Ignite Creation Date:
2025-12-25 @ 2:32 AM
Ignite Modification Date:
2025-12-28 @ 10:00 PM
Study NCT ID:
NCT06163534
Status:
RECRUITING
Last Update Posted:
2025-12-08
First Post:
2023-11-07
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D000077195', 'term': 'Squamous Cell Carcinoma of Head and Neck'}, {'id': 'D009369', 'term': 'Neoplasms'}], 'ancestors': [{'id': 'D002294', 'term': 'Carcinoma, Squamous Cell'}, {'id': 'D002277', 'term': 'Carcinoma'}, {'id': 'D009375', 'term': 'Neoplasms, Glandular and Epithelial'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D006258', 'term': 'Head and Neck Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}]}}, 'protocolSection': {'designModule': {'bioSpec': {'retention': 'SAMPLES_WITH_DNA', 'description': 'Blood and tissue will be collected.'}, 'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'OTHER'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 500}, 'targetDuration': '1 Year', 'patientRegistry': True}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2024-08-01', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2028-03-01', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-01', 'studyFirstSubmitDate': '2023-11-07', 'studyFirstSubmitQcDate': '2023-11-30', 'lastUpdatePostDateStruct': {'date': '2025-12-08', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2023-12-11', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2028-03-01', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Explore DNA, RNA, immune and other multiomic biomarkers to better understand prognostic or predictive biomarkers and to inform future research for new relevant biomarkers.', 'timeFrame': '5 years', 'description': 'Use NGS, ctNDA assessments, RNA analysis, and other multiomic testing to uncover biomarkers of collected blood and tissue samples that may predict outcomes, identify markers related to disease, identify markers related to mechanism of drug action, and inform future research.'}], 'secondaryOutcomes': [{'measure': 'Explore changes in relevant DNA, RNA, immune and multiomic biomarkers in longitudinal blood samples, and diagnostic and progression biopsy samples, to understand real-world outcomes and resistance mechanisms.', 'timeFrame': '5 years', 'description': 'Correlate biomarkers of collected blood and tissue samples with standard of care therapy real-world outcomes such as overall survival, progression free survival, time to next treatment, and time to treatment discontinuation.'}, {'measure': 'Explore changes in ctDNA from longitudinal blood samples to assess ctDNA as a response biomarker.', 'timeFrame': '5 years', 'description': 'Assess changes in ctNDA of collected blood samples using ctDNA clearance factors such as time to clearance, best overall clearance rate, best confirmed clearance, duration, time to ctDNA recurrence with standard of care therapy real-world outcomes such as overall survival, progression free survival, time to next treatment, and time to treatment discontinuation.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Oncology', 'Biomarkers', 'Genomic Profiling', 'HNSCC', 'Cancer', 'Observational', 'Registry', 'Precision Medicine', 'NGS'], 'conditions': ['Head and Neck Squamous Cell Carcinoma']}, 'referencesModule': {'references': [{'pmid': '34540672', 'type': 'BACKGROUND', 'citation': 'Hsieh RW, Borson S, Tsagianni A, Zandberg DP. Immunotherapy in Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck. Front Oncol. 2021 Sep 1;11:705614. doi: 10.3389/fonc.2021.705614. eCollection 2021.'}, {'type': 'BACKGROUND', 'citation': 'Head and neck cancer - risk factors and prevention. Cancer.Net. Published June 25, 2012. Accessed August 11, 2023. https://www.cancer.net/cancer-types/head-and-neck-cancer/risk-factors-and-prevention'}, {'pmid': '26046059', 'type': 'BACKGROUND', 'citation': 'Kimple RJ, Harari PM. The prognostic value of HPV in head and neck cancer patients undergoing postoperative chemoradiotherapy. Ann Transl Med. 2015 May;3(Suppl 1):S14. doi: 10.3978/j.issn.2305-5839.2015.01.37. No abstract available.'}, {'pmid': '34069092', 'type': 'BACKGROUND', 'citation': 'Ionna F, Bossi P, Guida A, Alberti A, Muto P, Salzano G, Ottaiano A, Maglitto F, Leopardo D, De Felice M, Longo F, Tafuto S, Della Vittoria Scarpati G, Perri F. Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: A Big and Intriguing Challenge Which May Be Resolved by Integrated Treatments Combining Locoregional and Systemic Therapies. Cancers (Basel). 2021 May 14;13(10):2371. doi: 10.3390/cancers13102371.'}, {'pmid': '29941547', 'type': 'BACKGROUND', 'citation': 'Samra B, Tam E, Baseri B, Shapira I. Checkpoint inhibitors in head and neck cancer: current knowledge and perspectives. J Investig Med. 2018 Oct;66(7):1023-1030. doi: 10.1136/jim-2018-000743. Epub 2018 Jun 25.'}, {'pmid': '18784101', 'type': 'BACKGROUND', 'citation': 'Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S, Erfan J, Zabolotnyy D, Kienzer HR, Cupissol D, Peyrade F, Benasso M, Vynnychenko I, De Raucourt D, Bokemeyer C, Schueler A, Amellal N, Hitt R. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med. 2008 Sep 11;359(11):1116-27. doi: 10.1056/NEJMoa0802656.'}, {'pmid': '31679945', 'type': 'BACKGROUND', 'citation': 'Burtness B, Harrington KJ, Greil R, Soulieres D, Tahara M, de Castro G Jr, Psyrri A, Baste N, Neupane P, Bratland A, Fuereder T, Hughes BGM, Mesia R, Ngamphaiboon N, Rordorf T, Wan Ishak WZ, Hong RL, Gonzalez Mendoza R, Roy A, Zhang Y, Gumuscu B, Cheng JD, Jin F, Rischin D; KEYNOTE-048 Investigators. Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study. Lancet. 2019 Nov 23;394(10212):1915-1928. doi: 10.1016/S0140-6736(19)32591-7. Epub 2019 Nov 1.'}, {'pmid': '33076306', 'type': 'BACKGROUND', 'citation': 'Wang HC, Yeh TJ, Chan LP, Hsu CM, Cho SF. Exploration of Feasible Immune Biomarkers for Immune Checkpoint Inhibitors in Head and Neck Squamous Cell Carcinoma Treatment in Real World Clinical Practice. Int J Mol Sci. 2020 Oct 15;21(20):7621. doi: 10.3390/ijms21207621.'}, {'pmid': '30115704', 'type': 'BACKGROUND', 'citation': 'Wei SC, Duffy CR, Allison JP. Fundamental Mechanisms of Immune Checkpoint Blockade Therapy. Cancer Discov. 2018 Sep;8(9):1069-1086. doi: 10.1158/2159-8290.CD-18-0367. Epub 2018 Aug 16.'}, {'pmid': '30546008', 'type': 'BACKGROUND', 'citation': 'Darvin P, Toor SM, Sasidharan Nair V, Elkord E. Immune checkpoint inhibitors: recent progress and potential biomarkers. Exp Mol Med. 2018 Dec 13;50(12):1-11. doi: 10.1038/s12276-018-0191-1.'}, {'pmid': '36092724', 'type': 'BACKGROUND', 'citation': 'Yu C, Li Q, Zhang Y, Wen ZF, Dong H, Mou Y. Current status and perspective of tumor immunotherapy for head and neck squamous cell carcinoma. Front Cell Dev Biol. 2022 Aug 26;10:941750. doi: 10.3389/fcell.2022.941750. eCollection 2022.'}, {'pmid': '33919778', 'type': 'BACKGROUND', 'citation': 'Kong L, Birkeland AC. Liquid Biopsies in Head and Neck Cancer: Current State and Future Challenges. Cancers (Basel). 2021 Apr 14;13(8):1874. doi: 10.3390/cancers13081874.'}, {'pmid': '26786940', 'type': 'BACKGROUND', 'citation': 'Mazurek AM, Rutkowski T, Fiszer-Kierzkowska A, Malusecka E, Skladowski K. Assessment of the total cfDNA and HPV16/18 detection in plasma samples of head and neck squamous cell carcinoma patients. Oral Oncol. 2016 Mar;54:36-41. doi: 10.1016/j.oraloncology.2015.12.002. Epub 2016 Jan 11.'}, {'pmid': '24553385', 'type': 'BACKGROUND', 'citation': 'Bettegowda C, Sausen M, Leary RJ, Kinde I, Wang Y, Agrawal N, Bartlett BR, Wang H, Luber B, Alani RM, Antonarakis ES, Azad NS, Bardelli A, Brem H, Cameron JL, Lee CC, Fecher LA, Gallia GL, Gibbs P, Le D, Giuntoli RL, Goggins M, Hogarty MD, Holdhoff M, Hong SM, Jiao Y, Juhl HH, Kim JJ, Siravegna G, Laheru DA, Lauricella C, Lim M, Lipson EJ, Marie SK, Netto GJ, Oliner KS, Olivi A, Olsson L, Riggins GJ, Sartore-Bianchi A, Schmidt K, Shih lM, Oba-Shinjo SM, Siena S, Theodorescu D, Tie J, Harkins TT, Veronese S, Wang TL, Weingart JD, Wolfgang CL, Wood LD, Xing D, Hruban RH, Wu J, Allen PJ, Schmidt CM, Choti MA, Velculescu VE, Kinzler KW, Vogelstein B, Papadopoulos N, Diaz LA Jr. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med. 2014 Feb 19;6(224):224ra24. doi: 10.1126/scitranslmed.3007094.'}, {'pmid': '26109104', 'type': 'BACKGROUND', 'citation': 'Wang Y, Springer S, Mulvey CL, Silliman N, Schaefer J, Sausen M, James N, Rettig EM, Guo T, Pickering CR, Bishop JA, Chung CH, Califano JA, Eisele DW, Fakhry C, Gourin CG, Ha PK, Kang H, Kiess A, Koch WM, Myers JN, Quon H, Richmon JD, Sidransky D, Tufano RP, Westra WH, Bettegowda C, Diaz LA Jr, Papadopoulos N, Kinzler KW, Vogelstein B, Agrawal N. Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas. Sci Transl Med. 2015 Jun 24;7(293):293ra104. doi: 10.1126/scitranslmed.aaa8507.'}, {'pmid': '25078109', 'type': 'BACKGROUND', 'citation': 'Ahn SM, Chan JY, Zhang Z, Wang H, Khan Z, Bishop JA, Westra W, Koch WM, Califano JA. Saliva and plasma quantitative polymerase chain reaction-based detection and surveillance of human papillomavirus-related head and neck cancer. JAMA Otolaryngol Head Neck Surg. 2014 Sep;140(9):846-54. doi: 10.1001/jamaoto.2014.1338.'}, {'pmid': '28792880', 'type': 'BACKGROUND', 'citation': 'Chan KCA, Woo JKS, King A, Zee BCY, Lam WKJ, Chan SL, Chu SWI, Mak C, Tse IOL, Leung SYM, Chan G, Hui EP, Ma BBY, Chiu RWK, Leung SF, van Hasselt AC, Chan ATC, Lo YMD. Analysis of Plasma Epstein-Barr Virus DNA to Screen for Nasopharyngeal Cancer. N Engl J Med. 2017 Aug 10;377(6):513-522. doi: 10.1056/NEJMoa1701717.'}, {'pmid': '15928666', 'type': 'BACKGROUND', 'citation': 'Hamana K, Uzawa K, Ogawara K, Shiiba M, Bukawa H, Yokoe H, Tanzawa H. Monitoring of circulating tumour-associated DNA as a prognostic tool for oral squamous cell carcinoma. Br J Cancer. 2005 Jun 20;92(12):2181-4. doi: 10.1038/sj.bjc.6602635.'}, {'pmid': '32017652', 'type': 'BACKGROUND', 'citation': 'Chera BS, Kumar S, Shen C, Amdur R, Dagan R, Green R, Goldman E, Weiss J, Grilley-Olson J, Patel S, Zanation A, Hackman T, Blumberg J, Patel S, Thorp B, Weissler M, Yarbrough W, Sheets N, Mendenhall W, Tan XM, Gupta GP. Plasma Circulating Tumor HPV DNA for the Surveillance of Cancer Recurrence in HPV-Associated Oropharyngeal Cancer. J Clin Oncol. 2020 Apr 1;38(10):1050-1058. doi: 10.1200/JCO.19.02444. Epub 2020 Feb 4.'}, {'pmid': '35740633', 'type': 'BACKGROUND', 'citation': 'Aulakh SS, Silverman DA, Young K, Dennis SK, Birkeland AC. The Promise of Circulating Tumor DNA in Head and Neck Cancer. Cancers (Basel). 2022 Jun 16;14(12):2968. doi: 10.3390/cancers14122968.'}, {'pmid': '34230613', 'type': 'BACKGROUND', 'citation': 'Liebs S, Eder T, Klauschen F, Schutte M, Yaspo ML, Keilholz U, Tinhofer I, Kidess-Sigal E, Braunholz D. Applicability of liquid biopsies to represent the mutational profile of tumor tissue from different cancer entities. Oncogene. 2021 Aug;40(33):5204-5212. doi: 10.1038/s41388-021-01928-w. Epub 2021 Jul 6.'}, {'pmid': '32460897', 'type': 'BACKGROUND', 'citation': "Russano M, Napolitano A, Ribelli G, Iuliani M, Simonetti S, Citarella F, Pantano F, Dell'Aquila E, Anesi C, Silvestris N, Argentiero A, Solimando AG, Vincenzi B, Tonini G, Santini D. Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples. J Exp Clin Cancer Res. 2020 May 27;39(1):95. doi: 10.1186/s13046-020-01601-2."}, {'pmid': '33508232', 'type': 'BACKGROUND', 'citation': 'Litchfield K, Reading JL, Puttick C, Thakkar K, Abbosh C, Bentham R, Watkins TBK, Rosenthal R, Biswas D, Rowan A, Lim E, Al Bakir M, Turati V, Guerra-Assuncao JA, Conde L, Furness AJS, Saini SK, Hadrup SR, Herrero J, Lee SH, Van Loo P, Enver T, Larkin J, Hellmann MD, Turajlic S, Quezada SA, McGranahan N, Swanton C. Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition. Cell. 2021 Feb 4;184(3):596-614.e14. doi: 10.1016/j.cell.2021.01.002. Epub 2021 Jan 27.'}, {'pmid': '32042196', 'type': 'BACKGROUND', 'citation': 'Fairfax BP, Taylor CA, Watson RA, Nassiri I, Danielli S, Fang H, Mahe EA, Cooper R, Woodcock V, Traill Z, Al-Mossawi MH, Knight JC, Klenerman P, Payne M, Middleton MR. Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma. Nat Med. 2020 Feb;26(2):193-199. doi: 10.1038/s41591-019-0734-6. Epub 2020 Feb 10.'}, {'pmid': '32110781', 'type': 'BACKGROUND', 'citation': 'Valpione S, Galvani E, Tweedy J, Mundra PA, Banyard A, Middlehurst P, Barry J, Mills S, Salih Z, Weightman J, Gupta A, Gremel G, Baenke F, Dhomen N, Lorigan PC, Marais R. Immune-awakening revealed by peripheral T cell dynamics after one cycle of immunotherapy. Nat Cancer. 2020 Feb;1(2):210-221. doi: 10.1038/s43018-019-0022-x. Epub 2020 Feb 10.'}, {'pmid': '33007267', 'type': 'BACKGROUND', 'citation': 'Nabet BY, Esfahani MS, Moding EJ, Hamilton EG, Chabon JJ, Rizvi H, Steen CB, Chaudhuri AA, Liu CL, Hui AB, Almanza D, Stehr H, Gojenola L, Bonilla RF, Jin MC, Jeon YJ, Tseng D, Liu C, Merghoub T, Neal JW, Wakelee HA, Padda SK, Ramchandran KJ, Das M, Plodkowski AJ, Yoo C, Chen EL, Ko RB, Newman AM, Hellmann MD, Alizadeh AA, Diehn M. Noninvasive Early Identification of Therapeutic Benefit from Immune Checkpoint Inhibition. Cell. 2020 Oct 15;183(2):363-376.e13. doi: 10.1016/j.cell.2020.09.001. Epub 2020 Oct 1.'}, {'pmid': '31040929', 'type': 'BACKGROUND', 'citation': 'Beaubier N, Tell R, Lau D, Parsons JR, Bush S, Perera J, Sorrells S, Baker T, Chang A, Michuda J, Iguartua C, MacNeil S, Shah K, Ellis P, Yeatts K, Mahon B, Taxter T, Bontrager M, Khan A, Huether R, Lefkofsky E, White KP. Clinical validation of the tempus xT next-generation targeted oncology sequencing assay. Oncotarget. 2019 Mar 22;10(24):2384-2396. doi: 10.18632/oncotarget.26797. eCollection 2019 Mar 22.'}, {'pmid': '31570899', 'type': 'BACKGROUND', 'citation': 'Beaubier N, Bontrager M, Huether R, Igartua C, Lau D, Tell R, Bobe AM, Bush S, Chang AL, Hoskinson DC, Khan AA, Kudalkar E, Leibowitz BD, Lozachmeur A, Michuda J, Parsons J, Perera JF, Salahudeen A, Shah KP, Taxter T, Zhu W, White KP. Integrated genomic profiling expands clinical options for patients with cancer. Nat Biotechnol. 2019 Nov;37(11):1351-1360. doi: 10.1038/s41587-019-0259-z. Epub 2019 Sep 30.'}, {'pmid': '34215841', 'type': 'BACKGROUND', 'citation': "Finkle JD, Boulos H, Driessen TM, Lo C, Blidner RA, Hafez A, Khan AA, Lozac'hmeur A, McKinnon KE, Perera J, Zhu W, Dowlati A, White KP, Tell R, Beaubier N. Validation of a liquid biopsy assay with molecular and clinical profiling of circulating tumor DNA. NPJ Precis Oncol. 2021 Jul 2;5(1):63. doi: 10.1038/s41698-021-00202-2."}]}, 'descriptionModule': {'briefSummary': 'The study is a prospective, longitudinal, non-interventional, multicenter study of participants with HNSCC who will have tissue and blood based molecular biomarker profiling during their standard of care treatment.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'This protocol targets patients with metastatic or unresectable, recurrent HNSCC intended for first line immunotherapy or combination therapy.', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* ≥18 years of age\n* Willing and able to provide informed consent\n* Histologically- or cytologically-confirmed metastatic or unresectable, recurrent HNSCC unsuitable for local therapies\n* Intended for first line anti-PD1 or PDL1 monotherapy or combination therapy\n* Must submit tumor tissue sample representative of current disease per laboratory manual\n\nExclusion Criteria:\n\n* Non-squamous histologies (eg, nasopharynx or salivary gland)\n* Relapse or recurrence within 6 months of first line chemotherapy and / or chemoradiotherapy\n* Tumors that are PD-L1 negative (CPS \\<1)\n* Clinical evidence of an active second invasive malignancy within \\<2 years of enrollment with the exception of stable prostate cancer on watchful waiting, in situ cervical cancer, in situ breast carcinoma or localized non-melanoma skin cancers\n* Unable to comply with study procedures (i.e., not willing or able to have additional blood samples collected)'}, 'identificationModule': {'nctId': 'NCT06163534', 'briefTitle': 'A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)', 'organization': {'class': 'INDUSTRY', 'fullName': 'Tempus AI'}, 'officialTitle': 'TEMPUS PHOENIX HNSCC STUDY: A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)', 'orgStudyIdInfo': {'id': 'TP-CA-006'}, 'secondaryIdInfos': [{'id': 'Pro00074943', 'type': 'OTHER', 'domain': 'Advarra'}]}, 'armsInterventionsModule': {'armGroups': [{'label': 'Metastatic or unresectable recurrent HNSCC', 'description': 'Up to 500 participants (including primary tumor location of pharynx, larynx, oral cavity and oropharynx) with metastatic or unresectable recurrent HNSCC who are intended for first line immunotherapy or combination therapy. No intervention.'}]}, 'contactsLocationsModule': {'locations': [{'zip': '91010', 'city': 'Duarte', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Sarah Ursu', 'role': 'CONTACT', 'email': 'sursu@coh.org'}, {'name': 'Victoria Villaflor', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'City of Hope', 'geoPoint': {'lat': 34.13945, 'lon': -117.97729}}, {'zip': '90033', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Sandy Tran', 'role': 'CONTACT', 'email': 'sandy.tran@med.usc.edu'}, {'name': 'Jacob Thomas', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'USC/Norris Comprehensive Cancer Center', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90095', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Youstina Zaki', 'role': 'CONTACT', 'email': 'YZaki@mednet.ucla.edu', 'phone': '310-794-4955'}, {'name': 'Deborah Wong', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of California, Los Angeles', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '94304', 'city': 'Palo Alto', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Savanna Biedermann', 'role': 'CONTACT', 'email': 'savannab@stanford.edu', 'phone': '650-497-7418'}, {'name': 'Saad Khan', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Stanford', 'geoPoint': {'lat': 37.44188, 'lon': -122.14302}}, {'zip': '95403', 'city': 'Santa Rosa', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Aubrey Adaio', 'role': 'CONTACT', 'email': 'aubrey.adiao@providence.org', 'phone': '707-521-3830'}, {'name': 'Ian Anderson', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Providence Medical Foundation', 'geoPoint': {'lat': 38.44047, 'lon': -122.71443}}, {'zip': '30310', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'DeAndre Scarborough', 'role': 'CONTACT', 'email': 'dscarborough@msm.edu', 'phone': '404-789-3828'}, {'name': 'Roland Matthews', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Morehouse', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30318', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jeff Whorton', 'role': 'CONTACT', 'email': 'Jeff.Whorton@piedmont.org', 'phone': '770-630-9299'}, {'name': 'Sope Olugbile', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Piedmont Healthcare', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30322', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Mosope Oyewole', 'role': 'CONTACT', 'email': 'mosope.desayo.oyewole@emory.edu', 'phone': '404-778-5351'}, {'name': 'Nabil Saba, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Winship Cancer Institute, Emory University', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '60611', 'city': 'Chicago', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Genesis Chase', 'role': 'CONTACT', 'email': 'genesis.chase@northwestern.edu', 'phone': '312-695-1519'}, {'name': 'Jochen Lorch', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Northwestern University Feinberg School of Medicine', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '62526', 'city': 'Decatur', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Kaitlynn Zeisset', 'role': 'CONTACT', 'email': 'kzeisset@ccsci.net'}, {'name': 'James Wade', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Cancer Care Specialists of Illinois', 'geoPoint': {'lat': 39.84031, 'lon': -88.9548}}, {'zip': '61615', 'city': 'Peoria', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Drea Ogundipe', 'role': 'CONTACT', 'email': 'aogundipe@illinoiscancercare.com'}, {'name': 'Fahad Asad', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Illinois Cancer Care', 'geoPoint': {'lat': 40.69365, 'lon': -89.58899}}, {'zip': '66205', 'city': 'Westwood', 'state': 'Kansas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Rahul Chanolian', 'role': 'CONTACT', 'email': 'rchanolian@kumc.edu', 'phone': '913-588-6029'}, {'name': 'Prakash Neupane', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Kansas', 'geoPoint': {'lat': 39.04056, 'lon': -94.6169}}, {'zip': '21202', 'city': 'Baltimore', 'state': 'Maryland', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Rehan Khan', 'role': 'CONTACT', 'email': 'Rehan.Khan@umm.edu', 'phone': '410-328-7496'}, {'name': 'Ranee Mehra', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Maryland', 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, {'zip': '02215', 'city': 'Boston', 'state': 'Massachusetts', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Sage Yenari', 'role': 'CONTACT', 'email': 'sage_yenari@dfci.harvard.edu', 'phone': '617-632-8039'}, {'name': 'Robert Haddad', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Dana Farber Cancer Institute', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '48201', 'city': 'Detroit', 'state': 'Michigan', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Walid Sukari', 'role': 'CONTACT', 'email': 'sukkarim@karmanos.org'}, {'name': 'Ammar Sukari, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Karmanos Cancer Institute', 'geoPoint': {'lat': 42.33143, 'lon': -83.04575}}, {'zip': '65807', 'city': 'Springfield', 'state': 'Missouri', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Adrianna Moore', 'role': 'CONTACT', 'email': 'adrianna.moore@aoncology.com', 'phone': '417-882-4880'}, {'name': 'V. Roger Holden, MD, PHD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Oncology Hematology Associates', 'geoPoint': {'lat': 37.21533, 'lon': -93.29824}}, {'zip': '63130', 'city': 'St Louis', 'state': 'Missouri', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Samuel Williams', 'role': 'CONTACT'}, {'name': 'Douglas Adkins, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Washington University in St. Louis', 'geoPoint': {'lat': 38.62727, 'lon': -90.19789}}, {'zip': '10029', 'city': 'New York', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Julia Miller', 'role': 'CONTACT', 'email': 'julia.miller@mssm.edu', 'phone': '212-824-5378'}, {'name': 'Kryzsztof Misiukiewicz', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Mount Sinai Hospital', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '58102', 'city': 'Fargo', 'state': 'North Dakota', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Signe Harris', 'role': 'CONTACT', 'email': 'signe.harris@sanfordhealth.org', 'phone': '701-234-7515'}, {'name': 'Daniel Almquist', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Sanford Fargo', 'geoPoint': {'lat': 46.87719, 'lon': -96.7898}}, {'zip': '45219', 'city': 'Cincinnati', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Tyler Hendrickson', 'role': 'CONTACT', 'email': 'hendritr@ucmail.uc.edu', 'phone': '513-584-0249'}, {'name': 'Chris Lemmon, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Cincinnati', 'geoPoint': {'lat': 39.12711, 'lon': -84.51439}}, {'zip': '44195', 'city': 'Cleveland', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Alfred Kotarja', 'role': 'CONTACT', 'email': 'kotarja@ccf.org', 'phone': '216-442-1947'}, {'name': 'Shlomo Koyfman', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Cleveland Clinic', 'geoPoint': {'lat': 41.4995, 'lon': -81.69541}}, {'zip': '43210', 'city': 'Columbus', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Harley Hamilton', 'role': 'CONTACT', 'email': 'Harley.Hamilton@osumc.edu', 'phone': '614-293-6522'}, {'name': 'Marcelo Bonomi', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Ohio State University', 'geoPoint': {'lat': 39.96118, 'lon': -82.99879}}, {'zip': '19104', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Daniel Huth', 'role': 'CONTACT', 'email': 'Daniel.Huth@PennMedicine.upenn.edu', 'phone': '541-778-0331'}, {'name': 'Lova Sun', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Pennsylvania', 'geoPoint': {'lat': 39.95238, 'lon': -75.16362}}, {'zip': '17403', 'city': 'York', 'state': 'Pennsylvania', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Clarissa Vega', 'role': 'CONTACT', 'email': 'cvega@cancercareyork.com'}, {'name': 'Chanh Huynh', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Cancer Care Associates of York', 'geoPoint': {'lat': 39.9626, 'lon': -76.72774}}, {'zip': '57104', 'city': 'Sioux Falls', 'state': 'South Dakota', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Brenna Many Horses', 'role': 'CONTACT', 'email': 'Brenna.Manyhorses@SanfordHealth.org', 'phone': '605-312-6217'}, {'name': 'Steven Powell', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Sanford Sioux Falls', 'geoPoint': {'lat': 43.54369, 'lon': -96.72796}}, {'zip': '37212', 'city': 'Nashville', 'state': 'Tennessee', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Gigi Wilson', 'role': 'CONTACT', 'email': 'gigi.wilson@vumc.org', 'phone': '615-875-8875'}, {'name': 'Jennifer Choe', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Vanderbilt University', 'geoPoint': {'lat': 36.16589, 'lon': -86.78444}}, {'zip': '98109', 'city': 'Seattle', 'state': 'Washington', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Marcus Schoenfeld', 'role': 'CONTACT', 'email': 'msschoen@fredhutch.org', 'phone': '206-606-7487'}, {'name': 'Cristinia Rodriguez', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Washington', 'geoPoint': {'lat': 47.60621, 'lon': -122.33207}}, {'zip': '54911', 'city': 'Appleton', 'state': 'Wisconsin', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Sarah Loether', 'role': 'CONTACT', 'email': 'sarah.loether@thedacare.org', 'phone': '920-364-3604'}, {'name': 'Matthias Weiss', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'ThedaCare', 'geoPoint': {'lat': 44.26193, 'lon': -88.41538}}, {'zip': '00909', 'city': 'San Juan', 'status': 'RECRUITING', 'country': 'Puerto Rico', 'contacts': [{'name': 'Andrea Aponte', 'role': 'CONTACT', 'email': 'andrea.aponte@panoncologytrials.com', 'phone': '787-407-3333', 'phoneExt': '128'}, {'name': 'Josselyn Molina-Avila', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Pan American Cancer for Oncology', 'geoPoint': {'lat': 18.46633, 'lon': -66.10572}}], 'centralContacts': [{'name': 'Phoenix HNSCC', 'role': 'CONTACT', 'email': 'phoenix@tempus.com', 'phone': '(833) 514-4187'}], 'overallOfficials': [{'name': 'Virginia Rhodes, MD', 'role': 'STUDY_DIRECTOR', 'affiliation': 'Tempus AI, Inc.'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Tempus AI', 'class': 'INDUSTRY'}, 'collaborators': [{'name': 'AstraZeneca', 'class': 'INDUSTRY'}], 'responsibleParty': {'type': 'SPONSOR'}}}}