Ignite Creation Date:
2025-12-25 @ 3:03 AM
Ignite Modification Date:
2025-12-26 @ 1:43 AM
Study NCT ID:
NCT00001633
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Safety and Effectiveness of Coronary Magnetic Resonance Angiography (CMRA) Imaging
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D003327', 'term': 'Coronary Disease'}, {'id': 'D003324', 'term': 'Coronary Artery Disease'}], 'ancestors': [{'id': 'D017202', 'term': 'Myocardial Ischemia'}, {'id': 'D006331', 'term': 'Heart Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D001161', 'term': 'Arteriosclerosis'}, {'id': 'D001157', 'term': 'Arterial Occlusive Diseases'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'primaryPurpose': 'TREATMENT'}, 'enrollmentInfo': {'count': 20}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '1997-09'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '1999-12', 'completionDateStruct': {'date': '2000-12'}, 'lastUpdateSubmitDate': '2008-03-03', 'studyFirstSubmitDate': '1999-11-03', 'studyFirstSubmitQcDate': '2002-12-09', 'lastUpdatePostDateStruct': {'date': '2008-03-04', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2002-12-10', 'type': 'ESTIMATED'}}, 'conditionsModule': {'keywords': ['Contrast Media', 'Coronary Artery Disease', 'Coronary Vessels', 'Magnetic Resonance Angiography', 'Magnetic Resonance Imaging'], 'conditions': ['Coronary Disease']}, 'descriptionModule': {'briefSummary': 'Magnetic resonance imaging (MRI) is a diagnostic tool that creates high quality images of the human body without the use of X-ray (radiation). MRI is especially useful when studying the arteries of the heart (CMRA, coronary magnetic resonance angiography).\n\nIn this study researchers from several laboratories and hospitals will work together to determine the safety and effectiveness of CMRA with MS-325. MS-325 is a contrast agent. It is given to patients undergoing CRMA in order to improve the appearance of the arteries of the heart.', 'detailedDescription': 'In this multicenter trial, the safety and efficacy of magnetic resonance imaging (MRI) for visualization of the coronary arteries (CMRA, coronary magnetic resonance angiography) with MS-325. MS-325 is a new blood pool radiological contrast agent which will be assessed as part of a phase II feasibility study. The Laboratory of Cardiac Energetics in collaboration with the Department of Cardiology at the George Washington Hospital Center will be one of the six participating sites for this study.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'healthyVolunteers': False, 'eligibilityCriteria': "Male or female greater than or equal to 18 years of age.\n\nBody weight less than or equal to 120 kg.\n\nIf female, be surgically sterile for at least one year, be post-menopausal for at least one year, or test negative on a pregnancy test by urine or blood within 48 hours prior to MS-325 administration.\n\nAbility to comprehend and a willingness to sign an Informed Consent Form.\n\nStable medical condition at time of MS-325 administration with no major clinical cardiovascular events within 30 days of MS-325 administration.\n\nFasted from liquids and solids for two hours prior to MS-325 administration.\n\nMust have a positive diagnostic quality coronary x-ray angiogram which demonstrated coronary artery stenosis(es) of at least 50 percent diameter stenosis in at least one proximal coronary artery vessel between five and 30 days prior to MS-325 administration; angiographic data must be available for loan to an angiographic core lab in order for the patient to be included in the trial.\n\nNormal sinus rhythm.\n\nWilling to abstain from alcohol from 24 hours prior to MS-325 administration through 72-96 hours following MS-325 administration.\n\nNo prior coronary bypass graft or coronary stent of the target vessel.\n\nNo acute or chronic condition which would limit the patient's ability to complete the study.\n\nNo history of claustrophobia.\n\nNo receipt of any investigational drug within 30 days prior to\n\nMS-325 administration.\n\nNo previous exposure to MS-325; no previous exposure to other contrast agents in other contrast enhanced MR or x-ray studies within five days prior to MS-325 administration.\n\nNo major clinical cardiovascular events, coronary angioplasty, or major surgery within 30 days prior to MS-325 administration.\n\nNo scheduled x-ray angiography within five days prior to MS-325 administration.\n\nNo supine blood pressure less than 100/60 mm HG with pulse rate less than 50 beats per minute (bpm), or supine blood pressure greater than 160/100 m HG with pulse rate greater than 100 bpm, unless deemed not clinically significant by the Principal Investigator.\n\nNo history of involuntary motion disorder.\n\nNo persons unable to lay on back for 120 minutes.\n\nNo persons with known serum creatinine levels greater than 1.5 mg/dL or clinical evidence of severe renal impairment; serum creatinine levels must be determined at least 72 hours post-x-ray angiography but prior to MS-325 administration.\n\nNo known SGPT (ALT) and SGOT (AST) levels exceeding three times the upper limit of the study center's normal range; no known serum bilirubin greater than 1.75 mg/dL or clinical evidence of severe hepatic disease.\n\nNo specific magnetic resonance (MR) exclusion criteria (i.e., pacemaker, ear implants, internal defibrillator, internal defibrillator, internal infusion pump), as well as institution-specific requirements.\n\nNo metal implants or clips in field of view (FOV).\n\nNo female who is pregnant or currently lactating.\n\nNo recent history of clinically significant anemia (less than or equal to 8.0 g/dL).\n\nNo history of sickle cell anemia.\n\nNo clinical suspicion of worsening in vascular status of target artery between time of x-ray angiogram and MS-325 administration.\n\nNot received warfarin within seven days prior to MS-325 administration."}, 'identificationModule': {'nctId': 'NCT00001633', 'briefTitle': 'Safety and Effectiveness of Coronary Magnetic Resonance Angiography (CMRA) Imaging', 'organization': {'class': 'NIH', 'fullName': 'National Institutes of Health Clinical Center (CC)'}, 'officialTitle': 'A Phase II Feasibility Study of the Safety and Efficacy of Coronary Magnetic Resonance Angiography (CMRA) Imaging', 'orgStudyIdInfo': {'id': '970193'}, 'secondaryIdInfos': [{'id': '97-H-0193'}]}, 'armsInterventionsModule': {'interventions': [{'name': 'Coronary magnetic resonance angiography imaging', 'type': 'PROCEDURE'}]}, 'contactsLocationsModule': {'locations': [{'zip': '20892', 'city': 'Bethesda', 'state': 'Maryland', 'country': 'United States', 'facility': 'National Heart, Lung and Blood Institute (NHLBI)', 'geoPoint': {'lat': 38.98067, 'lon': -77.10026}}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'National Heart, Lung, and Blood Institute (NHLBI)', 'class': 'NIH'}}}}