Ignite Creation Date:
2024-05-06 @ 5:54 PM
Last Modification Date:
2024-10-26 @ 2:37 PM
Study NCT ID:
NCT05471713
Status:
UNKNOWN
Last Update Posted:
2022-07-25
First Post:
2022-06-08
Brief Title:
MAPT Haploid H1b and the Damage of BBB in Dorsal Medulla Oblongata and Autonomic Dysfunction in PD
Sponsor:
Organization:
Zhujiang Hospital
Study Design
Study Type:
OBSERVATIONAL
Expanded Access Type Individual:
None
Expanded Access Type Intermediate:
None
Expanded Access Type Treatment:
None
Patient Registry:
True
Target Duration:
6 Months
Design Allocation:
Design Intervention Model:
Design Intervention Model Description:
Design Masking Description:
Bio Spec Retention:
SAMPLES_WITH_DNA
Bio Spec Description:
Microtubule associated protein tau MAPT gene is located in 17q213 and contains 16 exons Due to the linkage disequilibrium inheritance of genes MAPT mainly has two extended haplotypes H1 and H2 This gene is responsible for encoding the neuronal microtubule associated protein tau which is mainly distributed in the axons of neurons and plays an important role in the stability and assembly of microtubules The gene polymorphism of MAPT is related to the clinical subtype of PD in which MAPT H1J is related to sleep behavior disorder during rapid eye movement while the risk of postural hypotension in H1B patients is increased by 172 times The above studies suggest that the gene subtype of MAPT may be related to the occurrence and progression of early autd in PD patients
Enrollment Count:
80
Enrollment Type:
ESTIMATED
Design Primary Purpose:
Design Masking:
Phases:
Observational Models:
| Name |
|---|
| Case-Control |
Time Perspective List:
Clinical Trial Statuses
| Name |
|---|
| 87558 |
Who Masked List: