Ignite Creation Date:
2024-05-06 @ 3:39 AM
Last Modification Date:
2024-10-26 @ 11:37 AM
Study NCT ID:
NCT02347540
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2022-07-28
First Post:
2014-12-30
Brief Title:
Heart Failure and Related Risk-factors After Preeclampsia
Sponsor:
Organization:
Maastricht University Medical Center
Study Design
Study Type:
OBSERVATIONAL
Expanded Access Type Individual:
None
Expanded Access Type Intermediate:
None
Expanded Access Type Treatment:
None
Patient Registry:
False
Target Duration:
None
Design Allocation:
Design Intervention Model:
Design Intervention Model Description:
Design Masking Description:
Bio Spec Retention:
SAMPLES_WITH_DNA
Bio Spec Description:
The investigators will perform an unbiased screen for the human genome content of circulating microRNAs HF biomarkers will be included so that the added value of these novel HFpEF miRNAs can directly be compared to established HF biomarkers In this cohort of women who experienced pre-eclampsia and matched controls the investigators will profile miRNAs on a genome-wide scale using total RNA from plasma Differentially expressed miRNAs will be further investigated in relation to the pathogenesis of micro- and macrovascular disease Selected miRNAs will be placed on a custom megaplex array and used to screen a cohort of patients with HFpEF In patients with HFpEF the investigators will relate miRNA expression level to the circulating levels of angiopoietin-2ang-1ratios and micro-albuminuria Part of the obtained blood and urine will be stored at the Biobank in Maastricht for future studies
Enrollment Count:
2580
Enrollment Type:
ESTIMATED
Design Primary Purpose:
Design Masking:
Phases:
Observational Models:
| Name |
|---|
| Case-Control |
Time Perspective List:
Clinical Trial Statuses
| Name |
|---|
| 28636 |
Who Masked List: