Ignite Creation Date:
2025-12-25 @ 2:49 AM
Ignite Modification Date:
2025-12-31 @ 2:41 AM
Study NCT ID:
NCT01245933
Status:
COMPLETED
Last Update Posted:
2024-04-12
First Post:
2010-11-18
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Impact of Systemic Manifestations/Comorbidities on Clinical State, Prognosis, Utilisation of Health Care Resources in Patients With COPD
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D029424', 'term': 'Pulmonary Disease, Chronic Obstructive'}], 'ancestors': [{'id': 'D008173', 'term': 'Lung Diseases, Obstructive'}, {'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}, {'id': 'D002908', 'term': 'Chronic Disease'}, {'id': 'D020969', 'term': 'Disease Attributes'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}}, 'protocolSection': {'designModule': {'bioSpec': {'retention': 'SAMPLES_WITH_DNA', 'description': 'blood urine sputum'}, 'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 2741}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2010-11'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-04', 'completionDateStruct': {'date': '2023-12', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2024-04-11', 'studyFirstSubmitDate': '2010-11-18', 'studyFirstSubmitQcDate': '2010-11-22', 'lastUpdatePostDateStruct': {'date': '2024-04-12', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2010-11-23', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2013-12', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Change from baseline in BODE-Score at 18 months', 'timeFrame': 'at initial visite, after 18, 36, 54, 72, 90 and 108 months', 'description': 'The BODE-Score comprises BMI, airway obstruction, dyspnea and exercise capacity and is a good predictor for death in COPD patients. Progression is defined as a change in BODE-score by \\>=1 point over the observation period.'}], 'secondaryOutcomes': [{'measure': 'COPD related mortality', 'timeFrame': 'after 18 months', 'description': 'The rate of mortality was elevated after 6, 18, 36, 54, 72, 90 and 108 months'}, {'measure': 'COPD related hospitalization', 'timeFrame': 'after 18, 36, 54, 72, 90 and 108 months', 'description': 'The rate of hospitalizations was elevated in every visit.'}]}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'keywords': ['COPD', 'register', 'comorbidities', 'systemic inflammation'], 'conditions': ['Chronic Obstructive Pulmonary Disease (COPD)']}, 'referencesModule': {'availIpds': [{'url': 'http://www.asconet.net', 'type': 'general information'}], 'references': [{'pmid': '20198540', 'type': 'BACKGROUND', 'citation': 'Jorres RA, Welte T, Bals R, Koch A, Schnoor M, Vogelmeier C. [Systemic manifestations and comorbidities in patients with chronic obstructive pulmonary disease (COPD) and their effect on clinical state and course of the disease--an overview of the cohort study COSYCONET]. Dtsch Med Wochenschr. 2010 Mar;135(10):446-9. doi: 10.1055/s-0030-1249185. Epub 2010 Mar 2. German.'}, {'pmid': '26725462', 'type': 'RESULT', 'citation': 'Wacker ME, Jorres RA, Schulz H, Heinrich J, Karrasch S, Karch A, Koch A, Peters A, Leidl R, Vogelmeier C, Holle R; COSYCONET-Consortium. Direct and indirect costs of COPD and its comorbidities: Results from the German COSYCONET study. Respir Med. 2016 Feb;111:39-46. doi: 10.1016/j.rmed.2015.12.001. Epub 2015 Dec 10.'}, {'pmid': '27109808', 'type': 'RESULT', 'citation': 'Karch A, Vogelmeier C, Welte T, Bals R, Kauczor HU, Biederer J, Heinrich J, Schulz H, Glaser S, Holle R, Watz H, Korn S, Adaskina N, Biertz F, Vogel C, Vestbo J, Wouters EF, Rabe KF, Sohler S, Koch A, Jorres RA; COSYCONET Study Group. The German COPD cohort COSYCONET: Aims, methods and descriptive analysis of the study population at baseline. Respir Med. 2016 May;114:27-37. doi: 10.1016/j.rmed.2016.03.008. Epub 2016 Mar 11.'}, {'pmid': '27160582', 'type': 'RESULT', 'citation': 'Wacker ME, Jorres RA, Karch A, Wilke S, Heinrich J, Karrasch S, Koch A, Schulz H, Watz H, Leidl R, Vogelmeier C, Holle R; COSYCONET-Consortium. Assessing health-related quality of life in COPD: comparing generic and disease-specific instruments with focus on comorbidities. BMC Pulm Med. 2016 May 10;16(1):70. doi: 10.1186/s12890-016-0238-9.'}, {'pmid': '27405652', 'type': 'RESULT', 'citation': 'Wacker ME, Jorres RA, Karch A, Koch A, Heinrich J, Karrasch S, Schulz H, Peters A, Glaser S, Ewert R, Baumeister SE, Vogelmeier C, Leidl R, Holle R; COSYCONET study group. Relative impact of COPD and comorbidities on generic health-related quality of life: a pooled analysis of the COSYCONET patient cohort and control subjects from the KORA and SHIP studies. Respir Res. 2016 Jul 12;17(1):81. doi: 10.1186/s12931-016-0401-0.'}, {'pmid': '27792735', 'type': 'RESULT', 'citation': 'Lucke T, Herrera R, Wacker M, Holle R, Biertz F, Nowak D, Huber RM, Sohler S, Vogelmeier C, Ficker JH, Muckter H, Jorres RA; COSYCONET-Consortium. Systematic Analysis of Self-Reported Comorbidities in Large Cohort Studies - A Novel Stepwise Approach by Evaluation of Medication. PLoS One. 2016 Oct 28;11(10):e0163408. doi: 10.1371/journal.pone.0163408. eCollection 2016.'}, {'pmid': '29605197', 'type': 'RESULT', 'citation': 'Alter P, Watz H, Kahnert K, Pfeifer M, Randerath WJ, Andreas S, Waschki B, Kleibrink BE, Welte T, Bals R, Schulz H, Biertz F, Young D, Vogelmeier CF, Jorres RA. Airway obstruction and lung hyperinflation in COPD are linked to an impaired left ventricular diastolic filling. Respir Med. 2018 Apr;137:14-22. doi: 10.1016/j.rmed.2018.02.011. Epub 2018 Feb 19.'}, {'pmid': '28505167', 'type': 'RESULT', 'citation': 'Kahnert K, Lucke T, Huber RM, Behr J, Biertz F, Vogt A, Watz H, Alter P, Fahndrich S, Bals R, Holle R, Karrasch S, Sohler S, Wacker M, Ficker JH, Parhofer KG, Vogelmeier C, Jorres RA; COSYCONET consortium. Relationship of hyperlipidemia to comorbidities and lung function in COPD: Results of the COSYCONET cohort. PLoS One. 2017 May 15;12(5):e0177501. doi: 10.1371/journal.pone.0177501. eCollection 2017.'}, {'pmid': '28915894', 'type': 'RESULT', 'citation': 'Fahndrich S, Biertz F, Karch A, Kleibrink B, Koch A, Teschler H, Welte T, Kauczor HU, Janciauskiene S, Jorres RA, Greulich T, Vogelmeier CF, Bals R; COSYCONET investigators. Cardiovascular risk in patients with alpha-1-antitrypsin deficiency. Respir Res. 2017 Sep 15;18(1):171. doi: 10.1186/s12931-017-0655-1.'}, {'pmid': '29413512', 'type': 'RESULT', 'citation': 'Kahnert K, Alter P, Young D, Lucke T, Heinrich J, Huber RM, Behr J, Wacker M, Biertz F, Watz H, Bals R, Welte T, Wirtz H, Herth F, Vestbo J, Wouters EF, Vogelmeier CF, Jorres RA. The revised GOLD 2017 COPD categorization in relation to comorbidities. Respir Med. 2018 Jan;134:79-85. doi: 10.1016/j.rmed.2017.12.003. Epub 2017 Dec 5.'}, {'pmid': '28086884', 'type': 'RESULT', 'citation': 'Kahnert K, Lucke T, Biertz F, Lechner A, Watz H, Alter P, Bals R, Behr J, Holle R, Huber RM, Karrasch S, Stubbe B, Wacker M, Sohler S, Wouters EF, Vogelmeier C, Jorres RA; COSYCONET study group. Transfer factor for carbon monoxide in patients with COPD and diabetes: results from the German COSYCONET cohort. Respir Res. 2017 Jan 13;18(1):14. doi: 10.1186/s12931-016-0499-0.'}, {'pmid': '27532739', 'type': 'RESULT', 'citation': 'Houben-Wilke S, Jorres RA, Bals R, Franssen FM, Glaser S, Holle R, Karch A, Koch A, Magnussen H, Obst A, Schulz H, Spruit MA, Wacker ME, Welte T, Wouters EF, Vogelmeier C, Watz H. Peripheral Artery Disease and Its Clinical Relevance in Patients with Chronic Obstructive Pulmonary Disease in the COPD and Systemic Consequences-Comorbidities Network Study. Am J Respir Crit Care Med. 2017 Jan 15;195(2):189-197. doi: 10.1164/rccm.201602-0354OC.'}, {'pmid': '28416015', 'type': 'RESULT', 'citation': 'Karl FM, Holle R, Bals R, Greulich T, Jorres RA, Karch A, Koch A, Karrasch S, Leidl R, Schulz H, Vogelmeier C, Wacker ME; COSYCONET Study Group. Costs and health-related quality of life in Alpha-1-Antitrypsin Deficient COPD patients. Respir Res. 2017 Apr 17;18(1):60. doi: 10.1186/s12931-017-0543-8.'}, {'pmid': '29169740', 'type': 'RESULT', 'citation': "Smid DE, Franssen FME, Gonik M, Miravitlles M, Casanova C, Cosio BG, de Lucas-Ramos P, Marin JM, Martinez C, Mir I, Soriano JB, de Torres JP, Agusti A, Atalay NB, Billington J, Boutou AK, Brighenti-Zogg S, Chaplin E, Coster S, Dodd JW, Durr S, Fernandez-Villar A, Groenen MTJ, Guimaraes M, Hejduk K, Higgins V, Hopkinson NS, Horita N, Houben-Wilke S, Janssen DJA, Jehn M, Joerres R, Karch A, Kelly JL, Kim YI, Kimura H, Koblizek V, Kocks JH, Kon SSC, Kwon N, Ladeira I, Lee SD, Leuppi JD, Locantore N, Lopez-Campos JL, D-C Man W, Maricic L, Mendoza L, Miedinger D, Mihaltan F, Minami S, van der Molen T, Murrells TJ, Nakken N, Nishijima Y, Norman IJ, Novotna B, O'Donnell DE, Ogata Y, Pereira ED, Piercy J, Price D, Pothirat C, Raghavan N, Ringbaek T, Sajkov D, Sigari N, Singh S, Small M, da Silva GF, Tanner RJ, Tsiligianni IG, Tulek B, Tzanakis N, Vanfleteren LEGW, Watz H, Webb KA, Wouters EFM, Xie GG, Yoshikawa M, Spruit MA. Redefining Cut-Points for High Symptom Burden of the Global Initiative for Chronic Obstructive Lung Disease Classification in 18,577 Patients With Chronic Obstructive Pulmonary Disease. J Am Med Dir Assoc. 2017 Dec 1;18(12):1097.e11-1097.e24. doi: 10.1016/j.jamda.2017.09.003."}, {'pmid': '29270005', 'type': 'RESULT', 'citation': 'Wacker ME, Kitzing K, Jorres RA, Leidl R, Schulz H, Karrasch S, Karch A, Koch A, Vogelmeier CF, Holle R. The contribution of symptoms and comorbidities to the economic impact of COPD: an analysis of the German COSYCONET cohort. Int J Chron Obstruct Pulmon Dis. 2017 Dec 4;12:3437-3448. doi: 10.2147/COPD.S141852. eCollection 2017.'}, {'pmid': '29657040', 'type': 'RESULT', 'citation': 'Alter P, Jorres RA, Watz H, Welte T, Glaser S, Schulz H, Bals R, Karch A, Wouters EFM, Vestbo J, Young D, Vogelmeier CF. Left ventricular volume and wall stress are linked to lung function impairment in COPD. Int J Cardiol. 2018 Jun 15;261:172-178. doi: 10.1016/j.ijcard.2018.02.074.'}, {'pmid': '30197511', 'type': 'RESULT', 'citation': 'Alter P, Rabe KF, Schulz H, Vogelmeier CF, Jorres RA. Influence of body mass on predicted values of static hyperinflation in COPD. Int J Chron Obstruct Pulmon Dis. 2018 Aug 23;13:2551-2555. doi: 10.2147/COPD.S164096. eCollection 2018.'}, {'pmid': '29984808', 'type': 'RESULT', 'citation': 'Alter P, Jorres RA. Concomitance of cardiovascular and pulmonary disorders: mutual bystanders or causal interactions? Kardiol Pol. 2018;76(7):1027-1028. doi: 10.5603/KP.2018.0132. No abstract available.'}, {'pmid': '29421666', 'type': 'RESULT', 'citation': 'Graf J, Lucke T, Herrera R, Watz H, Holle R, Vogelmeier C, Ficker JH, Jorres RA. Compatibility of medication with PRISCUS criteria and identification of drug interactions in a large cohort of patients with COPD. Pulm Pharmacol Ther. 2018 Apr;49:123-129. doi: 10.1016/j.pupt.2018.01.011. Epub 2018 Feb 5.'}, {'pmid': '30282573', 'type': 'RESULT', 'citation': 'Graf J, Jorres RA, Lucke T, Nowak D, Vogelmeier CF, Ficker JH. Medical Treatment of COPD. Dtsch Arztebl Int. 2018 Sep 14;155(37):599-605. doi: 10.3238/arztebl.2018.0599.'}, {'pmid': '30319247', 'type': 'RESULT', 'citation': 'Greulich T, Mager S, Lucke T, Koczulla AR, Bals R, Fahndrich S, Jorres RA, Alter P, Kirsten A, Vogelmeier CF, Watz H. Longitudinal stability of blood eosinophil count strata in the COPD COSYCONET cohort. Int J Chron Obstruct Pulmon Dis. 2018 Sep 28;13:2999-3002. doi: 10.2147/COPD.S165909. eCollection 2018. No abstract available.'}, {'pmid': '29866121', 'type': 'RESULT', 'citation': 'Kahnert K, Alter P, Welte T, Huber RM, Behr J, Biertz F, Watz H, Bals R, Vogelmeier CF, Jorres RA. Uric acid, lung function, physical capacity and exacerbation frequency in patients with COPD: a multi-dimensional approach. Respir Res. 2018 Jun 4;19(1):110. doi: 10.1186/s12931-018-0815-y.'}, {'pmid': '29742906', 'type': 'RESULT', 'citation': 'Kahnert K, Jobst B, Biertz F, Biederer J, Watz H, Huber RM, Behr J, Grenier PA, Alter P, Vogelmeier CF, Kauczor HU, Jorres RA. Relationship of spirometric, body plethysmographic, and diffusing capacity parameters to emphysema scores derived from CT scans. Chron Respir Dis. 2019 Jan-Dec;16:1479972318775423. doi: 10.1177/1479972318775423. Epub 2018 May 9.'}, {'pmid': '30350440', 'type': 'RESULT', 'citation': 'Kaireit TF, Voskrebenzev A, Gutberlet M, Freise J, Jobst B, Kauczor HU, Welte T, Wacker F, Vogel-Claussen J. Comparison of quantitative regional perfusion-weighted phase resolved functional lung (PREFUL) MRI with dynamic gadolinium-enhanced regional pulmonary perfusion MRI in COPD patients. J Magn Reson Imaging. 2019 Apr;49(4):1122-1132. doi: 10.1002/jmri.26342. Epub 2018 Oct 22.'}, {'pmid': '29981854', 'type': 'RESULT', 'citation': 'Keller A, Fehlmann T, Ludwig N, Kahraman M, Laufer T, Backes C, Vogelmeier C, Diener C, Biertz F, Herr C, Jorres RA, Lenhof HP, Meese E, Bals R; COSYCONET Study Group. Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development. Genomics Proteomics Bioinformatics. 2018 Jun;16(3):162-171. doi: 10.1016/j.gpb.2018.06.001. Epub 2018 Jul 5.'}, {'pmid': '29975714', 'type': 'RESULT', 'citation': 'Triphan SMF, Biederer J, Burmester K, Fellhauer I, Vogelmeier CF, Jorres RA, Kauczor HU, Heussel CP, Wielputz MO, Jobst BJ. Design and application of an MR reference phantom for multicentre lung imaging trials. PLoS One. 2018 Jul 5;13(7):e0199148. doi: 10.1371/journal.pone.0199148. eCollection 2018.'}, {'pmid': '30917825', 'type': 'RESULT', 'citation': 'Alter P, Watz H, Kahnert K, Rabe KF, Biertz F, Fischer R, Jung P, Graf J, Bals R, Vogelmeier CF, Jorres RA. Effects of airway obstruction and hyperinflation on electrocardiographic axes in COPD. Respir Res. 2019 Mar 27;20(1):61. doi: 10.1186/s12931-019-1025-y.'}, {'pmid': '31308648', 'type': 'RESULT', 'citation': 'Byng D, Lutter JI, Wacker ME, Jorres RA, Liu X, Karrasch S, Schulz H, Vogelmeier C, Holle R. Determinants of healthcare utilization and costs in COPD patients: first longitudinal results from the German COPD cohort COSYCONET. Int J Chron Obstruct Pulmon Dis. 2019 Jul 5;14:1423-1439. doi: 10.2147/COPD.S201899. eCollection 2019.'}, {'pmid': '31203096', 'type': 'RESULT', 'citation': 'Trudzinski FC, Kahnert K, Vogelmeier CF, Alter P, Seiler F, Fahndrich S, Watz H, Welte T, Speer T, Zewinger S, Biertz F, Kauczor HU, Jorres RA, Bals R; COSYCONET consortium. Combined effects of lung function, blood gases and kidney function on the exacerbation risk in stable COPD: Results from the COSYCONET cohort. Respir Med. 2019 Jul-Aug;154:18-26. doi: 10.1016/j.rmed.2019.06.007. Epub 2019 Jun 11.'}, {'pmid': '31299972', 'type': 'RESULT', 'citation': 'Trudzinski FC, Alqudrah M, Omlor A, Zewinger S, Fliser D, Speer T, Seiler F, Biertz F, Koch A, Vogelmeier C, Welte T, Watz H, Waschki B, Fahndrich S, Jorres R, Bals R; German COSYCONET consortium. Consequences of chronic kidney disease in chronic obstructive pulmonary disease. Respir Res. 2019 Jul 12;20(1):151. doi: 10.1186/s12931-019-1107-x.'}, {'pmid': '30744630', 'type': 'RESULT', 'citation': 'von Siemens SM, Jorres RA, Behr J, Alter P, Lutter J, Lucke T, Sohler S, Welte T, Watz H, Vogelmeier CF, Trudzinski F, Rief W, Herbig B, Kahnert K; COSYCONET study group. Effect of COPD severity and comorbidities on the result of the PHQ-9 tool for the diagnosis of depression: results from the COSYCONET cohort study. Respir Res. 2019 Feb 11;20(1):30. doi: 10.1186/s12931-019-0997-y.'}, {'pmid': '31571852', 'type': 'RESULT', 'citation': 'Alter P, Mayerhofer BA, Kahnert K, Watz H, Waschki B, Andreas S, Biertz F, Bals R, Vogelmeier CF, Jorres RA. Prevalence of cardiac comorbidities, and their underdetection and contribution to exertional symptoms in COPD: results from the COSYCONET cohort. Int J Chron Obstruct Pulmon Dis. 2019 Sep 20;14:2163-2172. doi: 10.2147/COPD.S209343. eCollection 2019.'}, {'pmid': '31569706', 'type': 'RESULT', 'citation': 'Keller A, Ludwig N, Fehlmann T, Kahraman M, Backes C, Kern F, Vogelmeier CF, Diener C, Fischer U, Biertz F, Herr C, Jorres RA, Lenhof HP, Bals R, Meese E. Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients. Cells. 2019 Sep 27;8(10):1162. doi: 10.3390/cells8101162.'}, {'pmid': '31631986', 'type': 'RESULT', 'citation': 'Konigsdorfer N, Jorres RA, Sohler S, Welte T, Behr J, Ficker JH, Bals R, Watz H, Lutter JI, Lucke T, Biertz F, Alter P, Vogelmeier CF, Kahnert K. Adherence To Respiratory And Nonrespiratory Medication In Patients With COPD: Results Of The German COSYCONET Cohort. Patient Prefer Adherence. 2019 Oct 10;13:1711-1721. doi: 10.2147/PPA.S223438. eCollection 2019.'}, {'pmid': '31727165', 'type': 'RESULT', 'citation': 'von Siemens SM, Perneczky R, Vogelmeier CF, Behr J, Kauffmann-Guerrero D, Alter P, Trudzinski FC, Bals R, Grohe C, Sohler S, Waschki B, Lutter JI, Welte T, Jorres RA, Kahnert K; COSYCONET study group. The association of cognitive functioning as measured by the DemTect with functional and clinical characteristics of COPD: results from the COSYCONET cohort. Respir Res. 2019 Nov 14;20(1):257. doi: 10.1186/s12931-019-1217-5.'}, {'pmid': '31959163', 'type': 'RESULT', 'citation': 'Kahnert K, Fohrenbach M, Lucke T, Alter P, Trudzinski FT, Bals R, Lutter JI, Timmermann H, Sohler S, Forderreuther S, Nowak D, Watz H, Waschki B, Behr J, Welte T, Vogelmeier CF, Jorres RA. The impact of COPD on polyneuropathy: results from the German COPD cohort COSYCONET. Respir Res. 2020 Jan 20;21(1):28. doi: 10.1186/s12931-020-1293-6.'}, {'pmid': '32471493', 'type': 'RESULT', 'citation': 'Lutter JI, Jorres RA, Kahnert K, Schwarzkopf L, Studnicka M, Karrasch S, Schulz H, Vogelmeier CF, Holle R; COSYCONET Study Group. Health-related quality of life associates with change in FEV1 in COPD: results from the COSYCONET cohort. BMC Pulm Med. 2020 May 29;20(1):148. doi: 10.1186/s12890-020-1147-5.'}, {'pmid': '32601330', 'type': 'RESULT', 'citation': 'Trudzinski FC, Jorres RA, Alter P, Kahnert K, Waschki B, Herr C, Kellerer C, Omlor A, Vogelmeier CF, Fahndrich S, Watz H, Welte T, Jany B, Sohler S, Biertz F, Herth F, Kauczor HU, Bals R; COSYCONET consortium. Associations of oxygenated hemoglobin with disease burden and prognosis in stable COPD: Results from COSYCONET. Sci Rep. 2020 Jun 29;10(1):10544. doi: 10.1038/s41598-020-67197-x.'}, {'pmid': '31739262', 'type': 'RESULT', 'citation': 'Marietta von Siemens S, Alter P, Lutter JI, Kauczor HU, Jobst B, Bals R, Trudzinski FC, Sohler S, Behr J, Watz H, Waschki B, Bewig B, Jones PW, Welte T, Vogelmeier CF, Jorres RA, Kahnert K; COSYCONET study group; Names of participating study nurses. CAT score single item analysis in patients with COPD: Results from COSYCONET. Respir Med. 2019 Nov;159:105810. doi: 10.1016/j.rmed.2019.105810. Epub 2019 Nov 7.'}, {'pmid': '32917358', 'type': 'RESULT', 'citation': 'Lutter JI, Lukas M, Schwarzkopf L, Jorres RA, Studnicka M, Kahnert K, Karrasch S, Bewig B, Vogelmeier CF, Holle R; COSYCONET Study Group. Utilization and determinants of use of non-pharmacological interventions in COPD: Results of the COSYCONET cohort. Respir Med. 2020 Sep;171:106087. doi: 10.1016/j.rmed.2020.106087. Epub 2020 Jul 12.'}, {'pmid': '31831579', 'type': 'RESULT', 'citation': 'Waschki B, Alter P, Zeller T, Magnussen C, Neumann JT, Twerenbold R, Sinning C, Herr C, Kahnert K, Fahndrich S, Blankenberg S, Rabe KF, Welte T, Jorres RA, Vogelmeier CF, Bals R, Watz H; German COSYCONET Cohort. High-sensitivity troponin I and all-cause mortality in patients with stable COPD: an analysis of the COSYCONET study. Eur Respir J. 2020 Feb 27;55(2):1901314. doi: 10.1183/13993003.01314-2019. Print 2020 Feb.'}, {'pmid': '31734762', 'type': 'RESULT', 'citation': 'Omlor AJ, Trudzinski FC, Alqudrah M, Seiler F, Biertz F, Vogelmeier CF, Welte T, Watz H, Waschki B, Brinker TJ, Andreas S, Fahndrich S, Alter P, Jorres RA, Bohm M, Bals R; German COSYCONET Cohort. Time-updated resting heart rate predicts mortality in patients with COPD. Clin Res Cardiol. 2020 Jun;109(6):776-786. doi: 10.1007/s00392-019-01572-1. Epub 2019 Nov 16.'}, {'pmid': '34983515', 'type': 'RESULT', 'citation': 'Lommatzsch M, Speer T, Herr C, Jorres RA, Watz H, Muller A, Welte T, Vogelmeier CF, Bals R; COSYCONET study group. IgE is associated with exacerbations and lung function decline in COPD. Respir Res. 2022 Jan 4;23(1):1. doi: 10.1186/s12931-021-01847-0.'}, {'pmid': '34503520', 'type': 'RESULT', 'citation': 'Kellerer C, Jorres RA, Schneider A, Alter P, Kauczor HU, Jobst B, Biederer J, Bals R, Watz H, Behr J, Kauffmann-Guerrero D, Lutter J, Hapfelmeier A, Magnussen H, Trudzinski FC, Welte T, Vogelmeier CF, Kahnert K. Prediction of lung emphysema in COPD by spirometry and clinical symptoms: results from COSYCONET. Respir Res. 2021 Sep 9;22(1):242. doi: 10.1186/s12931-021-01837-2.'}, {'pmid': '35610473', 'type': 'RESULT', 'citation': 'Trudzinski FC, Jorres RA, Alter P, Walter J, Watz H, Koch A, John M, Lommatzsch M, Vogelmeier CF, Kauczor HU, Welte T, Behr J, Tufman A, Bals R, Herth FJF, Kahnert K; COSYCONET Study Group. Sex-specific associations of comorbidome and pulmorbidome with mortality in chronic obstructive pulmonary disease: results from COSYCONET. Sci Rep. 2022 May 24;12(1):8790. doi: 10.1038/s41598-022-12828-8.'}, {'pmid': '40963108', 'type': 'DERIVED', 'citation': 'Eichenlaub M, Frye BC, Lehrmann H, Biertz F, Jadidi AS, Kaier K, Melzer T, Alter P, Watz H, Waschki B, Weckler BC, Trudzinski FC, Michels-Zetsche JD, Trinkmann F, Herth FJ, Kauczor HU, Kahnert K, Jorres R, Bals R, Westermann D, Arentz T, Vogelmeier CF, Stolz D, Fahndrich S; German COSYCONET cohort. ECG-based identification of COPD patients at risk for atrial fibrillation and its impact on adverse clinical outcomes-a subgroup analysis of the prospective multicenter COSYCONET cohort. Respir Res. 2025 Sep 17;26(1):272. doi: 10.1186/s12931-025-03342-2.'}, {'pmid': '39655060', 'type': 'DERIVED', 'citation': 'Alter P, Kahnert K, Trudzinski FC, Bals R, Watz H, Speicher T, Sohler S, Rabe KF, Wouters EFM, Vogelmeier CF, Jorres RA. Unravelling the Information Contained in the Single Items of the COPD Assessment Test for Different Outcomes and Smoking Status in Patients with COPD: Results from COSYCONET. Int J Chron Obstruct Pulmon Dis. 2024 Dec 5;19:2629-2638. doi: 10.2147/COPD.S475112. eCollection 2024.'}, {'pmid': '39003487', 'type': 'DERIVED', 'citation': 'Trudzinski FC, Jorres RA, Alter P, Watz H, Vogelmeier CF, Kauczor HU, Thangamani S, Debic M, Welte T, Behr J, Kahnert K, Bals R, Herr C, Heussel CP, Biederer J, von Stackelberg O, Fahndrich S, Wouters EFM, Waschki B, Rabe KF, Herth FJF, Palm V; COSYCONET study group. Midregional Proatrial Natriuretic Peptide (MRproANP) is associated with vertebral fractures and low bone density in patients with chronic obstructive pulmonary disease (COPD). Respir Res. 2024 Jul 13;25(1):274. doi: 10.1186/s12931-024-02902-2.'}, {'pmid': '38984876', 'type': 'DERIVED', 'citation': 'Abdo M, Watz H, Alter P, Kahnert K, Trudzinski F, Groth EE, Claussen M, Kirsten AM, Welte T, Jorres RA, Vogelmeier CF, Bals R, Rabe KF, Waschki B. Characterization and Mortality Risk of Impaired Left Ventricular Filling in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2025 Mar;211(3):477-485. doi: 10.1164/rccm.202310-1848OC.'}, {'pmid': '38974817', 'type': 'DERIVED', 'citation': 'Stoleriu MG, Pienn M, Joerres RA, Alter P, Fero T, Urschler M, Kovacs G, Olschewski H, Kauczor HU, Wielputz M, Jobst B, Welte T, Behr J, Trudzinski FC, Bals R, Watz H, Vogelmeier CF, Biederer J, Kahnert K; COSYCONET Study Group. Expiratory Venous Volume and Arterial Tortuosity are Associated with Disease Severity and Mortality Risk in Patients with COPD: Results from COSYCONET. Int J Chron Obstruct Pulmon Dis. 2024 Jul 1;19:1515-1529. doi: 10.2147/COPD.S458905. eCollection 2024.'}, {'pmid': '38750572', 'type': 'DERIVED', 'citation': 'Frantzi N, Nguyen XP, Herr C, Alter P, Sohler S, Soriano D, Watz H, Waschki B, Trinkmann F, Eichenlaub M, Trudzinski FC, Michels-Zetsche JD, Omlor A, Seiler F, Moneke I, Biertz F, Rohde G, Stolz D, Welte T, Kauczor HU, Kahnert K, Jorres RA, Vogelmeier CF, Bals R, Fahndrich S; German COSYCONET Cohort. Statins did not reduce the frequency of exacerbations in individuals with COPD and cardiovascular comorbidities in the COSYCONET cohort. Respir Res. 2024 May 15;25(1):207. doi: 10.1186/s12931-024-02822-1.'}, {'pmid': '38160050', 'type': 'DERIVED', 'citation': 'Gerlich J, Ohlander J, Kromhout H, Vermeulen R, Sohler S, Radon K, Nowak D, Karrasch S, Adaskina N, Vogelmeier C, Ochmann U, Jorres RA. Cumulative occupational exposure to gases and fumes is associated with impairment in lung function and disease-related quality of life in a German COPD patient cohort. Occup Environ Med. 2023 Dec 30;81(1):26-33. doi: 10.1136/oemed-2023-108908. Online ahead of print.'}, {'pmid': '37936408', 'type': 'DERIVED', 'citation': 'Alter P, Kahnert K, Trudzinski FC, Bals R, Watz H, Speicher T, Sohler S, Welte T, Rabe KF, Wouters EFM, Vogelmeier CF, Jorres RA. Clinical factors linked to the type of respiratory medication in COPD: results from the COSYCONET cohort. Ther Adv Respir Dis. 2023 Jan-Dec;17:17534666231208584. doi: 10.1177/17534666231208584.'}, {'pmid': '36718763', 'type': 'DERIVED', 'citation': 'Kahnert K, Jorres RA, Kauczor HU, Alter P, Trudzinski FC, Herth F, Jobst B, Weinheimer O, Nauck S, Mertsch P, Kauffmann-Guerrero D, Behr J, Bals R, Watz H, Rabe KF, Welte T, Vogelmeier CF, Biederer J. Standardized airway wall thickness Pi10 from routine CT scans of COPD patients as imaging biomarker for disease severity, lung function decline, and mortality. Ther Adv Respir Dis. 2023 Jan-Dec;17:17534666221148663. doi: 10.1177/17534666221148663.'}, {'pmid': '36536050', 'type': 'DERIVED', 'citation': 'Alter P, Lucke T, Watz H, Andreas S, Kahnert K, Trudzinski FC, Speicher T, Sohler S, Bals R, Waschki B, Welte T, Rabe KF, Vestbo J, Wouters EFM, Vogelmeier CF, Jorres RA. Cardiovascular predictors of mortality and exacerbations in patients with COPD. Sci Rep. 2022 Dec 19;12(1):21882. doi: 10.1038/s41598-022-25938-0.'}, {'pmid': '34853511', 'type': 'DERIVED', 'citation': 'Kahnert K, Jorres RA, Lucke T, Trudzinski FC, Mertsch P, Bickert C, Ficker JH, Behr J, Bals R, Watz H, Welte T, Vogelmeier CF, Alter P; COSYCONET Study Group. Lower Prevalence of Osteoporosis in Patients with COPD Taking Anti-Inflammatory Compounds for the Treatment of Diabetes: Results from COSYCONET. Int J Chron Obstruct Pulmon Dis. 2021 Nov 24;16:3189-3199. doi: 10.2147/COPD.S335029. eCollection 2021.'}, {'pmid': '34331588', 'type': 'DERIVED', 'citation': 'Trudzinski FC, Kellerer C, Jorres RA, Alter P, Lutter JI, Trinkmann F, Herth FJF, Frankenberger M, Watz H, Vogelmeier CF, Kauczor HU, Welte T, Behr J, Bals R, Kahnert K. Gender-specific differences in COPD symptoms and their impact for the diagnosis of cardiac comorbidities. Clin Res Cardiol. 2023 Feb;112(2):177-186. doi: 10.1007/s00392-021-01915-x. Epub 2021 Jul 31.'}, {'pmid': '34116329', 'type': 'DERIVED', 'citation': 'Kellerer C, Kahnert K, Trudzinski FC, Lutter J, Berschneider K, Speicher T, Watz H, Bals R, Welte T, Vogelmeier CF, Jorres RA, Alter P. COPD maintenance medication is linked to left atrial size: Results from the COSYCONET cohort. Respir Med. 2021 Aug-Sep;185:106461. doi: 10.1016/j.rmed.2021.106461. Epub 2021 May 29.'}, {'pmid': '32743009', 'type': 'DERIVED', 'citation': 'Alter P, Orszag J, Kellerer C, Kahnert K, Speicher T, Watz H, Bals R, Welte T, Vogelmeier CF, Jorres RA. Prediction of air trapping or pulmonary hyperinflation by forced spirometry in COPD patients: results from COSYCONET. ERJ Open Res. 2020 Jul 27;6(3):00092-2020. doi: 10.1183/23120541.00092-2020. eCollection 2020 Jul.'}], 'seeAlsoLinks': [{'url': 'http://www.asconet.net', 'label': 'Description of the study, study results, links to relevant organisaton'}]}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to determine the prevalence and severity of extrapulmonary disorders and to quantify the impact of extrapulmonary organ manifestations on morbidity and mortality of COPD patients.\n\nFurthermore the investigators evaluate the relationship between systemic inflammation and organ involvement.', 'detailedDescription': 'Chronic diseases and comorbidities have an increasing impact on individual life and health care use, as exemplified in chronic obstructive pulmonary disease (COPD). Currently, independent, comprehensive databases allowing for an integrated view are lacking. The study will for the first time establish a large, comprehensive longitudinal database covering a broad panel of comorbidities an markers of systemic alterations. These data will be of unique value in revealing specific phenotypes of COPD via patterns and risk profiles of comorbidities, enabling a more precise diagnosis and targeting of therapy, and an efficient allocation of resources.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '40 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': "Since the original recruitment strategy was not as successful as expected,the mode of recruitment was extended to other physicians, patients' groups and organisations and advertising to local media. The recruitment is supported by professional measures of communication organized by the coordinating centre Marburg.", 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* aged 40 years and older\n* diagnosis of COPD (GOLD-Criteria) or chronic bronchitis\n* informed consent\n* available for repeated study visits pver 18 months\n\nExclusion Criteria:\n\n* having undergone big lung surgery (e.g. lung reduction, lung transplant)\n* Moderate or severe exacerbation within the last 4 weeks\n* having a lung tumor\n* Unable to walk or to understand the intention of the project'}, 'identificationModule': {'nctId': 'NCT01245933', 'acronym': 'COSYCONET', 'briefTitle': 'Impact of Systemic Manifestations/Comorbidities on Clinical State, Prognosis, Utilisation of Health Care Resources in Patients With COPD', 'organization': {'class': 'OTHER', 'fullName': 'Philipps University Marburg'}, 'officialTitle': 'Impact of Systemic Manifestations/Comorbidities on Clinical State, Prognosis and Utilisation of Health Care Resources in Patients With COPD', 'orgStudyIdInfo': {'id': '01GI0881'}}, 'contactsLocationsModule': {'locations': [{'zip': '13125', 'city': 'Berlin', 'country': 'Germany', 'facility': 'Ev. Lungenklinik (ELK), Krankenhausbetriebs gGmbH, Pneumologische Klinik', 'geoPoint': {'lat': 52.52437, 'lon': 13.41053}}, {'zip': '23845', 'city': 'Borstel', 'country': 'Germany', 'facility': 'Forschungszentrum Borstel, Medizinische Klinik', 'geoPoint': {'lat': 52.67034, 'lon': 8.96896}}, {'zip': '93093', 'city': 'Donaustauf', 'country': 'Germany', 'facility': 'Klinik Donaustauf, Zentrum für Pneumologie', 'geoPoint': {'lat': 49.03258, 'lon': 12.20459}}, {'zip': '45239', 'city': 'Essen', 'country': 'Germany', 'facility': 'Ruhrlandklinik Essen, Westdeutsches Lungenzentrum', 'geoPoint': {'lat': 51.45657, 'lon': 7.01228}}, {'zip': '82131', 'city': 'Gauting', 'country': 'Germany', 'facility': 'EvA-Study Center, Helholtz Zentrum München', 'geoPoint': {'lat': 48.06919, 'lon': 11.37703}}, {'city': 'Giessen', 'country': 'Germany', 'facility': 'Justus-Liebig-Universität, Medizinische Klinik II', 'geoPoint': {'lat': 50.58727, 'lon': 8.67554}}, {'zip': '17475', 'city': 'Greifswald', 'country': 'Germany', 'facility': 'Universitätsklinikum Greifswald der Ernst-Moritz-Arndt Universität, Zentrum für Innere Medizin', 'geoPoint': {'lat': 54.08905, 'lon': 13.40244}}, {'zip': '22927', 'city': 'Großhansdorf', 'country': 'Germany', 'facility': 'Krankenhaus Großhansdorf, Pneumologisches Forschungsinstitut', 'geoPoint': {'lat': 53.66528, 'lon': 10.28552}}, {'zip': '20354', 'city': 'Hamburg', 'country': 'Germany', 'facility': 'HIT-Hamburger Institut für Therapieforschung GmbH', 'geoPoint': {'lat': 53.55073, 'lon': 9.99302}}, {'zip': '30625', 'city': 'Hanover', 'country': 'Germany', 'facility': 'Medical School Hannover, Dep. of Pneumology', 'geoPoint': {'lat': 52.37052, 'lon': 9.73322}}, {'zip': '69126', 'city': 'Heidelberg', 'country': 'Germany', 'facility': 'Thoraxklinik Heidelberg', 'geoPoint': {'lat': 49.40768, 'lon': 8.69079}}, {'zip': '66421', 'city': 'Homburg', 'country': 'Germany', 'facility': 'University of Saarland', 'geoPoint': {'lat': 49.32637, 'lon': 7.33867}}, {'zip': '34376', 'city': 'Immenhausen', 'country': 'Germany', 'facility': 'Fachklinik für Lungenerkrankungen Philippsstiftung ev.', 'geoPoint': {'lat': 51.42763, 'lon': 9.48017}}, {'zip': '24105', 'city': 'Kiel', 'country': 'Germany', 'facility': 'Universitiy of Kiel', 'geoPoint': {'lat': 54.32133, 'lon': 10.13489}}, {'zip': '04103', 'city': 'Leipzig', 'country': 'Germany', 'facility': 'Universitätsklinikum Leipzig, Department Innere Medizin', 'geoPoint': {'lat': 51.33962, 'lon': 12.37129}}, {'zip': '35042', 'city': 'Marburg', 'country': 'Germany', 'facility': 'Philipps-University Marburg, Medical Center, Dep. of Pneumology', 'geoPoint': {'lat': 50.80904, 'lon': 8.77069}}, {'zip': '80336', 'city': 'Munich', 'country': 'Germany', 'facility': 'Ludwig-Maximilians-University, Medizinische Klinik Innenstadt', 'geoPoint': {'lat': 48.13743, 'lon': 11.57549}}, {'zip': '90419', 'city': 'Nuremberg', 'country': 'Germany', 'facility': 'Klinikum Nürnberg, Medizinische Klinik 3, Schwerpunkt Pneumologie, Allergologie und Schlafmedizin', 'geoPoint': {'lat': 49.45421, 'lon': 11.07752}}, {'zip': '18057', 'city': 'Rostock', 'country': 'Germany', 'facility': 'Universitätsklinikum Rostock, Zentrum für Innere Medizin, Abt. f. Pneumologie', 'geoPoint': {'lat': 54.0887, 'lon': 12.14049}}, {'zip': '83471', 'city': 'Schönau am Königssee', 'country': 'Germany', 'facility': 'Klinikum Berchtesgardener Land, Schön Kliniken, Fachzentrum für Pneumologie, Allergologie und Schlafmedizin', 'geoPoint': {'lat': 47.60055, 'lon': 12.98704}}, {'zip': '42699', 'city': 'Solingen', 'country': 'Germany', 'facility': 'Krankenhaus Bethanien gGmbH', 'geoPoint': {'lat': 51.17343, 'lon': 7.0845}}, {'zip': '97067', 'city': 'Würzburg', 'country': 'Germany', 'facility': 'Missionsärztliche Klinik GmbH, Innere Medizin', 'geoPoint': {'lat': 49.79391, 'lon': 9.95121}}], 'overallOfficials': [{'name': 'Claus Vogelmeier, Prof.', 'role': 'STUDY_CHAIR', 'affiliation': 'Philipps University Marburg'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Philipps University Marburg', 'class': 'OTHER'}, 'collaborators': [{'name': 'Hannover Medical School', 'class': 'OTHER'}, {'name': 'Ludwig-Maximilians - University of Munich', 'class': 'OTHER'}], 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Prof. Dr.', 'investigatorFullName': 'Claus Vogelmeier', 'investigatorAffiliation': 'Philipps University Marburg'}}}}