Ignite Creation Date:
2025-12-25 @ 2:38 AM
Ignite Modification Date:
2026-02-27 @ 2:33 AM
Study NCT ID:
NCT02799134
Status:
COMPLETED
Last Update Posted:
2022-04-22
First Post:
2016-04-06
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Neural Mechanism of Cortisol Awakening Response Suppression Effect on Human High-order and Social Cognitions
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'interventionBrowseModule': {'meshes': [{'id': 'D003907', 'term': 'Dexamethasone'}, {'id': 'D001205', 'term': 'Ascorbic Acid'}], 'ancestors': [{'id': 'D011246', 'term': 'Pregnadienetriols'}, {'id': 'D011245', 'term': 'Pregnadienes'}, {'id': 'D011278', 'term': 'Pregnanes'}, {'id': 'D013256', 'term': 'Steroids'}, {'id': 'D000072473', 'term': 'Fused-Ring Compounds'}, {'id': 'D011083', 'term': 'Polycyclic Compounds'}, {'id': 'D013259', 'term': 'Steroids, Fluorinated'}, {'id': 'D013400', 'term': 'Sugar Acids'}, {'id': 'D000144', 'term': 'Acids, Acyclic'}, {'id': 'D002264', 'term': 'Carboxylic Acids'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D006880', 'term': 'Hydroxy Acids'}, {'id': 'D002241', 'term': 'Carbohydrates'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR']}, 'primaryPurpose': 'BASIC_SCIENCE', 'interventionModel': 'FACTORIAL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 67}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2015-11', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2022-04', 'completionDateStruct': {'date': '2017-04-30', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2022-04-21', 'studyFirstSubmitDate': '2016-04-06', 'studyFirstSubmitQcDate': '2016-06-09', 'lastUpdatePostDateStruct': {'date': '2022-04-22', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2016-06-14', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2017-04-10', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Cortisol Awakening Response Level(nmol/L) after Taking Dexamethasone', 'timeFrame': 'one year', 'description': 'The dosage of Dexamethasone is 0.5mg.'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['Cortisol Awakening Response suppression', 'Dexamethasone Suppression Test', 'high-order cognition', 'social cognition'], 'conditions': ['Healthy']}, 'descriptionModule': {'briefSummary': 'CAR is short for cortisol awakening response. The neural mechanism of CAR effect on high-order cognition and social cognition is less known...'}, 'eligibilityModule': {'sex': 'MALE', 'stdAges': ['ADULT'], 'maximumAge': '26 Years', 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Healthy college students.\n\nExclusion Criteria:\n\n* Current or history of psychiatric or neurological illness.\n* Current use of any medications.'}, 'identificationModule': {'nctId': 'NCT02799134', 'acronym': 'NMCARSEHHSC', 'briefTitle': 'Neural Mechanism of Cortisol Awakening Response Suppression Effect on Human High-order and Social Cognitions', 'organization': {'class': 'OTHER', 'fullName': 'Beijing Normal University'}, 'officialTitle': 'Neural Mechanism of Cortisol Awakening Response Suppression Effect on Human High-order and Social Cognitions', 'orgStudyIdInfo': {'id': 'ICBIR_A_0098_002'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'group1', 'description': 'take Dexamethasone at 22:00 on the first day, 0.5mg', 'interventionNames': ['Drug: Dexamethasone']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'group2', 'description': 'take Vitamin C at 22:00 on the first day, 0.5mg', 'interventionNames': ['Drug: Vitamin C']}, {'type': 'OTHER', 'label': 'group3', 'description': 'take Dexamethasone at 15:00 on the second day, 0.5mg', 'interventionNames': ['Drug: Dexamethasone']}], 'interventions': [{'name': 'Dexamethasone', 'type': 'DRUG', 'armGroupLabels': ['group1', 'group3']}, {'name': 'Vitamin C', 'type': 'DRUG', 'armGroupLabels': ['group2']}]}, 'contactsLocationsModule': {'locations': [{'zip': '100875', 'city': 'Beijing', 'state': 'Beijing Municipality', 'country': 'China', 'facility': 'Beijing Normal University', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}], 'overallOfficials': [{'name': 'Shaozheng Qin, Doctor', 'role': 'STUDY_CHAIR', 'affiliation': 'Beijing Normal University'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'UNDECIDED'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'qinshaozheng', 'class': 'OTHER'}, 'collaborators': [{'name': 'Chinese Academy of Sciences', 'class': 'OTHER_GOV'}, {'name': 'Xuanwu Hospital, Beijing', 'class': 'OTHER'}], 'responsibleParty': {'type': 'SPONSOR_INVESTIGATOR', 'investigatorTitle': 'Professor', 'investigatorFullName': 'qinshaozheng', 'investigatorAffiliation': 'Beijing Normal University'}}}}