Ignite Creation Date:
2024-05-06 @ 8:18 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06337539
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-03-29
First Post:
2024-02-27
Brief Title:
Precision Psychiatry for Depression Immune Response and Affective Symptoms as Predictors of Response to Antidepressants
Sponsor:
Organization:
Germans Trias i Pujol Hospital
Study Design
Study Type:
OBSERVATIONAL
Expanded Access Type Individual:
None
Expanded Access Type Intermediate:
None
Expanded Access Type Treatment:
None
Patient Registry:
False
Target Duration:
None
Design Allocation:
Design Intervention Model:
Design Intervention Model Description:
Design Masking Description:
Bio Spec Retention:
SAMPLES_WITHOUT_DNA
Bio Spec Description:
Immunological and biochemical variables
Acute phase biomarkers CRP
Proinflammatory cytokines IL-1 IL-6 TNF-α IL-12 IL-23 IL-17 IL-22
Anti-inflammatory cytokines IL-10 IL-4 tumor growth factor TGF -β
Cortisol
Oxidative and nitrosative stress Zinc Glutathione Albumin Uric Acid Bilirubin Vitamin C and Vitamin E
Microglia activation microRNA miR-155 miR-126 miR-223 miR-146a miR-21 miR-124
Neurogenesis and neuroinflammation BDNF VILIP-1 CC chemokine ligand 2 MCP-1 sTREM-2 vascular endothelial growth factor VEGF sTREM-1 β-NGF sRAGE CX3CL1
Lymphocyte subpopulations in peripheral blood Th1 Th2 Th17 Th117 Treg naive cells total Tfh Tγδ1 Tγδ2 Tγδ17 Tγδ117 monocytes
Transcriptomic and proteomic lymphocyte study at the single-cell level
Enrollment Count:
50
Enrollment Type:
ESTIMATED
Design Primary Purpose:
Design Masking:
Phases:
Observational Models:
| Name |
|---|
| Cohort |
Time Perspective List:
Clinical Trial Statuses
| Name |
|---|
| 105177 |
Who Masked List: