Ignite Creation Date:
2025-12-25 @ 3:03 AM
Ignite Modification Date:
2025-12-26 @ 1:43 AM
Study NCT ID:
NCT00801333
Status:
RECRUITING
Last Update Posted:
2025-03-05
First Post:
2008-12-02
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic Cells
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D000690', 'term': 'Amyotrophic Lateral Sclerosis'}], 'ancestors': [{'id': 'D013118', 'term': 'Spinal Cord Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D016472', 'term': 'Motor Neuron Disease'}, {'id': 'D019636', 'term': 'Neurodegenerative Diseases'}, {'id': 'D057177', 'term': 'TDP-43 Proteinopathies'}, {'id': 'D009468', 'term': 'Neuromuscular Diseases'}, {'id': 'D057165', 'term': 'Proteostasis Deficiencies'}, {'id': 'D008659', 'term': 'Metabolic Diseases'}, {'id': 'D009750', 'term': 'Nutritional and Metabolic Diseases'}]}}, 'protocolSection': {'designModule': {'bioSpec': {'retention': 'SAMPLES_WITH_DNA', 'description': 'Existing banks of collected cells maintained.'}, 'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'OTHER'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 25}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2008-11', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-03', 'completionDateStruct': {'date': '2030-12', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-03-02', 'studyFirstSubmitDate': '2008-12-02', 'studyFirstSubmitQcDate': '2008-12-02', 'lastUpdatePostDateStruct': {'date': '2025-03-05', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2008-12-03', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2030-12', 'type': 'ESTIMATED'}}, 'conditionsModule': {'keywords': ['ALS'], 'conditions': ['Amyotrophic Lateral Sclerosis']}, 'referencesModule': {'references': [{'pmid': '18669821', 'type': 'BACKGROUND', 'citation': 'Dimos JT, Rodolfa KT, Niakan KK, Weisenthal LM, Mitsumoto H, Chung W, Croft GF, Saphier G, Leibel R, Goland R, Wichterle H, Henderson CE, Eggan K. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science. 2008 Aug 29;321(5893):1218-21. doi: 10.1126/science.1158799. Epub 2008 Jul 31.'}]}, 'descriptionModule': {'briefSummary': 'Induced pluripotent stem cells potentially may be useful in the future as an unlimited source of cells for transplantation.\n\nThe major goal of the project is to develop human iPS cells from various types of cell cultures or lines from existing collections. The IPS cells will be developed for modeling diseases, for developing the technology that may eventually allow the use of IPS cells for transplantation therapy, and for basic research.', 'detailedDescription': 'The potential to reprogram somatic cells into an embryonic state raises multiple basic research questions related both to the process of reprogramming and the properties of iPS cells. We will use various approaches to study the molecular mechanisms and processes that occur during reprogramming. We will use various experimental systems to characterize and study the properties of the iPS cells, their biology, developmental potential, capability to give rise to functional differentiated progeny etc.\n\nWe will induce the differentiation of the iPS cells towards specific cell lineages and the progeny can be used to study the pathogenesis of diseases. They will be used for developing new therapeutic approaches and for high throughput screening of factors for potential toxic or therapeutic effects.\n\nAll samples will be non-identified.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'We will use human somatic cells from existing collections.', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Volunteers\n* Male and Female\n\nExclusion Criteria:\n\n* Below the official age of consent'}, 'identificationModule': {'nctId': 'NCT00801333', 'briefTitle': 'Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic Cells', 'organization': {'class': 'OTHER', 'fullName': 'Hadassah Medical Organization'}, 'officialTitle': 'Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic Cells', 'orgStudyIdInfo': {'id': '0511-08-HMO'}}, 'contactsLocationsModule': {'locations': [{'zip': '91120', 'city': 'Jerusalem', 'status': 'RECRUITING', 'country': 'Israel', 'contacts': [{'name': 'Hadas Lemberg, PhD', 'role': 'CONTACT', 'email': 'Lhadas@hadassah.org.il', 'phone': '011-972-2-677-6095'}], 'facility': 'Hadassah Medical Organization - Ein Kerem Campus', 'geoPoint': {'lat': 31.76904, 'lon': 35.21633}}, {'zip': '9112100', 'city': 'Jerusalem', 'status': 'RECRUITING', 'country': 'Israel', 'contacts': [{'name': 'Benjamin E Reubinoff, Professor', 'role': 'CONTACT', 'email': 'benr@hadassah.org.il', 'phone': '972-2-6776424/5'}, {'name': 'Shelly E Tannenbaum, MSQA', 'role': 'CONTACT', 'email': 'stannenbaum@hadassah.org.il', 'phone': '972-2-6777945'}], 'facility': 'Hadassah Ein Kerem', 'geoPoint': {'lat': 31.76904, 'lon': 35.21633}}], 'centralContacts': [{'name': 'Benjamin E. Reubinoff, M.D. PhD.', 'role': 'CONTACT', 'email': 'benjaminr@ekmd.huji.ac.il', 'phone': '011-972-2-677-4569'}, {'name': 'Shelly E Tannenbaum, MSQA', 'role': 'CONTACT', 'email': 'stannenbaum@hadassah.org.il', 'phone': '011-972-2-677-7945'}], 'overallOfficials': [{'name': 'Benjamin E Reubinoff, MD PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Chairman of Department of Obstetrics & Gynecology/IVF, Hadassah Ein Kerem'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Hadassah Medical Organization', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Professor', 'investigatorFullName': 'Benjamin Reubinoff', 'investigatorAffiliation': 'Hadassah Medical Organization'}}}}