Ignite Creation Date:
2024-05-06 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 12:40 PM
Study NCT ID:
NCT03434262
Status:
COMPLETED
Last Update Posted:
2024-05-31
First Post:
2018-02-09
Brief Title:
SJDAWN St Jude Childrens Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors
Sponsor:
St Jude Childrens Research Hospital
Organization:
St Jude Childrens Research Hospital
Conditions & Keywords Data
Conditions:
| Name |
|---|
| Ependymoma RELA Fusion Positive |
| Anaplastic Astrocytoma |
| Anaplastic Ependymoma |
| Anaplastic Ganglioglioma |
| Anaplastic Meningioma |
| Anaplastic Oligodendroglioma |
| Pleomorphic Xanthoastrocytoma Anaplastic |
| Atypical TeratoidRhabdoid Tumor |
| Brain Cancer |
| Brain Tumor |
| Central Nervous System Neoplasms |
| Choroid Plexus Carcinoma |
| CNS Embryonal Tumor With Rhabdoid Features |
| Ganglioneuroblastoma of Central Nervous System |
| CNS Tumor |
| Embryonal Tumor of CNS |
| Ependymoma |
| Glioblastoma |
| Glioma |
| Glioma Malignant |
| Medulloblastoma |
| Medulloblastoma Unspecified Site |
| Medulloepithelioma |
| Neuroepithelial Tumor |
| Neoplasms |
| Neoplasms Neuroepithelial |
| Papillary Tumor of the Pineal Region High-grade Only |
| Pediatric Brain Tumor |
| Pineal Parenchymal Tumor of Intermediate Differentiation High-grade Only |
| Pineoblastoma |
| Primitive Neuroectodermal Tumor |
| Recurrent Medulloblastoma |
| Refractory Brain Tumor |
| Neuroblastoma CNS |
| Glioblastoma IDH-mutant |
| Glioblastoma IDH-wildtype |
| Medulloblastoma Group 3 |
| Medulloblastoma Group 4 |
| Glioma High Grade |
| Neuroepithelial Tumor High Grade |
| Medulloblastoma SHH-activated and TP53 Mutant |
| Medulloblastoma SHH-activated and TP53 Wildtype |
| Medulloblastoma Chromosome 9q Loss |
| Medulloblastoma Non-WNT Non-SHH NOS |
| Medulloblastoma Non-WNTNon-SHH |
| Medulloblastoma PTCH1 Mutation |
| Medulloblastoma WNT-activated |
| Ependymoma Recurrent |
| Glioma Recurrent High Grade |
| Glioma Recurrent Malignant |
| Embryonal Tumor NOS |
| Glioma Diffuse Midline H3K27M-mutant |
| Embryonal Tumor With Multilayered Rosettes ETMR |
| Ependymoma NOS WHO Grade III |
| Ependymoma NOS WHO Grade II |
| Medulloblastoma G3G4 |
Keywords:
| Name | View |
|---|---|
| Combination therapy | View |
| ATRT | View |
| Brain Tumors in Adolescents | View |
| Brain Tumors in Children | View |
| Brain Tumors in Young Adults | View |
| CDK4 amplification | View |
| CDK 46 | View |
| CDK 46 inhibitor | View |
| CDK 46 pathway | View |
| CDK 46cyclinRBE2F pathway | View |
| CDK6 amplification | View |
| CyclinD1 | View |
| DAWN | View |
| D-type Cyclins | View |
| Hedgehog pathway inhibitor | View |
| HGG | View |
| MAPK pathway | View |
| MEK | View |
| MEK inhibitor | View |
| MEK1 | View |
| MEK2 | View |
| Mekinist | View |
| Molecular | View |
| Molecular therapy | View |
| MYC amplification | View |
| PTCH1 | View |
| Rare brain tumor | View |
| Recurrent ATRT | View |
| Recurrent brain tumor | View |
| Recurrent ependymoma | View |
| Recurrent high grade glioma | View |
| Recurrent malignant glioma | View |
| Recurrent medulloblastoma | View |
| Refractory brain tumor | View |
| Small molecule inhibitor | View |
| SMO antagonist | View |
| Smoothened protein | View |
| Sonic hedgehog | View |