Ignite Creation Date:
2025-12-25 @ 3:21 AM
Ignite Modification Date:
2026-01-08 @ 12:48 PM
Study NCT ID:
NCT03261505
Status:
COMPLETED
Last Update Posted:
2025-11-05
First Post:
2017-08-22
Is NOT Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Mechanistic Studies on Video-guided Acupuncture Imagery Treatment of Knee Pain
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D020370', 'term': 'Osteoarthritis, Knee'}, {'id': 'D010003', 'term': 'Osteoarthritis'}], 'ancestors': [{'id': 'D001168', 'term': 'Arthritis'}, {'id': 'D007592', 'term': 'Joint Diseases'}, {'id': 'D009140', 'term': 'Musculoskeletal Diseases'}, {'id': 'D012216', 'term': 'Rheumatic Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D015670', 'term': 'Acupuncture Therapy'}], 'ancestors': [{'id': 'D000529', 'term': 'Complementary Therapies'}, {'id': 'D013812', 'term': 'Therapeutics'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'kongj@nmr.mgh.harvard.edu', 'phone': '16179620978', 'title': 'Prof. Jian Kong', 'organization': 'Massachusetts General Hospital'}, 'certainAgreement': {'piSponsorEmployee': False, 'restrictiveAgreement': False}}, 'adverseEventsModule': {'timeFrame': 'Through the whole interventions, average about one month.', 'eventGroups': [{'id': 'EG000', 'title': 'VGAIT', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.', 'otherNumAtRisk': 30, 'deathsNumAtRisk': 30, 'otherNumAffected': 0, 'seriousNumAtRisk': 30, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG001', 'title': 'VGAIT Control', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.', 'otherNumAtRisk': 30, 'deathsNumAtRisk': 30, 'otherNumAffected': 0, 'seriousNumAtRisk': 30, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG002', 'title': 'Real Acupuncture', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.', 'otherNumAtRisk': 34, 'deathsNumAtRisk': 34, 'otherNumAffected': 1, 'seriousNumAtRisk': 34, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG003', 'title': 'Sham Acupuncture', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.', 'otherNumAtRisk': 31, 'deathsNumAtRisk': 31, 'otherNumAffected': 0, 'seriousNumAtRisk': 31, 'deathsNumAffected': 0, 'seriousNumAffected': 0}], 'otherEvents': [{'term': 'Ringing of ear', 'notes': 'The subject experienced ear ring after MRI. It is not related to acupuncture treatment as the subject did not receive acupuncture treatment yet. The subject recovered without treatment.', 'stats': [{'groupId': 'EG000', 'numAtRisk': 30, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 30, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 34, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 31, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Ear and labyrinth disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT'}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'fMRI Signal Increases', 'denoms': [{'units': 'Participants', 'counts': [{'value': '23', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '24', 'groupId': 'OG002'}, {'value': '25', 'groupId': 'OG003'}]}], 'groups': [{'id': 'OG000', 'title': 'VGAIT', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.'}, {'id': 'OG001', 'title': 'VGAIT Control', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.'}, {'id': 'OG002', 'title': 'Real Acupuncture', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.'}, {'id': 'OG003', 'title': 'Sham Acupuncture', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.'}], 'classes': [{'categories': [{'measurements': [{'value': '.42', 'spread': '.27', 'groupId': 'OG000'}, {'value': '.48', 'spread': '.47', 'groupId': 'OG001'}, {'value': '.47', 'spread': '.37', 'groupId': 'OG002'}, {'value': '.33', 'spread': '.32', 'groupId': 'OG003'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Collected once during the first treatment session', 'description': 'fMRI measures changes in brain activity by detecting fluctuations in blood oxygenation levels. The primary signal used in fMRI is the Blood Oxygen Level Dependent (BOLD) signal, which reflects neuronal activity indirectly through hemodynamic responses.', 'unitOfMeasure': 'beta value of bold signal', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'SPM 12 was applied to investigate the brain responses to different interactions. Group analysis was performed using a random-effects model. A one-sample t-test was performed to compare the fMRI signal changes during manipulation vs. no manipulation within each treatment. Thresholds of p \\< 0.005 were applied. Peak values of fMRI signal increase brain regions (insula) were used for the report below.'}, {'type': 'SECONDARY', 'title': 'PAG Resting State Connectivity', 'denoms': [{'units': 'Participants', 'counts': [{'value': '22', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '21', 'groupId': 'OG002'}, {'value': '25', 'groupId': 'OG003'}]}], 'groups': [{'id': 'OG000', 'title': 'VGAIT', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.'}, {'id': 'OG001', 'title': 'VGAIT Control', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.'}, {'id': 'OG002', 'title': 'Real Acupuncture', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.'}, {'id': 'OG003', 'title': 'Sham Acupuncture', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.'}], 'classes': [{'categories': [{'measurements': [{'value': '.09', 'spread': '.13', 'groupId': 'OG000'}, {'value': '.09', 'spread': '.1', 'groupId': 'OG001'}, {'value': '.1', 'spread': '.08', 'groupId': 'OG002'}, {'value': '.08', 'spread': '.12', 'groupId': 'OG003'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'baseline and after one month treatment', 'description': 'The resting state functional connectivity of periaqueduct grey (PAG) before and after intervention. Resting-state functional connectivity (rsFC) is assessed by analyzing spontaneous BOLD signal fluctuations in different brain regions when a subject is at rest, providing insights into intrinsic brain network organization. Preprocessing steps, including motion correction, spatial normalization, and noise removal, ensure data accuracy.', 'unitOfMeasure': 'normalized correlation coefficient', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'The functional connectivity analysis was performed using CONN toolbox. A threshold of p \\< 0.005 was applied. We used peak brain regions showing significant functional connectivity increases after interventions to report (i.e. for VGAIT, insula was used; for VGAIT control, hippocampus was used; for verum acupuncture, insula was used; for sham acupuncture, prefrontal cortex was used). Please note this is NOT a result, rather a description on analysis details.'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'VGAIT', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.'}, {'id': 'FG001', 'title': 'VGAIT Control', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.'}, {'id': 'FG002', 'title': 'Real Acupuncture', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.'}, {'id': 'FG003', 'title': 'Sham Acupuncture', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '30'}, {'groupId': 'FG001', 'numSubjects': '30'}, {'groupId': 'FG002', 'numSubjects': '34'}, {'groupId': 'FG003', 'numSubjects': '31'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '27'}, {'groupId': 'FG001', 'numSubjects': '27'}, {'groupId': 'FG002', 'numSubjects': '27'}, {'groupId': 'FG003', 'numSubjects': '28'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '3'}, {'groupId': 'FG001', 'numSubjects': '3'}, {'groupId': 'FG002', 'numSubjects': '7'}, {'groupId': 'FG003', 'numSubjects': '3'}]}], 'dropWithdraws': [{'type': 'Withdrawal by Subject', 'reasons': [{'groupId': 'FG000', 'numSubjects': '2'}, {'groupId': 'FG001', 'numSubjects': '3'}, {'groupId': 'FG002', 'numSubjects': '4'}, {'groupId': 'FG003', 'numSubjects': '3'}]}, {'type': 'unrelated surgery preventing the subject participating the study', 'reasons': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '1'}, {'groupId': 'FG003', 'numSubjects': '0'}]}, {'type': 'Claustrophobic or can not provide proof of diagnosis', 'reasons': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '2'}, {'groupId': 'FG003', 'numSubjects': '0'}]}, {'type': 'the subject can not concentrate to complete the questionnaire', 'reasons': [{'groupId': 'FG000', 'numSubjects': '1'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '0'}]}]}]}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '30', 'groupId': 'BG000'}, {'value': '30', 'groupId': 'BG001'}, {'value': '34', 'groupId': 'BG002'}, {'value': '31', 'groupId': 'BG003'}, {'value': '125', 'groupId': 'BG004'}]}], 'groups': [{'id': 'BG000', 'title': 'VGAIT', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.'}, {'id': 'BG001', 'title': 'VGAIT Control', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.'}, {'id': 'BG002', 'title': 'Real Acupuncture', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.'}, {'id': 'BG003', 'title': 'Sham Acupuncture', 'description': 'Acupuncture: Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.'}, {'id': 'BG004', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Categorical', 'classes': [{'categories': [{'title': '<=18 years', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}]}, {'title': 'Between 18 and 65 years', 'measurements': [{'value': '19', 'groupId': 'BG000'}, {'value': '24', 'groupId': 'BG001'}, {'value': '24', 'groupId': 'BG002'}, {'value': '22', 'groupId': 'BG003'}, {'value': '89', 'groupId': 'BG004'}]}, {'title': '>=65 years', 'measurements': [{'value': '11', 'groupId': 'BG000'}, {'value': '6', 'groupId': 'BG001'}, {'value': '10', 'groupId': 'BG002'}, {'value': '9', 'groupId': 'BG003'}, {'value': '36', 'groupId': 'BG004'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '61.5', 'spread': '8.2', 'groupId': 'BG000'}, {'value': '59.7', 'spread': '7.8', 'groupId': 'BG001'}, {'value': '59.7', 'spread': '7.6', 'groupId': 'BG002'}, {'value': '61.6', 'spread': '7.4', 'groupId': 'BG003'}, {'value': '60.6', 'spread': '7.7', 'groupId': 'BG004'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'year', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '17', 'groupId': 'BG000'}, {'value': '20', 'groupId': 'BG001'}, {'value': '22', 'groupId': 'BG002'}, {'value': '20', 'groupId': 'BG003'}, {'value': '79', 'groupId': 'BG004'}]}, {'title': 'Male', 'measurements': [{'value': '13', 'groupId': 'BG000'}, {'value': '10', 'groupId': 'BG001'}, {'value': '12', 'groupId': 'BG002'}, {'value': '11', 'groupId': 'BG003'}, {'value': '46', 'groupId': 'BG004'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race (NIH/OMB)', 'classes': [{'categories': [{'title': 'American Indian or Alaska Native', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '1', 'groupId': 'BG004'}]}, {'title': 'Asian', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '2', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '1', 'groupId': 'BG003'}, {'value': '4', 'groupId': 'BG004'}]}, {'title': 'Native Hawaiian or Other Pacific Islander', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}]}, {'title': 'Black or African American', 'measurements': [{'value': '3', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '5', 'groupId': 'BG002'}, {'value': '3', 'groupId': 'BG003'}, {'value': '12', 'groupId': 'BG004'}]}, {'title': 'White', 'measurements': [{'value': '26', 'groupId': 'BG000'}, {'value': '27', 'groupId': 'BG001'}, {'value': '27', 'groupId': 'BG002'}, {'value': '26', 'groupId': 'BG003'}, {'value': '106', 'groupId': 'BG004'}]}, {'title': 'More than one race', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '1', 'groupId': 'BG004'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '1', 'groupId': 'BG003'}, {'value': '1', 'groupId': 'BG004'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Region of Enrollment', 'classes': [{'title': 'United States', 'categories': [{'measurements': [{'value': '30', 'groupId': 'BG000'}, {'value': '30', 'groupId': 'BG001'}, {'value': '34', 'groupId': 'BG002'}, {'value': '31', 'groupId': 'BG003'}, {'value': '125', 'groupId': 'BG004'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'participants'}]}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2023-02-28', 'size': 368178, 'label': 'Study Protocol', 'hasIcf': False, 'hasSap': False, 'filename': 'Prot_000.pdf', 'typeAbbrev': 'Prot', 'uploadDate': '2025-10-20T17:23', 'hasProtocol': True}, {'date': '2023-11-08', 'size': 145436, 'label': 'Statistical Analysis Plan', 'hasIcf': False, 'hasSap': True, 'filename': 'SAP_001.pdf', 'typeAbbrev': 'SAP', 'uploadDate': '2025-10-20T17:22', 'hasProtocol': False}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['PARTICIPANT']}, 'primaryPurpose': 'BASIC_SCIENCE', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 125}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2019-08-04', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-10', 'completionDateStruct': {'date': '2023-08-31', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2025-10-21', 'studyFirstSubmitDate': '2017-08-22', 'resultsFirstSubmitDate': '2023-12-08', 'studyFirstSubmitQcDate': '2017-08-24', 'lastUpdatePostDateStruct': {'date': '2025-11-05', 'type': 'ESTIMATED'}, 'resultsFirstSubmitQcDate': '2025-10-21', 'studyFirstPostDateStruct': {'date': '2017-08-25', 'type': 'ACTUAL'}, 'resultsFirstPostDateStruct': {'date': '2025-11-05', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2023-08-29', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'fMRI Signal Increases', 'timeFrame': 'Collected once during the first treatment session', 'description': 'fMRI measures changes in brain activity by detecting fluctuations in blood oxygenation levels. The primary signal used in fMRI is the Blood Oxygen Level Dependent (BOLD) signal, which reflects neuronal activity indirectly through hemodynamic responses.'}], 'secondaryOutcomes': [{'measure': 'PAG Resting State Connectivity', 'timeFrame': 'baseline and after one month treatment', 'description': 'The resting state functional connectivity of periaqueduct grey (PAG) before and after intervention. Resting-state functional connectivity (rsFC) is assessed by analyzing spontaneous BOLD signal fluctuations in different brain regions when a subject is at rest, providing insights into intrinsic brain network organization. Preprocessing steps, including motion correction, spatial normalization, and noise removal, ensure data accuracy.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['fMRI', 'acupuncture', 'osteoarthritis'], 'conditions': ['Osteoarthritis, Knee']}, 'descriptionModule': {'briefSummary': 'The aim of this study is to investigate brain response and connectivity changes evoked by video-guided acupuncture imagery treatment (VGAIT) and verum and sham acupuncture in knee osteoarthritis patients to elucidate the underlying brain mechanisms of mind-body interaction, imagery, and acupuncture.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '70 Years', 'minimumAge': '40 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Right-handed\n* Knee osteoarthritis patients\n* Ages 40 to 70 years old\n\nExclusion Criteria:\n\n* Any contraindications to MRI scanning (claustrophobia, metal implants)\n* Current or past history of major medical, neurological, or psychiatric illness other than knee osteoarthritis (including high blood pressure, heart disorders, impaired elimination, stomach problems, major kidney or liver problems, bleeding problems, severe dehydration, history of diabetes, history of asthma or other respiratory condition)\n* Pregnancy\n* Non fluent English speaker'}, 'identificationModule': {'nctId': 'NCT03261505', 'briefTitle': 'Mechanistic Studies on Video-guided Acupuncture Imagery Treatment of Knee Pain', 'organization': {'class': 'OTHER', 'fullName': 'Massachusetts General Hospital'}, 'officialTitle': 'Mechanistic Studies on Video-guided Acupuncture Imagery Treatment of Knee Pain', 'orgStudyIdInfo': {'id': '2017P000820'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'VGAIT', 'interventionNames': ['Device: Acupuncture']}, {'type': 'SHAM_COMPARATOR', 'label': 'VGAIT Control', 'interventionNames': ['Device: Acupuncture']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Real Acupuncture', 'interventionNames': ['Device: Acupuncture']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Sham Acupuncture', 'interventionNames': ['Device: Acupuncture']}], 'interventions': [{'name': 'Acupuncture', 'type': 'DEVICE', 'otherNames': ['Video of Acupuncture'], 'description': 'Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.', 'armGroupLabels': ['Real Acupuncture', 'Sham Acupuncture', 'VGAIT', 'VGAIT Control']}]}, 'contactsLocationsModule': {'locations': [{'zip': '02129', 'city': 'Charlestown', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Athinoula A. Martinos Center for Biomedical Imaging', 'geoPoint': {'lat': 42.37787, 'lon': -71.062}}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Massachusetts General Hospital', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Assistant Professor', 'investigatorFullName': 'Jian Kong', 'investigatorAffiliation': 'Massachusetts General Hospital'}}}}