Ignite Creation Date:
2025-12-24 @ 2:28 PM
Ignite Modification Date:
2026-01-02 @ 9:49 AM
Study NCT ID:
NCT07267559
Status:
RECRUITING
Last Update Posted:
2025-12-05
First Post:
2025-11-14
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Dual Orexin Antagonism and Emotion and Affective Processing Study
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'interventionBrowseModule': {'meshes': [{'id': 'C000634383', 'term': 'daridorexant'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE4'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR'], 'maskingDescription': 'Participant, Data Collectors, Outcomes Assessor'}, 'primaryPurpose': 'OTHER', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'Participants will be randomly assigned to receive either daridorexant or placebo. Randomisation will be conducted using a variance minimisation procedure (Sella, Raz \\& Cohen Kadosh, 2021) to balance baseline sleep chronotype and gender across groups. Each participant will receive a single oral dose of daridorexant (50 mg) or placebo, followed by pupillometry and cognitive/emotional assessments approximately one hour post-dose. The study aims to examine the effects of dual orexin antagonism on aversive learning and cognition, is not designed as an efficacy or safety trial.'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 62}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2025-10-01', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-10', 'completionDateStruct': {'date': '2026-10-01', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-04', 'studyFirstSubmitDate': '2025-11-14', 'studyFirstSubmitQcDate': '2025-12-04', 'lastUpdatePostDateStruct': {'date': '2025-12-05', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2025-12-05', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2026-09-01', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Pavlovian Aversive Learning Task Computational Parameter Estimates', 'timeFrame': '1-2 hours after single dose of drug or placebo.', 'description': 'Change in the participant-specific parameter estimates produced by task model fitting.'}, {'measure': 'Affective Go/No-Go Task Computational Parameter Estimates', 'timeFrame': '1-2 hours after single dose of drug or placebo.', 'description': 'Change in the participant-specific parameter estimates produced by task model fitting.'}], 'secondaryOutcomes': [{'measure': 'Pupilometry during Pavlovian Aversive Learning Task', 'timeFrame': '1-2 hours after single dose of drug or placebo.', 'description': 'Changes in pupil size (dilation or constriction) in response to task stimuli'}, {'measure': 'Pupilometry during Affective Go/No-Go Task', 'timeFrame': '1-2 hours after single dose of drug or placebo.', 'description': 'Changes in pupil size (dilation or constriction) in response to task stimuli.'}, {'measure': 'Salivary Alpha Amylase Levels', 'timeFrame': '1-2 hours after single dose of drug or placebo.', 'description': 'Changes in Salivary Alpha Amylase Levels before, during and after Pavlovian Aversive Learning Task'}, {'measure': 'Optimal choice selection during loss and reward conditions in Probabilistic Instrumental Learning Task (PILT)', 'timeFrame': '2-3 hours after single dose of drug or placebo.', 'description': 'Optimal choice selection during loss and reward conditions in Probabilistic Instrumental Learning Task (PILT) in drug group compared with the placebo group'}, {'measure': 'Accuracy of target selection on the Colour Change Detection Task', 'timeFrame': '2-3 hours after single dose of drug or placebo.', 'description': 'Accuracy of target selection on the Colour Change Detection Task in pilosant group compared with the placebo group.'}, {'measure': 'Accuracy of emotional labeling of facial expressions during the facial emotion recognition task', 'timeFrame': '2-3 hours after single dose of drug or placebo.', 'description': 'Accuracy of emotion labels (e.g. disgusted face) assigned by participants to expressive faces during the facial emotion recognition task in drug group compared with the placebo group'}, {'measure': 'Accuracy during categorisation of emotional words', 'timeFrame': '2-3 hours after single dose of drug or placebo.', 'description': 'Accuracy to categorise positive and negative descriptor words'}, {'measure': 'Accuracy during recall of emotional words', 'timeFrame': '2-3 hours after single dose of drug or placebo.', 'description': 'Number of words accurately recalled'}, {'measure': 'Pavlovian Aversive Learning Task Behavioural Performance', 'timeFrame': '1-2 hours after single dose of drug or placebo.', 'description': 'Change in behavioural performance (response time; accuracy)'}, {'measure': 'Affective Go/No-Go Task Behavioural Performance', 'timeFrame': '1-2 hours after single dose of drug or placebo.', 'description': 'Change in behavioural performance (response time; accuracy)'}]}, 'oversightModule': {'isUsExport': False, 'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Drug', 'Orexin', 'Hypocretin', 'Healthy volunteers', 'Learning', 'Cognition'], 'conditions': ['Learning', 'Cognitive Functioning', 'Emotional Processing']}, 'referencesModule': {'availIpds': [{'url': 'https://osf.io/8mvn6', 'type': 'Study Protocol'}, {'url': 'https://osf.io/5kuyn', 'type': 'Informed Consent Form'}]}, 'descriptionModule': {'briefSummary': 'In this study, the investigators will examine the effects of blocking the orexin system on human behaviour and brain function using daridorexant, a medication that inhibits orexin activity. Orexin is a brain chemical involved in regulating sleep, emotion, motivation, and stress responses, which are often disrupted in mental health disorders. Healthy volunteers will be randomly assigned to receive a single dose of daridorexant or placebo in a double-blind design. Participants will then complete behavioural and cognitive tasks assessing emotional processing, aversive learning, and executive function. The study aims to clarify the role of orexin in emotional and cognitive processes relevant to conditions such as depression and anxiety.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT'], 'maximumAge': '30 Years', 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Adult participant, aged 18 to 30 years\n* Willing and able to give informed consent for participation in the trial\n* Able to follow study procedures as laid out in the participant information sheet\n* Able to read and understand English\n* Willing to avoid drinking alcohol, using recreational drugs, drinking grapefruit juice 24 hours before and after the study visit\n* Willing to avoid driving or engaging in any activities requiring full alertness (e.g. cycling or operating heavy machinery) until the morning after the study visit day.\n* Able to complete computer tasks without eye glasses even if uses correction regularly\n\nExclusion Criteria:\n\n1. History of, receiving or seeking treatment for any sleep or circadian rhythm disorder or positive in screening questionnaires.\n2. History of, receiving or seeking treatment for any clinically significant mental health condition (including but not limited to schizophrenia, psychosis, bipolar affective disorder, major depressive disorder, obsessive compulsive disorder, post-traumatic stress disorder) or positive in screening questionnaires.\n3. History of, or current medical condition(s) which might increase the risk of oral administration of daridorexant, including:\n\n * ADHD requiring treatment with stimulants or other centrally-acting drugs\n * Neurological problems, including traumatic brain injury, epilepsy, Central Nervous System tumours or other severe neurological problems (e.g. Parkinson\'s disease; blackouts requiring hospitalisation)\n * Current Asthma, Chronic Obstructive Pulmonary Disease, emphysema or any medical condition that affects the lungs or breathing\n * Mild to severe hepatic impairment (Child-Pugh class A-C)\n * Severe renal disease\n * Severe gastrointestinal problems\n * History of, or current medical condition(s) which, in the opinion of the Investigator may interfere with the safety of the participant or the scientific integrity of the study\n4. Pregnancy (as determined by urine pregnancy test taken during screening visit), intention to become pregnant or breastfeeding during the study or over the following six months.\n5. Body mass index (BMI) below 18 or above 30kg/m2.\n6. Current or past history of drug or alcohol dependency.\n7. Use of recreational drugs or performance-enhancing drugs (e.g. cannabis, cocaine, amphetamines) within past three months.\n8. Excessive caffeine consumption, i.e., consumption higher than 400mg a day of caffeine. This corresponds to more than 4 cups of brewed coffee, 6 espressos or filtered coffees, 9 cups of black tea, 10 cans of cola, or two "energy shot" drinks.\n9. Smoking more than 5 cigarettes per day (or other nicotine replacement equivalent, including vaping on average more than 50 puffs a day).\n10. Current or recent (past two months) use of any medication or medical devices (e.g. implanted neurostimulator) that affect brain function for the exception of contraceptives (pill, the Depo-Provera injection or the progesterone implant). This includes drugs that cause sedation (e.g. benzodiazepines, opioids, tricyclic antidepressants or sedative antipsychotics) or antihistamines.\n11. Current use of any medications at risk of interaction with daridorexant; in particular:\n\n * strong or moderate CYP3A inhibitors (e.g. strong inhibitors - itraconazole, clarithromycin, ritonavir, grapefruit juice; moderate inhibitors - fluconazole, verapamil, diltiazem, erythromycin, ciprofloxacin, cyclosporine)\n * strong or moderate CYP3A inducers (e.g. of strong inducers - rifampicin, carbamazepine, St. John\'s wort; moderate inducers - bosentan, efavirenz, etravirine, modafinil)\n * Gastric pH-modifiers (e.g. famotidine and proton pump inhibitors such as omeprazole)\n * P-gp transporters (e.g. dabigatran, digoxin)\n12. Inability to ingest up to 95mg of lactose.\n13. Previous participation in any other drug study or sleep intervention study in the last three months.\n14. Previous participation in any other study by the Psychopharmacology and Emotion Research lab (Department of Psychiatry, University of Oxford) or which uses the same computer tasks in the last 6 months\n15. Participant is unlikely to comply with the clinical study protocol or is unsuitable for any other reason, in the opinion of the Investigator.'}, 'identificationModule': {'nctId': 'NCT07267559', 'acronym': 'DOREA', 'briefTitle': 'Dual Orexin Antagonism and Emotion and Affective Processing Study', 'organization': {'class': 'OTHER', 'fullName': 'University of Oxford'}, 'officialTitle': 'An Investigation of the Effects of Dual Orexin Antagonism on Emotional Processing and Learning in Healthy Individuals', 'orgStudyIdInfo': {'id': 'DOREA'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Daridorexant', 'description': 'Acute daridorexant (50mg)', 'interventionNames': ['Drug: Daridorexant 50 mg']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo', 'description': 'Inactive placebo comparator', 'interventionNames': ['Other: Placebo']}], 'interventions': [{'name': 'Daridorexant 50 mg', 'type': 'DRUG', 'description': 'Acute (single dose) daridorexant encapsulated in an opaque capsule. Oral administration. Daridorexant (brand name Quviviq) is FDA-approved for the treatment of insomnia in adults.', 'armGroupLabels': ['Daridorexant']}, {'name': 'Placebo', 'type': 'OTHER', 'description': 'Lactose film-coated tablet will be encapsulated in an opaque capsule (identical to the experimental arm drug).', 'armGroupLabels': ['Placebo']}]}, 'contactsLocationsModule': {'locations': [{'zip': 'OX3 7JX', 'city': 'Oxford', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Michael J Colwell, DPhil', 'role': 'CONTACT', 'email': 'michael.colwell@psych.ox.ac.uk', 'phone': '01865 618200', 'phoneExt': '+44'}, {'name': 'Daniela A Borges, MD', 'role': 'CONTACT', 'email': 'daniela.almeidaborges@psych.ox.ac.uk', 'phone': '01865 618200', 'phoneExt': '+44'}, {'name': 'Catherine J Harmer, DPhil', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Department of Psychiatry, University of Oxford', 'geoPoint': {'lat': 51.75222, 'lon': -1.25596}}], 'centralContacts': [{'name': 'Michael J Colwell, DPhil', 'role': 'CONTACT', 'email': 'michael.colwell@psych.ox.ac.uk', 'phone': '01865 618200', 'phoneExt': '+44'}, {'name': 'Daniela A Borges, MD', 'role': 'CONTACT', 'email': 'daniela.almeidaborges@psych.ox.ac.uk', 'phone': '01865 618200', 'phoneExt': '+44'}], 'overallOfficials': [{'name': 'Catherine J Harmer, DPhil', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'University of Oxford'}]}, 'ipdSharingStatementModule': {'url': 'https://osf.io/k6gmd/', 'infoTypes': ['STUDY_PROTOCOL', 'ICF', 'ANALYTIC_CODE'], 'timeFrame': 'A few months after all data has been completed (ETA Oct 2026), unblinding has occurred (ETA Dec 2026), and all data analyses has been completed (Dec 2027).', 'ipdSharing': 'YES', 'description': 'Data which has been fully de-identified may be shared with other academic and commercial organisations in the future, including those outside of the UK and the EU. Participants will be informed of this and specific consent to this is obtained within the Informed Consent Form.', 'accessCriteria': 'The data will be made publicly available. Access requests will not be required.'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'University of Oxford', 'class': 'OTHER'}, 'responsibleParty': {'type': 'SPONSOR'}}}}