Ignite Creation Date:
2025-12-25 @ 3:08 AM
Ignite Modification Date:
2025-12-31 @ 4:36 PM
Study NCT ID:
NCT00519805
Status:
UNKNOWN
Last Update Posted:
2011-08-08
First Post:
2007-08-21
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Dalteparin in Preventing Blood Clots in Patients With Lung Cancer
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D008175', 'term': 'Lung Neoplasms'}, {'id': 'D013923', 'term': 'Thromboembolism'}, {'id': 'D002289', 'term': 'Carcinoma, Non-Small-Cell Lung'}], 'ancestors': [{'id': 'D012142', 'term': 'Respiratory Tract Neoplasms'}, {'id': 'D013899', 'term': 'Thoracic Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}, {'id': 'D016769', 'term': 'Embolism and Thrombosis'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D002283', 'term': 'Carcinoma, Bronchogenic'}, {'id': 'D001984', 'term': 'Bronchial Neoplasms'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D017985', 'term': 'Dalteparin'}], 'ancestors': [{'id': 'D006495', 'term': 'Heparin, Low-Molecular-Weight'}, {'id': 'D006493', 'term': 'Heparin'}, {'id': 'D006025', 'term': 'Glycosaminoglycans'}, {'id': 'D011134', 'term': 'Polysaccharides'}, {'id': 'D002241', 'term': 'Carbohydrates'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'SUPPORTIVE_CARE'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 2200}}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2007-08'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2008-03', 'lastUpdateSubmitDate': '2011-08-05', 'studyFirstSubmitDate': '2007-08-21', 'studyFirstSubmitQcDate': '2007-08-21', 'lastUpdatePostDateStruct': {'date': '2011-08-08', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2007-08-23', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2012-08', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Overall survival'}], 'secondaryOutcomes': [{'measure': 'Venous thrombotic event-free survival'}, {'measure': 'Serious adverse events'}, {'measure': 'Metastasis-free survival'}, {'measure': 'Toxicity'}, {'measure': 'Quality of life as measured by EQ-5D'}, {'measure': 'Breathlessness (dyspnea) as measured by the Cancer Dyspnea Scale'}, {'measure': 'Anxiety and depression as measured by the Hospital Anxiety and Depression Scale'}, {'measure': 'Cost effectiveness'}, {'measure': 'Cost utility'}]}, 'conditionsModule': {'keywords': ['thromboembolism', 'extensive stage small cell lung cancer', 'limited stage small cell lung cancer', 'stage IV non-small cell lung cancer', 'stage II non-small cell lung cancer', 'stage IIIA non-small cell lung cancer', 'stage IIIB non-small cell lung cancer', 'stage I non-small cell lung cancer'], 'conditions': ['Lung Cancer', 'Thromboembolism']}, 'referencesModule': {'references': [{'pmid': '19807917', 'type': 'RESULT', 'citation': 'Griffiths GO, Burns S, Noble SI, Macbeth FR, Cohen D, Maughan TS. FRAGMATIC: a randomised phase III clinical trial investigating the effect of fragmin added to standard therapy in patients with lung cancer. BMC Cancer. 2009 Oct 6;9:355. doi: 10.1186/1471-2407-9-355.'}, {'pmid': '33337539', 'type': 'DERIVED', 'citation': 'Rutjes AW, Porreca E, Candeloro M, Valeriani E, Di Nisio M. Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy. Cochrane Database Syst Rev. 2020 Dec 18;12(12):CD008500. doi: 10.1002/14651858.CD008500.pub5.'}]}, 'descriptionModule': {'briefSummary': 'RATIONALE: Anticoagulants, such as dalteparin, may help prevent blood clots from forming in patients with lung cancer. It is not yet known whether dalteparin is effective in preventing blood clots in patients with lung cancer.\n\nPURPOSE: This randomized phase III trial is studying how well dalteparin works in preventing blood clots in patients with lung cancer.', 'detailedDescription': 'OBJECTIVES:\n\nPrimary\n\n* Determine whether the addition of dalteparin results in improved survival.\n\nSecondary\n\n* Determine venous thrombotic event-free survival and metastasis-free survival.\n* Determine serious adverse events in patients treated with this drug.\n* Determine the toxicity of this drug in these patients.\n* Determine the quality of life, breathlessness, anxiety, and depression in patients treated with this drug.\n* Determine the cost effectiveness and cost utility of this drug.\n\nOUTLINE: This is a multicenter study. Patients are randomized to 1 of 2 treatment arms.\n\n* Arm I (control): Patients receive anticancer treatment considered appropriate by the local medical team.\n* Arm II: Patients receive anticancer treatment considered appropriate by the local medical team. Beginning before the start of the first definitive anticancer treatment, patients receive dalteparin subcutaneously daily for up to 24 weeks.\n\nQuality of life, anxiety, depression, and dyspnea are assessed at baseline, at 12 and 24 weeks, and then at 9 and 12 months.\n\nAfter completion of therapy, patients are followed at 9 months, 1 year, and then every 6 months for at least 2 years.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'DISEASE CHARACTERISTICS:\n\n* Histopathological or cytological diagnosis of primary bronchial carcinoma (small cell or non-small cell lung cancer) within the past 6 weeks\n* No other intrathoracic tumors (e.g., carcinoid tumor, mesothelioma, lymphoma, or lung metastases from another primary site)\n* No clinically apparent brain metastases\n\nPATIENT CHARACTERISTICS:\n\n* ECOG performance status 0-3\n* Platelet count ≥ 100,000/mm³\n* Serum creatinine ≤ 150 µmol/L\n* Willing and able to self-administer dalteparin by daily subcutaneous injection or have it administered by a caregiver\n* Not pregnant or nursing\n* Fertile female patients must use effective contraception (if sexually active)\n* No hemorrhagic stroke within the past 3 months\n* No known bleeding disorder\n* No hemoptysis of CTC ≥ grade 2 (i.e., symptomatic hemoptysis requiring medical intervention)\n* No central venous catheter requiring the use of thromboprophylaxis\n* No known hypersensitivity to dalteparin, heparin, or other low molecular weight heparins (e.g., history of confirmed or suspected immunologically mediated heparin-induced thrombocytopenia; acute gastroduodenal ulcer; or subacute endocarditis)\n* No prior illness likely to interfere with study treatment or comparisons\n\nPRIOR CONCURRENT THERAPY:\n\n* No prior treatment likely to interfere with study treatment or comparisons\n* More than 12 months since prior and no concurrent therapeutic anticoagulation\n* No concurrent ketorolac (Toradol®)'}, 'identificationModule': {'nctId': 'NCT00519805', 'briefTitle': 'Dalteparin in Preventing Blood Clots in Patients With Lung Cancer', 'organization': {'class': 'NIH', 'fullName': 'National Cancer Institute (NCI)'}, 'officialTitle': 'FRAGMATIC - A Randomised Phase III Clinical Trial Investigating the Effect of FRAGMin Added to Standard Therapy In Patients With Lung Cancer', 'orgStudyIdInfo': {'id': 'CDR0000561532'}, 'secondaryIdInfos': [{'id': 'WCTU-FRAGMATIC'}, {'id': 'Velindre-FRAGMATIC'}, {'id': 'WCTU-02'}, {'id': 'EU-20753'}, {'id': 'PFIZER-WCTU-02'}, {'id': 'EUDRACT-2005-002438-37'}, {'id': 'ISRCTN80812769'}]}, 'armsInterventionsModule': {'interventions': [{'name': 'dalteparin', 'type': 'DRUG'}, {'name': 'quality-of-life assessment', 'type': 'PROCEDURE'}]}, 'contactsLocationsModule': {'locations': [{'zip': 'HP21 8AL', 'city': 'Aylesbury-Buckinghamshire', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Nicholas Bates, MD', 'role': 'CONTACT', 'phone': '44-1296-316-555'}], 'facility': 'Stoke Mandeville Hospital'}, {'zip': 'LA14 4LF', 'city': 'Barrow in Furness', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'David Fyfe, MD', 'role': 'CONTACT', 'phone': '44-1524-583-510'}], 'facility': 'Furness General Hospital', 'geoPoint': {'lat': 54.11094, 'lon': -3.22758}}, {'zip': 'BB2 3HH', 'city': 'Blackburn', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Wiebke Appel, MD, FRCR, MRCP', 'role': 'CONTACT', 'phone': '44-1772-522-792'}], 'facility': 'Royal Blackburn Hospital', 'geoPoint': {'lat': 53.75, 'lon': -2.48333}}, {'zip': 'FY3 8NR', 'city': 'Blackpool', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Andrew C. Hindley, MD', 'role': 'CONTACT', 'email': 'andrew.hindley@lthtr.nhs.uk', 'phone': '44-177-252-2908'}], 'facility': 'Blackpool Victoria Hospital', 'geoPoint': {'lat': 53.81667, 'lon': -3.05}}, {'zip': 'BH7 7DW', 'city': 'Bournemouth', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Tom Geldart', 'role': 'CONTACT', 'phone': '44-1202-726-088'}], 'facility': 'Royal Bournemouth Hospital', 'geoPoint': {'lat': 50.72048, 'lon': -1.8795}}, {'zip': 'BS2 8ED', 'city': 'Bristol', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Stephen J. Falk, MD', 'role': 'CONTACT', 'email': 'stephen.falk@ubht.nhs.uk', 'phone': '44-1935-384-559'}], 'facility': 'Bristol Haematology and Oncology Centre', 'geoPoint': {'lat': 51.45523, 'lon': -2.59665}}, {'zip': 'BB10 2PQ', 'city': 'Burnley', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Wiebke Appel, MD, FRCR, MRCP', 'role': 'CONTACT', 'phone': '44-772-522-792'}], 'facility': 'Burnley General Hospital', 'geoPoint': {'lat': 53.8, 'lon': -2.23333}}, {'zip': 'DE13 0RB', 'city': 'Burton-on-Trent', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'A.D. Chetiyawardana, MD', 'role': 'CONTACT', 'phone': '44-283-566-333'}], 'facility': "Queen's Hospital", 'geoPoint': {'lat': 52.80728, 'lon': -1.64263}}, {'zip': 'IP33 2QZ', 'city': 'Bury St Edmunds', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Contact Person', 'role': 'CONTACT', 'phone': '44-1284-713-195'}], 'facility': 'West Suffolk Hospital', 'geoPoint': {'lat': 52.2463, 'lon': 0.71111}}, {'zip': 'CV2 2DX', 'city': 'Coventry', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Caroline Humber, MD', 'role': 'CONTACT', 'phone': '44-2476-967-478'}], 'facility': 'Walsgrave Hospital', 'geoPoint': {'lat': 52.40656, 'lon': -1.51217}}, {'zip': 'DL3 6HX', 'city': 'Darlington', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Clive Peedell, MD', 'role': 'CONTACT', 'phone': '44-1643-850-850'}], 'facility': 'Darlington Memorial', 'geoPoint': {'lat': 54.52429, 'lon': -1.55039}}, {'zip': 'DE1 2QY', 'city': 'Derby', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Muthu Kumar, MD', 'role': 'CONTACT', 'email': 'muthu.kumar@derbyhospitals.nhs.uk', 'phone': '44-1332-347-141 ext. 2437'}], 'facility': 'Derbyshire Royal Infirmary', 'geoPoint': {'lat': 52.92277, 'lon': -1.47663}}, {'zip': 'DN2 5LT', 'city': 'Doncaster', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Contact Person', 'role': 'CONTACT', 'phone': '44-130-236-6666'}], 'facility': 'Doncaster Royal Infirmary', 'geoPoint': {'lat': 53.52285, 'lon': -1.13116}}, {'zip': 'DT1 2JY', 'city': 'Dorchester', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Mike Bayne, MD', 'role': 'CONTACT', 'phone': '44-1202-448-648'}], 'facility': 'Dorset County Hospital', 'geoPoint': {'lat': 50.71667, 'lon': -2.43333}}, {'zip': 'DY1 2HQ', 'city': 'Dudley', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Simon Grumett, MD', 'role': 'CONTACT', 'phone': '44-384-456-111'}], 'facility': 'Russells Hall Hospital', 'geoPoint': {'lat': 52.5, 'lon': -2.08333}}, {'zip': 'NE9 6SX', 'city': 'Gateshead', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Fiona McDonald, MD', 'role': 'CONTACT', 'phone': '44-191-256-3567'}], 'facility': 'Queen Elizabeth Hospital', 'geoPoint': {'lat': 54.96209, 'lon': -1.60168}}, {'city': 'High Wycombe', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Nicholas Bates, MD', 'role': 'CONTACT', 'phone': '44-865-225-601'}], 'facility': 'Wycombe General Hospital', 'geoPoint': {'lat': 51.62907, 'lon': -0.74934}}, {'zip': 'DY11 6RJ', 'city': 'Kidderminster Worcestershire', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Contact Person', 'role': 'CONTACT', 'phone': '44-1562-513-093'}], 'facility': 'Kidderminster Hospital'}, {'zip': 'LA1 4RP', 'city': 'Lancaster', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'David Fyfe, MD', 'role': 'CONTACT', 'phone': '44-1524-583-510'}], 'facility': 'Royal Lancaster Infirmary', 'geoPoint': {'lat': 54.04649, 'lon': -2.79988}}, {'zip': 'E11 1NR', 'city': 'London', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Paula Wells, MD', 'role': 'CONTACT', 'phone': '44-20-7601-8044'}], 'facility': 'Whipps Cross Hospital', 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'zip': 'EC1A 7BE', 'city': 'London', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Paula Wells, MD', 'role': 'CONTACT', 'phone': '44-207-601-8044'}], 'facility': "Saint Bartholomew's Hospital", 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'zip': 'N18 1QX', 'city': 'London', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Contact Person', 'role': 'CONTACT', 'phone': '44-20-7472-6115'}], 'facility': 'Helen Rollason Cancer Care Centre at North Middlesex Hospital', 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'zip': 'N19 5NF', 'city': 'London', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Siow M. Lee, MD, PhD, FRCP', 'role': 'CONTACT', 'phone': '44-20-7288-5227'}], 'facility': 'Whittington Hospital', 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'zip': 'NW1 2PG', 'city': 'London', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Siow M. Lee, MD, PhD, FRCP', 'role': 'CONTACT', 'email': 'sm.lee@uclh.org', 'phone': '44-20-7288-5227'}], 'facility': 'University College Hospital', 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'zip': 'NW3 2QG', 'city': 'London', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Contact Person', 'role': 'CONTACT', 'phone': '44-20-7472-6115'}], 'facility': 'UCL Cancer Institute', 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'zip': 'LU4 0DZ', 'city': 'Luton', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Contact Person', 'role': 'CONTACT', 'phone': '44-1582-497-513'}], 'facility': 'Luton and Dunstable Hospital', 'geoPoint': {'lat': 51.87967, 'lon': -0.41748}}, {'zip': 'TS4 3BW', 'city': 'Middlesbrough', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Clive Peedell, MD', 'role': 'CONTACT', 'phone': '44-643-850-850'}], 'facility': 'James Cook University Hospital', 'geoPoint': {'lat': 54.57623, 'lon': -1.23483}}, {'zip': 'MK6 5LD', 'city': 'Milton Keynes', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Hany Eldeeb, MD', 'role': 'CONTACT', 'phone': '44-1604-523-815'}], 'facility': 'Milton Keynes General Hospital', 'geoPoint': {'lat': 52.04172, 'lon': -0.75583}}, {'zip': 'NE7 7DN', 'city': 'Newcastle upon Tyne', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Contact Person', 'role': 'CONTACT', 'phone': '44-191-256-3555'}], 'facility': 'Newcastle Upon Tyne Hospitals NHS Trust', 'geoPoint': {'lat': 54.97328, 'lon': -1.61396}}, {'zip': 'NR31 6LA', 'city': 'Norfolk', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Contact Person', 'role': 'CONTACT', 'phone': '44-1603-287-674'}], 'facility': 'James Paget Hospital'}, {'zip': 'NE29 8NH', 'city': 'North Shields', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Contact Person', 'role': 'CONTACT', 'phone': '44-191-256-3555'}], 'facility': 'North Tyneside Hospital', 'geoPoint': {'lat': 55.01646, 'lon': -1.44925}}, {'zip': 'DL6 1JG', 'city': 'North Yorks', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Clive Peedell, MD', 'role': 'CONTACT', 'phone': '44-643-850-850'}], 'facility': 'Friarage Hospital', 'geoPoint': {'lat': 54.07369, 'lon': -0.95032}}, {'zip': 'NN1 5BD', 'city': 'Northampton', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Contact Person', 'role': 'CONTACT', 'phone': '44-1604-543-789'}], 'facility': 'Northampton General Hospital', 'geoPoint': {'lat': 52.25, 'lon': -0.88333}}, {'zip': 'HA6 2RN', 'city': 'Northwood', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Jeanette Dickson, MD', 'role': 'CONTACT', 'email': 'jeanette.dickson@nhs.net', 'phone': '44-923-844-551'}], 'facility': 'Mount Vernon Cancer Centre at Mount Vernon Hospital', 'geoPoint': {'lat': 51.61162, 'lon': -0.42454}}, {'zip': 'NR4 7UY', 'city': 'Norwich', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Tom W. Roques, MD', 'role': 'CONTACT', 'email': 'tom.roques@nnuh.nhs.uk', 'phone': '44-603-287-671'}], 'facility': 'Norfolk and Norwich University Hospital', 'geoPoint': {'lat': 52.62783, 'lon': 1.29834}}, {'zip': 'NG5 1PB', 'city': 'Nottingham', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Contact Person', 'role': 'CONTACT', 'phone': '44-115-969-1169'}], 'facility': 'Nottingham City Hospital', 'geoPoint': {'lat': 52.9536, 'lon': -1.15047}}, {'zip': 'CV10 7DJ', 'city': 'Nuneaton', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Mark Hocking, MD', 'role': 'CONTACT', 'phone': '44-2476-967-490'}], 'facility': 'George Eliot Hospital', 'geoPoint': {'lat': 52.52323, 'lon': -1.46523}}, {'zip': 'PL6 8DH', 'city': 'Plymouth', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Dennis Yiannakis, MD', 'role': 'CONTACT', 'phone': '44-1752-439-103'}], 'facility': 'Derriford Hospital', 'geoPoint': {'lat': 50.37153, 'lon': -4.14305}}, {'zip': 'BH15 2JB', 'city': 'Poole Dorset', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Virginia Laurence, MD', 'role': 'CONTACT', 'phone': '44-1202-448-262'}], 'facility': 'Dorset Cancer Centre'}, {'zip': 'PR2 9HT', 'city': 'Preston', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Geraldine Skailes, MD', 'role': 'CONTACT', 'phone': '44-1772-522-913'}], 'facility': 'Rosemere Cancer Centre at Royal Preston Hospital', 'geoPoint': {'lat': 53.76282, 'lon': -2.70452}}, {'zip': 'RG1 5AN', 'city': 'Reading', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Richard Brown, MD', 'role': 'CONTACT', 'phone': '44-118-322-8343'}], 'facility': 'Berkshire Cancer Centre at Royal Berkshire Hospital', 'geoPoint': {'lat': 51.45625, 'lon': -0.97113}}, {'zip': 'B98 7UB', 'city': 'Redditch, Worcestershire', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Joanna Hamilton, MD', 'role': 'CONTACT', 'phone': '44-2476-967-477'}], 'facility': 'Alexandra Healthcare NHS', 'geoPoint': {'lat': 52.3065, 'lon': -1.94569}}, {'zip': 'YO12 6QL', 'city': 'Scarborough', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Contact Person', 'role': 'CONTACT', 'phone': '44-1482-701-151'}], 'facility': 'Scarborough General Hospital', 'geoPoint': {'lat': 54.27966, 'lon': -0.40443}}, {'zip': 'S1O 2SJ', 'city': 'Sheffield', 'state': 'England', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Penella J. 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