Ignite Creation Date:
2025-12-25 @ 1:26 AM
Ignite Modification Date:
2026-03-05 @ 4:32 AM
Study NCT ID:
NCT03968393
Status:
RECRUITING
Last Update Posted:
2025-06-13
First Post:
2019-03-22
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative AF After Noncardiac Surgery
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'removedCountries': ['New Zealand']}, 'conditionBrowseModule': {'meshes': [{'id': 'D020521', 'term': 'Stroke'}, {'id': 'D001281', 'term': 'Atrial Fibrillation'}], 'ancestors': [{'id': 'D002561', 'term': 'Cerebrovascular Disorders'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D001145', 'term': 'Arrhythmias, Cardiac'}, {'id': 'D006331', 'term': 'Heart Diseases'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C522181', 'term': 'apixaban'}, {'id': 'D000069604', 'term': 'Dabigatran'}, {'id': 'C552171', 'term': 'edoxaban'}, {'id': 'D000069552', 'term': 'Rivaroxaban'}], 'ancestors': [{'id': 'D011725', 'term': 'Pyridines'}, {'id': 'D006573', 'term': 'Heterocyclic Compounds, 1-Ring'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}, {'id': 'D001562', 'term': 'Benzimidazoles'}, {'id': 'D006574', 'term': 'Heterocyclic Compounds, 2-Ring'}, {'id': 'D000072471', 'term': 'Heterocyclic Compounds, Fused-Ring'}, {'id': 'D013876', 'term': 'Thiophenes'}, {'id': 'D013457', 'term': 'Sulfur Compounds'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D009025', 'term': 'Morpholines'}, {'id': 'D010078', 'term': 'Oxazines'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE4'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'PREVENTION', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'Prospective, randomized, open-label clinical trial with blinded outcome assessment'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 2270}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2019-06-14', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-06', 'completionDateStruct': {'date': '2028-12', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-06-10', 'studyFirstSubmitDate': '2019-03-22', 'studyFirstSubmitQcDate': '2019-05-27', 'lastUpdatePostDateStruct': {'date': '2025-06-13', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2019-05-30', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2028-12', 'type': 'ESTIMATED'}}, 'outcomesModule': {'otherOutcomes': [{'measure': 'Incidence of composite of life-threatening, major, and critical organ bleeding', 'timeFrame': 'For the duration of follow-up, until final follow-up (occurs when the last global participant has been followed for 24 months)', 'description': 'Safety objective, measured as previously done in the MANAGE trial'}, {'measure': 'Incidence of major bleeding', 'timeFrame': 'For the duration of follow-up, until final follow-up (occurs when the last global participant has been followed for 24 months)', 'description': 'Safety objective, measured according to the ISTH criteria'}, {'measure': 'Incidence of hemorrhagic stroke', 'timeFrame': 'For the duration of follow-up, until final follow-up (occurs when the last global participant has been followed for 24 months)', 'description': 'Safety objective'}, {'measure': 'Hospitalization for vascular causes', 'timeFrame': 'For the duration of follow-up, until final follow-up (occurs when the last global participant has been followed for 24 months)', 'description': 'Tertiary Objective'}, {'measure': 'Hospitalization for all causes', 'timeFrame': 'For the duration of follow-up, until final follow-up (occurs when the last global participant has been followed for 24 months)', 'description': 'Tertiary Objective'}], 'primaryOutcomes': [{'measure': 'Incidence of Non-hemorrhagic stroke or systemic embolism', 'timeFrame': 'For the duration of follow-up, until final follow-up (occurs when the last global participant has been followed for 24 months)'}, {'measure': 'Incidence of vascular mortality, and non-fatal non-hemorrhagic stroke, myocardial infarction, peripheral arterial thrombosis, amputation, and symptomatic venous thromboembolism', 'timeFrame': 'For the duration of follow-up, until final follow-up (occurs when the last global participant has been followed for 24 months)'}], 'secondaryOutcomes': [{'measure': 'Incidence of vascular mortality', 'timeFrame': 'For the duration of follow-up, until final follow-up (occurs when the last global participant has been followed for 24 months)'}, {'measure': 'Incidence of non-fatal, non-hemorrhagic stroke', 'timeFrame': 'For the duration of follow-up, until final follow-up (occurs when the last global participant has been followed for 24 months)'}, {'measure': 'Incidence of Myocardial infarction', 'timeFrame': 'For the duration of follow-up, until final follow-up (occurs when the last global participant has been followed for 24 months)'}, {'measure': 'Incidence of peripheral arterial thrombosis', 'timeFrame': 'For the duration of follow-up, until final follow-up (occurs when the last global participant has been followed for 24 months)'}, {'measure': 'Incidence of amputation', 'timeFrame': 'For the duration of follow-up, until final follow-up (occurs when the last global participant has been followed for 24 months)'}, {'measure': 'Incidence of symptomatic venous thromboembolism', 'timeFrame': 'For the duration of follow-up, until final follow-up (occurs when the last global participant has been followed for 24 months)'}, {'measure': 'Incidence of all-cause stroke', 'timeFrame': 'For the duration of follow-up, until final follow-up (occurs when the last global participant has been followed for 24 months)'}, {'measure': 'Incidence of all-cause mortality', 'timeFrame': 'For the duration of follow-up, until final follow-up (occurs when the last global participant has been followed for 24 months)'}]}, 'oversightModule': {'isUsExport': False, 'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Transient Atrial Fibrillation', 'Perioperative Atrial Fibrillation', 'Non-vitamin K Oral Anticoagulation', 'Noncardiac Surgery', 'PROBE Design'], 'conditions': ['Stroke', 'Atrial Fibrillation']}, 'descriptionModule': {'briefSummary': 'Multinational, investigator-initiated study of oral anticoagulation versus no anticoagulation for the prevention of stroke and other adverse cardiovascular events in patients with transient perioperative atrial fibrillation after noncardiac surgery and additional stroke risk factors.', 'detailedDescription': 'ASPIRE-AF is a prospective, randomized, open-label trial of non-vitamin K oral anticoagulants (NOACs) versus no oral anticoagulation in patients with transient perioperative atrial fibrillation and additional stroke factors after noncardiac surgery. The primary objective is to assess the effects of NOACs versus no anticoagulation on the co-primary composite outcomes of 1. non-hemorrhagic stroke and systemic embolism, and 2. vascular mortality, and non-fatal non-hemorrhagic stroke, myocardial infarction, peripheral arterial thrombosis, amputation, and symptomatic venous thromboembolism over the duration of follow-up.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '55 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. noncardiac surgery in the past 35 days with at least one of the following:\n\n 1. an overnight hospital admission after surgery;\n 2. day surgery resulting in a large enough physiological insult to be able to cause perioperative AF, as judged by the local investigator\n2. ≥1 episode of clinically important perioperative AF during or after their surgery;\n3. sinus rhythm at the time of randomization; AND\n4. any of the following high-risk criteria:\n\n 1. age 55-64 years, and having either known cardiovascular disease, recent major vascular surgery, a CHA2DS2VASc score ≥3, or an elevated postoperative troponin level;\n 2. age 65-74 years, and having either known cardiovascular disease, recent major vascular surgery, a CHA2DS2VASc score ≥2, or an elevated postoperative troponin level; OR\n 3. age ≥75 years.\n5. provide written informed consent\n\nExclusion Criteria:\n\n1. history of documented chronic AF prior to noncardiac surgery;\n2. need for long-term systemic anticoagulation;\n3. ongoing need for long-term dual antiplatelet treatment;\n4. contraindication to oral anticoagulation;\n5. severe renal insufficiency (CrCl \\<20 ml/min);\n6. severe liver cirrhosis (i.e., Child-Pugh Class C)\n7. acute stroke in the past 14 days;\n8. underwent cardiac surgery in the past 35 days;\n9. history of nontraumatic intracranial, intraocular, or spinal bleeding;\n10. hemorrhagic disorder or bleeding diathesis;\n11. expected to be non-compliant with follow-up and/or study medications;\n12. known life expectancy less than 1 year due to concomitant disease;\n13. women who are pregnant, breastfeeding, or of childbearing potential who are not taking effective contraception; OR\n14. previously enrolled in the trial'}, 'identificationModule': {'nctId': 'NCT03968393', 'acronym': 'ASPIRE-AF', 'briefTitle': 'Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative AF After Noncardiac Surgery', 'organization': {'class': 'OTHER', 'fullName': 'Population Health Research Institute'}, 'officialTitle': 'Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative Atrial Fibrillation After Noncardiac Surgery - The ASPIRE-AF Trial', 'orgStudyIdInfo': {'id': '2019-ASPIREAF'}, 'secondaryIdInfos': [{'id': '2019-001336-62', 'type': 'EUDRACT_NUMBER'}, {'id': '2023-509142-35-00', 'type': 'CTIS'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Non-vitamin K oral anticoagulant (NOAC)', 'description': 'Participants randomized to the intervention arm will be prescribed one of the following NOACs for the duration of follow-up, unless they are undergoing a procedure with an increased risk of bleeding, have an adverse event or low calculated creatinine clearance, or decide to discontinue their use.', 'interventionNames': ['Drug: Non-vitamin K oral anticoagulant (NOAC)']}, {'type': 'NO_INTERVENTION', 'label': 'No anticoagulation', 'description': "Participants randomized to the control arm will not be prescribed an oral anticoagulant unless they develop a clear indication for one during follow-up (e.g., recurrent nonoperative AF). They can be newly prescribed or continue taking low dose aspirin or another single antiplatelet agent as per the protocol. This will be decided by the participant's physician."}], 'interventions': [{'name': 'Non-vitamin K oral anticoagulant (NOAC)', 'type': 'DRUG', 'otherNames': ['Apixaban', 'Dabigatran', 'Edoxaban', 'Rivaroxaban'], 'description': "Participants randomized to the intervention arm will be prescribed one of the following NOACs for the duration of follow-up: edoxaban 60 mg daily (dose reduction to 30 mg, if applicable), apixaban 5 mg twice daily (dose reduction to 2.5 mg, if applicable), dabigatran 110 mg twice daily, or rivaroxaban 20 mg daily (dose reduction to 15 mg, if applicable). The choice of NOAC will be left up to the participant's prescribing physician.", 'armGroupLabels': ['Non-vitamin K oral anticoagulant (NOAC)']}]}, 'contactsLocationsModule': {'locations': [{'zip': '90048', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Eric Braunstein, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Cedars-Sinai Medical Center', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '77030', 'city': 'Houston', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Sanjana Malviya, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Mcgovern Medical School at University of Texas', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '7540', 'city': 'Coronel Suárez', 'state': 'Buenos Aires', 'status': 'RECRUITING', 'country': 'Argentina', 'contacts': [{'name': 'Alberto Caccavo, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Clinica Coronel Suarez', 'geoPoint': {'lat': -37.45859, 'lon': -61.93294}}, {'zip': '2000', 'city': 'Rosario', 'state': 'Santa Fe Province', 'status': 'RECRUITING', 'country': 'Argentina', 'contacts': [{'name': 'Mariela Rasmussen, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Instituto de Investigaciones Clinicas Rosario', 'geoPoint': {'lat': -32.94682, 'lon': -60.63932}}, {'zip': 'S2000', 'city': 'Rosario', 'state': 'Santa Fe Province', 'status': 'RECRUITING', 'country': 'Argentina', 'contacts': [{'name': 'Alejandro Meirino, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Instituto Cardiovascular de Rosario', 'geoPoint': {'lat': -32.94682, 'lon': -60.63932}}, {'zip': '4000', 'city': 'San Miguel de Tucumán', 'state': 'Tucumán Province', 'status': 'RECRUITING', 'country': 'Argentina', 'contacts': [{'name': 'Maria Cecilia Moris, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centro Integral de Arritmias de Tucuman (CIAT)', 'geoPoint': {'lat': -26.81601, 'lon': -65.21051}}, {'zip': 'B6620', 'city': 'Chivilcoy', 'status': 'RECRUITING', 'country': 'Argentina', 'contacts': [{'name': 'Pablo Fernandez, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Municipal Chivilcoy', 'geoPoint': {'lat': -34.8969, 'lon': -60.01909}}, {'zip': 'T4000', 'city': 'San Miguel de Tucumán', 'status': 'RECRUITING', 'country': 'Argentina', 'contacts': [{'name': 'Guillermo Isa Messa, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Sanatorio Cisma', 'geoPoint': {'lat': -26.81601, 'lon': -65.21051}}, {'zip': 'S2000GAP', 'city': 'Santa Fe', 'status': 'NOT_YET_RECRUITING', 'country': 'Argentina', 'contacts': [{'name': 'Carlos Dumont, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Privado de Rosario', 'geoPoint': {'lat': -31.64881, 'lon': -60.70868}}, {'zip': '2605', 'city': 'Garran', 'state': 'Australian Capital Territory', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Walter Abhayaratna, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Canberra Hospital', 'geoPoint': {'lat': -35.34206, 'lon': 149.10846}}, {'zip': '2200', 'city': 'Bankstown', 'state': 'New South Wales', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Jens Killian, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Bankstown Hospital', 'geoPoint': {'lat': -33.91667, 'lon': 151.03333}}, {'zip': '2050', 'city': 'Camperdown', 'state': 'New South Wales', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Sanjay Patel, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Royal Prince Alfred Hospital', 'geoPoint': {'lat': -33.88965, 'lon': 151.17642}}, {'zip': '2139', 'city': 'Concord', 'state': 'New South Wales', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'David Brieger, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Concord Repatriation General Hospital', 'geoPoint': {'lat': -33.84722, 'lon': 151.10381}}, {'zip': '2170', 'city': 'Liverpool', 'state': 'New South Wales', 'status': 'NOT_YET_RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'John French, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Liverpool Hospital', 'geoPoint': {'lat': -33.91938, 'lon': 150.92588}}, {'zip': '2305', 'city': 'Newcastle', 'state': 'New South Wales', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Aaron Sverdlov, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'John Hunter Hospital', 'geoPoint': {'lat': -32.92953, 'lon': 151.7801}}, {'zip': '2145', 'city': 'Westmead', 'state': 'New South Wales', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Clara Chow, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Westmead Hospital', 'geoPoint': {'lat': -33.80383, 'lon': 150.98768}}, {'zip': '4575', 'city': 'Birtinya', 'state': 'Queensland', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Nicholas New, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Sunshine Coast Hospital and Health Service', 'geoPoint': {'lat': -26.74322, 'lon': 153.11913}}, {'zip': '4029', 'city': 'Herston', 'state': 'Queensland', 'status': 'NOT_YET_RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'John Atherton, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Royal Brisbane and Women's Hospital", 'geoPoint': {'lat': -27.44453, 'lon': 153.01852}}, {'zip': '4020', 'city': 'Redcliffe', 'state': 'Queensland', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Patrick Carroll, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Redcliffe Hospital', 'geoPoint': {'lat': -27.22649, 'lon': 153.10648}}, {'zip': '5000', 'city': 'Adelaide', 'state': 'South Australia', 'status': 'NOT_YET_RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Peter Psaltis, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Royal Adelaide Hospital', 'geoPoint': {'lat': -34.92866, 'lon': 138.59863}}, {'zip': '3128', 'city': 'Box Hill', 'state': 'Victoria', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Jaya Chandrasekhar, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Box Hill Hospital', 'geoPoint': {'lat': -37.81887, 'lon': 145.12545}}, {'zip': '3677', 'city': 'Wangaratta', 'state': 'Victoria', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Anthony Baird, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Northeast Health Wangaratta', 'geoPoint': {'lat': -36.35846, 'lon': 146.32056}}, {'zip': '6000', 'city': 'Perth', 'state': 'Western Australia', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Graham Hillis, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Royal Perth Hospital', 'geoPoint': {'lat': -31.95224, 'lon': 115.8614}}, {'zip': '05403-900', 'city': 'Cerqueira César', 'status': 'RECRUITING', 'country': 'Brazil', 'contacts': [{'name': 'Carlos Serrano, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Instituto do Coração do Hospital das Clínicas da FMUSP', 'geoPoint': {'lat': -23.03556, 'lon': -49.16611}}, {'zip': '90035-903', 'city': 'Porto Alegre', 'status': 'RECRUITING', 'country': 'Brazil', 'contacts': [{'name': 'Carisi Polanczyk, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital de Clinicas de Porto Alegre', 'geoPoint': {'lat': -30.03283, 'lon': -51.23019}}, {'zip': 'T2N 2T9', 'city': 'Calgary', 'state': 'Alberta', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Shannon Ruzycki, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Foothills Hospital', 'geoPoint': {'lat': 51.05011, 'lon': -114.08529}}, {'zip': 'T6G 2B7', 'city': 'Edmonton', 'state': 'Alberta', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Finlay McAlister, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Alberta Hospital', 'geoPoint': {'lat': 53.55014, 'lon': -113.46871}}, {'zip': 'T1A 4H6', 'city': 'Medicine Hat', 'state': 'Alberta', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Herbert Manosalva, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Medicine Hat Regional Hospital', 'geoPoint': {'lat': 50.03928, 'lon': -110.67661}}, {'zip': 'V1C 3H9', 'city': 'Cranbrook', 'state': 'British Columbia', 'status': 'NOT_YET_RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Denise Jaworsky, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'East Kootenay Regional Hospital', 'geoPoint': {'lat': 49.49991, 'lon': -115.76879}}, {'zip': 'V3V 1Z2', 'city': 'Surrey', 'state': 'British Columbia', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Mark Warwas, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Fraser Health Authority', 'geoPoint': {'lat': 49.10635, 'lon': -122.82509}}, {'zip': 'V5Z 1N1', 'city': 'Vancouver', 'state': 'British Columbia', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Mihalio Veljovic, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Vancouver General Hospital', 'geoPoint': {'lat': 49.24966, 'lon': -123.11934}}, {'zip': 'R3A 1R9', 'city': 'Winnipeg', 'state': 'Manitoba', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Sadeesh Srinathan, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Health Sciences Centre Winnipeg', 'geoPoint': {'lat': 49.8844, 'lon': -97.14704}}, {'zip': 'E1C 2Z3', 'city': 'Moncton', 'state': 'New Brunswick', 'status': 'NOT_YET_RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Remi LeBlanc, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Dr.-Georges-L.-Dumont University Hospital Centre', 'geoPoint': {'lat': 46.09454, 'lon': -64.7965}}, {'zip': 'B3H 3A6', 'city': 'Halifax', 'state': 'Nova Scotia', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Kim Styles, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Halifax Infirmary', 'geoPoint': {'lat': 44.64269, 'lon': -63.57688}}, {'zip': 'B1M 1A2', 'city': 'Sydney', 'state': 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