Ignite Creation Date:
2025-12-25 @ 2:39 AM
Ignite Modification Date:
2026-03-02 @ 10:05 PM
Study NCT ID:
NCT01252134
Status:
COMPLETED
Last Update Posted:
2012-06-11
First Post:
2010-12-01
Is NOT Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Evaluation of Silicone Hydrogel Lens Wettability With Marketed Lens Care Solutions
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'removedCountries': ['United States']}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'medinfo@alconlabs.com', 'phone': '888.451.3937', 'title': 'Director of Medical Affairs', 'organization': 'Alcon Research, Ltd.'}, 'certainAgreement': {'restrictionType': 'OTHER', 'piSponsorEmployee': False, 'restrictiveAgreement': True}}, 'adverseEventsModule': {'timeFrame': 'Adverse events were collected for the duration of the trial: 24-NOV-2010 to 8-FEB-2011.', 'description': 'This reporting group includes all enrolled and exposed participants', 'eventGroups': [{'id': 'EG000', 'title': 'Synergi', 'description': 'Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours.', 'otherNumAtRisk': 21, 'otherNumAffected': 0, 'seriousNumAtRisk': 21, 'seriousNumAffected': 0}, {'id': 'EG001', 'title': 'Bio-True', 'description': 'Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours.', 'otherNumAtRisk': 21, 'otherNumAffected': 0, 'seriousNumAtRisk': 21, 'seriousNumAffected': 0}, {'id': 'EG002', 'title': 'OTE Elements', 'description': 'Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours.', 'otherNumAtRisk': 20, 'otherNumAffected': 0, 'seriousNumAtRisk': 20, 'seriousNumAffected': 0}], 'frequencyThreshold': '5'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Ex Vivo Contact Angle', 'denoms': [{'units': 'Participants', 'counts': [{'value': '19', 'groupId': 'OG000'}, {'value': '20', 'groupId': 'OG001'}, {'value': '20', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Synergi', 'description': 'Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours.'}, {'id': 'OG001', 'title': 'Bio-True', 'description': 'Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours.'}, {'id': 'OG002', 'title': 'OTE Elements', 'description': 'Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours.'}], 'classes': [{'categories': [{'measurements': [{'value': '104.8', 'spread': '2.4', 'groupId': 'OG000'}, {'value': '104.9', 'spread': '3.7', 'groupId': 'OG001'}, {'value': '103.3', 'spread': '5.4', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '8 hours', 'description': 'Study lens was removed from the eye according to protocol-specified procedures. The OCA15 Dynamic Contact Angle Instrument was used to observe, record, and calculate contact angle measurements. The measurements from the right eye and left eye were averaged. A lower contact angle measurement indicates a more wettable lens.', 'unitOfMeasure': 'degrees', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'This reporting group includes all participants who completed the study, minus one response in Synergi group due to a measurement error.'}, {'type': 'SECONDARY', 'title': 'Subjective Comfort', 'denoms': [{'units': 'Participants', 'counts': [{'value': '20', 'groupId': 'OG000'}, {'value': '20', 'groupId': 'OG001'}, {'value': '20', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Synergi', 'description': 'Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours.'}, {'id': 'OG001', 'title': 'Bio-True', 'description': 'Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours.'}, {'id': 'OG002', 'title': 'OTE Elements', 'description': 'Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours.'}], 'classes': [{'categories': [{'measurements': [{'value': '87.3', 'spread': '7.9', 'groupId': 'OG000'}, {'value': '87.3', 'spread': '10.2', 'groupId': 'OG001'}, {'value': '86.4', 'spread': '15.0', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '8 hours', 'description': 'Subjective comfort was assessed by the participant on a scale of 0 to 100, with 0 being very poor comfort and 100 being excellent comfort. The ratings for the right eye and left eye were averaged.', 'unitOfMeasure': 'Units on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'This reporting group includes all participants who completed the study.'}, {'type': 'SECONDARY', 'title': 'Corneal Staining Type', 'denoms': [{'units': 'Participants', 'counts': [{'value': '20', 'groupId': 'OG000'}, {'value': '20', 'groupId': 'OG001'}, {'value': '20', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Synergi', 'description': 'Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours.'}, {'id': 'OG001', 'title': 'Bio-True', 'description': 'Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours.'}, {'id': 'OG002', 'title': 'OTE Elements', 'description': 'Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours.'}], 'classes': [{'categories': [{'measurements': [{'value': '5.4', 'spread': '8.4', 'groupId': 'OG000'}, {'value': '8.8', 'spread': '8.4', 'groupId': 'OG001'}, {'value': '3.0', 'spread': '4.7', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '8 hours', 'description': 'Five regions of the cornea (central, inferior, temporal, superior, and nasal) were evaluated for staining using cobalt light and a #12 Wratten filter. The type of staining was recorded on a scale of 0 to 100 for each corneal region with 0-none, 25=micropunctate, 50=macropunctate, 75=coalescent, and 100=patch. The five regions for each eye were averaged, and the eyes were averaged.', 'unitOfMeasure': 'Units on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'This reporting group includes all participants who completed the study.'}, {'type': 'SECONDARY', 'title': 'Corneal Staining Extent', 'denoms': [{'units': 'Participants', 'counts': [{'value': '20', 'groupId': 'OG000'}, {'value': '20', 'groupId': 'OG001'}, {'value': '20', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Synergi', 'description': 'Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours.'}, {'id': 'OG001', 'title': 'Bio-True', 'description': 'Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours.'}, {'id': 'OG002', 'title': 'OTE Elements', 'description': 'Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours.'}], 'classes': [{'categories': [{'measurements': [{'value': '0.7', 'spread': '0.8', 'groupId': 'OG000'}, {'value': '3.1', 'spread': '3.8', 'groupId': 'OG001'}, {'value': '0.9', 'spread': '4.7', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '8 hours', 'description': 'Area (extent) of corneal staining was estimated for each of the five regions of the cornea as a percentage i.e., 0%=no staining in the region and 100%=staining covering the entire region). A staining area percentage was calculated for each eye based on the average staining area measured across all five regions, and the eyes were averaged.', 'unitOfMeasure': 'percentage of cornea', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'This reporting group includes all participants who completed the study.'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Synergi, Then Biotrue, Then OTE', 'description': 'Three lens care systems randomly assigned. Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours, with a minimum two-day washout between each wear period.'}, {'id': 'FG001', 'title': 'Synergi, Then OTE, Then Biotrue', 'description': 'Three lens care systems randomly assigned. Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours, with a minimum two-day washout between each wear period.'}, {'id': 'FG002', 'title': 'Biotrue, Then OTE, Then Synergi', 'description': 'Three lens care systems randomly assigned. Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours, with a minimum two-day washout between each wear period.'}, {'id': 'FG003', 'title': 'Biotrue, Then Synergi, Then OTE', 'description': 'Three lens care systems randomly assigned. Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours, with a minimum two-day washout between each wear period.'}, {'id': 'FG004', 'title': 'OTE, Then Biotrue, Then Synergi', 'description': 'Three lens care systems randomly assigned. Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours, with a minimum two-day washout between each wear period.'}, {'id': 'FG005', 'title': 'OTE, Then Synergi, Then Biotrue', 'description': 'Three lens care systems randomly assigned. Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours, with a minimum two-day washout between each wear period.'}], 'periods': [{'title': 'Period 1, 8 Hours', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '3'}, {'groupId': 'FG001', 'numSubjects': '4'}, {'groupId': 'FG002', 'numSubjects': '3'}, {'groupId': 'FG003', 'numSubjects': '5'}, {'groupId': 'FG004', 'numSubjects': '3'}, {'groupId': 'FG005', 'numSubjects': '4'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '3'}, {'groupId': 'FG001', 'numSubjects': '3'}, {'groupId': 'FG002', 'numSubjects': '2'}, {'groupId': 'FG003', 'numSubjects': '5'}, {'groupId': 'FG004', 'numSubjects': '3'}, {'groupId': 'FG005', 'numSubjects': '4'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '1'}, {'groupId': 'FG002', 'numSubjects': '1'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '0'}, {'groupId': 'FG005', 'numSubjects': '0'}]}], 'dropWithdraws': [{'type': 'Personal Reasons', 'reasons': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '1'}, {'groupId': 'FG002', 'numSubjects': '1'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '0'}, {'groupId': 'FG005', 'numSubjects': '0'}]}]}, {'title': 'Period 2, 8 Hours', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '3'}, {'groupId': 'FG001', 'numSubjects': '3'}, {'groupId': 'FG002', 'numSubjects': '2'}, {'groupId': 'FG003', 'numSubjects': '5'}, {'groupId': 'FG004', 'numSubjects': '3'}, {'groupId': 'FG005', 'numSubjects': '4'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '3'}, {'groupId': 'FG001', 'numSubjects': '3'}, {'groupId': 'FG002', 'numSubjects': '2'}, {'groupId': 'FG003', 'numSubjects': '5'}, {'groupId': 'FG004', 'numSubjects': '3'}, {'groupId': 'FG005', 'numSubjects': '4'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '0'}, {'groupId': 'FG005', 'numSubjects': '0'}]}]}, {'title': 'Period 3, 8 Hours', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '3'}, {'groupId': 'FG001', 'numSubjects': '3'}, {'groupId': 'FG002', 'numSubjects': '2'}, {'groupId': 'FG003', 'numSubjects': '5'}, {'groupId': 'FG004', 'numSubjects': '3'}, {'groupId': 'FG005', 'numSubjects': '4'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '3'}, {'groupId': 'FG001', 'numSubjects': '3'}, {'groupId': 'FG002', 'numSubjects': '2'}, {'groupId': 'FG003', 'numSubjects': '5'}, {'groupId': 'FG004', 'numSubjects': '3'}, {'groupId': 'FG005', 'numSubjects': '4'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '0'}, {'groupId': 'FG005', 'numSubjects': '0'}]}]}], 'recruitmentDetails': 'Participants were recruited and enrolled from one Canadian study center.'}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '22', 'groupId': 'BG000'}]}], 'groups': [{'id': 'BG000', 'title': 'Overall', 'description': 'All enrolled participants'}], 'measures': [{'title': 'Age Continuous', 'classes': [{'categories': [{'measurements': [{'value': '24.8', 'spread': '9.5', 'groupId': 'BG000'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '13', 'groupId': 'BG000'}]}, {'title': 'Male', 'measurements': [{'value': '9', 'groupId': 'BG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}, 'primaryPurpose': 'SUPPORTIVE_CARE', 'interventionModel': 'CROSSOVER'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 22}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2010-11'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2012-05', 'completionDateStruct': {'date': '2011-02', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2012-05-08', 'studyFirstSubmitDate': '2010-12-01', 'resultsFirstSubmitDate': '2012-05-08', 'studyFirstSubmitQcDate': '2010-12-01', 'lastUpdatePostDateStruct': {'date': '2012-06-11', 'type': 'ESTIMATED'}, 'resultsFirstSubmitQcDate': '2012-05-08', 'studyFirstPostDateStruct': {'date': '2010-12-02', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2012-06-11', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2011-02', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Ex Vivo Contact Angle', 'timeFrame': '8 hours', 'description': 'Study lens was removed from the eye according to protocol-specified procedures. The OCA15 Dynamic Contact Angle Instrument was used to observe, record, and calculate contact angle measurements. The measurements from the right eye and left eye were averaged. A lower contact angle measurement indicates a more wettable lens.'}], 'secondaryOutcomes': [{'measure': 'Subjective Comfort', 'timeFrame': '8 hours', 'description': 'Subjective comfort was assessed by the participant on a scale of 0 to 100, with 0 being very poor comfort and 100 being excellent comfort. The ratings for the right eye and left eye were averaged.'}, {'measure': 'Corneal Staining Type', 'timeFrame': '8 hours', 'description': 'Five regions of the cornea (central, inferior, temporal, superior, and nasal) were evaluated for staining using cobalt light and a #12 Wratten filter. The type of staining was recorded on a scale of 0 to 100 for each corneal region with 0-none, 25=micropunctate, 50=macropunctate, 75=coalescent, and 100=patch. The five regions for each eye were averaged, and the eyes were averaged.'}, {'measure': 'Corneal Staining Extent', 'timeFrame': '8 hours', 'description': 'Area (extent) of corneal staining was estimated for each of the five regions of the cornea as a percentage i.e., 0%=no staining in the region and 100%=staining covering the entire region). A staining area percentage was calculated for each eye based on the average staining area measured across all five regions, and the eyes were averaged.'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['Soft Contact lens', 'Multi-purpose solution', 'Wettability'], 'conditions': ['Contact Lens Wear']}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to assess ex vivo wettability of a commonly prescribed silicone hydrogel (SiH) contact lens with three marketed contact lens care solutions.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* 18 years of age\n* Soft contact lens wear on a daily wear basis\n* Able to wear lenses at least 8 hours\n* Generally healthy with normal ocular health\n* Other protocol-defined inclusion criteria may apply\n\nExclusion Criteria:\n\n* Use of additional lens cleaners\n* Known sensitivities to any ingredient in any of the study products\n* History of ocular surgery/trauma within the last 6 months\n* Other protocol-defined exclusion criteria may apply'}, 'identificationModule': {'nctId': 'NCT01252134', 'acronym': 'SILVER', 'briefTitle': 'Evaluation of Silicone Hydrogel Lens Wettability With Marketed Lens Care Solutions', 'organization': {'class': 'INDUSTRY', 'fullName': 'Alcon Research'}, 'officialTitle': 'The Evaluation of Silicone Hydrogel Lens Wettability With Marketed Lens Care Solutions', 'orgStudyIdInfo': {'id': 'RDG10078 / SILVER'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'OTHER', 'label': 'Synergi, then Biotrue, then OTE', 'description': 'Three lens care systems randomly assigned. Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours, with a minimum two-day washout between each wear period.', 'interventionNames': ['Device: Biotrue multipurpose solution', 'Device: Sauflon Synergi multipurpose solution', 'Device: OTE Elements multipurpose solution', 'Device: Silicone hydrogel contact lenses (Acuvue Advance)']}, {'type': 'OTHER', 'label': 'Synergi, then OTE, then Biotrue', 'description': 'Three lens care systems randomly assigned. Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours, with a minimum two-day washout between each wear period.', 'interventionNames': ['Device: Biotrue multipurpose solution', 'Device: Sauflon Synergi multipurpose solution', 'Device: OTE Elements multipurpose solution', 'Device: Silicone hydrogel contact lenses (Acuvue Advance)']}, {'type': 'OTHER', 'label': 'Biotrue, then OTE, then Synergi', 'description': 'Three lens care systems randomly assigned. Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours, with a minimum two-day washout between each wear period.', 'interventionNames': ['Device: Biotrue multipurpose solution', 'Device: Sauflon Synergi multipurpose solution', 'Device: OTE Elements multipurpose solution', 'Device: Silicone hydrogel contact lenses (Acuvue Advance)']}, {'type': 'OTHER', 'label': 'Biotrue, then Synergi, then OTE', 'description': 'Three lens care systems randomly assigned. Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours, with a minimum two-day washout between each wear period.', 'interventionNames': ['Device: Biotrue multipurpose solution', 'Device: Sauflon Synergi multipurpose solution', 'Device: OTE Elements multipurpose solution', 'Device: Silicone hydrogel contact lenses (Acuvue Advance)']}, {'type': 'OTHER', 'label': 'OTE, then Biotrue, then Synergi', 'description': 'Three lens care systems randomly assigned. Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours, with a minimum two-day washout between each wear period.', 'interventionNames': ['Device: Biotrue multipurpose solution', 'Device: Sauflon Synergi multipurpose solution', 'Device: OTE Elements multipurpose solution', 'Device: Silicone hydrogel contact lenses (Acuvue Advance)']}, {'type': 'OTHER', 'label': 'OTE, then Synergi, then Biotrue', 'description': 'Three lens care systems randomly assigned. Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours, with a minimum two-day washout between each wear period.', 'interventionNames': ['Device: Biotrue multipurpose solution', 'Device: Sauflon Synergi multipurpose solution', 'Device: OTE Elements multipurpose solution', 'Device: Silicone hydrogel contact lenses (Acuvue Advance)']}], 'interventions': [{'name': 'Biotrue multipurpose solution', 'type': 'DEVICE', 'description': 'Contact lens care solution', 'armGroupLabels': ['Biotrue, then OTE, then Synergi', 'Biotrue, then Synergi, then OTE', 'OTE, then Biotrue, then Synergi', 'OTE, then Synergi, then Biotrue', 'Synergi, then Biotrue, then OTE', 'Synergi, then OTE, then Biotrue']}, {'name': 'Sauflon Synergi multipurpose solution', 'type': 'DEVICE', 'description': 'Contact lens care solution', 'armGroupLabels': ['Biotrue, then OTE, then Synergi', 'Biotrue, then Synergi, then OTE', 'OTE, then Biotrue, then Synergi', 'OTE, then Synergi, then Biotrue', 'Synergi, then Biotrue, then OTE', 'Synergi, then OTE, then Biotrue']}, {'name': 'OTE Elements multipurpose solution', 'type': 'DEVICE', 'description': 'Contact lens care solution', 'armGroupLabels': ['Biotrue, then OTE, then Synergi', 'Biotrue, then Synergi, then OTE', 'OTE, then Biotrue, then Synergi', 'OTE, then Synergi, then Biotrue', 'Synergi, then Biotrue, then OTE', 'Synergi, then OTE, then Biotrue']}, {'name': 'Silicone hydrogel contact lenses (Acuvue Advance)', 'type': 'DEVICE', 'otherNames': ['Acuvue® Advance™'], 'description': 'Commercially marketed contact lenses', 'armGroupLabels': ['Biotrue, then OTE, then Synergi', 'Biotrue, then Synergi, then OTE', 'OTE, then Biotrue, then Synergi', 'OTE, then Synergi, then Biotrue', 'Synergi, then Biotrue, then OTE', 'Synergi, then OTE, then Biotrue']}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Alcon Research', 'class': 'INDUSTRY'}, 'responsibleParty': {'type': 'SPONSOR'}}}}