Ignite Creation Date:
2025-12-25 @ 2:45 AM
Ignite Modification Date:
2026-03-03 @ 6:05 PM
Study NCT ID:
NCT06347133
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2025-10-08
First Post:
2024-03-29
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Phase 3 Study of Plozasiran in Adults With Hypertriglyceridemia
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D015228', 'term': 'Hypertriglyceridemia'}], 'ancestors': [{'id': 'D006949', 'term': 'Hyperlipidemias'}, {'id': 'D050171', 'term': 'Dyslipidemias'}, {'id': 'D052439', 'term': 'Lipid Metabolism Disorders'}, {'id': 'D008659', 'term': 'Metabolic Diseases'}, {'id': 'D009750', 'term': 'Nutritional and Metabolic Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C000731231', 'term': 'plozasiran'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 1456}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2024-05-21', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-10', 'completionDateStruct': {'date': '2026-09', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-10-03', 'studyFirstSubmitDate': '2024-03-29', 'studyFirstSubmitQcDate': '2024-03-29', 'lastUpdatePostDateStruct': {'date': '2025-10-08', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2024-04-04', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-05', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Percent Change in Fasting Serum Triglyceride (TG) Levels from Baseline to Month 12 Compared to Placebo', 'timeFrame': 'Baseline, Month 12'}], 'secondaryOutcomes': [{'measure': 'Percent Change in Fasting Serum TG Levels from Baseline to Month 10 Compared to Placebo', 'timeFrame': 'Baseline, Month 10'}, {'measure': 'Proportion of Participants who Achieve Fasting TG Levels of <150 mg/dL (<1.69 mmol/L) at Month 12 Compared to Placebo', 'timeFrame': 'Month 12'}, {'measure': 'Percent change in remnant cholesterol (VLDL-C) from baseline to Month 12 compared to placebo.', 'timeFrame': 'Baseline, Month 12'}, {'measure': 'Percent change in non-HDL-C from baseline to Month 12 compared to placebo', 'timeFrame': 'Baseline, Month 12'}, {'measure': 'Number of Participants with Adverse Events (AEs) and Serious Adverse Events (SAEs) Over Time through Month 12 as Compared to Placebo', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Incidence Rates of New-Onset Diabetes Mellitus (NODM) Throughout the Course of Treatment', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Incidence Rates of Impaired Glucose Tolerance Throughout the Course of Treatment', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Incidence Rates of Worsening of Existing Diabetes Throughout the Course of Treatment', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Change from Baseline in Hemoglobin A1c (HbA1c) and Other Glycemic Control Parameters During the Treatment Period Compared to Placebo', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Change from Baseline in Fasting Blood Glucose During the Treatment Period Compared to Placebo', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Change from Baseline in C-peptide During the Treatment Period Compared to Placebo', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Change from Baseline in Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) During the Treatment Period Compared to Placebo', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Change from Baseline in Treatment-Emergent Adverse Events (TEAEs) and Treatment-Related Adverse Events (TRAEs) Associated with Worsening Glycemic Control During the Treatment Period Compared to Placebo', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Initiation of New Medication for Hyperglycemia Among Study Participants Not Known to Have Pre-existing Diabetes Mellitus During the Treatment Period Compared to Placebo', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Adjudicated Major Adverse Cardiovascular Events (MACE) Rates During the Treatment Period Compared to Placebo', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Incidence of Anti-drug Antibodies (ADA) to Plozasiran in Participants Receiving Plozasiran Over Time Through Month 12', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Titers of Anti-drug Antibodies (ADA) to Plozasiran in Participants Receiving Plozasiran Over Time Through Month 12', 'timeFrame': 'From first dose of study drug through Month 12'}]}, 'oversightModule': {'isUsExport': False, 'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Hypertriglyceridemia']}, 'descriptionModule': {'briefSummary': 'This Phase 3 study will evaluate the safety and efficacy of plozasiran injection (ARO-APOC3) in adult participants with hypertriglyceridemia (HTG). After providing informed consent eligible participants will be randomized to receive 4 doses (once every 3 months) of plozasiran or placebo and be evaluated for efficacy and safety.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Males, or nonpregnant (who do not plan to become pregnant) nonlactating females, who are ≥18 years of age at screening\n* Established diagnosis of hypertriglyceridemia (HTG) and prior documented evidence (medical history) of mean fasting TG level ≥150 mg/dL (≥1.69 mm/L) and ≤499 mg/dL (≤5.64 mmol/L)\n* Mean fasting TG level ≥150 mg/dL (≥1.69 mmol/L) and ≤499 mg/dL (≤5.64 mmol/L) collected at 2 separate and consecutive visits at least 7 days apart and no more than 17 days apart during the screening period\n* Fasting low density lipoprotein-cholesterol (LDL-C) ≤ 130 mg/dL (≤3.37 mmol/L) at screening\n* Screening HbA1c ≤9.0%\n* Willing to follow diet counseling and maintain a stable low-fat diet\n* Must be on standard of care lipid and TG-lowering medications per local guidelines (unless documented as intolerant as determined by the Investigator, including an inability to safely administer or re-administer a specific drug because of fear, preference, genetic, clinical, or metabolic considerations, or due a previous adverse reaction associated with, attributed to, or caused by specific drug) prior to collection of qualifying TG levels.\n\nExclusion Criteria:\n\n* Use of any hepatocyte-targeted small interfering ribonucleic acid (siRNA) that targets lipids and/or triglycerides within 365 days before Day 1 (except inclisiran, which is permitted). Administration of investigational drug and inclisiran must be separated by at least 4 weeks.\n* Use of any other hepatocyte targeted siRNA or antisense Oligonucleotide molecule within 60 days or within 5-half-lives before Day 1 based on plasma pharmacokinetics (PK), whichever is longer\n* Acute pancreatitis within 4 weeks prior to screening\n* Body mass index \\>45 kg/m\\^2\n\nNote: Additional Inclusion/Exclusion criteria may apply per protocol'}, 'identificationModule': {'nctId': 'NCT06347133', 'acronym': 'MUIR-3', 'briefTitle': 'Phase 3 Study of Plozasiran in Adults With Hypertriglyceridemia', 'organization': {'class': 'INDUSTRY', 'fullName': 'Arrowhead Pharmaceuticals'}, 'officialTitle': 'Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Plozasiran in Adults With Hypertriglyceridemia', 'orgStudyIdInfo': {'id': 'AROAPOC3-3009'}, 'secondaryIdInfos': [{'id': '2023-509302-30', 'type': 'EUDRACT_NUMBER'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Plozasiran Injection', 'description': '4 doses of plozasiran by subcutaneous (sc) injection', 'interventionNames': ['Drug: Plozasiran Injection']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo', 'description': 'calculated volume to match active treatment by sc injection', 'interventionNames': ['Drug: Placebo']}], 'interventions': [{'name': 'Plozasiran Injection', 'type': 'DRUG', 'otherNames': ['ARO-APOC3'], 'description': 'ARO-APOC3 Injection', 'armGroupLabels': ['Plozasiran Injection']}, {'name': 'Placebo', 'type': 'DRUG', 'description': 'sterile normal saline (0.9% NaCl)', 'armGroupLabels': ['Placebo']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35205', 'city': 'Birmingham', 'state': 'Alabama', 'country': 'United States', 'facility': 'Research Site 1', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '36604', 'city': 'Mobile', 'state': 'Alabama', 'country': 'United States', 'facility': 'Research Site 2', 'geoPoint': {'lat': 30.69436, 'lon': -88.04305}}, {'zip': '90211', 'city': 'Beverly Hills', 'state': 'California', 'country': 'United States', 'facility': 'Research Site 3', 'geoPoint': {'lat': 34.07362, 'lon': -118.40036}}, {'zip': '91303', 'city': 'Canoga Park', 'state': 'California', 'country': 'United States', 'facility': 'Research Site 4', 'geoPoint': {'lat': 34.20112, 'lon': -118.59814}}, {'zip': '92844', 'city': 'Garden Grove', 'state': 'California', 'country': 'United States', 'facility': 'Research Site 5', 'geoPoint': {'lat': 33.77391, 'lon': -117.94145}}, {'zip': '92648', 'city': 'Huntington Beach', 'state': 'California', 'country': 'United States', 'facility': 'Research Site 6', 'geoPoint': {'lat': 33.6603, 'lon': -117.99923}}, {'zip': '92630', 'city': 'Lake Forest', 'state': 'California', 'country': 'United States', 'facility': 'Research Site 7', 'geoPoint': {'lat': 33.64697, 'lon': -117.68922}}, {'zip': '95648', 'city': 'Lincoln', 'state': 'California', 'country': 'United States', 'facility': 'Research Site 8', 'geoPoint': {'lat': 38.89156, 'lon': -121.29301}}, {'zip': '90822', 'city': 'Long Beach', 'state': 'California', 'country': 'United States', 'facility': 'Research Site 9', 'geoPoint': {'lat': 33.76696, 'lon': -118.18923}}, {'zip': '91763', 'city': 'Montclair', 'state': 'California', 'country': 'United States', 'facility': 'Research Site 10', 'geoPoint': {'lat': 34.07751, 'lon': -117.68978}}, {'zip': '93030', 'city': 'Oxnard', 'state': 'California', 'country': 'United States', 'facility': 'Research Site 11', 'geoPoint': {'lat': 34.1975, 'lon': -119.17705}}, {'zip': '96001', 'city': 'Redding', 'state': 'California', 'country': 'United States', 'facility': 'Research Site 12', 'geoPoint': {'lat': 40.58654, 'lon': -122.39168}}, {'zip': '91402', 'city': 'Van Nuys', 'state': 'California', 'country': 'United States', 'facility': 'Research Site 13', 'geoPoint': {'lat': 34.18667, 'lon': -118.44897}}, {'zip': '80909', 'city': 'Colorado Springs', 'state': 'Colorado', 'country': 'United States', 'facility': 'Research Site 14', 'geoPoint': {'lat': 38.83388, 'lon': -104.82136}}, {'zip': '33756', 'city': 'Clearwater', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Site 15', 'geoPoint': {'lat': 27.96585, 'lon': -82.8001}}, {'zip': '33016', 'city': 'Hialeah', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Site 16', 'geoPoint': {'lat': 25.8576, 'lon': -80.27811}}, {'zip': '32055', 'city': 'Lake City', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Site 17', 'geoPoint': {'lat': 30.18968, 'lon': -82.63929}}, {'zip': '33014', 'city': 'Miami Lakes', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Site 18', 'geoPoint': {'lat': 25.90871, 'lon': -80.30866}}, {'zip': '32757', 'city': 'Mt. Dora', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Site 19', 'geoPoint': {'lat': 28.80249, 'lon': -81.64452}}, {'zip': '33162', 'city': 'North Miami Beach', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Site 20', 'geoPoint': {'lat': 25.93315, 'lon': -80.16255}}, {'zip': '32825', 'city': 'Orlando', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Site 21', 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '32503', 'city': 'Pensacola', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Site 22', 'geoPoint': {'lat': 30.42131, 'lon': -87.21691}}, {'zip': '34239', 'city': 'Sarasota', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Site 23', 'geoPoint': {'lat': 27.33643, 'lon': -82.53065}}, {'zip': '33321', 'city': 'Tamarac', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Site 24', 'geoPoint': {'lat': 26.21286, 'lon': -80.24977}}, {'zip': '30044', 'city': 'Lawrenceville', 'state': 'Georgia', 'country': 'United States', 'facility': 'Research Site 25', 'geoPoint': {'lat': 33.95621, 'lon': -83.98796}}, {'zip': '31210', 'city': 'Macon', 'state': 'Georgia', 'country': 'United States', 'facility': 'Research Site 26', 'geoPoint': {'lat': 32.84069, 'lon': -83.6324}}, {'zip': '31406', 'city': 'Savannah', 'state': 'Georgia', 'country': 'United States', 'facility': 'Research Site 27', 'geoPoint': {'lat': 32.08354, 'lon': -81.09983}}, {'zip': '30518', 'city': 'Sugar Hill', 'state': 'Georgia', 'country': 'United States', 'facility': 'Research Site 28', 'geoPoint': {'lat': 34.10649, 'lon': -84.03352}}, {'zip': '60068', 'city': 'Park Ridge', 'state': 'Illinois', 'country': 'United States', 'facility': 'Research Site 29', 'geoPoint': {'lat': 42.01114, 'lon': -87.84062}}, {'zip': '46514', 'city': 'Elkhart', 'state': 'Indiana', 'country': 'United States', 'facility': 'Research Site 30', 'geoPoint': {'lat': 41.68199, 'lon': -85.97667}}, {'zip': '46290', 'city': 'Indianapolis', 'state': 'Indiana', 'country': 'United States', 'facility': 'Research Site 31', 'geoPoint': {'lat': 39.76838, 'lon': -86.15804}}, {'zip': '46617', 'city': 'South Bend', 'state': 'Indiana', 'country': 'United States', 'facility': 'Research Site 32', 'geoPoint': {'lat': 41.68338, 'lon': -86.25001}}, {'zip': '66211', 'city': 'Overland Park', 'state': 'Kansas', 'country': 'United States', 'facility': 'Research Site 33', 'geoPoint': {'lat': 38.98223, 'lon': -94.67079}}, {'zip': '66606', 'city': 'Topeka', 'state': 'Kansas', 'country': 'United States', 'facility': 'Research Site 34', 'geoPoint': {'lat': 39.04833, 'lon': -95.67804}}, {'zip': '40202', 'city': 'Louisville', 'state': 'Kentucky', 'country': 'United States', 'facility': 'Research Site 35', 'geoPoint': {'lat': 38.25424, 'lon': -85.75941}}, {'zip': '70791', 'city': 'Zachary', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Research Site 36', 'geoPoint': {'lat': 30.64852, 'lon': -91.1565}}, {'zip': '21401', 'city': 'Annapolis', 'state': 'Maryland', 'country': 'United States', 'facility': 'Research Site 37', 'geoPoint': {'lat': 38.97859, 'lon': -76.49184}}, {'zip': '21229', 'city': 'Baltimore', 'state': 'Maryland', 'country': 'United States', 'facility': 'Research Site 38', 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, {'zip': '48532', 'city': 'Flint', 'state': 'Michigan', 'country': 'United States', 'facility': 'Research Site 39', 'geoPoint': {'lat': 43.01253, 'lon': -83.68746}}, {'zip': '55455', 'city': 'Minneapolis', 'state': 'Minnesota', 'country': 'United States', 'facility': 'Research Site 40', 'geoPoint': {'lat': 44.97997, 'lon': -93.26384}}, {'zip': '38654', 'city': 'Olive Branch', 'state': 'Mississippi', 'country': 'United States', 'facility': 'Research Site 41', 'geoPoint': {'lat': 34.96176, 'lon': -89.82953}}, {'zip': '65109', 'city': 'Jefferson City', 'state': 'Missouri', 'country': 'United States', 'facility': 'Research Site 42', 'geoPoint': {'lat': 38.5767, 'lon': -92.17352}}, {'zip': '63136', 'city': 'St Louis', 'state': 'Missouri', 'country': 'United States', 'facility': 'Research Site 43', 'geoPoint': {'lat': 38.62727, 'lon': -90.19789}}, {'zip': '68701', 'city': 'Norfolk', 'state': 'Nebraska', 'country': 'United States', 'facility': 'Research Site 44', 'geoPoint': {'lat': 42.02834, 'lon': -97.417}}, {'zip': '68114', 'city': 'Omaha', 'state': 'Nebraska', 'country': 'United States', 'facility': 'Research Site 46', 'geoPoint': {'lat': 41.25626, 'lon': -95.94043}}, {'zip': '68144', 'city': 'Omaha', 'state': 'Nebraska', 'country': 'United States', 'facility': 'Research Site 45', 'geoPoint': {'lat': 41.25626, 'lon': -95.94043}}, {'zip': '89119', 'city': 'Las Vegas', 'state': 'Nevada', 'country': 'United States', 'facility': 'Research Site 47', 'geoPoint': {'lat': 36.17497, 'lon': -115.13722}}, {'zip': '07901', 'city': 'Summit', 'state': 'New Jersey', 'country': 'United States', 'facility': 'Research Site 48', 'geoPoint': {'lat': 40.71562, 'lon': -74.36468}}, {'zip': '10016', 'city': 'New York', 'state': 'New York', 'country': 'United States', 'facility': 'Research Site 52', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '10029', 'city': 'New York', 'state': 'New York', 'country': 'United States', 'facility': 'Research Site 51', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '11901', 'city': 'Riverhead', 'state': 'New York', 'country': 'United States', 'facility': 'Research Site 53', 'geoPoint': {'lat': 40.91704, 'lon': -72.66204}}, {'zip': '14642', 'city': 'Rochester', 'state': 'New York', 'country': 'United States', 'facility': 'Research Site 54', 'geoPoint': {'lat': 43.15478, 'lon': -77.61556}}, {'zip': '10455', 'city': 'The Bronx', 'state': 'New York', 'country': 'United States', 'facility': 'Research Site 49', 'geoPoint': {'lat': 40.84985, 'lon': -73.86641}}, {'zip': '10461', 'city': 'The Bronx', 'state': 'New York', 'country': 'United States', 'facility': 'Research Site 50', 'geoPoint': {'lat': 40.84985, 'lon': -73.86641}}, {'zip': '13850', 'city': 'Vestal', 'state': 'New York', 'country': 'United States', 'facility': 'Research Site 55', 'geoPoint': {'lat': 42.08507, 'lon': -76.05381}}, {'zip': '27203', 'city': 'Asheboro', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Research Site 56', 'geoPoint': {'lat': 35.70791, 'lon': -79.81364}}, {'zip': '28557', 'city': 'Morehead City', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Research Site 57', 'geoPoint': {'lat': 34.72294, 'lon': -76.72604}}, {'zip': '28412', 'city': 'Wilmington', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Research Site 58', 'geoPoint': {'lat': 34.23556, 'lon': -77.94604}}, {'zip': '27157', 'city': 'Winston-Salem', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Research Site 59', 'geoPoint': {'lat': 36.09986, 'lon': -80.24422}}, {'zip': '45431', 'city': 'Beavercreek', 'state': 'Ohio', 'country': 'United States', 'facility': 'Research Site 60', 'geoPoint': {'lat': 39.70923, 'lon': -84.06327}}, {'zip': '45267', 'city': 'Cincinnati', 'state': 'Ohio', 'country': 'United States', 'facility': 'Research Site 61', 'geoPoint': {'lat': 39.12711, 'lon': -84.51439}}, {'zip': '43210', 'city': 'Columbus', 'state': 'Ohio', 'country': 'United States', 'facility': 'Research Site 63', 'geoPoint': {'lat': 39.96118, 'lon': -82.99879}}, {'zip': '43214', 'city': 'Columbus', 'state': 'Ohio', 'country': 'United States', 'facility': 'Research Site 62', 'geoPoint': {'lat': 39.96118, 'lon': -82.99879}}, {'zip': '73072', 'city': 'Norman', 'state': 'Oklahoma', 'country': 'United States', 'facility': 'Research Site 64', 'geoPoint': {'lat': 35.22257, 'lon': -97.43948}}, {'zip': '73111', 'city': 'Oklahoma City', 'state': 'Oklahoma', 'country': 'United States', 'facility': 'Research Site 66', 'geoPoint': {'lat': 35.46756, 'lon': -97.51643}}, {'zip': '73112', 'city': 'Oklahoma City', 'state': 'Oklahoma', 'country': 'United States', 'facility': 'Research Site 65', 'geoPoint': {'lat': 35.46756, 'lon': -97.51643}}, {'zip': '19044', 'city': 'Horsham', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Research Site 67', 'geoPoint': {'lat': 40.17844, 'lon': -75.12851}}, {'zip': '17074', 'city': 'Newport', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Research Site 68', 'geoPoint': {'lat': 40.47786, 'lon': -77.13054}}, {'zip': '17074', 'city': 'Newport', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Research Site 69', 'geoPoint': {'lat': 40.47786, 'lon': -77.13054}}, {'zip': '19104', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Research Site 70', 'geoPoint': {'lat': 39.95238, 'lon': -75.16362}}, {'zip': '18711', 'city': 'Wilkes-Barre', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Research Site 71', 'geoPoint': {'lat': 41.24591, 'lon': -75.88131}}, {'zip': '29707', 'city': 'Fort Mill', 'state': 'South Carolina', 'country': 'United States', 'facility': 'Research Site 72', 'geoPoint': {'lat': 35.00737, 'lon': -80.94508}}, {'zip': '29607', 'city': 'Greenville', 'state': 'South Carolina', 'country': 'United States', 'facility': 'Research Site 73', 'geoPoint': {'lat': 34.85262, 'lon': -82.39401}}, {'zip': '37411', 'city': 'Chattanooga', 'state': 'Tennessee', 'country': 'United States', 'facility': 'Research Site 74', 'geoPoint': {'lat': 35.04563, 'lon': -85.30968}}, {'zip': '37849', 'city': 'Powell', 'state': 'Tennessee', 'country': 'United States', 'facility': 'Research Site 75', 'geoPoint': {'lat': 36.03175, 'lon': -84.02797}}, {'zip': '79905', 'city': 'El Paso', 'state': 'Texas', 'country': 'United States', 'facility': 'Research Site 76', 'geoPoint': {'lat': 31.75872, 'lon': -106.48693}}, {'zip': '76132', 'city': 'Fort Worth', 'state': 'Texas', 'country': 'United States', 'facility': 'Research Site 77', 'geoPoint': {'lat': 32.72541, 'lon': -97.32085}}, {'zip': '77029', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Research Site 86', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '77030', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Research Site 84', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '77030', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Research Site 85', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '77040', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Research Site 78', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '77061', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Research Site 80', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '77074', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Research Site 83', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '77079', 'city': 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