Ignite Creation Date:
2025-12-25 @ 2:12 AM
Ignite Modification Date:
2025-12-26 @ 7:00 PM
Study NCT ID:
NCT00434460
Status:
COMPLETED
Last Update Posted:
2010-09-01
First Post:
2007-02-12
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Study of Knowledge Translation of Clinical Practice Guidelines for Ventilator Associated Pneumonia
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D053717', 'term': 'Pneumonia, Ventilator-Associated'}], 'ancestors': [{'id': 'D000077299', 'term': 'Healthcare-Associated Pneumonia'}, {'id': 'D003428', 'term': 'Cross Infection'}, {'id': 'D007239', 'term': 'Infections'}, {'id': 'D011014', 'term': 'Pneumonia'}, {'id': 'D012141', 'term': 'Respiratory Tract Infections'}, {'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}, {'id': 'D007049', 'term': 'Iatrogenic Disease'}, {'id': 'D020969', 'term': 'Disease Attributes'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D004522', 'term': 'Educational Status'}], 'ancestors': [{'id': 'D012959', 'term': 'Socioeconomic Factors'}, {'id': 'D011154', 'term': 'Population Characteristics'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 1320}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2007-04'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2010-08', 'completionDateStruct': {'date': '2010-07', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2010-08-31', 'studyFirstSubmitDate': '2007-02-12', 'studyFirstSubmitQcDate': '2007-02-12', 'lastUpdatePostDateStruct': {'date': '2010-09-01', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2007-02-13', 'type': 'ESTIMATED'}}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['Ventilator Associated Pneumonia', 'Knowledge Translation', 'Clinical Practice Guidelines', 'Education', 'Behaviour Change'], 'conditions': ['Ventilator Associated Pneumonia']}, 'referencesModule': {'references': [{'pmid': '23222254', 'type': 'DERIVED', 'citation': 'Sinuff T, Muscedere J, Cook DJ, Dodek PM, Anderson W, Keenan SP, Wood G, Tan R, Haupt MT, Miletin M, Bouali R, Jiang X, Day AG, Overvelde J, Heyland DK; Canadian Critical Care Trials Group. Implementation of clinical practice guidelines for ventilator-associated pneumonia: a multicenter prospective study. Crit Care Med. 2013 Jan;41(1):15-23. doi: 10.1097/CCM.0b013e318265e874.'}]}, 'descriptionModule': {'briefSummary': 'The purpose of this prospective, multicentre, time-series study is to develop, implement, refine, and evaluate a sustainable behaviour change strategy in the intensive care unit (ICU).', 'detailedDescription': 'Background:\n\nIn order to improve the care of our patients, it is necessary for research evidence to be translated into clinical practice. There are gaps in our understanding of knowledge translation (KT) and this is evident in the Intensive Care Unit (ICU), specifically as it applies to the prevention, diagnosis and treatment of ventilator-associated pneumonia (VAP). VAP is associated with a high burden of illness in the critically ill and there is an extensive amount of research evidence on this disease. It has been demonstrated that best practice as defined by research evidence is not uniformly applied to VAP. In addition, recent advances in VAP knowledge need be disseminated and implemented in order to improve patient safety and outcomes from VAP. A systematic process of knowledge transfer is crucial to translate this research into evidence-based bedside practice and the development and implementation of evidence based Clinical Practice Guidelines (CPGs) may facilitate VAP knowledge uptake. In addition, there is a need to study knowledge translation (KT) in the ICU since there is little information about optimal KT and CPG implementation strategies in this environment and efforts that are effective in other clinical areas may not result in meaningful change in the ICU.\n\nResearch Question:\n\nWhat is the effect of VAP CPGs implemented by a multidisciplinary behaviour change strategy (consisting of multifaceted educational strategies led by local opinion leaders and augmented with reminders) on VAP guideline concordance and on clinical VAP outcomes in the ICU?\n\nResearch Plan:\n\nData will only be collected on consecutive patients mechanically ventilated for at least 48 hours. The following health care professionals will be studied to assess the behaviour change strategy for the VAP CPGs: physicians (intensivists, ICU fellows, ICU rotating residents), nurses, respiratory therapists, dieticians, physiotherapists and ICU administrators.\n\nThe study will be conducted in 3 phases:\n\n1. Development of a behaviour change strategy consisting of three components:\n\n * Local opinion leader team\n * Educational strategy\n * Reminder system\n2. Prospective implementation of the behaviour change strategy over a 24 month period\n3. Prospective evaluation of the behaviour change strategy over a 24 month period\n\n * Concordance with VAP guidelines over time\n * Factors associated with VAP guideline concordance\n * Clinical VAP outcomes pre- and post-guideline implementation'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'minimumAge': '17 Years', 'samplingMethod': 'PROBABILITY_SAMPLE', 'studyPopulation': 'Patients invasively mechanically ventilated \\> 48 hours in the critical care setting.', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Age \\>= 17 years old\n* Mechanically ventilated \\> 48 hours \\< 96 hours\n\nExclusion Criteria:\n\n* Previous enrollment in the study'}, 'identificationModule': {'nctId': 'NCT00434460', 'acronym': 'ABATEVAP', 'briefTitle': 'Study of Knowledge Translation of Clinical Practice Guidelines for Ventilator Associated Pneumonia', 'organization': {'class': 'OTHER', 'fullName': 'Canadian Critical Care Trials Group'}, 'officialTitle': 'Active Observational Study of the Adoption and Transfer of Clinical Practice Guidelines Through Education, for Ventilator Associated Pneumonia (ABATE VAP Study)', 'orgStudyIdInfo': {'id': 'ABATE VAP'}}, 'armsInterventionsModule': {'armGroups': [{'label': '1', 'description': 'Patients receiving invasive mechanical ventilation \\> 48 hours.', 'interventionNames': ['Behavioral: Education']}], 'interventions': [{'name': 'Education', 'type': 'BEHAVIORAL', 'description': 'Implementation of clinical practice guideline for ventilator associated pneumonia through education.', 'armGroupLabels': ['1']}]}, 'contactsLocationsModule': {'locations': [{'zip': '17821-4400', 'city': 'Danville', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Geisinger Health Centre, Temple University', 'geoPoint': {'lat': 40.96342, 'lon': -76.61273}}, {'zip': 'V3L 3W4', 'city': 'New Westminster', 'state': 'British Columbia', 'country': 'Canada', 'facility': 'Royal Columbian Hospital, University of British Columbia', 'geoPoint': {'lat': 49.20678, 'lon': -122.91092}}, {'zip': 'V6Z 1Y6', 'city': 'Vancouver', 'state': 'British Columbia', 'country': 'Canada', 'facility': 'St. Paul Hospital, University of British Columbia', 'geoPoint': {'lat': 49.24966, 'lon': -123.11934}}, {'zip': 'V8R 1J8', 'city': 'Victoria', 'state': 'British Columbia', 'country': 'Canada', 'facility': 'Vancouver Island Health Research Centre', 'geoPoint': {'lat': 48.4359, 'lon': -123.35155}}, {'zip': 'L8N 4A6', 'city': 'Hamilton', 'state': 'Ontario', 'country': 'Canada', 'facility': "St. Joseph's Healthcare, McMaster University", 'geoPoint': {'lat': 43.25011, 'lon': -79.84963}}, {'zip': 'K7L 2V7', 'city': 'Kingston', 'state': 'Ontario', 'country': 'Canada', 'facility': "Kingston General Hospital, Queen's University", 'geoPoint': {'lat': 44.22976, 'lon': -76.48098}}, {'zip': 'K1H 8L7', 'city': 'Ottawa', 'state': 'Ontario', 'country': 'Canada', 'facility': 'The Ottawa Hospital, University of Ottawa', 'geoPoint': {'lat': 45.41117, 'lon': -75.69812}}, {'zip': 'P7B 6V4', 'city': 'Thunder Bay', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Thunder Bay Regional Health Sciences Centre', 'geoPoint': {'lat': 48.38202, 'lon': -89.25018}}, {'zip': 'M4N 3M5', 'city': 'Toronto', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Sunnybrook Health Sciences Centre, University of Toronto', 'geoPoint': {'lat': 43.70643, 'lon': -79.39864}}, {'city': 'Toronto', 'state': 'Ontario', 'country': 'Canada', 'facility': 'William Osler Health Centre', 'geoPoint': {'lat': 43.70643, 'lon': -79.39864}}, {'zip': 'N4A 1E1', 'city': 'Windsor', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Hotel Dieu Grace Hospital', 'geoPoint': {'lat': 42.30008, 'lon': -83.01654}}], 'overallOfficials': [{'name': 'John Muscedere, MD', 'role': 'STUDY_CHAIR', 'affiliation': "Kingston General Hospital, Queen's University"}, {'name': 'Tasmin Sinuff, MD, PhD', 'role': 'STUDY_CHAIR', 'affiliation': 'Sunnybrook Health Sciences Centre, University of Toronto'}, {'name': 'Daren Heyland, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': "Kingston General Hospital, Queen's University"}, {'name': 'Deborah Cook, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': "St. Joseph's Healthcare, McMaster University"}, {'name': 'Peter Dodek, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': "St. Paul's University, University of British Columbia"}, {'name': 'Redouane Bouali, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'The Ottawa Hospital, University of Ottawa'}, {'name': 'Sean Keenan, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Royal Columbian Hospital, University of British Columbia'}, {'name': 'Kevin Eva, PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'McMaster University'}, {'name': 'Brenda Morgan, RN', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'London Health Sciences Centre, University of Western Ontario'}, {'name': 'Lori Hand, RRT', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Hamilton Health Sciences Centre, McMaster University'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Canadian Critical Care Trials Group', 'class': 'OTHER'}, 'collaborators': [{'name': 'Kingston Health Sciences Centre', 'class': 'OTHER'}, {'name': 'Canadian Institutes of Health Research (CIHR)', 'class': 'OTHER_GOV'}, {'name': 'AstraZeneca', 'class': 'INDUSTRY'}, {'name': 'Bayer', 'class': 'INDUSTRY'}], 'responsibleParty': {'oldNameTitle': 'Dr. John Muscedere', 'oldOrganization': "Kingston General Hospital, Queen's University"}}}}