Ignite Creation Date:
2025-12-25 @ 2:16 AM
Ignite Modification Date:
2025-12-26 @ 12:45 AM
Study NCT ID:
NCT00699660
Status:
COMPLETED
Last Update Posted:
2018-08-16
First Post:
2008-06-12
Is NOT Gene Therapy:
False
Has Adverse Events:
True
Brief Title:
Enhancing Equitable and Effective (E-3) Post Traumatic Stress Disorder (PTSD) Disability Assessment
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D013313', 'term': 'Stress Disorders, Post-Traumatic'}], 'ancestors': [{'id': 'D040921', 'term': 'Stress Disorders, Traumatic'}, {'id': 'D000068099', 'term': 'Trauma and Stressor Related Disorders'}, {'id': 'D001523', 'term': 'Mental Disorders'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'ted.speroff@va.gov', 'phone': '615-636-9476', 'title': 'Theodore Speroff PhD', 'organization': 'Veterans Affairs at TVHS'}, 'certainAgreement': {'piSponsorEmployee': True, 'restrictiveAgreement': False}, 'limitationsAndCaveats': {'description': 'Information external to interview such as psychological testing or charts were not available to the expert reviewers. Another limitation is that Veterans in our study did not undergo a concurrent, independent evaluation for assessment of PTSD.'}}, 'adverseEventsModule': {'timeFrame': 'Day of disability examination', 'eventGroups': [{'id': 'EG000', 'title': 'Arm 1', 'description': 'PTSD interview using CAPS and WHODAS\n\nClinician Assessment of PTSD Symptoms (CAPS): CAPS/WHODAS structured clinical PTSD interview', 'otherNumAtRisk': 176, 'otherNumAffected': 0, 'seriousNumAtRisk': 176, 'seriousNumAffected': 0}, {'id': 'EG001', 'title': 'Arm 2', 'description': 'Usual PTSD interview, without CAPS or WHODAS\n\nNonstructured Interview: Usual PTSD clinical PTSD interview, not CAPS or SCID', 'otherNumAtRisk': 208, 'otherNumAffected': 0, 'seriousNumAtRisk': 208, 'seriousNumAffected': 0}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Completeness and Quality of PTSD Interview', 'denoms': [{'units': 'Participants', 'counts': [{'value': '176', 'groupId': 'OG000'}, {'value': '208', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Arm 1', 'description': 'PTSD interview using CAPS and WHODAS\n\nClinician Assessment of PTSD Symptoms (CAPS): CAPS/WHODAS structured clinical PTSD interview'}, {'id': 'OG001', 'title': 'Arm 2', 'description': 'Usual PTSD interview, without CAPS or WHODAS\n\nNonstructured Interview: Usual PTSD clinical PTSD interview, not CAPS or SCID'}], 'classes': [{'title': 'completeness of diagnostic assessment', 'categories': [{'measurements': [{'value': '84.8', 'spread': '17.3', 'groupId': 'OG000'}, {'value': '29.8', 'spread': '24.4', 'groupId': 'OG001'}]}]}, {'title': 'completeness of functional assessment', 'categories': [{'measurements': [{'value': '76.2', 'spread': '24.4', 'groupId': 'OG000'}, {'value': '3.1', 'spread': '7.5', 'groupId': 'OG001'}]}]}], 'analyses': [{'pValue': '<.001', 'groupIds': ['OG000', 'OG001'], 'ciNumSides': 'TWO_SIDED', 'pValueComment': 'Comparison of CAPS/WHODAS vs Nonstructured Interview study arms: linear and logistic mixed effects regression with clinical examiner stratified by study group as a random effect and study group as a fixed effect.', 'groupDescription': 'Our sample size calculation yielded 466 for a power of 0.80 to detect a 10% absolute difference in sensitivity and adjusted for intraclass correlation. The number of covariates in regression models was limited to ensure the effective sample size remained ten times greater than the degrees of freedom in the model.', 'statisticalMethod': 'Regression, Linear', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER', 'statisticalComment': 'Covariates included experience, use of template,tests,reviewing records,age,education, study site,reviewer, and expert reviewer by group interaction.'}], 'paramType': 'MEAN', 'timeFrame': 'Post-exam, same day', 'description': 'total completeness of diagnostic assessment score, range from 0 to 100% and completeness of functional assessment', 'unitOfMeasure': 'percentage of criteria PTSD assessment', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'PTSD Diagnosis', 'denoms': [{'units': 'Participants', 'counts': [{'value': '176', 'groupId': 'OG000'}, {'value': '208', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Arm 1', 'description': 'PTSD interview using CAPS and WHODAS\n\nClinician Assessment of PTSD Symptoms (CAPS): CAPS/WHODAS structured clinical PTSD interview'}, {'id': 'OG001', 'title': 'Arm 2', 'description': 'Usual PTSD interview, without CAPS or WHODAS\n\nNonstructured Interview: Usual PTSD clinical PTSD interview, not CAPS or SCID'}], 'classes': [{'title': 'Uanble to determine clinician PTSD+ diagnosis', 'categories': [{'measurements': [{'value': '49', 'groupId': 'OG000'}, {'value': '110', 'groupId': 'OG001'}]}]}, {'title': 'Unable to determine PTSD- diagnosis', 'categories': [{'measurements': [{'value': '14', 'groupId': 'OG000'}, {'value': '73', 'groupId': 'OG001'}]}]}], 'analyses': [{'pValue': '<.01', 'groupIds': ['OG000', 'OG001'], 'ciNumSides': 'TWO_SIDED', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}], 'paramType': 'NUMBER', 'timeFrame': 'Post-exam, same day', 'description': 'Number of participants who were unable to receive a conclusive clinician PTSD diagnosis for positive or negative PTSD symptoms (unable to determine clinician diagnosis).', 'unitOfMeasure': 'participants', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Patient Satisfaction', 'denoms': [{'units': 'Participants', 'counts': [{'value': '176', 'groupId': 'OG000'}, {'value': '208', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Arm 1', 'description': 'PTSD interview using CAPS and WHODAS\n\nClinician Assessment of PTSD Symptoms (CAPS): CAPS/WHODAS structured clinical PTSD interview'}, {'id': 'OG001', 'title': 'Arm 2', 'description': 'Usual PTSD interview, without CAPS or WHODAS\n\nNonstructured Interview: Usual PTSD clinical PTSD interview, not CAPS or SCID'}], 'classes': [{'categories': [{'measurements': [{'value': '4.69', 'spread': '.44', 'groupId': 'OG000'}, {'value': '4.74', 'spread': '.38', 'groupId': 'OG001'}]}]}], 'analyses': [{'pValue': '>.05', 'groupIds': ['OG000', 'OG001'], 'ciNumSides': 'TWO_SIDED', 'pValueComment': 'Descriptive statistics on mean and standard deviation.', 'statisticalMethod': 't-test, 2 sided', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}], 'paramType': 'MEAN', 'timeFrame': 'post-exam, same day', 'description': 'Mean score on satisfaction survey rating scale from 1 to 5 (higher)', 'unitOfMeasure': 'units on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Resource Utilization', 'denoms': [{'units': 'Participants', 'counts': [{'value': '176', 'groupId': 'OG000'}, {'value': '208', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Arm 1', 'description': 'PTSD interview using CAPS and WHODAS\n\nClinician Assessment of PTSD Symptoms (CAPS): CAPS/WHODAS structured clinical PTSD interview'}, {'id': 'OG001', 'title': 'Arm 2', 'description': 'Usual PTSD interview, without CAPS or WHODAS\n\nNonstructured Interview: Usual PTSD clinical PTSD interview, not CAPS or SCID'}], 'classes': [{'categories': [{'measurements': [{'value': '216.6', 'spread': '88.6', 'groupId': 'OG000'}, {'value': '157.2', 'spread': '63.8', 'groupId': 'OG001'}]}]}], 'analyses': [{'pValue': '.012', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Slope', 'ciNumSides': 'TWO_SIDED', 'paramValue': '47.3', 'pValueComment': '0.05 level based on a two tailed test.', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '18.86', 'groupDescription': 'Estimates of the influence on total time and tests of statistical significance were derived from multilevel mixed-effects linear regression (xtmixed in Stata)', 'statisticalMethod': 'Regression, Linear', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER', 'statisticalComment': 'Covariates included years of experience, use of template, use of tests, age, education, study site.'}], 'paramType': 'MEAN', 'timeFrame': 'same day', 'description': 'time spent administering the exam', 'unitOfMeasure': 'minutes', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Arm 1', 'description': 'PTSD interview using CAPS and WHODAS\n\nClinician Assessment of PTSD Symptoms (CAPS): CAPS/WHODAS structured clinical PTSD interview'}, {'id': 'FG001', 'title': 'Arm 2', 'description': 'Usual PTSD interview, without CAPS or WHODAS\n\nNonstructured Interview: Usual PTSD clinical PTSD interview, not CAPS or SCID'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '190'}, {'groupId': 'FG001', 'numSubjects': '216'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '176'}, {'groupId': 'FG001', 'numSubjects': '208'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '14'}, {'groupId': 'FG001', 'numSubjects': '8'}]}], 'dropWithdraws': [{'type': 'Lost to Follow-up', 'reasons': [{'groupId': 'FG000', 'numSubjects': '4'}, {'groupId': 'FG001', 'numSubjects': '2'}]}, {'type': 'missing reports and recording failures', 'reasons': [{'groupId': 'FG000', 'numSubjects': '10'}, {'groupId': 'FG001', 'numSubjects': '6'}]}]}]}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '176', 'groupId': 'BG000'}, {'value': '208', 'groupId': 'BG001'}, {'value': '384', 'groupId': 'BG002'}]}], 'groups': [{'id': 'BG000', 'title': 'Arm 1', 'description': 'PTSD interview using CAPS and WHODAS\n\nClinician Assessment of PTSD Symptoms (CAPS): CAPS/WHODAS structured clinical PTSD interview'}, {'id': 'BG001', 'title': 'Arm 2', 'description': 'Usual PTSD interview, without CAPS or WHODAS\n\nNonstructured Interview: Usual PTSD clinical PTSD interview, not CAPS or SCID'}, {'id': 'BG002', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '60', 'groupId': 'BG000', 'lowerLimit': '41', 'upperLimit': '63'}, {'value': '59', 'groupId': 'BG001', 'lowerLimit': '41', 'upperLimit': '62'}, {'value': '59', 'groupId': 'BG002', 'lowerLimit': '41', 'upperLimit': '62'}]}]}], 'paramType': 'MEDIAN', 'unitOfMeasure': 'years', 'dispersionType': 'INTER_QUARTILE_RANGE'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '6', 'groupId': 'BG000'}, {'value': '13', 'groupId': 'BG001'}, {'value': '19', 'groupId': 'BG002'}]}, {'title': 'Male', 'measurements': [{'value': '170', 'groupId': 'BG000'}, {'value': '195', 'groupId': 'BG001'}, {'value': '365', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race (NIH/OMB)', 'classes': [{'categories': [{'title': 'American Indian or Alaska Native', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}, {'title': 'Asian', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}, {'title': 'Native Hawaiian or Other Pacific Islander', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}, {'title': 'Black or African American', 'measurements': [{'value': '44', 'groupId': 'BG000'}, {'value': '56', 'groupId': 'BG001'}, {'value': '100', 'groupId': 'BG002'}]}, {'title': 'White', 'measurements': [{'value': '103', 'groupId': 'BG000'}, {'value': '124', 'groupId': 'BG001'}, {'value': '227', 'groupId': 'BG002'}]}, {'title': 'More than one race', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '29', 'groupId': 'BG000'}, {'value': '28', 'groupId': 'BG001'}, {'value': '57', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Marital Status', 'classes': [{'title': 'Married', 'categories': [{'measurements': [{'value': '108', 'groupId': 'BG000'}, {'value': '130', 'groupId': 'BG001'}, {'value': '238', 'groupId': 'BG002'}]}]}, {'title': 'Single', 'categories': [{'measurements': [{'value': '28', 'groupId': 'BG000'}, {'value': '35', 'groupId': 'BG001'}, {'value': '63', 'groupId': 'BG002'}]}]}, {'title': 'Separated', 'categories': [{'measurements': [{'value': '32', 'groupId': 'BG000'}, {'value': '37', 'groupId': 'BG001'}, {'value': '69', 'groupId': 'BG002'}]}]}, {'title': 'Other/Missing', 'categories': [{'measurements': [{'value': '8', 'groupId': 'BG000'}, {'value': '6', 'groupId': 'BG001'}, {'value': '14', 'groupId': 'BG002'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'participants'}], 'populationDescription': 'Veterans undergoing compensation and pension examination for PTSD'}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'DIAGNOSTIC', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 406}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2009-05'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2018-07', 'completionDateStruct': {'date': '2011-09', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2018-07-19', 'studyFirstSubmitDate': '2008-06-12', 'resultsFirstSubmitDate': '2014-09-23', 'studyFirstSubmitQcDate': '2008-06-17', 'lastUpdatePostDateStruct': {'date': '2018-08-16', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2014-10-14', 'studyFirstPostDateStruct': {'date': '2008-06-18', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2014-10-16', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2010-09', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Completeness and Quality of PTSD Interview', 'timeFrame': 'Post-exam, same day', 'description': 'total completeness of diagnostic assessment score, range from 0 to 100% and completeness of functional assessment'}], 'secondaryOutcomes': [{'measure': 'PTSD Diagnosis', 'timeFrame': 'Post-exam, same day', 'description': 'Number of participants who were unable to receive a conclusive clinician PTSD diagnosis for positive or negative PTSD symptoms (unable to determine clinician diagnosis).'}, {'measure': 'Patient Satisfaction', 'timeFrame': 'post-exam, same day', 'description': 'Mean score on satisfaction survey rating scale from 1 to 5 (higher)'}, {'measure': 'Resource Utilization', 'timeFrame': 'same day', 'description': 'time spent administering the exam'}]}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'keywords': ['Disability Examination', 'Clinician Administered PTSD Scale', 'Quality of Care'], 'conditions': ['Post-Traumatic Stress Disorder']}, 'referencesModule': {'references': [{'pmid': '23821175', 'type': 'RESULT', 'citation': 'Rosen MI, Afshartous D, Marx BP. Did microinsults and microaggressions play a role?: in reply. Psychiatr Serv. 2013 Jul 1;64(7):713. doi: 10.1176/appi.ps.640703. No abstract available.'}, {'pmid': '23318842', 'type': 'RESULT', 'citation': "Rosen MI, Afshartous DR, Nwosu S, Scott MC, Jackson JC, Marx BP, Murdoch M, Sinnott PL, Speroff T. Racial differences in veterans' satisfaction with examination of disability from posttraumatic stress disorder. Psychiatr Serv. 2013 Apr 1;64(4):354-9. doi: 10.1176/appi.ps.201100526."}, {'pmid': '23225029', 'type': 'RESULT', 'citation': 'Speroff T, Sinnott PL, Marx B, Owen RR, Jackson JC, Greevy R, Sayer N, Murdoch M, Shane AC, Smith J, Alvarez J, Nwosu SK, Keane T, Weathers F, Schnurr PP, Friedman MJ. Impact of evidence-based standardized assessment on the disability clinical interview for diagnosis of service-connected PTSD: a cluster-randomized trial. J Trauma Stress. 2012 Dec;25(6):607-15. doi: 10.1002/jts.21759.'}, {'type': 'RESULT', 'citation': 'Marx BP, Jackson JC, Schnuff PP, Murdoch M, Sayer NA, Keane TM, Friedman MJ, Greevy RA, Owen RR, Sinnott PL, Speroff T. The reality of malingered PTSD among Veterans: Reply to McNally and Frueh. Journal of traumatic stress. 2012 Aug 1; 25(4):457-60.'}, {'pmid': '21913226', 'type': 'RESULT', 'citation': 'Jackson JC, Sinnott PL, Marx BP, Murdoch M, Sayer NA, Alvarez JM, Greevy RA, Schnurr PP, Friedman MJ, Shane AC, Owen RR, Keane TM, Speroff T. Variation in practices and attitudes of clinicians assessing PTSD-related disability among veterans. J Trauma Stress. 2011 Oct;24(5):609-13. doi: 10.1002/jts.20688. Epub 2011 Sep 12.'}, {'pmid': '18410194', 'type': 'RESULT', 'citation': 'Marx BP, Marshall PJ, Castro F. The moderating effects of stimulus valence and arousal on memory suppression. Emotion. 2008 Apr;8(2):199-207. doi: 10.1037/1528-3542.8.2.199.'}, {'pmid': '18410204', 'type': 'RESULT', 'citation': 'Sloan DM, Marx BP, Epstein EM, Dobbs JL. Expressive writing buffers against maladaptive rumination. Emotion. 2008 Apr;8(2):302-6. doi: 10.1037/1528-3542.8.2.302.'}]}, 'descriptionModule': {'briefSummary': 'This project evaluated the impact of semi-structured, standardized interviews on the initial PTSD C\\&P on the examination.', 'detailedDescription': 'Our objective is to compare the process and outcomes of C\\&P exams for PTSD conducted with CAPS and WHODAS-II interviews versus the PTSD exams conducted without the CAPS and WHODAS-II interviews. This project will conduct a randomized controlled trial on 688 veterans to evaluate the effects of the CAPS/WHODAS instruments on the initial PTSD C\\&P examination process. Study outcomes include variation in assessing the DSM-IV components of PTSD, diagnostic accuracy, veteran perception of the exam process, VBA rater utility and resource utilization. This project will 1) demonstrate the feasibility of conducting program evaluation and intervention studies on the PTSD C\\&P examination process, 2) develop research tools, instruments and methods for C\\&P evaluation, 3) provide data on the value-added contribution of CAPS and WHODAS-II to the PTSD assessment process and examination report, and 4) inform the business case of utilizing the CAPS and WHODAS-II in the PTSD C\\&P process. The ultimate aim is to improve the reproducibility, consistency and validity of the PTSD examination process while maintaining a level of efficiency and cost restraint that provides veterans with an exam process that is fair, accurate and equitable across VHA.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '99 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. Veterans referred to VHA for an Initial PTSD Compensation and Pension Examination\n2. Informed consent\n\nExclusion Criteria:\n\n1. Mentally impaired, not able to give informed consent\n2. English speaking'}, 'identificationModule': {'nctId': 'NCT00699660', 'acronym': 'E-3PTSD', 'briefTitle': 'Enhancing Equitable and Effective (E-3) Post Traumatic Stress Disorder (PTSD) Disability Assessment', 'organization': {'class': 'FED', 'fullName': 'VA Office of Research and Development'}, 'officialTitle': 'Enhancing Equitable and Effective PTSD Disability Assessment', 'orgStudyIdInfo': {'id': 'SDR 06-331'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'CAPS/WHODAS', 'description': 'PTSD assessed using Clinical Assessment of PTSD Symptoms (CAPS) and WHODAS functional impairment structured evidence-based interview', 'interventionNames': ['Behavioral: CAPS/WHODAS']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Nonstructured Interview', 'description': 'Usual clinical interview to assess PTSD, without CAPS or WHODAS', 'interventionNames': ['Behavioral: Nonstructured Interview']}], 'interventions': [{'name': 'CAPS/WHODAS', 'type': 'BEHAVIORAL', 'description': 'CAPS/WHODAS structured clinical PTSD interview', 'armGroupLabels': ['CAPS/WHODAS']}, {'name': 'Nonstructured Interview', 'type': 'BEHAVIORAL', 'otherNames': ['Usual Clinical Interview'], 'description': 'Usual PTSD clinical PTSD interview, not CAPS or SCID', 'armGroupLabels': ['Nonstructured Interview']}]}, 'contactsLocationsModule': {'locations': [{'zip': '72114-1706', 'city': 'North Little Rock', 'state': 'Arkansas', 'country': 'United States', 'facility': 'Central Arkansas Veterans Healthcare System Eugene J. Towbin Healthcare Center, Little Rock, AR', 'geoPoint': {'lat': 34.76954, 'lon': -92.26709}}, {'zip': '94304-1290', 'city': 'Palo Alto', 'state': 'California', 'country': 'United States', 'facility': 'VA Palo Alto Health Care System, Palo Alto, CA', 'geoPoint': {'lat': 37.44188, 'lon': -122.14302}}, {'zip': '06516', 'city': 'West Haven', 'state': 'Connecticut', 'country': 'United States', 'facility': 'VA Connecticut Healthcare System West Haven Campus, West Haven, CT', 'geoPoint': {'lat': 41.27065, 'lon': -72.94705}}, {'zip': '70112', 'city': 'New Orleans', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Southeast Louisiana Veterans Health Care System, New Orleans, LA', 'geoPoint': {'lat': 29.95465, 'lon': -90.07507}}, {'zip': '02130', 'city': 'Boston', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '48201', 'city': 'Detroit', 'state': 'Michigan', 'country': 'United States', 'facility': 'John D. Dingell VA Medical Center, Detroit, MI', 'geoPoint': {'lat': 42.33143, 'lon': -83.04575}}, {'zip': '55417', 'city': 'Minneapolis', 'state': 'Minnesota', 'country': 'United States', 'facility': 'Minneapolis VA Health Care System, Minneapolis, MN', 'geoPoint': {'lat': 44.97997, 'lon': -93.26384}}, {'zip': '87108-5153', 'city': 'Albuquerque', 'state': 'New Mexico', 'country': 'United States', 'facility': 'New Mexico VA Health Care System, Albuquerque, NM', 'geoPoint': {'lat': 35.08449, 'lon': -106.65114}}, {'zip': '38104', 'city': 'Memphis', 'state': 'Tennessee', 'country': 'United States', 'facility': 'Memphis VA Medical Center, Memphis, TN', 'geoPoint': {'lat': 35.14953, 'lon': -90.04898}}, {'zip': '37212-2637', 'city': 'Nashville', 'state': 'Tennessee', 'country': 'United States', 'facility': 'Tennessee Valley Healthcare System Nashville Campus, Nashville, TN', 'geoPoint': {'lat': 36.16589, 'lon': -86.78444}}, {'zip': '53295-1000', 'city': 'Milwaukee', 'state': 'Wisconsin', 'country': 'United States', 'facility': 'Clement J. Zablocki VA Medical Center, Milwaukee, WI', 'geoPoint': {'lat': 43.0389, 'lon': -87.90647}}], 'overallOfficials': [{'name': 'Theodore Speroff, PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Tennessee Valley Healthcare System Nashville Campus, Nashville, TN'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'VA Office of Research and Development', 'class': 'FED'}, 'responsibleParty': {'type': 'SPONSOR'}}}}