Ignite Creation Date:
2025-12-25 @ 2:38 AM
Ignite Modification Date:
2025-12-26 @ 1:16 AM
Study NCT ID:
NCT07284134
Status:
NOT_YET_RECRUITING
Last Update Posted:
2025-12-16
First Post:
2025-12-03
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
JS107 vs Investigator's Choice as Second-line or Later Therapy for Advanced CLDN18.2-Positive Gastricor GEJ Adenocarcinoma.
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'interventionBrowseModule': {'meshes': [{'id': 'D007267', 'term': 'Injections'}, {'id': 'D000077146', 'term': 'Irinotecan'}, {'id': 'D017239', 'term': 'Paclitaxel'}, {'id': 'D000077143', 'term': 'Docetaxel'}], 'ancestors': [{'id': 'D004333', 'term': 'Drug Administration Routes'}, {'id': 'D004358', 'term': 'Drug Therapy'}, {'id': 'D013812', 'term': 'Therapeutics'}, {'id': 'D002166', 'term': 'Camptothecin'}, {'id': 'D000470', 'term': 'Alkaloids'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}, {'id': 'D043823', 'term': 'Taxoids'}, {'id': 'D043822', 'term': 'Cyclodecanes'}, {'id': 'D003516', 'term': 'Cycloparaffins'}, {'id': 'D006840', 'term': 'Hydrocarbons, Alicyclic'}, {'id': 'D006844', 'term': 'Hydrocarbons, Cyclic'}, {'id': 'D006838', 'term': 'Hydrocarbons'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D004224', 'term': 'Diterpenes'}, {'id': 'D013729', 'term': 'Terpenes'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 560}}, 'statusModule': {'overallStatus': 'NOT_YET_RECRUITING', 'startDateStruct': {'date': '2025-12-20', 'type': 'ESTIMATED'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2028-10-17', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-15', 'studyFirstSubmitDate': '2025-12-03', 'studyFirstSubmitQcDate': '2025-12-15', 'lastUpdatePostDateStruct': {'date': '2025-12-16', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2025-12-16', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2027-10-13', 'type': 'ESTIMATED'}}, 'outcomesModule': {'otherOutcomes': [{'measure': 'HRQOL', 'timeFrame': 'up to 2 years', 'description': 'HRQOL (based on FACT-Ga and EORTC QLQ-C30 questionnaires)'}, {'measure': 'expression levels of CLDN18.2', 'timeFrame': 'up to 2 years', 'description': 'Detect different expression levels of CLDN18.2 in tumor tissues and analyze the correlation with therapeutic efficacy'}], 'primaryOutcomes': [{'measure': 'BICR-PFS', 'timeFrame': 'up to 2 years', 'description': 'Progression-Free Survival (BICR-PFS) evaluated based on Blinded Independent Central Review (BICR) (according to the RECIST v1.1 criteria)'}, {'measure': 'Overall Survival', 'timeFrame': 'up to 5 years', 'description': "The primary endpoint of overall survival (OS) in this multicenter, randomized, open-label Phase III study is the time from randomization to death from any cause, aiming to compare the benefit between JS107 and investigator's choice of therapy in patients with CLDN18.2-positive, HER2-negative advanced gastric or gastroesophageal junction adenocarcinoma who have received at least one prior line of systemic therapy."}], 'secondaryOutcomes': [{'measure': 'INV-PFS', 'timeFrame': 'up to 2 years', 'description': 'Progression-Free Survival evaluated by investigators (INV-PFS, according to the RECIST v1.1 criteria)'}, {'measure': 'BICR-ORR or INV-ORR', 'timeFrame': 'up to 2 years', 'description': 'ORR evaluated by investigators or BICR (according to the RECIST v1.1 criteria)'}, {'measure': 'BICR-DCR or INV -DCR', 'timeFrame': 'up to 2 years', 'description': 'Progression-Free Survival evaluated by investigators (INV-PFS, according to the RECIST v1.1 criteria)'}, {'measure': 'BICR-DoR or INV -DoR', 'timeFrame': 'up to 2 years', 'description': 'DoR (based on the RECIST v1.1 criteria) evaluated by investigators or BICR'}, {'measure': 'The incidence rate and severity of AE', 'timeFrame': 'up to 2 years', 'description': 'The incidence and severity of adverse events (AEs) evaluated according to the NCI-CTC AE v5.0 standard'}, {'measure': 'Valley concentration of JS107', 'timeFrame': 'up to 2 years', 'description': 'Valley concentration of JS107 (including ADC, total antibody, and toxin)'}, {'measure': 'anti-drug antibodies (ADA) for JS107', 'timeFrame': 'up to 2 years', 'description': 'Incidence and titer of anti-drug antibodies (ADA) for JS107 (including ADC, total antibody, and toxin)'}, {'measure': 'Incidence of neutralizing antibodies (NAb) to JS107', 'timeFrame': 'up to 2 years', 'description': 'Incidence of neutralizing antibodies (NAb) to JS107 (including ADC, total antibody, and toxin)'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Advanced Gastric or Gastroesophageal Junction Adenocarcinoma']}, 'descriptionModule': {'briefSummary': 'This is a multicenter, randomized, controlled, open-label, Phase III study, designed to evaluate the efficacy and safety of JS107 versus investigator-selected therapy in the second-line or later treatment of patients with advanced gastric or gastroesophageal junction adenocarcinoma positive for CLDN18.2.\n\nThe study population consists of patients with CLDN18.2-positive, HER2-negative, locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma who have received at least one prior line of systemic therapy. The primary endpoints of the study are BICR-assessed progression-free survival and overall survival.\n\nNumber of subjects and allocation:This study plans to enroll approximately 560 subjects, who will be randomized in a 1:1 ratio to receive either JS107 (experimental group) or investigator-selected therapy (control group).', 'detailedDescription': 'Patients with HER2 negative G/GEJ adenocarcinoma confirmed by histology/cytology. who have received at one prior line of systemic treatment and developed PD, and the previous treatment must include fluorouracil and platinum; CLDN18.2-positive, HER2-negative.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. Voluntarily participate in this study, have ICF signed after sufficient informed consent, and have good compliance.\n2. Age ≥ 18 years, male or female.\n3. ECOG PS 0 or 1.\n4. Expected survival period≥ 3 months.\n5. Patients with HER2 negative G/GEJ adenocarcinoma confirmed by histology/cytology.\n6. Patients who have received at least one prior line of systemic treatments and developed PD, and the previous treatment must include fluorouracil and platinum.\n7. Fresh or archival tumor tissue (blocks of formalin-fixed, paraffin-embedded \\[FFPE\\] tissue or unstained FFPE tumor tissue sections) must be available and comfirmed CLDN18.2 positivity by for central laboratory through immunohistochemistry (IHC) before randomization.\n8. Having ≥ 1 measurable lesion according to RECIST v1.1 (per investigator assessment).\n9. Any AEs and/or complications caused by previous therapies including surgery or radiotherapy have been adequately resolved to Grade 0 or 1 (per NCI-CTCAE v5.0 criteria) or have been stabilized in the judgment of investigators.\n\nExclusion Criteria:\n\n1. Previous treatment with any drug or cellular therapy targeting CLDN18.2 (except CLDN18.2 monotarget monoclonal antibody).\n2. Previously treated with an ADC loaded with a tubulin inhibitor.\n3. Received strong CYP3A inhibitor or inducer within 2 weeks or 5 half-lives prior to randomization, whichever is longer.\n4. Use of chemotherapy, immunotherapy or other anti-tumor therapies or participation in other clinical trials within 3 weeks prior to randomization, or use of oral fluorouracil, small molecule targeted drugs or traditional Chinese medicine for gastric cancer within 2 weeks prior to randomization.\n5. Major surgery (requiring general anaesthesia and \\>24 hours of Hospitalisation) or other clincal trial drug treatment within 4 weeks prior to randomization, or radiotherapy within 2 weeks prior to randomization.\n6. Imaging demonstrating brain metastases (except patients who have completed whole brain radiotherapy or local therapy (such as surgery), have discontinued prednisone for at least 4 weeks prior to randomization, and have stable radiologically confirmed tumor lesions and no clinical symptoms of tumor during 4 weeks prior to randomization), metastases to meninges, or spinal cord compression.\n7. Tumor invades important surrounding structures (e.g., large blood vessels, trachea, etc.) with high risk of rupture and hemorrhage or airway fistula, or metastases to bone with high risk of paraplegia.\n8. Thromboembolic events within 3 months prior to randomization (except patients with non-pulmonary Thromboembolism who do not require treatment or have been stably treated with anticoagulants for 14 days or longer prior to randomization).\n9. History of other neoplasm malignant within 5 years prior to randomization, except for neoplasm malignant cured after treatment.\n10. Having active autoimmune diseases requiring systemic treatment (i.e., immunologic modulator, corticosteroid, or Immunosuppression) within 2 years prior to randomization; replacement therapy (such as thyroid hormone, Insulin, or physiologic corticosteroid replacement therapy due to adrenal or pituitary insufficiency) is not considered systemic treatment.\n11. Known severe allergic reaction to any component in the investigational drug formula.'}, 'identificationModule': {'nctId': 'NCT07284134', 'briefTitle': "JS107 vs Investigator's Choice as Second-line or Later Therapy for Advanced CLDN18.2-Positive Gastricor GEJ Adenocarcinoma.", 'organization': {'class': 'OTHER', 'fullName': 'Shanghai Junshi Bioscience Co., Ltd.'}, 'officialTitle': "JS107 vs Investigator's Choice as Second-line or Later Therapy for Advanced CLDN18.2-Positive Gastricor GEJ Adenocarcinoma.", 'orgStudyIdInfo': {'id': 'JS107-006-III-GC'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Experimental group', 'description': 'JS107: 3mg/kg, intravenous infusion, on Day 1, with a treatment cycle of every 21 days.', 'interventionNames': ['Drug: JS107 for Injection']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Control group', 'description': "Including 3 treatment regimens: irinotecan, paclitaxel, and docetaxel. investigators will select one regimen based on the patient's previous treatment medications, clinical benefits, and tolerability, and the administration will follow clinical guidelines and/or clinical practices. In addition, before administration, corresponding premedications (including antiemetics, preventive anti-allergy drugs, etc.) can be given with reference to clinical guidelines or drug instructions.\n\nIrinotecan: 150mg/m², intravenous infusion, on days 1 and 15, with a 28-day treatment cycle.\n\nPaclitaxel: 80mg/m², intravenous infusion, on days 1, 8, and 15, with a 28-day treatment cycle.\n\nDocetaxel: 75mg/m², intravenous infusion, on day 1, with a 21-day treatment cycle.", 'interventionNames': ['Drug: Irinotecan', 'Drug: Paclitaxel', 'Drug: Docetaxel']}], 'interventions': [{'name': 'JS107 for Injection', 'type': 'DRUG', 'description': "Subjects who are confirmed to meet the inclusion and exclusion criteria after screening will be randomly assigned in a 1:1 ratio to receive JS107 treatment (experimental group) or investigator's chosen treatment (control group) until the criteria for terminating the study treatment as specified in the protocol are met (including subjects experiencing BICR-confirmed radiological PD, death, loss to follow-up, withdrawal of informed consent, or termination of the study by the sponsor, whichever occurs first).", 'armGroupLabels': ['Experimental group']}, {'name': 'Irinotecan', 'type': 'DRUG', 'description': "Subjects who are confirmed to meet the inclusion and exclusion criteria after screening will be randomly assigned in a 1:1 ratio to receive JS107 treatment (experimental group) or investigator's chosen treatment (control group) until the criteria for terminating the study treatment as specified in the protocol are met (including subjects experiencing BICR-confirmed radiological PD, death, loss to follow-up, withdrawal of informed consent, or termination of the study by the sponsor, whichever occurs first).", 'armGroupLabels': ['Control group']}, {'name': 'Paclitaxel', 'type': 'DRUG', 'description': "Subjects who are confirmed to meet the inclusion and exclusion criteria after screening will be randomly assigned in a 1:1 ratio to receive JS107 treatment (experimental group) or investigator's chosen treatment (control group) until the criteria for terminating the study treatment as specified in the protocol are met (including subjects experiencing BICR-confirmed radiological PD, death, loss to follow-up, withdrawal of informed consent, or termination of the study by the sponsor, whichever occurs first).", 'armGroupLabels': ['Control group']}, {'name': 'Docetaxel', 'type': 'DRUG', 'description': "Subjects who are confirmed to meet the inclusion and exclusion criteria after screening will be randomly assigned in a 1:1 ratio to receive JS107 treatment (experimental group) or investigator's chosen treatment (control group) until the criteria for terminating the study treatment as specified in the protocol are met (including subjects experiencing BICR-confirmed radiological PD, death, loss to follow-up, withdrawal of informed consent, or termination of the study by the sponsor, whichever occurs first).", 'armGroupLabels': ['Control group']}]}, 'contactsLocationsModule': {'locations': [{'zip': '230031', 'city': 'Hefei', 'state': 'Anhui', 'country': 'China', 'contacts': [{'name': 'Yifu He, Doctor', 'role': 'CONTACT', 'email': '834638033@qq.com'}], 'facility': 'AnHui Provincial Cancer Hospital', 'geoPoint': {'lat': 31.86389, 'lon': 117.28083}}, {'zip': '100034', 'city': 'Beijing', 'state': 'Beijing Municipality', 'country': 'China', 'contacts': [{'name': 'Shikai Wu, Doctor', 'role': 'CONTACT', 'email': 'skywu4923@sina.com'}], 'facility': 'Peking University First Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100050', 'city': 'Beijing', 'state': 'Beijing Municipality', 'country': 'China', 'contacts': [{'name': 'Zhongtao Zhang, Doctor', 'role': 'CONTACT', 'email': 'zhangzht@ccmu.edu.cn'}], 'facility': 'Beijing Friendship Hospital, Capital Medical University', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '350014', 'city': 'Fuzhou', 'state': 'Fujian', 'country': 'China', 'contacts': [{'name': 'Rongbo Lin, Doctor', 'role': 'CONTACT', 'email': 'linrongbo@fjzlhospital.com'}], 'facility': 'Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital', 'geoPoint': {'lat': 26.06139, 'lon': 119.30611}}, {'zip': '365110', 'city': 'Fuzhou', 'state': 'Fujian', 'country': 'China', 'contacts': [{'name': 'Xiaoyan Lin, Doctor', 'role': 'CONTACT', 'email': 'xiaoyanlin@yahoo.com'}], 'facility': 'Union Hospital Affiliated to Fujian Medical University', 'geoPoint': {'lat': 26.06139, 'lon': 119.30611}}, {'zip': '730000', 'city': 'Lanzhou', 'state': 'Gansu', 'country': 'China', 'contacts': [{'name': 'Xiaoming Hou, Doctor', 'role': 'CONTACT', 'email': '1795950416@qq.com'}], 'facility': 'The First Hospital of Lanzhou University', 'geoPoint': {'lat': 36.05701, 'lon': 103.83987}}, {'zip': '730050', 'city': 'Lanzhou', 'state': 'Gansu', 'country': 'China', 'contacts': [{'name': 'Zhihu Li, Doctor', 'role': 'CONTACT', 'email': 'zhihu_li666@163.com'}], 'facility': 'Gansu Provincial Cancer Hospital', 'geoPoint': {'lat': 36.05701, 'lon': 103.83987}}, {'zip': '733000', 'city': 'Wuwei', 'state': 'Gansu', 'country': 'China', 'contacts': [{'name': 'Peng Nie, Doctor', 'role': 'CONTACT', 'email': 'nie.peng2008@163.com'}], 'facility': 'Gansu wuwei tumor hospital', 'geoPoint': {'lat': 37.92672, 'lon': 102.63202}}, {'zip': '510000', 'city': 'Guangzhou', 'state': 'Guangdong', 'country': 'China', 'contacts': [{'name': 'Ruihua Xu, Doctor', 'role': 'CONTACT', 'email': 'xurh@sysucc.org.cn'}, {'name': 'Ruihua Xu, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Sun Yat-sen University Cancer Center', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '510515', 'city': 'Guangzhou', 'state': 'Guangdong', 'country': 'China', 'contacts': [{'name': 'Liying Zhao, Doctor', 'role': 'CONTACT', 'email': 'zlyblue11@163.com'}], 'facility': 'Nanfang hospital', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '510655', 'city': 'Guangzhou', 'state': 'Guangdong', 'country': 'China', 'contacts': [{'name': 'Yanhong Deng, Doctor', 'role': 'CONTACT', 'email': '13925106525@163.com'}], 'facility': 'The sixth affiliated hospital sun yat-sen university', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '514031', 'city': 'Meizhou', 'state': 'Guangdong', 'country': 'China', 'contacts': [{'name': 'Xiaoyang Wang, Doctor', 'role': 'CONTACT', 'email': '1002192141@qq.com'}], 'facility': "Meizhou People's Hospital（Huangtang Hospital）", 'geoPoint': {'lat': 24.28859, 'lon': 116.11768}}, {'zip': '515041', 'city': 'Shantou', 'state': 'Guangdong', 'country': 'China', 'contacts': [{'name': 'Yi Jiang, Doctor', 'role': 'CONTACT', 'email': 'jiangyi_123@sina.com'}], 'facility': 'Cancer Hospital of Shantou University Medical College', 'geoPoint': {'lat': 23.35489, 'lon': 116.67876}}, {'zip': '530000', 'city': 'Nanning', 'state': 'Guangxi', 'country': 'China', 'contacts': [{'name': 'Yongqiang Li, Doctor', 'role': 'CONTACT', 'email': 'lyq702702@126.com'}], 'facility': 'Cancer Hospital Affiliated to Guangxi Medical University', 'geoPoint': {'lat': 22.81667, 'lon': 108.31667}}, {'zip': '530000', 'city': 'Nanning', 'state': 'Guangxi', 'country': 'China', 'contacts': [{'name': 'Kehe Chen, Doctor', 'role': 'CONTACT', 'email': 'ckh@163.com'}], 'facility': "People's Hospital of Guangxi Zhuang Autonomous Region", 'geoPoint': {'lat': 22.81667, 'lon': 108.31667}}, {'zip': '065001', 'city': 'Langfang', 'state': 'Hebei', 'country': 'China', 'contacts': [{'name': 'Yongkun Sun, Doctor', 'role': 'CONTACT', 'email': 'hsunyk@126.com'}], 'facility': 'Cancer Hospital Chinese Academy of Medical Sciences Langfang Campus', 'geoPoint': {'lat': 39.52079, 'lon': 116.71471}}, {'zip': '050011', 'city': 'Shijiazhuang', 'state': 'Hebei', 'country': 'China', 'contacts': [{'name': 'Fengbin Zhang, Doctor', 'role': 'CONTACT', 'email': 'zhangfengbin1981@163.com'}], 'facility': 'The Fourth Hospital of Hebei Medical University', 'geoPoint': {'lat': 38.04139, 'lon': 114.47861}}, {'zip': '063000', 'city': 'Tangshan', 'state': 'Hebei', 'country': 'China', 'contacts': [{'name': 'Guogui Sun, Doctor', 'role': 'CONTACT', 'email': 'guogui_sun2021@sina.com'}], 'facility': 'Affiliated Hospital of North China University of Technology', 'geoPoint': {'lat': 39.64381, 'lon': 118.18319}}, {'zip': '150081', 'city': 'Harbin', 'state': 'Heilongjiang', 'country': 'China', 'contacts': [{'name': 'Yanqiao Zhang, Doctor', 'role': 'CONTACT', 'email': 'yanqiaozhanggcp@163.com'}], 'facility': 'Harbin Medical University Cancer Hospital', 'geoPoint': {'lat': 45.75, 'lon': 126.65}}, {'zip': '455000', 'city': 'Anyang', 'state': 'Henan', 'country': 'China', 'contacts': [{'name': 'Jin Xia, Doctor', 'role': 'CONTACT', 'email': '15890750990@126.com'}], 'facility': 'Anyang Tumor Hospital', 'geoPoint': {'lat': 36.096, 'lon': 114.38278}}, {'zip': '471003', 'city': 'Luoyang', 'state': 'Henan', 'country': 'China', 'contacts': [{'name': 'Ruinuo Jia, Doctor', 'role': 'CONTACT', 'email': 'power7722@sina.com'}], 'facility': 'The First Affiliated Hospital of Henan University of Science & Technology', 'geoPoint': {'lat': 34.67345, 'lon': 112.43684}}, {'zip': '473010', 'city': 'Nanyang', 'state': 'Henan', 'country': 'China', 'contacts': [{'name': 'Zhen Zhang, Doctor', 'role': 'CONTACT', 'email': 'zhangzhen1771@163.com'}], 'facility': "Nanyang First People's Hospital National Third Class A Hospltal", 'geoPoint': {'lat': 32.99472, 'lon': 112.53278}}, {'zip': '457100', 'city': 'Puyang', 'state': 'Henan', 'country': 'China', 'contacts': [{'name': 'Honglin Zhou, Doctor', 'role': 'CONTACT', 'email': '28442127@qq.com'}], 'facility': "Puyang People's Hospital", 'geoPoint': {'lat': 35.75641, 'lon': 115.04363}}, {'zip': '472099', 'city': 'Sanmenxia', 'state': 'Henan', 'country': 'China', 'contacts': [{'name': 'Xiangqian Zhang, Doctor', 'role': 'CONTACT', 'email': '39343883@qq.com'}], 'facility': 'Sanmenxia Central Hospital', 'geoPoint': {'lat': 34.78081, 'lon': 111.19287}}, {'zip': '450008', 'city': 'Zhengzhou', 'state': 'Henan', 'country': 'China', 'contacts': [{'name': 'Shujun Yang, Doctor', 'role': 'CONTACT', 'email': 'nkyang@126.com'}], 'facility': 'Henan Cancer Hospital', 'geoPoint': {'lat': 34.75778, 'lon': 113.64861}}, {'zip': '450052', 'city': 'Zhengzhou', 'state': 'Henan', 'country': 'China', 'contacts': [{'name': 'Yanru Qin, Doctor', 'role': 'CONTACT', 'email': 'yanruqin@163.com'}], 'facility': 'The First Affiliated Hospital of Zhengzhouuniversity', 'geoPoint': {'lat': 34.75778, 'lon': 113.64861}}, {'zip': '466099', 'city': 'Zhoukou', 'state': 'Henan', 'country': 'China', 'contacts': [{'name': 'Jiye Xu, Doctor', 'role': 'CONTACT', 'email': 'xujiye1998@163.com'}], 'facility': 'Zhoukou Central Hospital', 'geoPoint': {'lat': 33.63333, 'lon': 114.63333}}, {'zip': '430000', 'city': 'Wuhan', 'state': 'Hubei', 'country': 'China', 'contacts': [{'name': 'Hong Qiu, Doctor', 'role': 'CONTACT', 'email': 'tjqiuhong@163.com'}], 'facility': 'Tongji Hospital, Tongji Medical College, Huazhong University', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '430040', 'city': 'Wuhan', 'state': 'Hubei', 'country': 'China', 'contacts': [{'name': 'Hongli Liu, Doctor', 'role': 'CONTACT', 'email': 'hongli_liu@hust.edu.cn'}], 'facility': 'Union Hospital Tongji Medical College Huazhong University of Science and Technology', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '430079', 'city': 'Wuhan', 'state': 'Hubei', 'country': 'China', 'contacts': [{'name': 'Xinjun Liang, Doctor', 'role': 'CONTACT', 'email': 'Doctorlxj@163.com'}], 'facility': 'Hubei Cancer Hospital', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '441199', 'city': 'Xiangyang', 'state': 'Hubei', 'country': 'China', 'contacts': [{'name': 'Wei Gong, Doctor', 'role': 'CONTACT', 'email': '44828977@qq.com'}], 'facility': 'Xiangyang Cancer Hospital', 'geoPoint': {'lat': 32.0422, 'lon': 112.14479}}, {'zip': '443003', 'city': 'Yichang', 'state': 'Hubei', 'country': 'China', 'contacts': [{'name': 'Qiao Huang, Doctor', 'role': 'CONTACT', 'email': 'huangqiao929@hotmail.com'}], 'facility': "Yichang Central People's Hospital", 'geoPoint': {'lat': 30.71444, 'lon': 111.28472}}, {'zip': '410008', 'city': 'Changsha', 'state': 'Hunan', 'country': 'China', 'contacts': [{'name': 'Jie Ge, Doctor', 'role': 'CONTACT', 'email': 'goaljay@qq.com'}], 'facility': 'Xiangya Hospital of Central South University', 'geoPoint': {'lat': 28.19874, 'lon': 112.97087}}, {'zip': '410013', 'city': 'Changsha', 'state': 'Hunan', 'country': 'China', 'contacts': [{'name': 'Haiyan Yang, Doctor', 'role': 'CONTACT', 'email': 'yanghaiyan@hnca.org.cn'}], 'facility': 'Hunan Cancer Hospital', 'geoPoint': {'lat': 28.19874, 'lon': 112.97087}}, {'zip': '014030', 'city': 'Baotou', 'state': 'Inner Mongolia', 'country': 'China', 'contacts': [{'name': 'Weidong Guo, Doctor', 'role': 'CONTACT', 'email': 'gwd11152023@163.com'}], 'facility': 'Baotou Tumor Hospital', 'geoPoint': 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