Ignite Creation Date:
2025-12-25 @ 1:43 AM
Ignite Modification Date:
2025-12-26 @ 12:01 AM
Study NCT ID:
NCT00099294
Status:
COMPLETED
Last Update Posted:
2009-04-30
First Post:
2004-12-10
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Study of the Efficacy and Safety of Glufosfamide Compared With Best Supportive Care in Metastatic Pancreatic Cancer
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D010190', 'term': 'Pancreatic Neoplasms'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D009362', 'term': 'Neoplasm Metastasis'}], 'ancestors': [{'id': 'D004067', 'term': 'Digestive System Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D004701', 'term': 'Endocrine Gland Neoplasms'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D010182', 'term': 'Pancreatic Diseases'}, {'id': 'D004700', 'term': 'Endocrine System Diseases'}, {'id': 'D009385', 'term': 'Neoplastic Processes'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C092028', 'term': 'beta-D-glucosylisophosphoramide mustard'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'count': 300}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2004-09'}, 'statusVerifiedDate': '2009-04', 'completionDateStruct': {'date': '2007-01', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2009-04-28', 'studyFirstSubmitDate': '2004-12-10', 'studyFirstSubmitQcDate': '2004-12-09', 'lastUpdatePostDateStruct': {'date': '2009-04-30', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2004-12-10', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2007-01', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Overall Survival'}], 'secondaryOutcomes': [{'measure': 'Objective tumor response rate'}, {'measure': 'Duration of objective tumor response rate'}, {'measure': 'Progression-free survival'}, {'measure': '6 month and 12 month survival'}, {'measure': 'Serum CA 19-9'}, {'measure': 'Pain Intensity'}, {'measure': 'Performance Status'}]}, 'conditionsModule': {'keywords': ['Pancreas', 'Cancer', 'Pancreatic Adenocarcinoma', 'Metastatic', 'Glufosfamide'], 'conditions': ['Pancreatic Cancer']}, 'referencesModule': {'seeAlsoLinks': [{'url': 'http://www.thresholdpharm.com', 'label': 'Threshold Pharmaceuticals Website'}]}, 'descriptionModule': {'briefSummary': 'The primary objectives of the study is to evaluate the effectiveness and safety of glufosfamide in subjects with pancreatic cancer who have been previously treated with gemcitabine as measured by overall survival compared with best supportive care.', 'detailedDescription': 'TH-CR-302 is a randomized Phase 3 study that will evaluate the efficacy and safety of glufosfamide plus best supportive care (BSC) compared to BSC alone for second line treatment of metastatic pancreatic cancer. BSC includes all medical or surgical interventions that a pancreatic cancer patient should receive to palliate the cancer but excludes treatment with systemic therapies intended to kill the cancer cells.\n\nStudy Hypothesis: Glufosfamide will provide benefits in survival to patients with metastatic pancreatic cancer over best supportive care.\n\nComparison: Glufosfamide versus best supportive care.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* At least 18 years of age\n* Pancreatic adenocarcinoma proven either by histology (surgical biopsy) or cytology (CT- or endoscopic-guided)\n* Metastatic pancreatic cancer\n* Disease progression during or after treatment with gemcitabine (alone or in combination with other agents; at regular, not radiosensitizing, doses) for advanced/metastatic pancreatic cancer\n* Measurable or nonmeasurable disease by RECIST criteria (at least one target or nontarget lesion)\n* Recovered from reversible toxicities of prior therapy\n* Karnofsky performance status ≥70\n* All women of childbearing potential and all men must agree to use effective means of contraception (surgical sterilization or the use of barrier contraception with either a condom or diaphragm in conjunction with spermicidal gel or an IUD) from entry into the study through 6 months after the last dose\n* Ability to understand the purposes and risks of the study and has signed a written informed consent form approved by the investigator's IRB/Ethics Committee\n\nExclusion Criteria:\n\n* More than one prior systemic therapy regimen for metastatic/locally advanced pancreatic cancer (radiosensitizing doses of 5FU or gemcitabine at the time of initial radiotherapy do not count as a prior systemic therapy regimen)\n* Hormonal therapy, radiation therapy, biologic therapy, chemotherapy or other systemic antitumor therapy for pancreatic cancer within 14 days prior to study start\n* Symptomatic brain metastases (baseline CT scan is not required in asymptomatic subjects)\n* Active clinically significant infection requiring antibiotics\n* Known HIV positive or active hepatitis B or C\n* Recent (one year) history or symptoms of cardiovascular disease (NYHA Class 2, 3, or 4), particularly coronary artery disease, arrhythmias or conduction defects with risk of cardiovascular instability, uncontrolled hypertension, clinically significant pericardial effusion, or congestive heart failure\n* No other active malignancies (other than treated non-melanoma skin cancer or treated in situ cancer) within the past year\n* Major surgery within 3 weeks of the start of study treatment, without complete recovery\n* Clinically significant abnormalities in laboratory test results (including complete blood count, chemistry panel including electrolytes, and urinalysis) (Hemoglobin \\<9 g/dL (may receive transfusion or erythropoietin to maintain))"}, 'identificationModule': {'nctId': 'NCT00099294', 'briefTitle': 'Study of the Efficacy and Safety of Glufosfamide Compared With Best Supportive Care in Metastatic Pancreatic Cancer', 'organization': {'class': 'INDUSTRY', 'fullName': 'Threshold Pharmaceuticals'}, 'officialTitle': 'A Randomized Phase 3 Study of the Efficacy and Safety of Glufosfamide Compared With Best Supportive Care in Metastatic Pancreatic Adenocarcinoma Previously Treated With Gemcitabine', 'orgStudyIdInfo': {'id': 'TH-CR-302'}}, 'armsInterventionsModule': {'interventions': [{'name': 'Glufosfamide', 'type': 'DRUG'}]}, 'contactsLocationsModule': {'locations': [{'zip': '90057', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'Augusta Oncology Associates', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90057', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'Kenmar Research Institute', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '80210', 'city': 'Denver', 'state': 'Colorado', 'country': 'United States', 'facility': 'Mile High Oncology', 'geoPoint': {'lat': 39.73915, 'lon': -104.9847}}, {'zip': '06790', 'city': 'Torrington', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Northwestern Connecticut Oncology - Hematology Associates', 'geoPoint': {'lat': 41.80065, 'lon': -73.12122}}, {'zip': '33435', 'city': 'Boynton Beach', 'state': 'Florida', 'country': 'United States', 'facility': 'Palm Beach Institute of Hematology and Oncology', 'geoPoint': {'lat': 26.52535, 'lon': -80.06643}}, {'zip': '60076', 'city': 'Skokie', 'state': 'Illinois', 'country': 'United States', 'facility': 'Hematology/Oncology of the North Shore', 'geoPoint': {'lat': 42.03336, 'lon': -87.73339}}, {'zip': '46815', 'city': 'Fort Wayne', 'state': 'Indiana', 'country': 'United States', 'facility': 'Fort Wayne Medical Oncology/Hem', 'geoPoint': {'lat': 41.1306, 'lon': -85.12886}}, {'zip': '40202', 'city': 'Louisville', 'state': 'Kentucky', 'country': 'United States', 'facility': 'Norton Healthcare Center', 'geoPoint': {'lat': 38.25424, 'lon': -85.75941}}, {'zip': '49007', 'city': 'Kalamazoo', 'state': 'Michigan', 'country': 'United States', 'facility': 'West Michigan Cancer Center', 'geoPoint': {'lat': 42.29171, 'lon': -85.58723}}, {'zip': '39401', 'city': 'Hattiesburg', 'state': 'Mississippi', 'country': 'United States', 'facility': 'Hattiesburg Clinic Oncology', 'geoPoint': {'lat': 31.32712, 'lon': -89.29034}}, {'zip': '65201', 'city': 'Columbia', 'state': 'Missouri', 'country': 'United States', 'facility': 'Columbia Comprehensive Cancer Care Clinic', 'geoPoint': {'lat': 38.95171, 'lon': -92.33407}}, {'zip': '65401', 'city': 'Rolla', 'state': 'Missouri', 'country': 'United States', 'facility': 'Bond Clinic', 'geoPoint': {'lat': 37.95143, 'lon': -91.77127}}, {'zip': '59101', 'city': 'Billings', 'state': 'Montana', 'country': 'United States', 'facility': 'Deaconess Billings Clinic', 'geoPoint': {'lat': 45.78329, 'lon': -108.50069}}, {'zip': '07652', 'city': 'Paramus', 'state': 'New Jersey', 'country': 'United States', 'facility': 'Office of Clinical Trials', 'geoPoint': {'lat': 40.94454, 'lon': -74.07542}}, {'zip': '87109', 'city': 'Albuquerque', 'state': 'New Mexico', 'country': 'United States', 'facility': 'New Mexico Oncology Hematology Consultants', 'geoPoint': {'lat': 35.08449, 'lon': -106.65114}}, {'zip': '28401', 'city': 'Wilmington', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Hanover Medical Specialists', 'geoPoint': {'lat': 34.23556, 'lon': -77.94604}}, {'zip': '18015', 'city': 'Bethlehem', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Vita Hematology Oncology PC', 'geoPoint': {'lat': 40.62593, 'lon': -75.37046}}, {'zip': '38017', 'city': 'Collierville', 'state': 'Tennessee', 'country': 'United States', 'facility': 'The Family Cancer Center , PLLC', 'geoPoint': {'lat': 35.04204, 'lon': -89.66453}}, {'zip': '75230', 'city': 'Dallas', 'state': 'Texas', 'country': 'United States', 'facility': 'Center for Oncology Research and Treatment', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '76104', 'city': 'Fort Worth', 'state': 'Texas', 'country': 'United States', 'facility': 'JPS Center for Cancer Care', 'geoPoint': {'lat': 32.72541, 'lon': -97.32085}}, {'zip': '84403', 'city': 'Ogden', 'state': 'Utah', 'country': 'United States', 'facility': 'Northern Utah Associates', 'geoPoint': {'lat': 41.223, 'lon': -111.97383}}, {'zip': '24211', 'city': 'Abingdon', 'state': 'Virginia', 'country': 'United States', 'facility': 'Cancer Outreach Association', 'geoPoint': {'lat': 36.70983, 'lon': -81.97735}}, {'zip': '54449', 'city': 'Marshfield', 'state': 'Wisconsin', 'country': 'United States', 'facility': 'Marshfield Clinic Research Foundation', 'geoPoint': {'lat': 44.66885, 'lon': -90.1718}}, {'zip': '1650', 'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Hospital Interzonal General de Agudos', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'zip': '1706', 'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Hospital Posadas', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'zip': 'B8000FTS', 'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Policlinica Privada Instituto de Medicina Nuclear', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'zip': 'C1120AAF', 'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Hospital Udaondo', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'zip': 'C1406FWY', 'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Hospital Alvarez', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'zip': 'C1437JCP', 'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Hospital Churruca - Visca', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Instituto Medico Alexander Fleming', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'city': 'Santa Fe', 'country': 'Argentina', 'facility': 'Instituto CAICI', 'geoPoint': {'lat': -31.64881, 'lon': -60.70868}}, {'zip': '14784-400', 'city': 'Barretos', 'country': 'Brazil', 'facility': 'Fundacao Pio XII - Hospital de Cancer de Barretos', 'geoPoint': {'lat': -20.55722, 'lon': -48.56778}}, {'zip': '14784-400', 'city': 'Barretos', 'country': 'Brazil', 'facility': 'Fundação Pio XII - Hospital de Câncer de Barretos', 'geoPoint': {'lat': -20.55722, 'lon': -48.56778}}, {'zip': '30180-090', 'city': 'Belo Horizonte', 'country': 'Brazil', 'facility': 'Hospital Vera Cruz - Clinica de Oncologia', 'geoPoint': {'lat': -19.92083, 'lon': -43.93778}}, {'zip': '30380-490', 'city': 'Belo Horizonte', 'country': 'Brazil', 'facility': 'Hospital Luxemburgo', 'geoPoint': {'lat': -19.92083, 'lon': -43.93778}}, {'zip': '80060-900', 'city': 'Curitiba', 'country': 'Brazil', 'facility': 'Hospital de Clínicas da UFPR', 'geoPoint': {'lat': -25.42778, 'lon': -49.27306}}, {'zip': '74605-070', 'city': 'Goiânia', 'country': 'Brazil', 'facility': 'Associacao de Combate ao Cancer em Goias, Hospital Araujo Jorge, Setor de Oncologia Clinica', 'geoPoint': {'lat': -16.67861, 'lon': -49.25389}}, {'zip': '91350-200', 'city': 'Porto Alegre', 'country': 'Brazil', 'facility': 'Hospital Nossa Senhora da Conceicao', 'geoPoint': {'lat': -30.03283, 'lon': -51.23019}}, {'zip': '20231-050', 'city': 'Rio de Janeiro', 'country': 'Brazil', 'facility': 'Instituto Nacional do Cancer - INCA', 'geoPoint': {'lat': -22.90642, 'lon': -43.18223}}, {'zip': '01331-020', 'city': 'São Paulo', 'country': 'Brazil', 'facility': 'Grupo Paulista Oncologia Integrada', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '01406100', 'city': 'São Paulo', 'country': 'Brazil', 'facility': 'Clinica de Oncologia Medica S/C Ltda', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '01509-900', 'city': 'São Paulo', 'country': 'Brazil', 'facility': 'Hospital do Cancer - AC Camargo', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '5800', 'city': 'Pleven', 'country': 'Bulgaria', 'facility': 'Department of Chemotherapy Dr. Georgi Stranski General Hospital of Pleven University', 'geoPoint': {'lat': 43.41791, 'lon': 24.61666}}, {'zip': '4004', 'city': 'Plovdiv', 'country': 'Bulgaria', 'facility': 'First Internal Department Plovdiv Regional Oncology Center with In-patient Department', 'geoPoint': {'lat': 42.15387, 'lon': 24.75001}}, {'zip': '1233', 'city': 'Sofia', 'country': 'Bulgaria', 'facility': 'Department of Chemotherapy Sofia Regional Oncology Center', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '1527', 'city': 'Sofia', 'country': 'Bulgaria', 'facility': 'Chemotherapy Clinic Queen Joanna General Hospital', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '1606', 'city': 'Sofia', 'country': 'Bulgaria', 'facility': 'Haematology and Oncology Clinic Military Medical Academy', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '1756', 'city': 'Sofia', 'country': 'Bulgaria', 'facility': 'Chemotherapy Clinic Specialized Oncology Hospital', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '9010', 'city': 'Varna', 'country': 'Bulgaria', 'facility': 'Department of Medicinal Oncotherapy and Palliative Care Dr. Marko Markov Regional Oncology Center', 'geoPoint': {'lat': 43.21912, 'lon': 27.91024}}, {'zip': '5000', 'city': 'Veliko Tarnovo', 'country': 'Bulgaria', 'facility': 'Department of Chemotherapy Veliko Tarnovo Regional Oncology Center', 'geoPoint': {'lat': 43.08124, 'lon': 25.62904}}, {'city': 'Brno', 'country': 'Czechia', 'facility': 'Fakultni nemocnice Brno Oddeleni Klinicke Onkologie', 'geoPoint': {'lat': 49.19522, 'lon': 16.60796}}, {'city': 'Brno', 'country': 'Czechia', 'facility': 'Masarykuv onkologicky Ustav', 'geoPoint': {'lat': 49.19522, 'lon': 16.60796}}, {'city': 'Kyjevska', 'country': 'Czechia', 'facility': 'Krajska nemocnice Pardubice,oddeleni Radiacni Onkologie'}, {'city': 'Olomouc', 'country': 'Czechia', 'facility': 'Onkologicka Klinika, Fakultni nemocnice Olomouc', 'geoPoint': {'lat': 49.59552, 'lon': 17.25175}}, {'city': 'Zlín', 'country': 'Czechia', 'facility': 'Onkologicke Oddeleni, Batova krajska nemocnice Zlin', 'geoPoint': {'lat': 49.22645, 'lon': 17.67065}}, {'city': 'Budapest', 'country': 'Hungary', 'facility': 'National Institute of Oncology', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'city': 'Budapest', 'country': 'Hungary', 'facility': 'Szent Imre Korhaz Onkologia', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'city': 'Budapest', 'country': 'Hungary', 'facility': 'Szent László Kórház, Onkológia', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'city': 'Esztergom', 'country': 'Hungary', 'facility': 'Vaszary Kolos Korhaz', 'geoPoint': {'lat': 47.7928, 'lon': 18.74148}}, {'city': 'Győr', 'country': 'Hungary', 'facility': 'Petz Aladar County Hospital, Department of Oncology', 'geoPoint': {'lat': 47.68333, 'lon': 17.63512}}, {'city': 'Rakoczi', 'country': 'Hungary', 'facility': 'Baranya megyei Korhaz Onkologial osztaly'}, {'zip': '560027', 'city': 'Bangalore', 'country': 'India', 'facility': 'Bangalore Institute of Oncology', 'geoPoint': {'lat': 12.97194, 'lon': 77.59369}}, {'city': 'Bangalore', 'country': 'India', 'facility': 'Curie Centre of Oncology', 'geoPoint': {'lat': 12.97194, 'lon': 77.59369}}, {'zip': '302004', 'city': 'Jaipur', 'country': 'India', 'facility': 'Radhakrishan Birla Cancer Centre', 'geoPoint': {'lat': 26.91962, 'lon': 75.78781}}, {'zip': '400026', 'city': 'Mumbai', 'country': 'India', 'facility': 'Jaslok Hospital and Research Centre', 'geoPoint': {'lat': 19.07283, 'lon': 72.88261}}, {'city': 'New Delhi', 'country': 'India', 'facility': 'Sir Ganga Ram Hospital', 'geoPoint': {'lat': 28.62137, 'lon': 77.2148}}, {'zip': '31000', 'city': 'Chihuahua City', 'state': 'Chihuahua', 'country': 'Mexico', 'facility': 'Hospital Clinica del Parque', 'geoPoint': {'lat': 28.63528, 'lon': -106.08889}}, {'zip': '45200', 'city': 'Zapopan', 'state': 'Jalisco', 'country': 'Mexico', 'facility': 'Hospital Universitario "Dr. Angel Leano"', 'geoPoint': {'lat': 20.72111, 'lon': -103.38742}}, {'zip': '64000', 'city': 'Monterrey', 'state': 'Nuevo León', 'country': 'Mexico', 'facility': 'Hospital y Clinica OCA S.A. De C.V.', 'geoPoint': {'lat': 25.68435, 'lon': -100.31721}}, {'zip': '78240', 'city': 'San Luis Potosí City', 'state': 'San Luis Potosí', 'country': 'Mexico', 'facility': 'Hospital Central "Dr. Ignacio Morones Prieto" Departamento de Radioterapia.', 'geoPoint': {'lat': 22.15234, 'lon': -100.97135}}, {'zip': '97219', 'city': 'Mérida', 'state': 'Yucatán', 'country': 'Mexico', 'facility': 'Hospital regional ISSSTE "Merida"', 'geoPoint': {'lat': 20.967, 'lon': -89.62318}}, {'zip': '31000', 'city': 'Chihuahua City', 'country': 'Mexico', 'facility': 'Centro Estatal de Cancerologia', 'geoPoint': {'lat': 28.63528, 'lon': -106.08889}}, {'zip': '52410', 'city': 'Metepec', 'country': 'Mexico', 'facility': 'Centro Medico ISSEMYM', 'geoPoint': {'lat': 19.25934, 'lon': -99.60175}}, {'zip': '21100', 'city': 'Mexicali', 'country': 'Mexico', 'facility': 'Hospital general "5 de Diciembre" ISSSTE', 'geoPoint': {'lat': 32.62781, 'lon': -115.45446}}, {'zip': '21100', 'city': 'Mexicali', 'country': 'Mexico', 'facility': 'Hospital Regional de Especialidades No. 30 IMSS', 'geoPoint': {'lat': 32.62781, 'lon': -115.45446}}, {'zip': '06720', 'city': 'Mexico City', 'country': 'Mexico', 'facility': 'Hospital de Oncologia Centro Medico', 'geoPoint': {'lat': 19.42847, 'lon': -99.12766}}, {'zip': '14000', 'city': 'Mexico City', 'country': 'Mexico', 'facility': 'Instituto Nacional de Ciencias Medicas u Nutricion "Salvador Zubiran"', 'geoPoint': {'lat': 19.42847, 'lon': -99.12766}}, {'city': 'Bucharest', 'country': 'Romania', 'facility': 'Fundeni Clinical Institute', 'geoPoint': {'lat': 44.43225, 'lon': 26.10626}}, {'city': 'Bucharest', 'country': 'Romania', 'facility': 'Trestioreanu Institute of Oncology', 'geoPoint': {'lat': 44.43225, 'lon': 26.10626}}, {'city': 'Cluj-Napoca', 'country': 'Romania', 'facility': '"I. Chiricuta" Institute of Oncology', 'geoPoint': {'lat': 46.76667, 'lon': 23.6}}, {'zip': '1100', 'city': 'Craiova', 'country': 'Romania', 'facility': 'Craiova Emergency Clinical County Hospital', 'geoPoint': {'lat': 44.31667, 'lon': 23.8}}, {'city': 'Timișoara', 'country': 'Romania', 'facility': 'Timisoara City Hospital', 'geoPoint': {'lat': 45.75372, 'lon': 21.22571}}, {'zip': '249020', 'city': 'Obninsk', 'state': 'Kaluga Oblast', 'country': 'Russia', 'facility': 'Institute of Medical Radiology, Russian Academy of Medical Science', 'geoPoint': {'lat': 55.10993, 'lon': 36.61238}}, {'zip': '454087', 'city': 'Chelyabinsk', 'country': 'Russia', 'facility': 'Cheliabinsk Regional Oncology Center', 'geoPoint': {'lat': 55.1611, 'lon': 61.42877}}, {'zip': '664035', 'city': 'Irkutsk', 'country': 'Russia', 'facility': 'Irkutsk Regional Oncology Center', 'geoPoint': {'lat': 52.29566, 'lon': 104.29076}}, {'zip': '420029', 'city': "Kazan'", 'country': 'Russia', 'facility': 'Clinical Oncology Center', 'geoPoint': {'lat': 55.78874, 'lon': 49.12214}}, {'zip': '350040', 'city': 'Krasnodar', 'country': 'Russia', 'facility': 'Krasnodar City Oncology Center', 'geoPoint': {'lat': 45.04534, 'lon': 38.98178}}, {'zip': '115478', 'city': 'Moscow', 'country': 'Russia', 'facility': 'Blokhin Cancer Research Center, Dept of Clinical Pharmacology and Chemotherapy', 'geoPoint': {'lat': 55.75204, 'lon': 37.61781}}, {'zip': '121356', 'city': 'Moscow', 'country': 'Russia', 'facility': 'Central Clinical Hospital of the presidentof the Russian Federation', 'geoPoint': {'lat': 55.75204, 'lon': 37.61781}}, {'zip': '125284', 'city': 'Moscow', 'country': 'Russia', 'facility': 'Hertzen Research Institute of Oncology', 'geoPoint': {'lat': 55.75204, 'lon': 37.61781}}, {'zip': '129128', 'city': 'Moscow', 'country': 'Russia', 'facility': 'Central Clinical Hospital of the Ministru of Transport n.a. Semashko', 'geoPoint': {'lat': 55.75204, 'lon': 37.61781}}, {'zip': '460021', 'city': 'Orenburg', 'country': 'Russia', 'facility': 'Orenburg, Regional Oncology Center', 'geoPoint': {'lat': 51.76712, 'lon': 55.09883}}, {'zip': '189646', 'city': 'Saint Petersburg', 'country': 'Russia', 'facility': 'St. Petersburg, Central Research Institute of Radiology', 'geoPoint': {'lat': 59.93863, 'lon': 30.31413}}, {'zip': '193015', 'city': 'Saint Petersburg', 'country': 'Russia', 'facility': 'Medical Academy of Postgraduate Education', 'geoPoint': {'lat': 59.93863, 'lon': 30.31413}}, {'zip': '195065', 'city': 'Saint Petersburg', 'country': 'Russia', 'facility': 'Mechnikov State Medical Academy', 'geoPoint': {'lat': 59.93863, 'lon': 30.31413}}, {'city': 'Saint Petersburg', 'country': 'Russia', 'facility': 'St. Petersburg Oncology Center', 'geoPoint': {'lat': 59.93863, 'lon': 30.31413}}, {'zip': '443066', 'city': 'Samara', 'country': 'Russia', 'facility': 'Samara Oncology Center', 'geoPoint': {'lat': 53.20767, 'lon': 50.13553}}, {'zip': '394000', 'city': 'Voronezh', 'country': 'Russia', 'facility': 'Voronezh Regional Clinical Oncology Center', 'geoPoint': {'lat': 51.66833, 'lon': 39.19204}}, {'zip': '150054', 'city': 'Yaroslavl', 'country': 'Russia', 'facility': 'Yaroslavl Regional Oncology Center', 'geoPoint': {'lat': 57.62987, 'lon': 39.87368}}, {'zip': '49102', 'city': 'Dnipro', 'country': 'Ukraine', 'facility': 'Dnepropetrovsk City Clinical Hospital', 'geoPoint': {'lat': 48.46664, 'lon': 35.04066}}, {'zip': '83092', 'city': 'Donetsk', 'country': 'Ukraine', 'facility': 'Donetsk Regional Antitumor Center', 'geoPoint': {'lat': 48.023, 'lon': 37.80224}}, {'zip': '61070', 'city': 'Kharkiv', 'country': 'Ukraine', 'facility': 'State Communal Healthcare Institution: Kharkov Regional Clinical Oncological Center', 'geoPoint': {'lat': 49.98177, 'lon': 36.25475}}, {'zip': '03022', 'city': 'Kiev', 'country': 'Ukraine', 'facility': 'Institute of Oncology under the Academy of Medical Sciences of Ukraine', 'geoPoint': {'lat': 50.45466, 'lon': 30.5238}}, {'zip': '03039', 'city': 'Kiev', 'country': 'Ukraine', 'facility': 'Kiev Municipal Clinical Hospital #10, Kiev Center for Biliary, Biliary tracts and Pancreas Surgery', 'geoPoint': {'lat': 50.45466, 'lon': 30.5238}}, {'zip': '50048', 'city': 'Kryvyi Rih', 'country': 'Ukraine', 'facility': 'Krivoy Rog City Oncology Center', 'geoPoint': {'lat': 47.90572, 'lon': 33.39404}}, {'zip': '91047', 'city': 'Luhansk', 'country': 'Ukraine', 'facility': 'Lugansk Regional Clinical Oncological Center', 'geoPoint': {'lat': 48.56814, 'lon': 39.30553}}, {'zip': '54044', 'city': 'Mykolayiv', 'country': 'Ukraine', 'facility': 'Nikolaev Regional Oncology Centre', 'geoPoint': {'lat': 46.97625, 'lon': 31.99296}}, {'zip': '65025', 'city': 'Odesa', 'country': 'Ukraine', 'facility': 'Odessa Regional Clinical Hospital', 'geoPoint': {'lat': 46.48572, 'lon': 30.74383}}, {'zip': '21029', 'city': 'Vinnitsa', 'country': 'Ukraine', 'facility': 'Vinnitsa Regional Clinical Oncology Center', 'geoPoint': {'lat': 49.84639, 'lon': 37.71861}}, {'zip': '69096', 'city': 'Zaporizhzhya', 'country': 'Ukraine', 'facility': 'Zaporozhye Medical Academy of Postgraduate Education', 'geoPoint': {'lat': 47.85167, 'lon': 35.11714}}, {'zip': '10002', 'city': 'Zhytomyr', 'country': 'Ukraine', 'facility': 'Zhitomir Regional Clinical Hospital n.a. O.F. Gerbachevsky', 'geoPoint': {'lat': 50.26235, 'lon': 28.67913}}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Threshold Pharmaceuticals', 'class': 'INDUSTRY'}, 'collaborators': [{'name': 'PPD Development, LP', 'class': 'INDUSTRY'}]}}}