Ignite Creation Date:
2025-12-25 @ 1:24 AM
Ignite Modification Date:
2025-12-25 @ 11:34 PM
Study NCT ID:
NCT00262093
Status:
UNKNOWN
Last Update Posted:
2007-03-20
First Post:
2005-12-04
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Angiogenesis Markers in Primiparas Versus Multiparas: Relevance to Preeclampsia Incidence
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D011225', 'term': 'Pre-Eclampsia'}], 'ancestors': [{'id': 'D046110', 'term': 'Hypertension, Pregnancy-Induced'}, {'id': 'D011248', 'term': 'Pregnancy Complications'}, {'id': 'D005261', 'term': 'Female Urogenital Diseases and Pregnancy Complications'}, {'id': 'D000091642', 'term': 'Urogenital Diseases'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'OTHER', 'observationalModel': 'CASE_CONTROL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 200}}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2005-11'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2005-11', 'lastUpdateSubmitDate': '2007-03-19', 'studyFirstSubmitDate': '2005-12-04', 'studyFirstSubmitQcDate': '2005-12-04', 'lastUpdatePostDateStruct': {'date': '2007-03-20', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2005-12-06', 'type': 'ESTIMATED'}}, 'conditionsModule': {'keywords': ['preeclampsia', 'sFlt1', 'PlGF', 'parity', 'angiogenesis'], 'conditions': ['Pre-Eclampsia']}, 'descriptionModule': {'briefSummary': 'The reason for having a higher incidence of preeclampsia in primiparas may involve angiogenesis imbalance in these patients.', 'detailedDescription': 'Primiparity is one of the main risk factors for having preeclampsia during pregnancy. Recently, sFlt-1, soluble FMS-like tyrosine kinase-1, has been shown to be a major molecule involved in the pathogenesis of preeclampsia. Higher sFlt-1 mRNA, higher serum levels of sFlt-1 as well as lower PlGF, placental growth factor, have been found in preeclamptic patients.\n\nWe intend to check the angiogenesis profile of primiparas as compared to multiparas.'}, 'eligibilityModule': {'sex': 'FEMALE', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Every delivery\n\nExclusion Criteria:\n\n* Preeclampsia or pregnancy induced hypertension'}, 'identificationModule': {'nctId': 'NCT00262093', 'briefTitle': 'Angiogenesis Markers in Primiparas Versus Multiparas: Relevance to Preeclampsia Incidence', 'organization': {'class': 'OTHER', 'fullName': 'Hadassah Medical Organization'}, 'officialTitle': 'Angiogenesis Markers in Primiparas Versus Multiparas: Relevance to Preeclampsia Incidence', 'orgStudyIdInfo': {'id': 'PRIMIMULTI-HMO-CTIL'}}, 'contactsLocationsModule': {'locations': [{'zip': '91240', 'city': 'Jerusalem', 'status': 'RECRUITING', 'country': 'Israel', 'contacts': [{'name': 'Arik Tzukert, DMD', 'role': 'CONTACT', 'email': 'arik@hadassah.org.il', 'phone': '972 2 6776095'}, {'name': 'Hadas Lemberg, PhD', 'role': 'CONTACT', 'email': 'lhadas@hadassah.org.il', 'phone': '972 2 6777572'}, {'name': 'Yuval Bdolah, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hadassah Medical Organization', 'geoPoint': {'lat': 31.76904, 'lon': 35.21633}}], 'centralContacts': [{'name': 'Yuval Bdolah, MD, MSc', 'role': 'CONTACT', 'email': 'ybdolah@hadassah.org.il', 'phone': '972-2-5844111'}, {'name': 'Hadas Lemberg, PhD', 'role': 'CONTACT', 'email': 'lhadas@hadassah.org.il', 'phone': '972-2-6777572'}], 'overallOfficials': [{'name': 'Yuval Bdolah, MD, MSc', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Hadassah-Hebrew University Medical School'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Hadassah Medical Organization', 'class': 'OTHER'}, 'collaborators': [{'name': 'Beth Israel Deaconess Medical Center', 'class': 'OTHER'}]}}}