Ignite Creation Date:
2025-12-25 @ 1:39 AM
Ignite Modification Date:
2026-02-28 @ 9:32 AM
Study NCT ID:
NCT03108794
Status:
RECRUITING
Last Update Posted:
2017-11-06
First Post:
2017-04-06
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
A Nation-wide Hospital-based Hepatitis B Registry:China Registry of Hepatitis B
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D019694', 'term': 'Hepatitis B, Chronic'}, {'id': 'D005355', 'term': 'Fibrosis'}], 'ancestors': [{'id': 'D006509', 'term': 'Hepatitis B'}, {'id': 'D000086982', 'term': 'Blood-Borne Infections'}, {'id': 'D003141', 'term': 'Communicable Diseases'}, {'id': 'D007239', 'term': 'Infections'}, {'id': 'D018347', 'term': 'Hepadnaviridae Infections'}, {'id': 'D004266', 'term': 'DNA Virus Infections'}, {'id': 'D014777', 'term': 'Virus Diseases'}, {'id': 'D006525', 'term': 'Hepatitis, Viral, Human'}, {'id': 'D006521', 'term': 'Hepatitis, Chronic'}, {'id': 'D006505', 'term': 'Hepatitis'}, {'id': 'D008107', 'term': 'Liver Diseases'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D002908', 'term': 'Chronic Disease'}, {'id': 'D020969', 'term': 'Disease Attributes'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 200000}, 'targetDuration': '10 Years', 'patientRegistry': True}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2012-06-30', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2017-11', 'completionDateStruct': {'date': '2025-12-31', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2017-11-02', 'studyFirstSubmitDate': '2017-04-06', 'studyFirstSubmitQcDate': '2017-04-06', 'lastUpdatePostDateStruct': {'date': '2017-11-06', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2017-04-11', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2022-12-31', 'type': 'ESTIMATED'}}, 'outcomesModule': {'otherOutcomes': [{'measure': 'HBsAg loss and seroconversion rates with or without antiviral therapy', 'timeFrame': '10 years'}, {'measure': 'Quality of life', 'timeFrame': '10 years'}], 'primaryOutcomes': [{'measure': 'Rate of liver-related events after antiviral therapy', 'timeFrame': '10 years', 'description': 'Rates of cirrhosis,decompensation and hepatocellular carcinoma with or without antiviral therapy'}], 'secondaryOutcomes': [{'measure': 'The HBV DNA undetectable rate with or without antiviral therapy', 'timeFrame': '10 years'}, {'measure': 'HBeAg loss and seroconversion rates with or without antiviral therapy', 'timeFrame': '10 years'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['hepatitis B，registry,cirrhosis, HCC'], 'conditions': ['Chronic Hepatitis B']}, 'referencesModule': {'references': [{'pmid': '27892487', 'type': 'BACKGROUND', 'citation': 'You H, Kong Y, Hou J, Wei L, Zhang Y, Niu J, Han T, Ou X, Dou X, Shang J, Tang H, Xie Q, Ding H, Ren H, Xu X, Xie W, Liu X, Xu Y, Li Y, Li J, Chow SC, Zhuang H, Jia J. Female gender lost protective effect against disease progression in elderly patients with chronic hepatitis B. Sci Rep. 2016 Nov 28;6:37498. doi: 10.1038/srep37498.'}, {'pmid': '41272517', 'type': 'DERIVED', 'citation': 'Zhang Y, Wang Y, Jiao S, Li S, Liu X, Li T, Qu Y. Nonlinear relationship between age and the risk of hepatocellular carcinoma in patients with hepatitis B virus-related cirrhosis. BMC Infect Dis. 2025 Nov 21;25(1):1635. doi: 10.1186/s12879-025-12016-9.'}, {'pmid': '29716439', 'type': 'DERIVED', 'citation': 'Shan S, Wei W, Kong Y, Niu J, Shang J, Xie W, Zhang Y, Ren H, Tang H, Ding H, Nan Y, Dou X, Han T, Xu X, Duan Z, Wei L, Hou J, Zhuang H, You H, Jia J; CR-Hepb Study Group, Beijing, China. China Registry of Hepatitis B (CR-HepB): Protocol and implementation of a nationwide hospital-based registry of hepatitis B. Scand J Public Health. 2020 Mar;48(2):233-239. doi: 10.1177/1403494818772188. Epub 2018 May 1.'}]}, 'descriptionModule': {'briefSummary': 'CR-HepB registry started in June 30,2012 to collect HBV cases from general hospitals or specialized hospitals for infectious diseases in mainland China. Demographics, diagnosis, laboratory test results, family history and prescriptions were recorded. The main criteria for registration is HBsAg-positivity more than 6 months, and these patients will receive followed-up visits every three to six months.', 'detailedDescription': 'This web-based database was launched on June 30, 2012 and consists of tertiary or secondary hospitals with special interest and expertise on managing hepatitis B patients across mainland China. The main inclusion criteria for this registration are HBsAg-positivity ≥ 6 months, HBeAg positive or negative, with or without cirrhosis, either treatment-naïve or treatment experienced. At the first time of data entry, demographics, medical history, virology, biochemistry and hematology results, radiology reports, diagnosis and treatment information were recorded. Then the registered patients received standard of care and follow-up every 3 to 6 months. On each visit, virological, biochemical, and radiological reports, as well as clinical progress were recorded.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'The registry is a multicentre and observational study enrolling patients with hepatitis B across China. The main criteria for patients registration within the system was HBsAg-positivity over a continuous six months. The core exclusion criteria are: 1) HCC patients for their treatment mainly depends on surgical operation and interventional therapy, but not the antiviral therapy; 2) patients who are unable or unwilling to provide informed consent. All potential subjects meeting enrollment criteria are offered the opportunity to participate.', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* HBsAg-positivity over a continuous six months.\n\nThe core exclusion criteria are: 1) HCC patients for their treatment mainly depends on surgical operation and interventional therapy, but not the antiviral therapy; 2) patients who are unable or unwilling to provide informed consent.'}, 'identificationModule': {'nctId': 'NCT03108794', 'briefTitle': 'A Nation-wide Hospital-based Hepatitis B Registry:China Registry of Hepatitis B', 'organization': {'class': 'OTHER', 'fullName': 'Beijing Friendship Hospital'}, 'officialTitle': 'A Nation-wide Hospital-based Hepatitis B Registry:China Registry of Hepatitis B', 'orgStudyIdInfo': {'id': 'CR-HepB'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Immune tolerance phase', 'description': 'Immune tolerance phase is diagnosed based on the presence of high serum levels of HBV-DNA, hepatitis B e antigen (HBeAg), but normal or minimally elevated serum alanine aminotransferase (ALT), and normal liver or only minimal histological activity and scant fibrosis.'}, {'label': 'HBeAg positive CHB', 'description': 'HBeAg positive CHB is defined as those with HBsAg positive for more 6 months, HBeAg positive, high HBV DNA, elevated serum levels of ALT and histological activity.'}, {'label': 'HBeAg negative CHB', 'description': 'HBeAg negative CHB is defined as those with HBeAg negative, anti-HBe positive, lower serum HBV DNA levels and histological necroinflammation and fibrosis.'}, {'label': 'Inactive HBsAg carriers', 'description': 'Inactive HBsAg carriers was defined as those with HBsAg positive than 6 months, with low HBV DNA and persistently normal ALT, without evidence of cirrhosis.'}, {'label': 'Compensated cirrhosis', 'description': 'Diagnosis of compensated cirrhosis can be made if one of the following criteria was met:\n\n1. by liver histology: Ishak fibrosis stage 5-6 or METAVIR F4.\n2. endoscopy-proven gastroesophageal varices, afrter excluding non-cirrhotic portal hypertension.\n3. at least 2 features of cirrhosis:\n\n 1. irregular liver surface, granular or nodular liver parenchyma, with or without splenomegaly (spleen thickness \\> 4.0cm or \\> 5 rib units) on ultrasound ,CT or MRI;\n 2. PLT\\<100×109/L without other causes;\n 3. Serum album in\\<35 g/L or INR\\>1.3 or PT prolongs\\>3s;\n 4. LSM\\>13 kpa (ALT\\<5×ULN).'}, {'label': 'Decompensated cirrhosis', 'description': 'Decompensated cirrhosis was diagnosed based on the presence of ascites, bleeding esophageal varices and/or hepatic encephalopathy in cirrhotic patients.'}, {'label': 'Hepatocellular carcinoma', 'description': 'Diagnosis of hepatocellular carcinoma（HCC）can be established when one of the following one of the following 2 criteria:（1）in cirrhotic patients with nodules of 1cm or larger with typical features of HCC ( arterial enhancement with washout in venous or delay phase) on 2 radiological studies or with 1 radiological study and elevation of serum AFP; or（2）histological evidence of HCC.'}]}, 'contactsLocationsModule': {'locations': [{'zip': '100015', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Wen Xie, MD', 'role': 'CONTACT', 'email': 'xiewen6218@163.com'}], 'facility': 'Beijing Ditan Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100032', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaoqing Liu, MD', 'role': 'CONTACT', 'email': 'liuxqpumch@hotmail.com'}], 'facility': 'Peking Union Medical College Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100034', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaoyuan Xu, MD', 'role': 'CONTACT', 'email': 'xiaoyuanxu6@163.com'}], 'facility': 'Peking University First Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100044', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Lai Wei, doctor', 'role': 'CONTACT', 'email': 'weelai@163.com'}], 'facility': "Peking University People's Hospital", 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100050', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Youqing Xu, MD', 'role': 'CONTACT', 'email': 'youqingxu@gmail.com'}], 'facility': 'Beijing Tiantan Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100069', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Huiguo Ding, MD', 'role': 'CONTACT', 'email': 'dinghuiguo@medmail.com.cn'}], 'facility': 'Beijing Youan Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '400010', 'city': 'Chongqing', 'state': 'Chongqing Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Hong Ren, MD', 'role': 'CONTACT', 'email': 'renhong0531@vip.sina.com.cn'}], 'facility': 'The Second Affiliated Hospital of Chongqing Medical University', 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}, {'zip': '400016', 'city': 'Chongqing', 'state': 'Chongqing Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Wenxiang Huang, MD', 'role': 'CONTACT', 'email': 'wenxiang_huang@163.com'}], 'facility': 'The First Affiliated Hospital of Chongqing Medical University', 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}, {'zip': '730030', 'city': 'Lanzhou', 'state': 'Gansu', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Lingyi Zhang, MD', 'role': 'CONTACT', 'email': 'zhanglymd@126.com'}], 'facility': 'Lanzhou University Second Hospital', 'geoPoint': {'lat': 36.05701, 'lon': 103.83987}}, {'zip': '730099', 'city': 'Lanzhou', 'state': 'Gansu', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaorong Mao, MD', 'role': 'CONTACT', 'email': 'mxr2013@126.com'}], 'facility': 'The First Hospital of Lanzhou University', 'geoPoint': {'lat': 36.05701, 'lon': 103.83987}}, {'zip': '510515', 'city': 'Guangzhou', 'state': 'Guangdong', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Jinlin Hou, MD', 'role': 'CONTACT', 'email': 'jlhousmu@163.com'}], 'facility': 'Nanfang Hospital, Southern Medical University', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '550004', 'city': 'Guiyang', 'state': 'Guizhou', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Mingliang Cheng, MD', 'role': 'CONTACT', 'email': 'chengml@21cn.com'}], 'facility': 'The Affiliated Hospital of Guizhou Medical University', 'geoPoint': {'lat': 26.58333, 'lon': 106.71667}}, {'city': 'Guiyang', 'state': 'Guizhou', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xinhua Luo, MD', 'role': 'CONTACT', 'email': 'luoxh09@163.com'}], 'facility': "Guizhou provincial people's hospital", 'geoPoint': {'lat': 26.58333, 'lon': 106.71667}}, {'zip': '570311', 'city': 'Haikou', 'state': 'Hainan', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Feng Lin, MD', 'role': 'CONTACT', 'email': 'lin_fenghn@126.com'}], 'facility': 'Hainan General Hospital', 'geoPoint': {'lat': 20.03421, 'lon': 110.34651}}, {'zip': '050000', 'city': 'Shijiazhuang', 'state': 'Hebei', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaolan Zhang, MD', 'role': 'CONTACT', 'email': 'xiaolanzh@126.com'}], 'facility': 'The Second Hospital of Hebei Medical University', 'geoPoint': {'lat': 38.04139, 'lon': 114.47861}}, {'zip': '050021', 'city': 'Shijiazhuang', 'state': 'Hebei', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Huanwei Deng, MD', 'role': 'CONTACT', 'email': '13323119317@163.com'}], 'facility': 'The Fifth Hospital of Shijiazhuang', 'geoPoint': {'lat': 38.04139, 'lon': 114.47861}}, {'zip': '050051', 'city': 'Shijiazhuang', 'state': 'Hebei', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yuemin Nan, MD', 'role': 'CONTACT', 'email': 'nanyuemin@163.com'}], 'facility': 'The Third Hospital of Hebei Medical University', 'geoPoint': {'lat': 38.04139, 'lon': 114.47861}}, {'zip': '450003', 'city': 'Zhengzhou', 'state': 'Henan', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Jia Shang, MD', 'role': 'CONTACT', 'email': 'shangjia666@126.com'}], 'facility': "Henan Provincial People's Hospital", 'geoPoint': {'lat': 34.75778, 'lon': 113.64861}}, {'zip': '430022', 'city': 'Wuhan', 'state': 'Hubei', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Dongliang Yang, MD', 'role': 'CONTACT', 'email': 'dlyang@hust.edu.cn'}], 'facility': 'Union Hospital,Tong Ji Medical College,Huazhong University of Science and Technology', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '430071', 'city': 'Wuhan', 'state': 'Hubei', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yong Xiong, MD', 'role': 'CONTACT', 'email': 'yongxiong64@163.com'}], 'facility': 'Zhongnan Hospital of Wuhan University', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '410005', 'city': 'Changsha', 'state': 'Hunan', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaoxuan Hu, MD', 'role': 'CONTACT', 'email': 'hxx5527392@sina.com'}], 'facility': "Hunan Provincial People's Hospital", 'geoPoint': {'lat': 28.19874, 'lon': 112.97087}}, {'zip': '410008', 'city': 'Changsha', 'state': 'Hunan', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yan Huang, MD', 'role': 'CONTACT', 'email': 'drhyan@163.com'}], 'facility': 'Xiangya Hospital Central South University', 'geoPoint': {'lat': 28.19874, 'lon': 112.97087}}, {'zip': '016099', 'city': 'Wuhai', 'state': 'Inner Mongolia', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Caixia Yang, MD', 'role': 'CONTACT', 'email': 'ycx7276@126.com'}], 'facility': 'Infectious Disease Hospital of Wuhai', 'geoPoint': {'lat': 39.68442, 'lon': 106.81583}}, {'zip': '221006', 'city': 'Xuzhou', 'state': 'Jiangsu', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xuebing Yan, MD', 'role': 'CONTACT', 'email': 'yxbxuzhou@126.com'}], 'facility': 'The Affiliated Hospital of Xuzhou Medical University', 'geoPoint': {'lat': 34.20442, 'lon': 117.28386}}, {'zip': '130021', 'city': 'Changchun', 'state': 'Jilin', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Junqi Niu, MD', 'role': 'CONTACT', 'email': 'junqiniu@aliyun.com'}], 'facility': 'First Hospital of Jilin University', 'geoPoint': {'lat': 43.88, 'lon': 125.32278}}, {'zip': '133000', 'city': 'Yanbian', 'state': 'Jilin', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Hongxin Piao, MD', 'role': 'CONTACT', 'email': '15526770394@163.com'}], 'facility': 'The Affiliated Hospital of Yanbian University'}, {'zip': '110004', 'city': 'Shenyang', 'state': 'Liaoning', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaoguang Dou, MD', 'role': 'CONTACT', 'email': 'guang40@163.com'}], 'facility': 'Shengjing Hospital of China Medical University', 'geoPoint': {'lat': 41.79222, 'lon': 123.43278}}, {'zip': '70004', 'city': 'Yinchuan', 'state': 'Ningxia', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yufang Li, MD', 'role': 'CONTACT', 'email': 'liyufang5@163.com'}], 'facility': 'General Hospital of Ningxia Medical University', 'geoPoint': {'lat': 38.46806, 'lon': 106.27306}}, {'zip': '250033', 'city': 'Jinan', 'state': 'Shandong', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Lei Wang, MD', 'role': 'CONTACT', 'email': 'wlcrb@sdu.edu.cn'}], 'facility': 'The Second Hospital of Shandong University', 'geoPoint': {'lat': 36.66833, 'lon': 116.99722}}, {'zip': '261031', 'city': 'Weifang', 'state': 'Shandong', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Shiping Li, MD', 'role': 'CONTACT', 'email': '13406674038@163.com'}], 'facility': 'Affiliated Hospital of Weifang Medical University', 'geoPoint': {'lat': 36.71, 'lon': 119.10194}}, {'zip': '200025', 'city': 'Shanghai', 'state': 'Shanghai Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Qing Xie, MD', 'role': 'CONTACT', 'email': 'xieqingrjh@163.com'}], 'facility': 'Shanghai Ruijin Hospital', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '201508', 'city': 'Shanghai', 'state': 'Shanghai Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Peiyan Ye, MD', 'role': 'CONTACT', 'email': 'yepeiyan@shaphc.org'}], 'facility': 'Shanghai Public Health Clinical Center', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '030001', 'city': 'Taiyuan', 'state': 'Shanxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Liaoyun Zhang, MD', 'role': 'CONTACT', 'email': '13603518852@163.com'}], 'facility': 'The First Affiliated Hospital of Shanxi Medical University', 'geoPoint': {'lat': 37.86944, 'lon': 112.56028}}, {'zip': '030012', 'city': 'Taiyuan', 'state': 'Shanxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xihong Wang, MD', 'role': 'CONTACT', 'email': 'tycy5003@163.com'}], 'facility': 'Taiyuan No.3 Hospital', 'geoPoint': {'lat': 37.86944, 'lon': 112.56028}}, {'zip': '710061', 'city': 'Xi’an', 'state': 'Shanxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Shumei Lin, MD', 'role': 'CONTACT', 'email': 'linshumei123@126.com'}], 'facility': "First Affiliated Hospital of Xi'an Jiaotong University", 'geoPoint': {'lat': 35.99785, 'lon': 113.52486}}, {'zip': '716000', 'city': 'Yanan', 'state': 'Shanxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Guanghua Xu, MD', 'role': 'CONTACT', 'email': 'yaxugh@163.com'}], 'facility': 'Yanan University Affiliated Hospital'}, {'zip': '610041', 'city': 'Chengdu', 'state': 'Sichuan', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Hong Tang, MD', 'role': 'CONTACT', 'email': 'htang6198@hotmail.com'}], 'facility': 'West China Hospital of Sichuan University', 'geoPoint': {'lat': 30.66667, 'lon': 104.06667}}, {'zip': '646099', 'city': 'Luzhou', 'state': 'Sichuan', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Cunliang Deng, MD', 'role': 'CONTACT', 'email': 'dengcunl64@vip.sina.com'}], 'facility': 'The Affiliated Hospital of Southwest Medical University', 'geoPoint': {'lat': 28.8903, 'lon': 105.42575}}, {'zip': '300163', 'city': 'Tianjin', 'state': 'Tianjin Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Hai Li, MD', 'role': 'CONTACT', 'email': '15202265600@163.com'}], 'facility': "Affiliated Hospital, Logistics University of People's Armed Police Force", 'geoPoint': {'lat': 39.14222, 'lon': 117.17667}}, {'zip': '610041', 'city': 'Tianjin', 'state': 'Tianjin Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Tao Han, MD', 'role': 'CONTACT', 'email': 'hantaomd@126.com'}], 'facility': 'Tianjin Third Central Hospital', 'geoPoint': {'lat': 39.14222, 'lon': 117.17667}}, {'zip': '831118', 'city': 'Changji', 'state': 'Xinjiang', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Weijin Gong, MD', 'role': 'CONTACT', 'email': 'gwj689@163.com'}], 'facility': "People's Hospital of Changji Hui Autonomous Prefecture，Xinjiang", 'geoPoint': {'lat': 44.00782, 'lon': 87.30461}}, {'zip': '830054', 'city': 'Ürümqi', 'state': 'Xinjiang', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yuexin Zhang, MD', 'role': 'CONTACT', 'email': 'zhangyx3103@sina.com'}], 'facility': 'First Affiliated Hospital of Xinjiang Medical University', 'geoPoint': {'lat': 43.80096, 'lon': 87.60046}}, {'zip': '830099', 'city': 'Ürümqi', 'state': 'Xinjiang', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaozhong Wang, MD', 'role': 'CONTACT', 'email': 'wxz125@sina.com'}], 'facility': 'Xinjiang Uygur Autonomous Region Traditional Chinese Medicine Hospital', 'geoPoint': {'lat': 43.80096, 'lon': 87.60046}}, {'zip': '650032', 'city': 'Kunming', 'state': 'Yunnan', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Wu Li, MD', 'role': 'CONTACT', 'email': '528227089@qq.com'}], 'facility': 'First Affiliated Hospital of Kunming Medical University', 'geoPoint': {'lat': 25.03889, 'lon': 102.71833}}, {'zip': '310023', 'city': 'Hangzhou', 'state': 'Zhejiang', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Shourong Liu, MD', 'role': 'CONTACT', 'email': 'lsr85463990@sina.com'}], 'facility': 'Xixi Hospital of Hangzhou', 'geoPoint': {'lat': 30.29365, 'lon': 120.16142}}], 'centralContacts': [{'name': 'Jidong Jia, MD', 'role': 'CONTACT', 'email': 'jia_jd@ccmu.edu.cn', 'phone': '010-63139816'}, {'name': 'Hong You, MD', 'role': 'CONTACT', 'email': 'youhongliver@ccmu.edu.cn', 'phone': '010-63139019'}], 'overallOfficials': [{'name': 'Jidong Jia, Doctor', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Beijing Friendship Hospital'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Beijing Friendship Hospital', 'class': 'OTHER'}, 'collaborators': [{'name': 'Beijing YouAn Hospital', 'class': 'OTHER'}, {'name': 'The First Hospital of Jilin University', 'class': 'OTHER'}, {'name': "Henan Provincial People's Hospital", 'class': 'OTHER'}, {'name': 'Beijing Ditan Hospital', 'class': 'OTHER'}, {'name': 'First Affiliated Hospital of Xinjiang Medical University', 'class': 'OTHER'}, {'name': 'LanZhou University', 'class': 'OTHER'}, {'name': 'The Second Affiliated Hospital of Chongqing Medical University', 'class': 'OTHER'}, {'name': 'West China Hospital', 'class': 'OTHER'}, {'name': "The Third People's Hospital of Taiyuan", 'class': 'OTHER'}, {'name': 'Hebei Medical University Third Hospital', 'class': 'OTHER'}, {'name': 'Shengjing Hospital', 'class': 'OTHER'}, {'name': 'Tianjin Third Central Hospital', 'class': 'OTHER'}, {'name': 'Peking University First Hospital', 'class': 'OTHER'}, {'name': 'Peking Union Medical College Hospital', 'class': 'OTHER'}, {'name': 'The Affiliated Hospital Of Southwest Medical University', 'class': 'OTHER'}, {'name': 'Shanghai Public Health Clinical Center', 'class': 'OTHER_GOV'}, {'name': 'Ruijin Hospital', 'class': 'OTHER'}, {'name': "First Affiliated Hospital Xi'an Jiaotong University", 'class': 'OTHER'}, {'name': 'Xiangya Hospital of Central South University', 'class': 'OTHER'}, {'name': 'Beijing Tiantan Hospital', 'class': 'OTHER'}, {'name': 'Wuhan University', 'class': 'OTHER'}, {'name': 'First Affiliated Hospital of Kunming Medical University', 'class': 'OTHER'}, {'name': 'The Affiliated Hospital of Xuzhou Medical University', 'class': 'OTHER'}, {'name': 'The Affiliated Hospital of Yanbian University', 'class': 'OTHER'}, {'name': 'First Affiliated Hospital of Chongqing Medical University', 'class': 'OTHER'}, {'name': "The Fourth People's Hospital of Qinghai Province", 'class': 'OTHER'}, {'name': 'Weifang Medical University', 'class': 'OTHER'}, {'name': "Hunan Provincial People's Hospital", 'class': 'OTHER'}, {'name': 'The Second Hospital of Hebei Medical University', 'class': 'OTHER'}, {'name': 'Xixi Hospital of Hangzhou', 'class': 'UNKNOWN'}, {'name': 'General Hospital of Ningxia Medical University', 'class': 'OTHER'}, {'name': 'Union Hospital, Tongji Medical College, Huazhong University of Science and Technology', 'class': 'OTHER'}, {'name': 'Xinjiang Uygur Autonomous Region Traditional Chinese Medicine Hospital', 'class': 'UNKNOWN'}, {'name': "Peking University People's Hospital", 'class': 'OTHER'}, {'name': 'Nanfang Hospital, Southern Medical University', 'class': 'OTHER'}, {'name': 'The Affiliated Hospital Of Guizhou Medical University', 'class': 'OTHER'}, {'name': "Guizhou Provincial People's Hospital", 'class': 'OTHER'}, {'name': 'Hainan General Hospital', 'class': 'OTHER'}, {'name': 'The Second Hospital of Shandong University', 'class': 'OTHER'}, {'name': 'The First Affiliated Hospital of Shanxi Medical University', 'class': 'OTHER'}, {'name': 'Fifth Hospital of Shijiazhuang City', 'class': 'OTHER'}, {'name': "Yan'an University Affiliated Hospital", 'class': 'OTHER'}, {'name': 'Infectious Disease Hospital of Wuhai', 'class': 'UNKNOWN'}, {'name': "Logistics University of Chinese People's Armed Police Forces", 'class': 'OTHER'}, {'name': "People's Hospital of Changji Hui Autonomous Prefecture，Xinjiang", 'class': 'UNKNOWN'}], 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Liver Research Center', 'investigatorFullName': 'Jidong Jia', 'investigatorAffiliation': 'Beijing Friendship Hospital'}}}}