Ignite Creation Date:
2025-12-25 @ 2:38 AM
Ignite Modification Date:
2025-12-26 @ 1:15 AM
Study NCT ID:
NCT00156234
Status:
UNKNOWN
Last Update Posted:
2005-09-12
First Post:
2005-09-08
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Skeletal Muscle Dysfunction in Heart Failure
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D006333', 'term': 'Heart Failure'}], 'ancestors': [{'id': 'D006331', 'term': 'Heart Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'SINGLE'}, 'primaryPurpose': 'ECT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'count': 45}}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2005-03'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2005-09', 'lastUpdateSubmitDate': '2005-09-08', 'studyFirstSubmitDate': '2005-09-08', 'studyFirstSubmitQcDate': '2005-09-08', 'lastUpdatePostDateStruct': {'date': '2005-09-12', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2005-09-12', 'type': 'ESTIMATED'}}, 'conditionsModule': {'conditions': ['Heart Failure, Congestive']}, 'referencesModule': {'references': [{'pmid': '19996998', 'type': 'DERIVED', 'citation': 'Munkvik M, Rehn TA, Slettalokken G, Hasic A, Hallen J, Sjaastad I, Sejersted OM, Lunde PK. Training effects on skeletal muscle calcium handling in human chronic heart failure. Med Sci Sports Exerc. 2010 May;42(5):847-55. doi: 10.1249/MSS.0b013e3181c29ec1.'}]}, 'descriptionModule': {'briefSummary': 'Patients suffering from congestive heart failure report reduced exercise capacity. This skeletal muscle dysfunction is also detectable when using small muscle groups which should not put any demand on the heart.\n\nWe hypothesize that congestive heart failure has systemic effects that causes the skeletal muscle dysfunction.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '78 Years', 'minimumAge': '40 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Coronary Heart Failure\n* Ejection fraction \\<35%\n* NYHA 2-3\n* Spirometry FEV1 \\> 80%\n\nExclusion Criteria:\n\n* Cardiomyopathy\n* Transplantation candidate\n* Active malignancy\n* Restraining skeletal-muscular disease\n* Claudication in legs\n* Hospitalized last 30 days due to acute ischemic episode\n* Intravenous inotrope or vasodilatating drugs last 14 days prior to inclusion\n* AMI last 8 weeks prior to inclusion\n* Organized training last 4 months\n* Smoking on daily basis last 4 months\n* Creatinin \\< 150microliters/liter'}, 'identificationModule': {'nctId': 'NCT00156234', 'briefTitle': 'Skeletal Muscle Dysfunction in Heart Failure', 'organization': {'class': 'OTHER', 'fullName': 'Ullevaal University Hospital'}, 'officialTitle': 'Training and Congestive Heart Failure', 'orgStudyIdInfo': {'id': 'TRUST-001'}, 'secondaryIdInfos': [{'id': 'Helse Øst'}, {'id': 'Helse og rehabilitering'}]}, 'armsInterventionsModule': {'interventions': [{'name': 'One-knee extension ergometer', 'type': 'BEHAVIORAL'}]}, 'contactsLocationsModule': {'locations': [{'zip': '0407', 'city': 'Oslo', 'state': 'Oslo County', 'status': 'RECRUITING', 'country': 'Norway', 'contacts': [{'name': 'Ole M Sejersted, Professor', 'role': 'CONTACT', 'email': 'o.m.sejersted@medisin.uio.no', 'phone': '23 01 68 00', 'phoneExt': '47'}, {'name': 'Per Kristian B Lunde, Post Doc', 'role': 'CONTACT', 'email': 'p.k.lunde@medisin.uio.no', 'phone': '23 01 68 35', 'phoneExt': '47'}], 'facility': 'Institute for Experimental Medical Research', 'geoPoint': {'lat': 59.91273, 'lon': 10.74609}}, {'zip': '0806', 'city': 'Oslo', 'state': 'Oslo County', 'status': 'RECRUITING', 'country': 'Norway', 'contacts': [{'name': 'Jostein Hallén, Professor', 'role': 'CONTACT', 'email': 'jostein.hallen@nih.no', 'phone': '23 26 23 14', 'phoneExt': '47'}, {'name': 'Gunnar Petersen, Ph.D student', 'role': 'CONTACT', 'email': 'gunnar.petersen@nih.no'}, {'name': 'Jostein Hallen, Professor', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'Norwegian School of Sport Sciences', 'geoPoint': {'lat': 59.91273, 'lon': 10.74609}}], 'overallOfficials': [{'name': 'Ole M Sejersted, Professor', 'role': 'STUDY_CHAIR', 'affiliation': 'Institute for Experimental Medical Research, Ullevaal University Hospital'}, {'name': 'Per Kristian B Lunde, Post Doc', 'role': 'STUDY_DIRECTOR', 'affiliation': 'Institute for Experimental Medical Research, Ullevaal University Hospital'}, {'name': 'Ivar Sjaastad, Post Doc', 'role': 'STUDY_DIRECTOR', 'affiliation': 'Institute for Experimental Medical Research, Ullevaal University Hospital'}, {'name': 'Jostein Hallen, Professor', 'role': 'STUDY_CHAIR', 'affiliation': 'Norwegian School of Sport Sciences'}, {'name': 'Morten Munkvik, Ph.D student', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Institute for Experimental Medical Research, Ullevaal University Hospital'}, {'name': 'Tommy A Rehn, Vit.ass.', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Institute for Experimental Medical Research, Ullevaal University Hospital'}, {'name': 'Gunnar S Petersen, Ph.D student', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Norwegian School of Sport Sciences'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Ullevaal University Hospital', 'class': 'OTHER'}, 'collaborators': [{'name': 'Norwegian Health Association', 'class': 'OTHER'}, {'name': 'Norwegian School of Sport Sciences', 'class': 'OTHER'}, {'name': 'The Research Council of Norway', 'class': 'OTHER'}, {'name': 'University of Oslo', 'class': 'OTHER'}]}}}