Ignite Creation Date:
2025-12-25 @ 1:23 AM
Ignite Modification Date:
2025-12-27 @ 11:56 PM
Study NCT ID:
NCT00410293
Status:
COMPLETED
Last Update Posted:
2006-12-12
First Post:
2006-12-11
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
NT-proBNP in Acute Dyspnea: Effects on Treatment, Hospitalisation and Costs
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D006333', 'term': 'Heart Failure'}, {'id': 'D004417', 'term': 'Dyspnea'}, {'id': 'D004194', 'term': 'Disease'}], 'ancestors': [{'id': 'D006331', 'term': 'Heart Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D012120', 'term': 'Respiration Disorders'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}, {'id': 'D012818', 'term': 'Signs and Symptoms, Respiratory'}, {'id': 'D012816', 'term': 'Signs and Symptoms'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}, {'id': 'D010335', 'term': 'Pathologic Processes'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'SINGLE'}, 'primaryPurpose': 'DIAGNOSTIC', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'count': 500}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2004-12'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2006-12', 'completionDateStruct': {'date': '2006-08'}, 'lastUpdateSubmitDate': '2006-12-11', 'studyFirstSubmitDate': '2006-12-11', 'studyFirstSubmitQcDate': '2006-12-11', 'lastUpdatePostDateStruct': {'date': '2006-12-12', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2006-12-12', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Time to discharge'}, {'measure': 'Cost of treatment'}], 'secondaryOutcomes': [{'measure': 'Duration of stay at the ED'}, {'measure': 'Proportion of patients admitted to the hospital'}, {'measure': 'Proportion of patients admitted to an intensive or coronary care unit'}, {'measure': 'Specialist consultations'}, {'measure': 'Medical treatment'}, {'measure': 'Diagnostic investigations'}]}, 'conditionsModule': {'keywords': ['Heart failure', 'Diagnostic', 'Natriuretic peptide', 'NT-pro B-type natriuretic peptide', 'Length of stay', 'Costs'], 'conditions': ['Heart Failure', 'Dyspnea']}, 'descriptionModule': {'briefSummary': 'Diagnostic uncertainty in patients with complaints of shortness of breath presenting to the Emergency Department of a hospital may delay treatment and proper care. In patients with shortness of breath due to heart failure increased plasma levels of NT-pro-B-type natriuretic peptide (NT-proBNP) can be demonstrated. The use of NT-proBNP as a biomarker for heart failure in patients presenting to the emergency department with dyspnea might improve care and reduce length of hospital stay.\n\nTo investigate the effect of NT-proBNP testing on patient care and time to discharge the NT-proBNP test will be randomized. In patients in the study group, the NT-proBNP plasma level is determined at admission and the physician in charge will immediately receive the result of the test. In patients in the control group blood will be sampled but the physician will recieve no information on the NT-proBNP plasma level.\n\nIn our study we will investigate the effect of introduction of NT-proBNP as biomarker for heart failure on treatment, time to discharge and costs.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Age 18 years or older\n* Acute dyspnea as their most prominent complaint\n\nExclusion Criteria:\n\n* Acute dyspnea due to a trauma\n* Acute dyspnea due to cardiogenic shock\n* Renal failure requiring dialysis'}, 'identificationModule': {'nctId': 'NCT00410293', 'briefTitle': 'NT-proBNP in Acute Dyspnea: Effects on Treatment, Hospitalisation and Costs', 'organization': {'class': 'OTHER', 'fullName': 'Erasmus Medical Center'}, 'officialTitle': 'NT-proBNP Testing in Patients Presenting to the Emergency Department With Acute Dyspnea: Evaluation of Effects on Treatment, Hospitalisation Rate and Costs', 'orgStudyIdInfo': {'id': 'MEC-2004-201'}}, 'armsInterventionsModule': {'interventions': [{'name': 'NT-proBNP testing', 'type': 'PROCEDURE'}]}, 'contactsLocationsModule': {'locations': [{'zip': '3015 CE', 'city': 'Rotterdam', 'country': 'Netherlands', 'facility': 'Erasmus MC', 'geoPoint': {'lat': 51.9225, 'lon': 4.47917}}], 'overallOfficials': [{'name': 'Anton H. van den Meiracker, MD, PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Erasmus Medical Center'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Erasmus Medical Center', 'class': 'OTHER'}}}}