Ignite Creation Date:
2025-12-25 @ 1:34 AM
Ignite Modification Date:
2026-03-04 @ 12:02 PM
Study NCT ID:
NCT06596694
Status:
RECRUITING
Last Update Posted:
2025-11-18
First Post:
2024-09-11
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D005770', 'term': 'Gastrointestinal Neoplasms'}], 'ancestors': [{'id': 'D004067', 'term': 'Digestive System Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D005767', 'term': 'Gastrointestinal Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C000710748', 'term': 'patritumab deruxtecan'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE1', 'PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NA', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 180}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2024-11-03', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-11', 'completionDateStruct': {'date': '2028-12-07', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-11-14', 'studyFirstSubmitDate': '2024-09-11', 'studyFirstSubmitQcDate': '2024-09-11', 'lastUpdatePostDateStruct': {'date': '2025-11-18', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2024-09-19', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2028-12-07', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Number of Participants Experiencing Dose-Limiting Toxicity (DLT) (Dose-Escalation Phase)', 'timeFrame': 'Up to 21 days', 'description': 'DLT will be defined as any drug-related adverse event observed during the DLT evaluation period that results in a change to a given dose or a delay in initiating the next 21-day cycle. The number of participants in the dose-escalation phase who experience a DLT will be presented.'}, {'measure': 'Number of Participants with One or More Adverse Events (AEs)', 'timeFrame': 'Up to approximately 44 months', 'description': 'An AE is defined as any unfavorable and unintended sign, symptom, disease, or worsening of preexisting condition temporally associated with study treatment and irrespective of causality to study treatment. The number of participants who experience an AE will be presented.'}, {'measure': 'Number of Participants who Discontinue Study Intervention Due to an AE', 'timeFrame': 'Up to approximately 44 months', 'description': 'An AE is defined as any unfavorable and unintended sign, symptom, disease, or worsening of preexisting condition temporally associated with study treatment and irrespective of causality to study treatment. The number of participants who discontinue study treatment due to an AE will be presented.'}, {'measure': 'Objective Response Rate (ORR)', 'timeFrame': 'Up to approximately 44 months', 'description': 'ORR is defined as the percentage of participants with Complete Response (CR: disappearance of all target lesions) or Partial Response (PR: at least a 30% decrease in the sum of diameters of target lesions) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. The percentage of participants who experience CR or PR as assessed by Blinded Independent Central Review (BICR) will be presented.'}], 'secondaryOutcomes': [{'measure': 'Duration of Response (DOR)', 'timeFrame': 'Up to approximately 44 months', 'description': 'For participants who demonstrate a confirmed Complete Response (CR: disappearance of all target lesions) or Partial Response (PR: at least a 30% decrease in the sum of diameters of target lesions) per RECIST 1.1, DOR is defined as the time from first documented evidence of CR or PR until progressive disease (PD) or death. Per RECIST 1.1, PD is defined as at least a 20% increase in the sum of diameters of target lesions. In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 mm. The appearance of one or more new lesions is also considered PD. DOR as assessed by BICR will be presented.'}, {'measure': 'Progression Free Survival (PFS)', 'timeFrame': 'Up to approximately 44 months', 'description': 'PFS is defined as the time from first day of study intervention to the first documented progressive disease (PD) or death due to any cause, whichever occurs first as assessed by BICR. Per RECIST 1.1, PD is defined as ≥20% increase in the sum of diameters of target lesions. In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of ≥5 mm. The appearance of one or more new lesions is also considered PD. The appearance of one or more new lesions is also considered PD. PFS as assessed by BICR will be presented.'}, {'measure': 'Overall Survival (OS)', 'timeFrame': 'Up to approximately 44 months', 'description': 'OS is the length of time from when the participant starts treatment until death from any cause.'}, {'measure': 'Maximum Plasma Concentration (Cmax) of Patritumab Deruxtecan', 'timeFrame': 'At designated time points (up to ~44 months)', 'description': 'Blood samples collected at protocol specific time points will be used to determine the Cmax of patritumab deruxtecan.'}, {'measure': 'Trough Concentration (Ctrough) of Patritumab Deruxtecan', 'timeFrame': 'At designated time points (up to ~44 months)', 'description': 'Blood samples collected at protocol specific time points will be used to determine the Ctrough of patritumab deruxtecan.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Gastrointestinal Cancer']}, 'referencesModule': {'seeAlsoLinks': [{'url': 'https://www.merckclinicaltrials.com/', 'label': 'Merck Clinical Trials Information'}, {'url': 'https://msd.trialsummaries.com/Study/StudyDetails?id=26305&tenant=MT_MSD_9011', 'label': 'Plain Language Summary'}]}, 'descriptionModule': {'briefSummary': 'Researchers want to learn if patritumab deruxtecan (MK-1022) can treat certain gastrointestinal (GI) cancers. The GI cancers being studied are advanced (the cancer has spread to other parts of the body). The goals of this study are to learn:\n\n* About the safety and how well people tolerate of patritumab deruxtecan\n* How many people have the cancer respond (get smaller or go away) to treatment'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\nThe main inclusion criteria include but are not limited to the following:\n\n* Has one of the following cancers:\n\n * Unresectable or metastatic colorectal cancer.\n * Advanced and/or unresectable biliary tract cancer (BTC)\n * Hepatocellular carcinoma (HCC) not amenable to locoregional therapy\n * Locally advanced unresectable or metastatic gastroesophageal cancer\n* Has received prior therapy for the cancer.\n* Has recovered from any side effects due to previous cancer treatment\n\nExclusion Criteria:\n\nThe main exclusion criteria include but are not limited to the following:\n\n* Has a history of (noninfectious) interstitial lung disease (ILD) or pneumonitis that required steroids, or has current ILD or pneumonitis, and/or suspected ILD or pneumonitis that cannot be ruled out by standard diagnostic assessments at Screening\n* Has clinically severe respiratory compromise (based on the investigator's assessment) resulting from intercurrent pulmonary illnesses\n* Has evidence of any leptomeningeal disease\n* Has clinically significant corneal disease\n* Has uncontrolled, significant cardiovascular disease or cerebrovascular disease\n* Has evidence of ongoing uncontrolled systemic bacterial, fungal, or viral infection"}, 'identificationModule': {'nctId': 'NCT06596694', 'briefTitle': 'Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)', 'organization': {'class': 'INDUSTRY', 'fullName': 'Merck Sharp & Dohme LLC'}, 'officialTitle': 'A Phase 1/2 Study to Evaluate the Safety and Efficacy of Patritumab Deruxtecan in Gastrointestinal Cancers', 'orgStudyIdInfo': {'id': '1022-011'}, 'secondaryIdInfos': [{'id': 'MK-1022-011', 'type': 'OTHER', 'domain': 'MSD'}, {'id': '2024-512442-41-00', 'type': 'REGISTRY', 'domain': 'EU CT'}, {'id': 'U1111-1305-0677', 'type': 'REGISTRY', 'domain': 'UTN'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Patritumab deruxtecan', 'description': 'Participants receive patritumab deruxtecan intravenous (IV) infusion on Day 1 of each 21-day cycle (every 3 weeks) until disease progression, intolerable toxicity, or investigator decision.', 'interventionNames': ['Biological: Patritumab deruxtecan']}], 'interventions': [{'name': 'Patritumab deruxtecan', 'type': 'BIOLOGICAL', 'otherNames': ['MK-1022', 'HER3-DXd', 'U3-1402'], 'description': 'Administered via intravenous (IV) infusion', 'armGroupLabels': ['Patritumab deruxtecan']}]}, 'contactsLocationsModule': {'locations': [{'zip': '90404', 'city': 'Santa Monica', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '888-577-8839'}], 'facility': 'UCLA Hematology Oncology Santa Monica ( Site 1205)', 'geoPoint': {'lat': 34.01949, 'lon': -118.49138}}, {'zip': '80045', 'city': 'Aurora', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '720-848-0300'}], 'facility': 'University of Colorado Cancer Center ( Site 1200)', 'geoPoint': {'lat': 39.72943, 'lon': -104.83192}}, {'zip': '20016', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '202-660-6500'}], 'facility': 'Sibley Memorial Hospital ( Site 1208)', 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '32610', 'city': 'Gainesville', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '888-577-8839'}], 'facility': 'University of Florida ( Site 1202)', 'geoPoint': {'lat': 29.65163, 'lon': -82.32483}}, {'zip': '33140', 'city': 'Miami Beach', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '888-577-8839'}], 'facility': 'Mount Sinai Medical Center Comprehensive Cancer Center ( Site 1213)', 'geoPoint': {'lat': 25.79065, 'lon': -80.13005}}, {'zip': '30060', 'city': 'Marietta', 'state': 'Georgia', 'status': 'COMPLETED', 'country': 'United States', 'facility': 'Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 1203)', 'geoPoint': {'lat': 33.9526, 'lon': -84.54993}}, {'zip': '60637', 'city': 'Chicago', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '888-577-8839'}], 'facility': 'University of Chicago Medical Center ( Site 1204)', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '89502', 'city': 'Reno', 'state': 'Nevada', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '888-577-8839'}], 'facility': 'Renown Regional Medical Center ( Site 1221)', 'geoPoint': {'lat': 39.52963, 'lon': -119.8138}}, {'zip': '11501', 'city': 'Mineola', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '516-663-8358'}], 'facility': 'NYU Langone Hospital - Long Island ( Site 1230)', 'geoPoint': {'lat': 40.74927, 'lon': -73.64068}}, {'zip': '10016', 'city': 'New York', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '888-577-8839'}], 'facility': 'Perlmutter NYU Cancer Center ( Site 1212)', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '76508', 'city': 'Temple', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '254-760-0867'}], 'facility': 'Scott & White Medical Center-Temple ( Site 1224)', 'geoPoint': {'lat': 31.09823, 'lon': -97.34278}}, {'zip': '24014', 'city': 'Roanoke', 'state': 'Virginia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '540-982-0237'}], 'facility': 'Oncology and Hematology Associates of Southwest Virginia (BRCC) ( Site 1207)', 'geoPoint': {'lat': 37.27097, 'lon': -79.94143}}, {'zip': '53792', 'city': 'Madison', 'state': 'Wisconsin', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '800-622-8922'}], 'facility': 'University of Wisconsin ( Site 1210)', 'geoPoint': {'lat': 43.07305, 'lon': -89.40123}}, {'zip': '2145', 'city': 'Sydney', 'state': 'New South Wales', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+61403170371'}], 'facility': 'Westmead Hospital ( Site 0100)', 'geoPoint': {'lat': -33.86785, 'lon': 151.20732}}, {'zip': '3004', 'city': 'Melbourne', 'state': 'Victoria', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+61390763129'}], 'facility': 'Alfred Health ( Site 0102)', 'geoPoint': {'lat': -37.814, 'lon': 144.96332}}, {'zip': '3084', 'city': 'Melbourne', 'state': 'Victoria', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '0394965000'}], 'facility': 'Austin Health ( Site 0103)', 'geoPoint': {'lat': -37.814, 'lon': 144.96332}}, {'zip': '6009', 'city': 'Mount Pleasant', 'state': 'Western Australia', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '0862799466'}], 'facility': 'One Clinical Research ( Site 0104)', 'geoPoint': {'lat': -32.03974, 'lon': 115.84993}}, {'zip': 'B3H 2Y9', 'city': 'Halifax', 'state': 'Nova Scotia', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '9024736106'}], 'facility': 'QEII Health Sciences Centre - Victoria General Site ( Site 0200)', 'geoPoint': {'lat': 44.64269, 'lon': -63.57688}}, {'zip': 'M4N 3M5', 'city': 'Toronto', 'state': 'Ontario', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '416-480-5000 x64270'}], 'facility': 'Sunnybrook Research Institute - Odette Cancer Centre ( Site 0206)', 'geoPoint': {'lat': 43.70643, 'lon': -79.39864}}, {'zip': 'H4A 3J1', 'city': 'Montreal', 'state': 'Quebec', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '5145772241'}], 'facility': 'McGill University Health Centre ( Site 0202)', 'geoPoint': {'lat': 45.50884, 'lon': -73.58781}}, {'zip': '7500921', 'city': 'Santiago', 'state': 'Region M. de Santiago', 'status': 'RECRUITING', 'country': 'Chile', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '1-888-577-8839'}], 'facility': 'Fundacion Arturo Lopez Perez ( Site 0301)', 'geoPoint': {'lat': -33.45694, 'lon': -70.64827}}, {'zip': '7560908', 'city': 'Santiago', 'state': 'Region M. de Santiago', 'status': 'RECRUITING', 'country': 'Chile', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+56225189885'}], 'facility': 'Centro de Oncología de Precisión ( Site 0305)', 'geoPoint': {'lat': -33.45694, 'lon': -70.64827}}, {'zip': '7620002', 'city': 'Santiago', 'state': 'Region M. de Santiago', 'status': 'RECRUITING', 'country': 'Chile', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+569 3427 1024'}], 'facility': 'Clínica UC San Carlos de Apoquindo ( Site 0302)', 'geoPoint': {'lat': -33.45694, 'lon': -70.64827}}, {'zip': '8420383', 'city': 'Santiago', 'state': 'Region M. de Santiago', 'status': 'RECRUITING', 'country': 'Chile', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+569 9874 4662'}], 'facility': 'Bradfordhill ( Site 0300)', 'geoPoint': {'lat': -33.45694, 'lon': -70.64827}}, {'zip': '230088', 'city': 'Hefei', 'state': 'Anhui', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+8613956012561'}], 'facility': 'The First Affiliated Hospital of Anhui Medical University ( Site 0405)', 'geoPoint': {'lat': 31.86389, 'lon': 117.28083}}, {'zip': '350014', 'city': 'Fuzhou', 'state': 'Fujian', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '0591-62752500'}], 'facility': 'Fujian Provincial Cancer Hospital ( Site 0408)', 'geoPoint': {'lat': 26.06139, 'lon': 119.30611}}, {'zip': '361015', 'city': 'Xiamen', 'state': 'Fujian', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '05923501990'}], 'facility': 'Zhongshan Hospital Fudan University (Xiamen Branch) ( Site 0412)', 'geoPoint': {'lat': 24.47979, 'lon': 118.08187}}, {'zip': '510515', 'city': 'Fuzhou', 'state': 'Guangdong', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '02061641888'}], 'facility': 'Southern Medical University Nanfang Hospital ( Site 0413)', 'geoPoint': {'lat': 24.17034, 'lon': 116.59933}}, {'zip': '510080', 'city': 'Guangzhou', 'state': 'Guangdong', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '020-87331952'}], 'facility': 'The First Affiliated Hospital, Sun Yat-sen University ( Site 0404)', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '530201', 'city': 'Nanning', 'state': 'Guangxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '07715333909'}], 'facility': 'Affiliated Cancer Hospital of Guangxi Medical University ( Site 0411)', 'geoPoint': {'lat': 22.81667, 'lon': 108.31667}}, {'zip': '450008', 'city': 'Zhengzhou', 'state': 'Henan', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '0371-65587625'}], 'facility': 'Henan Cancer Hospital ( Site 0403)', 'geoPoint': {'lat': 34.75778, 'lon': 113.64861}}, {'zip': '200032', 'city': 'Shanghai', 'state': 'Shanghai Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+8602164041990'}], 'facility': 'Zhongshan Hospital,Fudan University ( Site 0400)', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '030001', 'city': 'Taiyuan', 'state': 'Shanxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '0351-4639931'}], 'facility': 'First Hospital of Shanxi Medical University ( Site 0409)', 'geoPoint': {'lat': 37.86944, 'lon': 112.56028}}, {'zip': '69004', 'city': 'Lyon', 'state': 'Auvergne-Rhône-Alpes', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+33426732716'}], 'facility': 'Hopital de la Croix Rousse ( Site 0502)', 'geoPoint': {'lat': 45.74906, 'lon': 4.84789}}, {'zip': '92110', 'city': 'Clichy', 'state': 'Hauts-de-Seine', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+33140875553'}], 'facility': 'Hopital Beaujon ( Site 0500)', 'geoPoint': {'lat': 48.90018, 'lon': 2.30952}}, {'zip': '35042', 'city': 'Rennes', 'state': 'Ille-et-Vilaine', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+33299254417'}], 'facility': 'Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer ( Site 0501)', 'geoPoint': {'lat': 48.11109, 'lon': -1.67431}}, {'zip': '3109601', 'city': 'Haifa', 'status': 'RECRUITING', 'country': 'Israel', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+97247776234'}], 'facility': 'Rambam Health Care Campus ( Site 0603)', 'geoPoint': {'lat': 32.81303, 'lon': 34.99928}}, {'zip': '9112001', 'city': 'Jerusalem', 'status': 'RECRUITING', 'country': 'Israel', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+9722677896'}], 'facility': 'Hadassah Medical Center ( Site 0602)', 'geoPoint': {'lat': 31.76904, 'lon': 35.21633}}, {'zip': '6423906', 'city': 'Tel Aviv', 'status': 'RECRUITING', 'country': 'Israel', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+97236947832'}], 'facility': 'Sourasky Medical Center ( Site 0601)', 'geoPoint': {'lat': 32.08088, 'lon': 34.78057}}, {'zip': '20133', 'city': 'Milan', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '390223903807'}], 'facility': 'Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 0700)', 'geoPoint': {'lat': 42.78235, 'lon': 12.59836}}, {'zip': '20162', 'city': 'Milan', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+390264443695'}], 'facility': 'ASST Grande Ospedale Metropolitano Niguarda ( Site 0701)', 'geoPoint': {'lat': 42.78235, 'lon': 12.59836}}, {'zip': '00168', 'city': 'Roma', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+390630155202'}], 'facility': 'Fondazione Policlinico Universitario Agostino Gemelli ( Site 0702)', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'zip': '1023', 'city': 'Auckland', 'status': 'RECRUITING', 'country': 'New Zealand', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+6492203333'}], 'facility': 'Harbour Cancer & Wellness ( Site 0800)', 'geoPoint': {'lat': -36.84853, 'lon': 174.76349}}, {'zip': '03080', 'city': 'Seodaemun-gu', 'state': 'Seoul', 'status': 'RECRUITING', 'country': 'South Korea', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+82220722995'}], 'facility': 'Seoul National University Hospital ( Site 0900)'}, {'zip': '03722', 'city': 'Seoul', 'status': 'RECRUITING', 'country': 'South Korea', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+82222288137'}], 'facility': 'Severance Hospital, Yonsei University Health System ( Site 0903)', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'zip': '05505', 'city': 'Seoul', 'status': 'RECRUITING', 'country': 'South Korea', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+82-2-3010-3910'}], 'facility': 'Asan Medical Center ( Site 0902)', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'zip': '06351', 'city': 'Seoul', 'status': 'RECRUITING', 'country': 'South Korea', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+82-2-3410-3459'}], 'facility': 'Samsung Medical Center ( Site 0901)', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'zip': '33011', 'city': 'Oviedo', 'state': 'Principality of Asturias', 'status': 'RECRUITING', 'country': 'Spain', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '34 985108000 x36582'}], 'facility': 'Hospital Central de Asturias ( Site 1001)', 'geoPoint': {'lat': 43.36029, 'lon': -5.84476}}, {'zip': '08035', 'city': 'Barcelona', 'status': 'RECRUITING', 'country': 'Spain', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+34 93 274 60 60'}], 'facility': "Hospital Universitari Vall d'Hebron ( Site 1000)", 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'zip': '28007', 'city': 'Madrid', 'status': 'RECRUITING', 'country': 'Spain', 'contacts': [{'name': 'Study Coordinator', 'role': 'CONTACT', 'phone': '+34 914269070'}], 'facility': 'Hospital Universitario 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