 'facility': 'Hospital Severo Ochoa', 'geoPoint': {'lat': 40.32718, 'lon': -3.7635}}, {'zip': '28006', 'city': 'Madrid', 'state': 'Madrid', 'country': 'Spain', 'facility': 'Hospital La Princesa', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'zip': '28935', 'city': 'Móstoles', 'state': 'Madrid', 'country': 'Spain', 'facility': 'Hospital de Móstoles', 'geoPoint': {'lat': 40.32234, 'lon': -3.86496}}, {'zip': '28223', 'city': 'Pozuelo de Alarcón', 'state': 'Madrid', 'country': 'Spain', 'facility': 'Hospital Quirón', 'geoPoint': {'lat': 40.43293, 'lon': -3.81338}}, {'zip': '30008', 'city': 'Murcia', 'state': 'Murcia', 'country': 'Spain', 'facility': 'Hospital Morales Messeguer', 'geoPoint': {'lat': 37.98704, 'lon': -1.13004}}, {'zip': '31500', 'city': 'Tudela', 'state': 'Navarre', 'country': 'Spain', 'facility': 'Hospital Reina Sofía de Tudela', 'geoPoint': {'lat': 42.06166, 'lon': -1.60452}}, {'zip': '36214', 'city': 'Vigo', 'state': 'Pontevedra', 'country': 'Spain', 'facility': 'Hospital do Meixoeiro', 'geoPoint': {'lat': 42.23282, 'lon': -8.72264}}, {'zip': '33203', 'city': 'Gijón', 'state': 'Principality of Asturias', 'country': 'Spain', 'facility': 'Hospital de Cabueñes', 'geoPoint': {'lat': 43.53573, 'lon': -5.66152}}, {'zip': '40002', 'city': 'Segovia', 'state': 'Segovia', 'country': 'Spain', 'facility': 'Hospital General de Segovia', 'geoPoint': {'lat': 40.94808, 'lon': -4.11839}}, {'zip': '41009', 'city': 'Seville', 'state': 'Sevilla', 'country': 'Spain', 'facility': 'Hospital Virgen de la Macarena', 'geoPoint': {'lat': 37.38283, 'lon': -5.97317}}, {'zip': '38320', 'city': 'San Cristóbal de La Laguna', 'state': 'Tenerife', 'country': 'Spain', 'facility': 'Hospital Universitario de Canarias', 'geoPoint': {'lat': 28.4853, 'lon': -16.32014}}, {'zip': '38010', 'city': 'Santa Cruz de Tenerife', 'state': 'Tenerife', 'country': 'Spain', 'facility': 'Hospital Universitario de la Candelaria', 'geoPoint': {'lat': 28.46824, 'lon': -16.25462}}, {'zip': '44600', 'city': 'Alcañiz', 'state': 'Teruel', 'country': 'Spain', 'facility': 'Hospital de Alcañiz', 'geoPoint': {'lat': 41.05, 'lon': -0.13333}}, {'zip': '46014', 'city': 'Valencia', 'state': 'Valencia', 'country': 'Spain', 'facility': 'Hospital General Universitario de Valencia', 'geoPoint': {'lat': 39.47391, 'lon': -0.37966}}, {'zip': '46017', 'city': 'Valencia', 'state': 'Valencia', 'country': 'Spain', 'facility': 'Hospital Dr.Peset', 'geoPoint': {'lat': 39.47391, 'lon': -0.37966}}, {'zip': '47005', 'city': 'Valladolid', 'state': 'Valladolid', 'country': 'Spain', 'facility': 'Hospital Clínico de Valladolid', 'geoPoint': {'lat': 41.65541, 'lon': -4.72353}}, {'zip': '47012', 'city': 'Valladolid', 'state': 'Valladolid', 'country': 'Spain', 'facility': 'Hospital Universitario Rio Hortega', 'geoPoint': {'lat': 41.65541, 'lon': -4.72353}}, {'zip': '48960', 'city': 'Galdakao', 'state': 'Vizcaya', 'country': 'Spain', 'facility': 'Hospital de Galdakao', 'geoPoint': {'lat': 43.23073, 'lon': -2.8429}}, {'zip': '49021', 'city': 'Zamora', 'state': 'Zamora', 'country': 'Spain', 'facility': 'Hospital de Zamora', 'geoPoint': {'lat': 41.50633, 'lon': -5.74456}}, {'zip': '01009', 'city': 'Vitoria-Gasteiz', 'state': 'Álava', 'country': 'Spain', 'facility': 'Hospital de Txagorritxu', 'geoPoint': {'lat': 42.84998, 'lon': -2.67268}}], 'overallOfficials': [{'name': 'Mª Helena López Ceballos, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Hospital San Pedro Alcántara'}, {'name': 'Santiago González Santiago, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Hospital San Pedro Alcántara'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Asociación Cacereña para la Investigación y el Desarrollo en Oncología Médica', 'class': 'NETWORK'}, 'responsibleParty': {'type': 'SPONSOR'}}}}