Ignite Creation Date:
2024-05-05 @ 11:06 PM
Last Modification Date:
2024-10-26 @ 10:28 AM
Study NCT ID:
NCT01250912
Status:
COMPLETED
Last Update Posted:
2022-01-27
First Post:
2010-07-28
Brief Title:
Imaging With a Radio Tracer to Guide VT Ablations
Sponsor:
University of Maryland Baltimore
Organization:
University of Maryland Baltimore
Study Overview
Official Title:
Three Dimension Neuron Imaging Using 123I-metaiodobenzylguanidine Single Photon Emission Computed Tomography to Guide Ventricular Tachycardia Ablations
Status:
COMPLETED
Status Verified Date:
2022-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Some patients are at risk for life-threatening fast heart rates These can frequently be treated by using a catheter inside the heart to burn away the cells that create the fast heart rates The purpose of this study is to image the nerves inside the heart of those patients The investigators want to find out if abnormalities in the nervous system in the heart can help the physician to find the area that needs to be burnt away
Detailed Description:
Ventricular tachycardia is the next frontier in cardiology Patients that have scar in the heart for example after heart attacks are at an increased risk of developing ventricular tachycardia In these patients ventricular tachycardia represents an electrical wave front that circulates in the heart muscle using the scar in the heart An increasing number of patients with ventricular tachycardia require cauterization burning away of the tissue to treat this life-threatening condition The goal of this cauterization or ablation is to destroy highways of surviving tissue inside the scar that allow ventricular tachycardia to exist However this can be very lengthy procedure 5 hours that has only a moderate success in the long run Therefore new treatment approaches are needed to make this procedure better
The purpose of this study is to assess if radio tracers showing the nerve distribution in the heart cardiac innervation can be used in addition to the current technology voltage mapping to identify the area that needs to be ablated burnt away to treat life-threatening fast heart rates ventricular tachycardia
Certain patterns of nerve distribution in the heart sympathetic cardiac innervation have been shown to predict outcome for different heart diseases like heart transplant coronary artery disease heart failure arrhythmias One substance that allows visualization of the cardiac innervation is 123I-metaiodobenzylguanidine 123I-MIBG which could provide additional information to understand and treat ventricular tachycardia
The purpose of this study is to assess if radio tracers showing the nerve distribution in the heart cardiac innervation can be used in addition to the current technology voltage mapping to identify the area that needs to be ablated burnt away to treat life-threatening fast heart rates ventricular tachycardia
Certain patterns of nerve distribution in the heart sympathetic cardiac innervation have been shown to predict outcome for different heart diseases like heart transplant coronary artery disease heart failure arrhythmias One substance that allows visualization of the cardiac innervation is 123I-metaiodobenzylguanidine 123I-MIBG which could provide additional information to understand and treat ventricular tachycardia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None