Ignite Creation Date:
2025-12-25 @ 2:19 AM
Ignite Modification Date:
2026-02-06 @ 6:57 AM
Study NCT ID:
NCT04155034
Status:
RECRUITING
Last Update Posted:
2025-05-25
First Post:
2019-11-05
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D055752', 'term': 'Small Cell Lung Carcinoma'}], 'ancestors': [{'id': 'D002283', 'term': 'Carcinoma, Bronchogenic'}, {'id': 'D001984', 'term': 'Bronchial Neoplasms'}, {'id': 'D008175', 'term': 'Lung Neoplasms'}, {'id': 'D012142', 'term': 'Respiratory Tract Neoplasms'}, {'id': 'D013899', 'term': 'Thoracic Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D009682', 'term': 'Magnetic Resonance Spectroscopy'}], 'ancestors': [{'id': 'D013057', 'term': 'Spectrum Analysis'}, {'id': 'D002623', 'term': 'Chemistry Techniques, Analytical'}, {'id': 'D008919', 'term': 'Investigative Techniques'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 668}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2020-05-04', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-05', 'completionDateStruct': {'date': '2029-11-15', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-05-20', 'studyFirstSubmitDate': '2019-11-05', 'studyFirstSubmitQcDate': '2019-11-05', 'lastUpdatePostDateStruct': {'date': '2025-05-25', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2019-11-07', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-11-15', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Overall survival (OS)', 'timeFrame': 'From the date of registration to date of death due to any cause, assessed up to 2 years after randomization', 'description': 'Will evaluate OS with magnetic resonance imaging (MRI) surveillance alone and MRI surveillance combined with prophylactic cranial irradiation (PCI) for the treatment of small cell lung cancer (SCLC).'}], 'secondaryOutcomes': [{'measure': 'Cognitive failure-free survival (CFFS)', 'timeFrame': 'Baseline to first neurocognitive failure CF or death due to any cause, assessed up to 12 months after randomization', 'description': 'The comparison of CFFS up to 12 months between the arms will be done using a 1-sided 5% level log-rank test.'}, {'measure': 'CFFS rate', 'timeFrame': 'Baseline to first neurocognitive failure CF or death due to any cause, assessed at 90, 180, 270, 360, 540, and 720 days after randomization', 'description': 'There will be a comparison of the CFFS rates between the arms at each of the assessment times and the cumulative incidence of cognitive failure, evaluating death as a competing risk. The CFFS rates at the landmark times will be estimated using the method of Kaplan-Meier and the difference in rates will be evaluated using a 90% confidence interval using Greenwood?s formula.'}, {'measure': 'Cumulative incidence of cognitive failure', 'timeFrame': 'Neurocognitive function test will be assessed at 90, 180, 270, 360, 540, and 720 days after randomization', 'description': 'The cumulative incidence of cognitive failure in the presence of the competing risk of death will be estimated used the method of Fine and Gray.'}, {'measure': 'OS in an "as-treated" analysis', 'timeFrame': 'From the date of registration to date of death due to any cause, assessed up to 2 years after randomization. Patients will be seen at day 90, 180, 270, 360, 540, and 720', 'description': 'The comparison of OS in the ?as-treated? analysis will be done as described for the primary analysis, however patients will be categorized per treatment received (patients who do not accept their randomized assignment will be analyzed per treatment received). The number of patients not accepting the randomized assignment will also be summarized.'}, {'measure': 'Brain metastases-free survival (BMFS)', 'timeFrame': 'Up to 2 years after randomization. Patients will have MRI on day 90, 180, 270, 360, 540, and 720', 'description': 'This will be estimated using the method of Kaplan-Meier and comparisons will be done using a log-rank test at the 1-sided 0.05 level. Hazard ratios and associated confidence intervals will be estimated using a Cox Proportional hazards model. Confidence intervals for medians will be estimated using the method of Brookmeyer-Crowley.'}, {'measure': 'Incidence of adverse events', 'timeFrame': 'Up to 2 years after randomization. Patients will be assessed for adverse event after PCI (for patients on PCI + MRI arm) and at month 3 (all patients)', 'description': 'Binary proportions and associated confidence intervals will be estimated.'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': True}, 'conditionsModule': {'conditions': ['Extensive Stage Lung Small Cell Carcinoma', 'Limited Stage Lung Small Cell Carcinoma', 'Lung Small Cell Carcinoma']}, 'descriptionModule': {'briefSummary': "This phase III trial studies magnetic resonance imaging (MRI) surveillance and prophylactic cranial irradiation (PCI) to see how well they work compared to MRI surveillance alone in treating patients with small cell lung cancer. MRI scans are used to monitor the possible spread of the cancer with an MRI machine over time. PCI is radiation therapy that is delivered to the brain in hopes of preventing spread of cancer into the brain. The use of brain MRI alone may reduce side effects of receiving PCI and prolong patients' lifespan. Monitoring with MRI scans alone (delaying radiation until the actual spread of the cancer) may be at least as good as the combination of PCI with MRI scans.", 'detailedDescription': 'PRIMARY OBJECTIVE:\n\nI. To evaluate whether overall survival (OS) with magnetic resonance imaging (MRI) surveillance alone is not inferior to MRI surveillance combined with prophylactic cranial irradiation (PCI) for the treatment of small cell lung cancer (SCLC).\n\nSECONDARY OBJECTIVES:\n\nI. To compare cognitive failure free survival (CFFS) rate up to 12 months after randomization between the arms.\n\nII. To compare brain-metastasis-free survival between the arms. III. To compare OS between the arms within the subgroups of patients with limited-stage and extensive-stage disease.\n\nIV. To compare cognitive failure free survival (CFFS) rates at the assessment times between the arms.\n\nV. To compare the cumulative incidence of cognitive failure with death as a competing risk between the arms.\n\nVI. To compare the frequency and severity of toxicities between the two arms.\n\nADDITIONAL OBJECTIVE:\n\nI. To collect blood for banking.\n\nOUTLINE: Patients are randomized to 1 of 2 arms.\n\nARM I: Patients undergo conventional or hippocampal avoidance PCI over 20 minutes 5 days per week for 2 weeks. Patients also undergo MRI scan at 3, 6, 9, 12, 18, and 24 months.\n\nARM II: Patients undergo MRI scan at 3, 6, 9, 12, 18, and 24 months.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Patient must have a histologically confirmed diagnosis of small-cell lung cancer (SCLC)\n* Patient must have an MRI of the brain performed within 28 days prior to registration documenting no evidence of brain metastases or leptomeningeal disease. Patient also must not have a history of brain metastases or leptomeningeal disease\n* Immunotherapy concurrent with and/or adjuvant to first-line therapy is allowed at the discretion of the treating physician. Patients with limited-stage (LS)-SCLC must have completed platinum-based chemotherapy and either definitive thoracic radiotherapy (including stereotactic body radiation therapy \\[SBRT\\] for early-stage T1-2 N0 M0 disease who do not undergo surgery) or definitive surgical resection; thoracic radiation in addition to definitive surgical resection is allowed at the discretion of the treating physician, but is not required. Patients with extensive-stage (ES)-SCLC must have completed platinum-based chemotherapy either with or without thoracic radiotherapy at the discretion of the treating physician\n* All adverse events from prior treatment must have resolved to =\\< grade 2 (Common Terminology Criteria for Adverse Events \\[CTCAE\\] version 5.0) prior to randomization\n* Patient must have had a response to first-line therapy and no evidence of progression in opinion of the treating investigator. Systemic imaging (computed tomography \\[CT\\] or positron emission tomography \\[PET\\]/CT including the chest and abdomen) must be performed within 28 days prior to randomization\n* No more than 8 weeks may have elapsed between day 1 of the last cycle of chemotherapy and randomization\n* Patient must not have received prior radiotherapy to the brain or whole brain radiotherapy. Patients who have undergone prior stereotactic radiosurgery for benign tumors or conditions (e.g., acoustic neuroma, grade I meningioma, trigeminal neuralgia) may be considered on a case-by-case basis\n* Patient must have Zubrod performance status of 0-2\n* Patient must not have a contraindication to MR imaging, such as implanted metal devices or foreign bodies\n* Patient must not have a contraindication to gadolinium contrast administration during MR imaging, such as allergy or insufficient renal function\n* Patient must not have other metastatic malignancies requiring current active treatment\n* Patient must not have any severe active comorbidities, defined as follows:\n\n * Unstable angina and/or congestive heart failure requiring hospitalization within 6 months prior to randomization\n * Transmural myocardial infarction within 6 months prior to randomization\n * Acute bacterial or fungal infection requiring intravenous antibiotics at the time of randomization\n * Chronic obstructive pulmonary disease exacerbation or other acute respiratory illness precluding study therapy at the time of randomization\n * Severe hepatic disease defined as a diagnosis of Child-Pugh class B or C hepatic disease\n * Human immunodeficiency virus (HIV) positive with CD4 count \\< 200 cells/microliter\n\n * Note that patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count \\>= 200 cells/microliter within 16 weeks prior to randomization\n * Note also that HIV testing is not required for eligibility for this protocol\n* Patient must not be pregnant because of fetal risks from radiation exposure. Men must have agreed to use an effective contraceptive method during PCI and for six months after completing PCI. Women of reproductive potential must have agreed to use an effective contraceptive method during PCI. A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures\n* Patients who speak and understand English or French must agree to participate in cognitive function testing\n* Patient must be offered the opportunity to have specimens submitted for banking\n* Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines\n* As a part of the Oncology Patient Enrollment Network (OPEN) randomization process the treating institution?s identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system'}, 'identificationModule': {'nctId': 'NCT04155034', 'briefTitle': 'S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer', 'organization': {'class': 'NETWORK', 'fullName': 'SWOG Cancer Research Network'}, 'officialTitle': 'MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK)', 'orgStudyIdInfo': {'id': 'S1827'}, 'secondaryIdInfos': [{'id': 'NCI-2019-05338', 'type': 'REGISTRY', 'domain': 'CTRP (Clinical Trial Reporting Program)'}, {'id': 'S1827', 'type': 'OTHER', 'domain': 'SWOG'}, {'id': 'S1827', 'type': 'OTHER', 'domain': 'CTEP'}, {'id': 'U10CA180888', 'link': 'https://reporter.nih.gov/quickSearch/U10CA180888', 'type': 'NIH'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'ACTIVE_COMPARATOR', 'label': 'Arm I (PCI, MRI)', 'description': 'Patients undergo conventional or hippocampal avoidance PCI over 20 minutes 5 days per week for 2 weeks. Patients also undergo MRI scan at 3, 6, 9, 12, 18, and 24 months.', 'interventionNames': ['Procedure: Magnetic Resonance Imaging', 'Radiation: Prophylactic Cranial Irradiation']}, {'type': 'EXPERIMENTAL', 'label': 'Arm II (MRI)', 'description': 'Patients undergo MRI scan at 3, 6, 9, 12, 18, and 24 months.', 'interventionNames': ['Procedure: Magnetic Resonance Imaging']}], 'interventions': [{'name': 'Magnetic Resonance Imaging', 'type': 'PROCEDURE', 'otherNames': ['Magnetic Resonance Imaging Scan', 'Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance', 'MR Imaging', 'MRI', 'MRI Scan', 'NMR Imaging', 'NMRI', 'Nuclear Magnetic Resonance Imaging'], 'description': 'Undergo MRI', 'armGroupLabels': ['Arm I (PCI, MRI)', 'Arm II (MRI)']}, {'name': 'Prophylactic Cranial Irradiation', 'type': 'RADIATION', 'otherNames': ['PCI'], 'description': 'Undergo PCI', 'armGroupLabels': ['Arm I (PCI, MRI)']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35233', 'city': 'Birmingham', 'state': 'Alabama', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'University of Alabama at Birmingham Cancer Center', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '99508', 'city': 'Anchorage', 'state': 'Alaska', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'email': 'AKPAMC.OncologyResearchSupport@providence.org', 'phone': '907-212-6871'}, {'name': 'Charles W. Drescher', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Katmai Oncology Group', 'geoPoint': {'lat': 61.21806, 'lon': -149.90028}}, {'zip': '99701', 'city': 'Fairbanks', 'state': 'Alaska', 'status': 'SUSPENDED', 'country': 'United States', 'facility': 'Fairbanks Memorial Hospital', 'geoPoint': {'lat': 64.83778, 'lon': -147.71639}}, {'zip': '85704', 'city': 'Tucson', 'state': 'Arizona', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'University of Arizona Cancer Center-Orange Grove Campus', 'geoPoint': {'lat': 32.22174, 'lon': -110.92648}}, {'zip': '85719', 'city': 'Tucson', 'state': 'Arizona', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'University of Arizona Cancer Center-North Campus', 'geoPoint': {'lat': 32.22174, 'lon': -110.92648}}, {'zip': '92882', 'city': 'Corona', 'state': 'California', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'City of Hope Corona', 'geoPoint': {'lat': 33.87529, 'lon': -117.56644}}, {'zip': '91010', 'city': 'Duarte', 'state': 'California', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'City of Hope Comprehensive Cancer Center', 'geoPoint': {'lat': 34.13945, 'lon': -117.97729}}, {'zip': '92357', 'city': 'Loma Linda', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'phone': '800-741-8387'}, {'name': 'Zarah Dulce F. Lucas', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Veterans Affairs Loma Linda Healthcare System', 'geoPoint': {'lat': 34.04835, 'lon': -117.26115}}, {'zip': '90822', 'city': 'Long Beach', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'phone': '562-826-8000'}, {'name': 'Pankaj Gupta', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Tibor Rubin VA Medical Center', 'geoPoint': {'lat': 33.76696, 'lon': -118.18923}}, {'zip': '90033', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'email': 'uscnorrisinfo@med.usc.edu', 'phone': '323-865-0451'}, {'name': 'Jason C. Ye', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Los Angeles General Medical Center', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90033', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'phone': '323-865-0451'}, {'name': 'Jason C. Ye', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'USC / Norris Comprehensive Cancer Center', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '95817', 'city': 'Sacramento', 'state': 'California', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'University of California Davis Comprehensive Cancer Center', 'geoPoint': {'lat': 38.58157, 'lon': -121.4944}}, {'zip': '94121', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'phone': '415-221-4810'}, {'name': 'Sunny Wang', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Veterans Affairs Medical Center - San Francisco', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '91030', 'city': 'South Pasadena', 'state': 'California', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'City of Hope South Pasadena', 'geoPoint': {'lat': 34.11612, 'lon': -118.15035}}, {'zip': '80045', 'city': 'Aurora', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'phone': '888-336-8262'}, {'name': 'Jessica D. McDermott', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Rocky Mountain Regional VA Medical Center', 'geoPoint': {'lat': 39.72943, 'lon': -104.83192}}, {'zip': '80045', 'city': 'Aurora', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'phone': '720-848-0650'}, {'name': 'Timothy V. Waxweiler', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'UCHealth University of Colorado Hospital', 'geoPoint': {'lat': 39.72943, 'lon': -104.83192}}, {'zip': '80909', 'city': 'Colorado Springs', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'phone': '719-365-2406'}, {'name': 'Timothy V. Waxweiler', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'UCHealth Memorial Hospital Central', 'geoPoint': {'lat': 38.83388, 'lon': -104.82136}}, {'zip': '80920', 'city': 'Colorado Springs', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'phone': '719-364-6700'}, {'name': 'Timothy V. Waxweiler', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Memorial Hospital North', 'geoPoint': {'lat': 38.83388, 'lon': -104.82136}}, {'zip': '80524', 'city': 'Fort Collins', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'phone': '970-297-6150'}, {'name': 'Timothy V. Waxweiler', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Poudre Valley Hospital', 'geoPoint': {'lat': 40.58526, 'lon': -105.08442}}, {'zip': '80528', 'city': 'Fort Collins', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'email': 'protocols@swog.org'}, {'name': 'Timothy V. Waxweiler', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Cancer Care and Hematology-Fort Collins', 'geoPoint': {'lat': 40.58526, 'lon': -105.08442}}, {'zip': '80631', 'city': 'Greeley', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'email': 'BMDACCResearchCOMailbox@bannerhealth.com', 'phone': '970-810-3046'}, {'name': 'Mark Dziemianowicz', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Banner North Colorado Medical Center', 'geoPoint': {'lat': 40.42331, 'lon': -104.70913}}, {'zip': '80631', 'city': 'Greeley', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'email': 'protocols@swog.org'}, {'name': 'Timothy V. Waxweiler', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'UCHealth Greeley Hospital', 'geoPoint': {'lat': 40.42331, 'lon': -104.70913}}, {'zip': '80129', 'city': 'Highlands Ranch', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'phone': '720-848-0650'}, {'name': 'Timothy V. Waxweiler', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'UCHealth Highlands Ranch Hospital', 'geoPoint': {'lat': 39.55388, 'lon': -104.96943}}, {'zip': '80228', 'city': 'Lakewood', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'email': 'ResearchInstituteInquiries@CommonSpirit.org', 'phone': '720-874-1881'}, {'name': 'Shahzad Siddique', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Saint Anthony Hospital', 'geoPoint': {'lat': 39.70471, 'lon': -105.08137}}, {'zip': '80538', 'city': 'Loveland', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'phone': '970-203-7083'}, {'name': 'Timothy V. Waxweiler', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Medical Center of the Rockies', 'geoPoint': {'lat': 40.39776, 'lon': -105.07498}}, {'zip': '80539', 'city': 'Loveland', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'email': 'BMDACCResearchCOMailbox@bannerhealth.com', 'phone': '970-810-3046'}, {'name': 'Mark Dziemianowicz', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Banner McKee Medical Center', 'geoPoint': {'lat': 40.39776, 'lon': -105.07498}}, {'zip': '06830', 'city': 'Greenwich', 'state': 'Connecticut', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'email': 'canceranswers@yale.edu', 'phone': '203-785-5702'}, {'name': 'Henry S. Park', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Smilow Cancer Hospital Care Center at Greenwich', 'geoPoint': {'lat': 41.02649, 'lon': -73.62846}}, {'zip': '06437', 'city': 'Guilford', 'state': 'Connecticut', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'email': 'canceranswers@yale.edu', 'phone': '203-785-5702'}, {'name': 'Henry S. Park', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Smilow Cancer Hospital Care Center - Guilford', 'geoPoint': {'lat': 41.28899, 'lon': -72.68176}}, {'zip': '06518', 'city': 'Hamden', 'state': 'Connecticut', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Public Contact', 'role': 'CONTACT', 'email': 'canceranswers@yale.edu', 'phone': '203-785-5702'}, {'name': 'Henry S. 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