Ignite Creation Date:
2025-12-25 @ 2:47 AM
Ignite Modification Date:
2026-02-28 @ 9:05 PM
Study NCT ID:
NCT02137733
Status:
UNKNOWN
Last Update Posted:
2014-05-14
First Post:
2014-05-01
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
The Cardiac Insufficiency BIsoprolol Study in Japanese Patients With Chronic Heart Failure (CIBIS-J)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'interventionBrowseModule': {'meshes': [{'id': 'D017298', 'term': 'Bisoprolol'}, {'id': 'D000077261', 'term': 'Carvedilol'}], 'ancestors': [{'id': 'D050198', 'term': 'Phenoxypropanolamines'}, {'id': 'D011412', 'term': 'Propanolamines'}, {'id': 'D000605', 'term': 'Amino Alcohols'}, {'id': 'D000438', 'term': 'Alcohols'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D020005', 'term': 'Propanols'}, {'id': 'D000588', 'term': 'Amines'}, {'id': 'D002227', 'term': 'Carbazoles'}, {'id': 'D007211', 'term': 'Indoles'}, {'id': 'D006574', 'term': 'Heterocyclic Compounds, 2-Ring'}, {'id': 'D000072471', 'term': 'Heterocyclic Compounds, Fused-Ring'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}, {'id': 'D006575', 'term': 'Heterocyclic Compounds, 3-Ring'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 220}}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2013-06'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2014-05', 'lastUpdateSubmitDate': '2014-05-10', 'studyFirstSubmitDate': '2014-05-01', 'studyFirstSubmitQcDate': '2014-05-10', 'lastUpdatePostDateStruct': {'date': '2014-05-14', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2014-05-14', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2016-05', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Tolerability: The probability that administered maintenance dose reaches the maximum (bisoprolol 5 mg/day, carvedilol 20 mg/day)', 'timeFrame': '48 weeks'}], 'secondaryOutcomes': [{'measure': 'Efficacy: New York Heart Association (NYHA) Functional Classification', 'timeFrame': '24 and 48 weeks'}, {'measure': 'Efficacy: Left Ventricular Ejection Fraction (LVEF)', 'timeFrame': '24 and 48 weeks'}, {'measure': 'Efficacy: Left Ventricular End Diastolic Volume (LVEDV), Left Ventricular End Systolic Volume (LVESV)', 'timeFrame': '24 and 48 weeks'}, {'measure': 'Efficacy: Heart rate', 'timeFrame': '24 and 48 weeks'}, {'measure': 'Efficacy: Plasma brain natriuretic peptide (BNP)', 'timeFrame': '24 and 48 weeks'}, {'measure': 'Safety: All deaths', 'timeFrame': '48 weeks'}, {'measure': 'Safety: Deaths with cardiovascular causes', 'timeFrame': '48 weeks'}, {'measure': 'Safety: Hospitalization for cardiovascular causes', 'timeFrame': '48 weeks'}, {'measure': 'Safety: Exacerbation of heart failure, resulting in hospitalization, and/or intensification of treatment (increase in dose of any diuretics, vasodilators or cardiotonics, in comparison with the dose-setting period), or administration of new drugs.', 'timeFrame': '48 weeks'}, {'measure': 'Safety: Deaths due to heart failure (pump-failure deaths, and deaths associated with exacerbation of heart failure)', 'timeFrame': '48 weeks'}, {'measure': 'Safety: Sudden deaths, including deaths due to arrhythmia', 'timeFrame': '48 weeks'}, {'measure': 'Safety: Deaths with non-cardiovascular causes', 'timeFrame': '48 weeks'}, {'measure': 'Safety: Adverse events', 'timeFrame': '48 weeks'}, {'measure': 'Safety: Changes in clinical laboratory test results', 'timeFrame': '48 weeks'}]}, 'conditionsModule': {'conditions': ['Chronic Heart Failure']}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to investigate the non-inferiority of bisoprolol to carvedilol by evaluating tolerability (The probability that administered maintenance dose reaches the maximum will be determined as an indicator) as a primary endpoint when bisoprolol or carvedilol is administered for 48 weeks to Japanese chronic heart failure patients. In addition, the safety and efficacy of bisoprolol will be investigated.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '85 Years', 'minimumAge': '20 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\nAs a result of diagnosis and tests before registration, a patient who is considered by an investigator to meet all requirements and to have ability to consent can be enrolled.\n\n1. Primary disease: In principle, ischemic heart disease or dilated cardiomyopathy.\n2. Heart failure patients with 40% or less of left ventricular ejection fraction (LVEF) .\n3. Patients in NYHA functional classification Class II, III, or IV (including a medical history).\n4. Basic treatment: In principle, patients undergoing treatment with an ACE inhibitor (or angiotensin receptor blocker (ARB)), a diuretic, a digitalis preparation, etc.\n5. Patients who had not undergone treatment with a beta-blocker (except eye drops) within 8 weeks before the registration date.\n6. Age: Patients aged 20 to less than 85 on the day of obtaining written informed consent.\n7. Hospitalized/outpatient: Either hospitalized or outpatient status.\n8. Gender: Male or Female\n\nExclusion Criteria:\n\nPatients who meet any of the following exclusion criteria at the time of registration will be excluded:\n\n1. Patients who are considered not to be candidates for administration of bisoprolol or carvedilol.\n2. Patients who have developed acute myocardial infarction within 8 weeks before the registration day.\n3. Patients who have history of stroke or serious cerebrovascular accident within 1 year before the registration day.\n4. Patients with poor prognosis and life-threatening disease, such as malignant tumor, or such medical history within 5 years before the registration day.\n5. Patients who are scheduled to undergo coronary revascularization (Coronary artery bypass grafting; CABG, Percutaneous coronary intervention; PCI) during the study period.\n6. Patients who are pregnant, lactating, may become pregnant, or want to become pregnant during the study.\n7. Patients from whom written informed consent cannot be obtained.\n8. Patients who are judged by an investigator to be inappropriate for this study for any other reason.'}, 'identificationModule': {'nctId': 'NCT02137733', 'briefTitle': 'The Cardiac Insufficiency BIsoprolol Study in Japanese Patients With Chronic Heart Failure (CIBIS-J)', 'organization': {'class': 'INDUSTRY', 'fullName': 'Mebix Inc'}, 'officialTitle': 'The Cardiac Insufficiency BIsoprolol Study in Japanese Patients With Chronic Heart Failure (CIBIS-J)', 'orgStudyIdInfo': {'id': 'Ji 012-0386'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'ACTIVE_COMPARATOR', 'label': 'Bisoprolol group', 'description': 'Daily oral administration of bisoprolol 0.625 mg tablet once a day should be given (Step 1). If tolerability is confirmed by an investigator, the dose should be increased to 1.25 mg (bisoprolol 0.625 mg, 2 tablets; or bisoprolol 2.5 mg, half tablet; once daily) (Step 2). In the same manner, the doses should be increased to 2.5 mg (bisoprolol 2.5 mg, 1 tablet; or bisoprolol 5 mg, half tablet; once daily, Step 3), to 3.75 mg (bisoprolol 2.5 mg, 1.5 tablets once daily, Step 4), and to 5 mg (bisoprolol 2.5 mg, 2 tablets; or bisoprolol 5 mg, 1 tablet; once daily, Step 5).', 'interventionNames': ['Drug: Bisoprolol']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Carvedilol group', 'description': 'Daily oral administration of carvedilol 1.25 mg, 1 tablet twice a day (after breakfast and supper) should be given (Step 1). If tolerability is confirmed by an investigator after administering 2.5 mg/day of carvedilol, the dose should be increased to 5 mg (carvedilol 2.5 mg, 1 tablet twice daily) (Step 2). In the same manner, the dose should be increased to 10 mg (carvedilol 2.5 mg, 2 tablets twice daily, Step 3), to 15 mg (carvedilol 2.5 mg, 3 tablets twice daily, Step 4), and to 20 mg (carvedilol 10 mg, 1 tablet twice daily, Step 5).', 'interventionNames': ['Drug: Carvedilol']}], 'interventions': [{'name': 'Bisoprolol', 'type': 'DRUG', 'armGroupLabels': ['Bisoprolol group']}, {'name': 'Carvedilol', 'type': 'DRUG', 'armGroupLabels': ['Carvedilol group']}]}, 'contactsLocationsModule': {'locations': [{'city': 'Nagoya', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Hideo Izawa', 'role': 'CONTACT', 'phone': '052-321-8171'}], 'facility': 'Banbuntane Hotokukai Hospital', 'geoPoint': {'lat': 35.18147, 'lon': 136.90641}}, {'city': 'Nagoya', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Naoya Tsuboi', 'role': 'CONTACT', 'phone': '052-691-7151'}], 'facility': 'Chukyo Hospital', 'geoPoint': {'lat': 35.18147, 'lon': 136.90641}}, {'city': 'Nagoya', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Hidekatsu Fukuda', 'role': 'CONTACT', 'phone': '052-851-5511'}], 'facility': 'Nagoya City University Hospital', 'geoPoint': {'lat': 35.18147, 'lon': 136.90641}}, {'city': 'Nagoya', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Hiroto Takezawa', 'role': 'CONTACT', 'phone': '052-837-7500'}], 'facility': 'Takezawa Clinic', 'geoPoint': {'lat': 35.18147, 'lon': 136.90641}}, {'city': 'Akita', 'state': 'Akita', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Hiroshi Ito', 'role': 'CONTACT', 'phone': '018-834-1111'}], 'facility': 'Akita University Hospital', 'geoPoint': {'lat': 39.71667, 'lon': 140.11667}}, {'city': 'Hirosaki', 'state': 'Aomori', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Shingo Sasaki', 'role': 'CONTACT', 'phone': '0172-33-5111'}], 'facility': 'Hirosaki University School of Medicine & Hospital', 'geoPoint': {'lat': 40.59306, 'lon': 140.4725}}, {'city': 'Matsuyama', 'state': 'Ehime', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Hideki Okayama', 'role': 'CONTACT', 'phone': '089-947-1111'}], 'facility': 'Ehime Prefectural Central Hospital', 'geoPoint': {'lat': 33.83916, 'lon': 132.76574}}, {'city': 'Matsuyama', 'state': 'Ehime', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Koki Watanabe', 'role': 'CONTACT', 'phone': '089-951-6111'}], 'facility': 'Saiseikai Matsuyama Hospital', 'geoPoint': {'lat': 33.83916, 'lon': 132.76574}}, {'city': 'Tōon', 'state': 'Ehime', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Akiyoshi Ogimoto', 'role': 'CONTACT', 'phone': '089-964-5111'}], 'facility': 'Ehime University Hospital', 'geoPoint': {'lat': 33.79427, 'lon': 132.89011}}, {'city': 'Yoshida-gun', 'state': 'Fukui', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Ryuichiro Shimao', 'role': 'CONTACT', 'phone': '0776-61-3111'}], 'facility': 'University of Fukui Hospital'}, {'city': 'Fukuoka', 'state': 'Fukuoka', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Nobuhide Tanaka', 'role': 'CONTACT', 'phone': '092-891-2511'}], 'facility': 'Hakujyuji Hospital', 'geoPoint': {'lat': 33.6, 'lon': 130.41667}}, {'city': 'Fukuoka', 'state': 'Fukuoka', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Takaaki Sakai', 'role': 'CONTACT', 'phone': '092-691-3881'}], 'facility': 'Haradoi Hospital', 'geoPoint': {'lat': 33.6, 'lon': 130.41667}}, {'city': 'Fukuoka', 'state': 'Fukuoka', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Tomomi Ide', 'role': 'CONTACT', 'phone': '092-641-1151'}], 'facility': 'Kyushu University Hospital', 'geoPoint': {'lat': 33.6, 'lon': 130.41667}}, {'city': 'Fukuoka', 'state': 'Fukuoka', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Ryuichi Matsukawa', 'role': 'CONTACT', 'phone': '092-771-8151'}], 'facility': 'Saiseikai Fukuoka General Hospital', 'geoPoint': {'lat': 33.6, 'lon': 130.41667}}, {'city': 'Kitakyushu', 'state': 'Fukuoka', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Hiroyoshi Hirayama', 'role': 'CONTACT', 'phone': '093-614-5558'}], 'facility': 'Chiyo Clinic', 'geoPoint': {'lat': 33.85181, 'lon': 130.85034}}, {'city': 'Kitakyushu', 'state': 'Fukuoka', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Kiyoshi Ozumi', 'role': 'CONTACT', 'phone': '093-662-6565'}], 'facility': 'Kitakyushu Municipal Yahata Hospital', 'geoPoint': {'lat': 33.85181, 'lon': 130.85034}}, {'city': 'Ōkawa', 'state': 'Fukuoka', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Tsuyoshi Yoshihiro', 'role': 'CONTACT', 'phone': '0944-87-0001'}], 'facility': 'Takagi Hospital', 'geoPoint': {'lat': 33.20566, 'lon': 130.37527}}, {'city': 'Fukushima', 'state': 'Fukushima', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Tomohiro Ogawa', 'role': 'CONTACT', 'phone': '024-557-5111'}], 'facility': 'Fukushima Daiichi Hospital', 'geoPoint': {'lat': 37.75, 'lon': 140.46667}}, {'city': 'Fukushima', 'state': 'Fukushima', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Osamu Yamaguchi', 'role': 'CONTACT', 'phone': '024-554-2001'}], 'facility': 'Ohara General Hospital', 'geoPoint': {'lat': 37.75, 'lon': 140.46667}}, {'city': 'Gifu', 'state': 'Gifu', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Shinya Minatokuchi', 'role': 'CONTACT', 'phone': '058-230-6000'}], 'facility': 'Gifu University Hospital', 'geoPoint': {'lat': 35.42291, 'lon': 136.76039}}, {'city': 'Minokamo', 'state': 'Gifu', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Takuma Aoyama', 'role': 'CONTACT', 'phone': '0574-25-2181'}], 'facility': 'Kizawa memorial hospital', 'geoPoint': {'lat': 35.48199, 'lon': 137.02166}}, {'city': 'Maebashi', 'state': 'Gunma', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Norimichi Koitabashi', 'role': 'CONTACT', 'phone': '027-220-7111'}], 'facility': 'Gunma University Hospital', 'geoPoint': {'lat': 36.4, 'lon': 139.08333}}, {'city': 'Maebashi', 'state': 'Gunma', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Akihiko Nakano', 'role': 'CONTACT', 'phone': '027-252-6011'}], 'facility': 'Gunmaken Saiseikai Maebashi Hospital', 'geoPoint': {'lat': 36.4, 'lon': 139.08333}}, {'city': 'Maebashi', 'state': 'Gunma', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Shoichi Tange', 'role': 'CONTACT', 'phone': '027-224-4585'}], 'facility': 'Maebashi Red Cross Hospital', 'geoPoint': {'lat': 36.4, 'lon': 139.08333}}, {'city': 'Fukuyama', 'state': 'Hiroshima', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Kotaro Yasuda', 'role': 'CONTACT', 'phone': '084-931-8650'}], 'facility': 'Ota Memorial Hospital', 'geoPoint': {'lat': 34.48333, 'lon': 133.36667}}, {'city': 'Hiroshima', 'state': 'Hiroshima', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Hiroki Teragawa', 'role': 'CONTACT', 'phone': '082-262-1171'}], 'facility': 'Hiroshima General Hospital of West Japan Railway Company', 'geoPoint': {'lat': 34.4, 'lon': 132.45}}, {'city': 'Hiroshima', 'state': 'Hiroshima', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Yasuki Kihara', 'role': 'CONTACT', 'phone': '082-257-5555'}], 'facility': 'Hiroshima University Hospital', 'geoPoint': {'lat': 34.4, 'lon': 132.45}}, {'city': 'Kure', 'state': 'Hiroshima', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Ritsu Tamura', 'role': 'CONTACT', 'phone': '0823-22-3111'}], 'facility': 'National Hospital Organization Kure Medical Center', 'geoPoint': {'lat': 34.23222, 'lon': 132.56658}}, {'city': 'Shōbara', 'state': 'Hiroshima', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Hiroshi Sugino', 'role': 'CONTACT', 'phone': '0824-72-3111'}], 'facility': 'Shobara Red Cross Hospital', 'geoPoint': {'lat': 34.85, 'lon': 133.01667}}, {'city': 'Asahikawa', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Yuji Ogawa', 'role': 'CONTACT', 'phone': '0166-33-7171'}], 'facility': 'Hokkaido P.W.F.A.C Asahikawa-Kosei General Hospital', 'geoPoint': {'lat': 43.77063, 'lon': 142.36489}}, {'city': 'Asahikawa', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Hajime Kihara', 'role': 'CONTACT', 'phone': '0166-35-5555'}], 'facility': 'Kihara cardiovascular clinic', 'geoPoint': {'lat': 43.77063, 'lon': 142.36489}}, {'city': 'Ebetsu', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Kenji Aoki', 'role': 'CONTACT', 'phone': '011-382-5151'}], 'facility': 'Ebetsu City Hospital', 'geoPoint': {'lat': 43.10806, 'lon': 141.55056}}, {'city': 'Iwami', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Hideyuki Takano', 'role': 'CONTACT', 'phone': '0126-22-1300'}], 'facility': 'Hokkaido Chuo Rosai Hospital'}, {'city': 'Otaru', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Shigeo Kakinoki', 'role': 'CONTACT', 'phone': '0134-23-6234'}], 'facility': 'Otaru Kyokai Hospital', 'geoPoint': {'lat': 43.18944, 'lon': 141.00222}}, {'city': 'Sapporo', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Hiroshi Okamoto', 'role': 'CONTACT', 'phone': '011-611-8111'}], 'facility': 'Hokkaido Medical Center', 'geoPoint': {'lat': 43.06667, 'lon': 141.35}}, {'city': 'Sapporo', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Akihito Tsuchida', 'role': 'CONTACT', 'phone': '011-208-7150'}], 'facility': 'JR Sapporo Hospital', 'geoPoint': {'lat': 43.06667, 'lon': 141.35}}, {'city': 'Sapporo', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Naofumi Ito', 'role': 'CONTACT', 'phone': '011-841-4572'}], 'facility': 'KKR Sapporo Medical Center', 'geoPoint': {'lat': 43.06667, 'lon': 141.35}}, {'city': 'Sapporo', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Tetsuro Kohya', 'role': 'CONTACT', 'phone': '011-726-2211'}], 'facility': 'Sapporo City General Hospital', 'geoPoint': {'lat': 43.06667, 'lon': 141.35}}, {'city': 'Sapporo', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Noriyuki Miyamoto', 'role': 'CONTACT', 'phone': '011-623-7000'}], 'facility': 'Sapporo Medical Center NTT East', 'geoPoint': {'lat': 43.06667, 'lon': 141.35}}, {'city': 'Sapporo', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Tetsuji Miura', 'role': 'CONTACT', 'phone': '011-611-2111'}], 'facility': 'Sapporo Medical University Hospital', 'geoPoint': {'lat': 43.06667, 'lon': 141.35}}, {'city': 'Sunagawa', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Takayuki Hirabayashi', 'role': 'CONTACT', 'phone': '0125-54-2131'}], 'facility': 'Sunagawa City Medical Center', 'geoPoint': {'lat': 43.48639, 'lon': 141.90556}}, {'city': 'Himeji', 'state': 'Hyōgo', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Yoshinori Yasaka', 'role': 'CONTACT', 'phone': '079-293-3131'}], 'facility': 'Hyogo Brain and Heart Center', 'geoPoint': {'lat': 34.81667, 'lon': 134.7}}, {'city': 'Kobe', 'state': 'Hyōgo', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Kenichi Hirata', 'role': 'CONTACT', 'phone': '078-382-5111'}], 'facility': 'Kobe University Hospital', 'geoPoint': {'lat': 34.6913, 'lon': 135.183}}, {'city': 'Nishinomiya', 'state': 'Hyōgo', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Tohru Masuyama', 'role': 'CONTACT', 'phone': '0798-45-6111'}], 'facility': 'Hyogo College Of Medicine', 'geoPoint': {'lat': 34.71562, 'lon': 135.33199}}, {'city': 'Nishiwaki', 'state': 'Hyōgo', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Ryuichiro Shimao', 'role': 'CONTACT', 'phone': '0795-22-0111'}], 'facility': 'Nishiwaki Municipal Hospital', 'geoPoint': {'lat': 34.98419, 'lon': 134.97407}}, {'city': 'Hitachi', 'state': 'Ibaraki', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Yutaka Eki', 'role': 'CONTACT', 'phone': '0294-23-1111'}], 'facility': 'Hitachi General Hospital', 'geoPoint': {'lat': 36.6, 'lon': 140.65}}, {'city': 'Kanazawa', 'state': 'Ishikawa-ken', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Masatoshi Ikeda', 'role': 'CONTACT', 'phone': '076-253-8000'}], 'facility': 'Kanazawa Cardiovascular Hospital', 'geoPoint': {'lat': 36.6, 'lon': 136.61667}}, {'city': 'Kanazawa', 'state': 'Ishikawa-ken', 'status': 'RECRUITING', 'country': 'Japan', 'contacts': [{'name': 'Masakazu Yamagishi', 'role': 'CONTACT', 'phone': '076-265-2000'}], 'facility': 'Kanazawa University 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