Ignite Creation Date:
2025-12-25 @ 1:38 AM
Ignite Modification Date:
2026-03-01 @ 11:27 AM
Study NCT ID:
NCT02922894
Status:
RECRUITING
Last Update Posted:
2025-11-25
First Post:
2016-09-23
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D012891', 'term': 'Sleep Apnea Syndromes'}, {'id': 'D013119', 'term': 'Spinal Cord Injuries'}], 'ancestors': [{'id': 'D001049', 'term': 'Apnea'}, {'id': 'D012120', 'term': 'Respiration Disorders'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}, {'id': 'D020919', 'term': 'Sleep Disorders, Intrinsic'}, {'id': 'D020920', 'term': 'Dyssomnias'}, {'id': 'D012893', 'term': 'Sleep Wake Disorders'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D013118', 'term': 'Spinal Cord Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D020196', 'term': 'Trauma, Nervous System'}, {'id': 'D014947', 'term': 'Wounds and Injuries'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D014196', 'term': 'Trazodone'}, {'id': 'C005703', 'term': 'salicylhydroxamic acid'}], 'ancestors': [{'id': 'D010879', 'term': 'Piperazines'}, {'id': 'D006573', 'term': 'Heterocyclic Compounds, 1-Ring'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}, {'id': 'D011728', 'term': 'Pyridones'}, {'id': 'D011725', 'term': 'Pyridines'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE4'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['PARTICIPANT']}, 'primaryPurpose': 'OTHER', 'interventionModel': 'CROSSOVER'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 100}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2017-06-09', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-03', 'completionDateStruct': {'date': '2026-06-30', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-11-20', 'studyFirstSubmitDate': '2016-09-23', 'studyFirstSubmitQcDate': '2016-10-03', 'lastUpdatePostDateStruct': {'date': '2025-11-25', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2016-10-04', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2026-01-31', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Change in Tidal Volume', 'timeFrame': '1 Week', 'description': 'Change in tidal volume from baseline to recovery period.'}, {'measure': 'Change in CO2 reserve (Delta-PETCO2-AT)', 'timeFrame': '1 Week', 'description': 'CO2 reserve is the requisite change to induce central apnea is referred to as the CO2 reserve, which can be positive or negative'}, {'measure': 'Change in Apnea Hypopnea Index (AHI)', 'timeFrame': '1 week', 'description': 'AHI is used to indicate the severity of sleep apnea.'}, {'measure': 'Change in hypocapnic apneic threshold', 'timeFrame': '1 week', 'description': 'The nadir pressure in the upper airway (supra-glotic pressure) prior to the occurrence of an arousal. This is a physiological parameter.'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Sleep Apnea', 'Spinal Cord Injury']}, 'descriptionModule': {'briefSummary': 'This study will investigate potential therapeutic approaches for sleep-disordered breathing (SDB) in patients with chronic cervical spine injury (\\>6 months post-injury).', 'detailedDescription': 'Patients with cervical spinal cord injury demonstrate central sleep disordered breathing manifesting as central sleep apnea or a periodic breathing pattern. Understanding the causes of central sleep apnea may be critically important to understanding upper airway obstruction in susceptible individuals, given the critical role of ventilatory motor output in maintaining upper airway patency as evidenced by upper airway narrowing or occlusion at the nadir of ventilator drive during periodic breathing. This study is likely to identify therapeutic strategies that could be tested in large clinical trials, with the ultimate goal of improving quality of life among patients with cervical SCI who also experience central sleep disordered breathing.\n\nTo this end the research proposal is aimed as follows:\n\nSpecific Aim 1: Test the hypothesis that patients with cervical SCI will demonstrate greater magnitude of long-term facilitation (LTF) following episodic hypoxia during sleep, compared to patients with thoracic Spinal cord injury. This aim will be accomplished by measuring the effect of acute episodic hypoxic ventilation and upper airway mechanics in both groups.\n\nSpecific Aim 2: Test the hypothesis that dampening peripheral chemoreceptor activity in patients with cervical SCI and central sleep disordered breathing (SDB) with supplemental oxygen will reduce central respiratory events and decrease respiratory variability during sleep. The aim will be accomplished by providing supplemental oxygen to participants with cervical SCI and central SDB.\n\nSpecific Aim 3: Test the hypothesis that administration of trazodone, in patients with cervical spinal cord injury and central SDB will decrease respiratory related arousals and central apnea index, and the propensity to develop central apnea, compared to placebo. To accomplish this aim, the investigators will test the acute effect of trazodone on respiratory related arousals and central sleep apnea, and the chronic effect on central apnea indices and the CO2 reserve.\n\nThe investigators will study subjects with SCI at T6 or above who are not on artificial ventilation. To characterize the sleep and breathing state of each subject, polysomnography and upper airway collapsibility will be measured at baseline. Then the following experiments will be conducted: an episodic hypoxia protocol vs normoxia will be used to determine whether cervical SCI will demonstrate greater magnitude of LTF. Experiments will be conducted to see whether dampening peripheral chemoreceptor activity in cervical SCI by giving supplemental oxygen will reduce the central respiratory events and reduce the breathing variability during sleep. A cross over experiment will be done to see whether administration of trazodone in patients with cervical SCI and central SDB decreases respiratory-related arousals and central apnea. The participant will be given the drug/placebo for one week then cross over after a 1 week wash out period to placebo.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '89 Years', 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. healthy adults between the ages of 18 - 89\n2. chronic spinal cord injury patients (T6 and above), \\> 3 months since injury and not on mechanical ventilation, and have not received mechanical ventilation via tracheostomy in the past.\n\nExclusion Criteria:\n\n1. subjects ≤ 17 yrs old\n2. Pregnant and lactating females\n3. History of head trauma that resulted in neurological symptoms or loss of consciousness\n4. advanced heart, lung, metabolic, liver or chronic kidney disease.\n5. severe obstructive or restrictive respiratory defect by PFTs or history of tracheostomy\n6. extreme obesity defined for this protocol as BMI ≥ 40 kg/m2 (to avoid the effect of morbid obesity on ventilation).'}, 'identificationModule': {'nctId': 'NCT02922894', 'briefTitle': 'Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury', 'organization': {'class': 'FED', 'fullName': 'John D. Dingell VA Medical Center'}, 'officialTitle': 'Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury', 'orgStudyIdInfo': {'id': '1607015110'}, 'secondaryIdInfos': [{'id': 'CDMRP-SC150201', 'type': 'OTHER', 'domain': 'Congressionally Directed Medical Research Program Office'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Acute episodic hypoxia', 'description': 'To test development of ventilatory augmentation following episodic hypoxia, defined as increased Hypoxic Ventilatory Response (HVR) from early to late hypoxic exposure episodes.', 'interventionNames': ['Procedure: Acute episodic hypoxia', 'Procedure: Sham']}, {'type': 'EXPERIMENTAL', 'label': 'Supplemental oxygen', 'description': 'To use supplemental oxygen to decrease peripheral chemoreceptor activity in patients with SCI and central SDB. In addition, perform a repeat evaluation after treatment with supplemental oxygen or sham O2 for 6 weeks to determine if correction of chronic intermittent hypoxia, which mitigates sensory LTF, results in decreased propensity to central apnea.', 'interventionNames': ['Procedure: Supplemental oxygen', 'Procedure: Sham']}, {'type': 'EXPERIMENTAL', 'label': 'Trazodone or placebo', 'description': 'examine the effect of trazodone on breathing during sleep', 'interventionNames': ['Drug: Trazodone', 'Drug: Placebo']}], 'interventions': [{'name': 'Acute episodic hypoxia', 'type': 'PROCEDURE', 'description': 'The subjects will undergo 30 minutes of baseline monitoring followed by 15 episodes of one minute of episodic hypoxia with supplemental CO2 to maintain isocapnia. This is followed by a 45 minute recovery period.', 'armGroupLabels': ['Acute episodic hypoxia']}, {'name': 'Supplemental oxygen', 'type': 'PROCEDURE', 'description': 'Supplemental oxygen therapy for 6 weeks', 'armGroupLabels': ['Supplemental oxygen']}, {'name': 'Trazodone', 'type': 'DRUG', 'description': '100mg before bedtime', 'armGroupLabels': ['Trazodone or placebo']}, {'name': 'Placebo', 'type': 'DRUG', 'description': 'One placebo pill before-bedtime', 'armGroupLabels': ['Trazodone or placebo']}, {'name': 'Sham', 'type': 'PROCEDURE', 'description': 'Room air will be administered instead of episodic hypoxia or supplemental oxygen..', 'armGroupLabels': ['Acute episodic hypoxia', 'Supplemental oxygen']}]}, 'contactsLocationsModule': {'locations': [{'zip': '48201', 'city': 'Detroit', 'state': 'Michigan', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'M. Safwan Badr, MD', 'role': 'CONTACT', 'phone': '313-576-3548'}], 'facility': 'John D. Dingell VA Medical Center', 'geoPoint': {'lat': 42.33143, 'lon': -83.04575}}], 'centralContacts': [{'name': 'M Safwan Badr, M.D.', 'role': 'CONTACT', 'email': 'm.badr@va.gov', 'phone': '313-576-3548'}], 'overallOfficials': [{'name': 'M Safwan Badr, M.D.', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'John D. Dingell VA Medical Center'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'John D. Dingell VA Medical Center', 'class': 'FED'}, 'collaborators': [{'name': 'United States Department of Defense', 'class': 'FED'}], 'responsibleParty': {'type': 'SPONSOR'}}}}