Ignite Creation Date:
2025-12-24 @ 2:16 PM
Ignite Modification Date:
2026-02-21 @ 11:18 PM
Study NCT ID:
NCT00332995
Status:
COMPLETED
Last Update Posted:
2009-09-01
First Post:
2006-06-01
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Safety and Feasibility Study of Dapivirine (TMC120) Vaginal Ring in Belgium
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D015658', 'term': 'HIV Infections'}], 'ancestors': [{'id': 'D000086982', 'term': 'Blood-Borne Infections'}, {'id': 'D003141', 'term': 'Communicable Diseases'}, {'id': 'D007239', 'term': 'Infections'}, {'id': 'D015229', 'term': 'Sexually Transmitted Diseases, Viral'}, {'id': 'D012749', 'term': 'Sexually Transmitted Diseases'}, {'id': 'D016180', 'term': 'Lentivirus Infections'}, {'id': 'D012192', 'term': 'Retroviridae Infections'}, {'id': 'D012327', 'term': 'RNA Virus Infections'}, {'id': 'D014777', 'term': 'Virus Diseases'}, {'id': 'D000091662', 'term': 'Genital Diseases'}, {'id': 'D000091642', 'term': 'Urogenital Diseases'}, {'id': 'D007153', 'term': 'Immunologic Deficiency Syndromes'}, {'id': 'D007154', 'term': 'Immune System Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C481671', 'term': 'Dapivirine'}, {'id': 'D003274', 'term': 'Contraceptive Devices, Female'}], 'ancestors': [{'id': 'D003273', 'term': 'Contraceptive Devices'}, {'id': 'D004864', 'term': 'Equipment and Supplies'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE1'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'DOUBLE'}, 'primaryPurpose': 'PREVENTION', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'count': 13}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2005-07'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2009-08', 'completionDateStruct': {'date': '2005-08'}, 'lastUpdateSubmitDate': '2009-08-31', 'studyFirstSubmitDate': '2006-06-01', 'studyFirstSubmitQcDate': '2006-06-01', 'lastUpdatePostDateStruct': {'date': '2009-09-01', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2006-06-02', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Safety and tolerability of seven-day use of a vaginal ring containing dapivirine (TMC120).'}, {'measure': 'Assess dapivirine (TMC120) concentrations in vaginal fluids, vaginal and cervical epithelial tissue, and plasma during and after seven-day use of a vaginal ring containing dapivirine (TMC120).'}]}, 'conditionsModule': {'keywords': ['HIV Seronegativity'], 'conditions': ['HIV Infections']}, 'descriptionModule': {'briefSummary': 'This Phase I trial will assess the feasibility of using a vaginal ring to deliver the candidate microbicide dapivirine (TMC120) for 7 days. The study population will consist of 13 healthy, sexually abstinent women. Safety and tolerability will be assessed through clinical and laboratory assessments. Feasibility of drug delivery will be assessed by measuring dapivirine (TMC120) concentrations in vaginal fluids, vaginal and cervical epithelial tissue, and plasma.'}, 'eligibilityModule': {'sex': 'FEMALE', 'stdAges': ['ADULT'], 'maximumAge': '50 Years', 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Female, age 18-50 years\n* Willing and able to provide written informed consent\n* HIV-uninfected and otherwise healthy\n* Willing to abstain from sexual activity and from use of vaginal products while participating in the study\n* Currently using oral contraceptives for pregnancy prevention\n* Willing to use oral contraceptives as needed to avoid menstruation while taking part in this study\n\nExclusion Criteria:\n\n* History of allergy to TMC120 or to the constituents of the vaginal ring\n* History of diagnosis of and/or treatment for a sexually transmitted disease within the last three months\n* History of genital tract surgery within the last month\n* Currently pregnant or breastfeeding, or within two months of last pregnancy outcome\n* Currently or within one month of participating in any other clinical research study\n* Current vulvar or vaginal symptoms / abnormalities that could influence the study results\n* Current non-iatrogenic pelvic/colposcopic exam findings involving deep epithelial disruption\n* Current diagnosis of any genital infection\n* Smoking more than 10 cigarettes / day'}, 'identificationModule': {'nctId': 'NCT00332995', 'briefTitle': 'Safety and Feasibility Study of Dapivirine (TMC120) Vaginal Ring in Belgium', 'organization': {'class': 'INDUSTRY', 'fullName': 'International Partnership for Microbicides, Inc.'}, 'officialTitle': 'Double-blind, Randomized, Placebo Controlled Trial to Study Safety, Local and Systemic Availability of TMC120 From a Vaginal Ring.', 'orgStudyIdInfo': {'id': 'IPM008, TMC120-C131'}}, 'armsInterventionsModule': {'interventions': [{'name': 'dapivirine (TMC120) vaginal ring', 'type': 'DRUG'}]}, 'contactsLocationsModule': {'locations': [{'zip': '9000', 'city': 'Ghent', 'country': 'Belgium', 'facility': 'Drug Research Unit Gent', 'geoPoint': {'lat': 51.05, 'lon': 3.71667}}], 'overallOfficials': [{'name': 'Dr. Luc Van Bortel', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'University Ghent'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'International Partnership for Microbicides, Inc.', 'class': 'INDUSTRY'}, 'collaborators': [{'name': 'Tibotec Pharmaceutical Limited', 'class': 'INDUSTRY'}], 'responsibleParty': {'oldNameTitle': 'Zeda Rosenberg ScD', 'oldOrganization': 'International Partnership for Microbicides'}}}}