Ignite Creation Date:
2025-12-25 @ 1:41 AM
Ignite Modification Date:
2025-12-27 @ 10:05 AM
Study NCT ID:
NCT00707694
Status:
RECRUITING
Last Update Posted:
2024-12-20
First Post:
2008-06-27
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
The Longevity Genes in Founder Populations Project
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'CASE_CONTROL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 2000}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '1998-07', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-12', 'completionDateStruct': {'date': '2032-12', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2024-12-19', 'studyFirstSubmitDate': '2008-06-27', 'studyFirstSubmitQcDate': '2008-06-30', 'lastUpdatePostDateStruct': {'date': '2024-12-20', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2008-07-01', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2032-12', 'type': 'ESTIMATED'}}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'keywords': ['95 years of age and older'], 'conditions': ['Extreme Longevity']}, 'referencesModule': {'references': [{'pmid': '34498278', 'type': 'RESULT', 'citation': 'DeVito LM, Barzilai N, Cuervo AM, Niedernhofer LJ, Milman S, Levine M, Promislow D, Ferrucci L, Kuchel GA, Mannick J, Justice J, Gonzales MM, Kirkland JL, Cohen P, Campisi J. Extending human healthspan and longevity: a symposium report. Ann N Y Acad Sci. 2022 Jan;1507(1):70-83. doi: 10.1111/nyas.14681. Epub 2021 Sep 8.'}, {'pmid': '37657418', 'type': 'RESULT', 'citation': 'Moqri M, Herzog C, Poganik JR; Biomarkers of Aging Consortium; Justice J, Belsky DW, Higgins-Chen A, Moskalev A, Fuellen G, Cohen AA, Bautmans I, Widschwendter M, Ding J, Fleming A, Mannick J, Han JJ, Zhavoronkov A, Barzilai N, Kaeberlein M, Cummings S, Kennedy BK, Ferrucci L, Horvath S, Verdin E, Maier AB, Snyder MP, Sebastiano V, Gladyshev VN. Biomarkers of aging for the identification and evaluation of longevity interventions. Cell. 2023 Aug 31;186(18):3758-3775. doi: 10.1016/j.cell.2023.08.003.'}, {'pmid': '38355974', 'type': 'RESULT', 'citation': 'Moqri M, Herzog C, Poganik JR, Ying K, Justice JN, Belsky DW, Higgins-Chen AT, Chen BH, Cohen AA, Fuellen G, Hagg S, Marioni RE, Widschwendter M, Fortney K, Fedichev PO, Zhavoronkov A, Barzilai N, Lasky-Su J, Kiel DP, Kennedy BK, Cummings S, Slagboom PE, Verdin E, Maier AB, Sebastiano V, Snyder MP, Gladyshev VN, Horvath S, Ferrucci L. Validation of biomarkers of aging. Nat Med. 2024 Feb;30(2):360-372. doi: 10.1038/s41591-023-02784-9. Epub 2024 Feb 14.'}, {'pmid': '20926537', 'type': 'DERIVED', 'citation': 'Barzilai N, Gabriely I, Atzmon G, Suh Y, Rothenberg D, Bergman A. Genetic studies reveal the role of the endocrine and metabolic systems in aging. J Clin Endocrinol Metab. 2010 Oct;95(10):4493-500. doi: 10.1210/jc.2010-0859.'}]}, 'descriptionModule': {'briefSummary': 'We believe extreme longevity is due to specific genes which function to delay aging and prevent disease. The purpose of our research is to identify the genes/mutations associated with healthier aging; to understand the biological functions of these genes/mutations; and to develop therapies to replicate these preservative genetic activities in individuals who do not have the genetic profile for longevity.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['OLDER_ADULT'], 'minimumAge': '65 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Ashkenazi Jews:\n\nAges 95 and older, their offspring and control group with no family history of longevity.', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Ashkenazi Jewish, age 95+,\n* Offspring of person age 95+,\n* Offspring of parents who died age 70 or younger.\n\nExclusion Criteria:\n\n* Non-Ashkenazis'}, 'identificationModule': {'nctId': 'NCT00707694', 'briefTitle': 'The Longevity Genes in Founder Populations Project', 'organization': {'class': 'OTHER', 'fullName': 'Albert Einstein College of Medicine'}, 'officialTitle': 'Searching for Longevity Genes in the Historically Unique Ashkenazi Jewish Population', 'orgStudyIdInfo': {'id': '1998-125'}, 'secondaryIdInfos': [{'id': '2U19AG056278-07A1', 'link': 'https://reporter.nih.gov/quickSearch/2U19AG056278-07A1', 'type': 'NIH'}, {'id': '3U19AG056278-06S1', 'link': 'https://reporter.nih.gov/quickSearch/3U19AG056278-06S1', 'type': 'NIH'}, {'id': 'P01AG021654', 'link': 'https://reporter.nih.gov/quickSearch/P01AG021654', 'type': 'NIH'}, {'id': '1R56AG088624-01', 'link': 'https://reporter.nih.gov/quickSearch/1R56AG088624-01', 'type': 'NIH'}, {'id': 'R01AG088659', 'link': 'https://reporter.nih.gov/quickSearch/R01AG088659', 'type': 'NIH'}, {'id': 'G42988', 'type': 'OTHER_GRANT', 'domain': 'American Federation for Aging Research'}]}, 'armsInterventionsModule': {'armGroups': [{'label': 'Probands', 'description': 'Ashkenazi Jews ages 95 and older'}, {'label': 'Offspring', 'description': 'Ashkenazi Jewish offspring of Ashkenazi Jewish parent(s) who lived to at least the age of 95'}, {'label': 'Controls', 'description': 'Ashkenazi Jewish people with no family history of longevity'}]}, 'contactsLocationsModule': {'locations': [{'city': 'New York', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Wanda I Guzman, BA', 'role': 'CONTACT', 'email': 'WANDA.GUZMAN@EINSTEINMED.EDU', 'phone': '718-430-3838'}], 'facility': 'Private Homes', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '10471', 'city': 'Riverdale', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Charlotte Dell, LMSW', 'role': 'CONTACT', 'phone': '718-581-1139'}], 'facility': 'Hebrew Home Riverdale', 'geoPoint': {'lat': 40.90056, 'lon': -73.90639}}], 'centralContacts': [{'name': 'Deborah Davidson, MBA', 'role': 'CONTACT', 'email': 'longevity@aecom.yu.edu', 'phone': '718-430-3237'}], 'overallOfficials': [{'name': 'Nir Barzilai, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Albert Einstein College of Medicine'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Albert Einstein College of Medicine', 'class': 'OTHER'}, 'collaborators': [{'name': 'National Institute on Aging (NIA)', 'class': 'NIH'}, {'name': 'American Federation for Aging Research', 'class': 'OTHER'}], 'responsibleParty': {'type': 'SPONSOR'}}}}