Ignite Creation Date:
2024-05-06 @ 7:24 PM
Last Modification Date:
2024-10-26 @ 3:06 PM
Study NCT ID:
NCT06001645
Status:
RECRUITING
Last Update Posted:
2024-01-17
First Post:
2023-07-31
Brief Title:
Laboratory Biomarkers and Pulmonary Interstitial Emphysema in ARDS PIE-ARDS
Sponsor:
Organization:
Università Vita-Salute San Raffaele
Study Design
Study Type:
OBSERVATIONAL
Expanded Access Type Individual:
None
Expanded Access Type Intermediate:
None
Expanded Access Type Treatment:
None
Patient Registry:
False
Target Duration:
None
Design Allocation:
Design Intervention Model:
Design Intervention Model Description:
Design Masking Description:
Bio Spec Retention:
SAMPLES_WITH_DNA
Bio Spec Description:
Blood and bronchoalveolar lavage fluid will be collected within 12 hours after intubation blood samples will be centrifuged and the serum immediately stored at less than 70 C The following biomarkers will be analysed in the serum and bronchoalveolar lavage fluid Interleukin-8 IL-8 Interleukin IL-6 IL-1Ra IL-18 interferon IFN Angiopoietin-2 Ang-2 Tumour Necrosis Factor receptor-1 TNFr1 Plasminogen Activator Inhibitor-1PAI-1 Receptor for Advanced Glycation Endproducts RAGE Intercellular adhesion molecule-1 ICAM-1 Surfactant Protein D SPD protein C Von Willebrand Factor VWF CXCL10CXCR3 and metalloproteases MMP9 MMP10 Blood and BAL samples obtained from the patients will be placed in specimen tubes containing heparin for plasma centrifuged at 1500 G for 10 minutes and then stored at -70 C
Enrollment Count:
110
Enrollment Type:
ESTIMATED
Design Primary Purpose:
Design Masking:
Phases:
Observational Models:
| Name |
|---|
| Case-Control |
Time Perspective List:
Clinical Trial Statuses
| Name |
|---|
| 98266 |
Who Masked List: