Ignite Creation Date:
2024-05-05 @ 11:07 PM
Last Modification Date:
2024-10-26 @ 10:28 AM
Study NCT ID:
NCT01250535
Status:
COMPLETED
Last Update Posted:
2013-01-21
First Post:
2010-11-29
Brief Title:
Human Cytochrome P450 4F Enzymes and Drug Interactions
Sponsor:
University of North Carolina Chapel Hill
Organization:
University of North Carolina Chapel Hill
Study Overview
Official Title:
Human Cytochrome P450 4F Enzymes and Drug Interactions
Status:
COMPLETED
Status Verified Date:
2013-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Drug-drug interactions play an important role in clinical adverse events due to the prevalence of multi-drug therapy Co-administration of warfarin and a statin has expanded substantially in the US over the last decades The purpose of this study is to develop a mechanistic understanding of the role of a drug-metabolizing enzyme CYP4F2 in the interaction between warfarin and statins This study will test the hypothesis that lovastatin potentiates the anticoagulant effect of warfarin by inducing vitamin K-metabolizing enzyme CYP4F2 in humans thus increasing warfarins anticoagulant effect
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1R01GM089994-01A1 | NIH | None | httpsreporternihgovquickSearch1R01GM089994-01A1 |