Ignite Creation Date:
2025-12-25 @ 1:33 AM
Ignite Modification Date:
2026-02-27 @ 11:20 AM
Study NCT ID:
NCT00663494
Status:
COMPLETED
Last Update Posted:
2011-07-21
First Post:
2008-04-18
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Matrix Metalloproteinase (MMP) in Heart Failure
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D006333', 'term': 'Heart Failure'}], 'ancestors': [{'id': 'D006331', 'term': 'Heart Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'CASE_CONTROL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 22}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2003-02'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2008-04', 'completionDateStruct': {'date': '2006-07', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2011-07-20', 'studyFirstSubmitDate': '2008-04-18', 'studyFirstSubmitQcDate': '2008-04-18', 'lastUpdatePostDateStruct': {'date': '2011-07-21', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2008-04-22', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'MMPs level of coronary sinus'}]}, 'conditionsModule': {'keywords': ['heart failure', 'MMP', 'coronary sinus'], 'conditions': ['Chronic Stable Heart Failure']}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to evaluate the production of MMP in failing hearts.', 'detailedDescription': 'Myocardial fibrosis is observed in failing hearts and parallel to the progression of chronic heart failure (CHF) and myocardial remodeling. Matrix metalloproteinases (MMPs) are considered markers of fibrosis. Recently, circulating MMPs can be measured and are elevated in patients with CHF. However, MMPs it is still unclear whether MMPs are produced in failing hearts. Thus, the purpose of this study is to evaluate the production of MMP in failing hearts.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'chronic heart failure', 'eligibilityCriteria': 'Inclusion Criteria:\n\n* chronic stable heart failure'}, 'identificationModule': {'nctId': 'NCT00663494', 'briefTitle': 'Matrix Metalloproteinase (MMP) in Heart Failure', 'organization': {'class': 'OTHER', 'fullName': 'Tottori University Hospital'}, 'officialTitle': 'MMP is Produced in Failing Hearts', 'orgStudyIdInfo': {'id': '#244'}}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Tottori University Hospital', 'class': 'OTHER'}, 'responsibleParty': {'oldNameTitle': 'Kazuhide Ogino', 'oldOrganization': 'Tottori University Hospital'}}}}