Ignite Creation Date:
2025-12-25 @ 1:46 AM
Ignite Modification Date:
2026-03-07 @ 9:24 PM
Study NCT ID:
NCT03129594
Status:
COMPLETED
Last Update Posted:
2017-10-04
First Post:
2017-04-23
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Plasma Glucagon-like Peptide-1 Levels and Acute Myocardial Infarction
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'OTHER', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 709}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2013-02', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2017-10', 'completionDateStruct': {'date': '2015-02', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2017-10-03', 'studyFirstSubmitDate': '2017-04-23', 'studyFirstSubmitQcDate': '2017-04-25', 'lastUpdatePostDateStruct': {'date': '2017-10-04', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2017-04-26', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2015-02', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'all-cause mortality', 'timeFrame': 'The median follow-up was 29 months'}, {'measure': 'cardiovascular mortality', 'timeFrame': 'The median follow-up was 29 months'}], 'secondaryOutcomes': [{'measure': 'non-cardiovascular mortality', 'timeFrame': 'The median follow-up was 29 months'}, {'measure': 'Myocardial infarction', 'timeFrame': 'The median follow-up was 29 months'}, {'measure': 'heart failure readmission', 'timeFrame': 'The median follow-up was 29 months', 'description': 'readmission to any hospital due to diagnosed heart failure'}, {'measure': 'Stroke', 'timeFrame': 'The median follow-up was 29 months', 'description': 'defined using the World Health Organization criteria'}, {'measure': 'repeated revascularization', 'timeFrame': 'The median follow-up was 29 months', 'description': 'defined as repeated PCI or bypass grafting of not only infarct related artery'}]}, 'oversightModule': {'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Coronary Angiography', 'Glucagon-like Peptide-1']}, 'descriptionModule': {'briefSummary': 'GLP-1(9-36) amide and (9-37), which was previously thought to be the inactive metabolite of GLP-1, also exerts cardioprotective effects. Direct administration of GLP-1(9-36) during reperfusion reduced ischaemic damage in isolated hearts and increased cGMP release, vasodilatation and coronary flow in AMI mouse model, one may speculate that total GLP-1 level may associate with adverse cardiovascular events in AMI patients, the hypothesis is therefore tested in this study.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'A single center study on PCI-treated myocardial infarction patients', 'eligibilityCriteria': 'Inclusion Criteria:\n\n* consecutive patients of acute AMI come to our department,absent of cardiogenic shock, and survival for at least 24 h after PCI treatment.\n\nExclusion Criteria:\n\n* patients with cancer, and patients who were taking a DPP4 inhibitor or a glucagon-like peptide-1 (GLP-1) analogue'}, 'identificationModule': {'nctId': 'NCT03129594', 'briefTitle': 'Plasma Glucagon-like Peptide-1 Levels and Acute Myocardial Infarction', 'organization': {'class': 'OTHER', 'fullName': 'Chinese PLA General Hospital'}, 'officialTitle': 'Prognostic Value of Plasma Glucagon-like Peptide-1 Levels in Acute Myocardial Infarction', 'orgStudyIdInfo': {'id': 'GLP1AMI'}}, 'armsInterventionsModule': {'interventions': [{'name': 'plasma glucagon-like peptide-1 levels', 'type': 'DIAGNOSTIC_TEST', 'description': 'The plasma GLP-1 levels was determined by enzymatic assays.'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Chinese PLA General Hospital', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Doctor', 'investigatorFullName': 'Li Jing Wei', 'investigatorAffiliation': 'Chinese PLA General Hospital'}}}}