Ignite Creation Date:
2024-05-05 @ 10:34 PM
Last Modification Date:
2024-10-26 @ 10:20 AM
Study NCT ID:
NCT01137929
Status:
WITHDRAWN
Last Update Posted:
2014-10-02
First Post:
2010-06-03
Brief Title:
Bacterial and Host Genetic Risk Factors in Acute Pyelonephritis
Sponsor:
Organization:
Childrens National Research Institute
Study Design
Study Type:
OBSERVATIONAL
Expanded Access Type Individual:
None
Expanded Access Type Intermediate:
None
Expanded Access Type Treatment:
None
Patient Registry:
None
Target Duration:
None
Design Allocation:
Design Intervention Model:
Design Intervention Model Description:
Design Masking Description:
Bio Spec Retention:
SAMPLES_WITH_DNA
Bio Spec Description:
Urine samples Urine is routinely collected at the time of presentation with fever to diagnose UTI and an aliquot of this urine sample will be frozen for microbial genomic and metagenomic sequencing and analysis that will allow us to identify uniquepathogenicvirulence factors in the genomes of these bacterial species when compared to non-pathogenic strains that have been subject to whole genome sequencing
Blood DNA samples will be obtained at the time of renal scanning from the study subjects The genomic DNA is used in PCR reactions and the resulting PCR products are screened for single nucelotide polymorphisms Although we will be performing a genome wide association study we will be particularly curious as to the behavior of SNPs among certain previously described candidates for the risk of renal scarring such as TLR2 TLR4 TGF-beta and TNF-alpha DNA samples will be stored for possible use in other future association studies
Enrollment Count:
0
Enrollment Type:
ACTUAL
Design Primary Purpose:
Design Masking:
Phases:
Observational Models:
| Name |
|---|
| Case-Control |
Time Perspective List:
Clinical Trial Statuses
| Name |
|---|
| 11324 |
Who Masked List: