Ignite Creation Date:
2024-05-05 @ 11:31 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00073606
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2003-12-01
Brief Title:
Spinal Cord Plasticity
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Intraspinal Plasticity Associated With Locomotor Learning
Status:
COMPLETED
Status Verified Date:
2008-05-20
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine the role of the spinal cord in improving leg movements after physical training in healthy people The results of this study may be helpful in developing new rehabilitation therapies for people with impaired leg function
Healthy volunteers between 21 and 65 years of age may be eligible for this study Candidates will be screened with a brief medical history and physical examination
Participants will undergo EMG-H reflex measurement while pedaling on a stationary bicycle For this test the subject is given an electrical stimulation at the nerve at the back of the knee while pedaling on a stationary bicycle The shock produces a jerky movement called the H reflex The muscular activity causing these reflexes is measured using electrodes small metal disks filled with a conductive gel and taped to the skin over the calf muscle The nerve is stimulated at four different frequencies during the experiment While cycling pedal resistance changes making it harder or easier to pedal
On study day 1 participants have EMG-H reflex measurement to determine baseline performance then a training session to prepare for the actual test and then a post-training test to measure performance again The test is repeated on days 2 then between days 5 and 8 and again between days 11 and 14 The screening and first visit last 2 hours the remaining test visits are 1 hour each The bicycling time is only 15 minutes during training and 5 minutes at each test session
Healthy volunteers between 21 and 65 years of age may be eligible for this study Candidates will be screened with a brief medical history and physical examination
Participants will undergo EMG-H reflex measurement while pedaling on a stationary bicycle For this test the subject is given an electrical stimulation at the nerve at the back of the knee while pedaling on a stationary bicycle The shock produces a jerky movement called the H reflex The muscular activity causing these reflexes is measured using electrodes small metal disks filled with a conductive gel and taped to the skin over the calf muscle The nerve is stimulated at four different frequencies during the experiment While cycling pedal resistance changes making it harder or easier to pedal
On study day 1 participants have EMG-H reflex measurement to determine baseline performance then a training session to prepare for the actual test and then a post-training test to measure performance again The test is repeated on days 2 then between days 5 and 8 and again between days 11 and 14 The screening and first visit last 2 hours the remaining test visits are 1 hour each The bicycling time is only 15 minutes during training and 5 minutes at each test session
Detailed Description:
Objectives
We aim to determine whether the development of a motor memory in the human spinal cord circuitry expressed as a down regulation of the monosynaptic soleus H reflex after a brief period of learning of a locomotor skill is intrinsically encoded at the spinal cord level or if it is determined by descending suprasegmental influences
The results of this study would be useful for designing new rehabilitation strategies based upon manipulation of peripheral inputs aimed at activating spinal cord circuitry for motor recovery independent of the higher centers
Study population
Seventy 70 healthy volunteers median age 21-65 will participate in the study
Design
Subjects will complete one training session using a recumbent cycle ergometer and will be tested physiologically and behaviorally once before training and four times after training through 14 to 16 days
Outcome measures
We will assess homosynaptic depression of the soleus H reflex an expression of the excitability of the alpha-motorneuron pool a phenomenon that is not susceptible to descending suprasegmental influences but depends on the history of information arriving to the alpha-motorneuron from the periphery Amount of homosynaptic depression will be correlated with the behavioral learning assessed by improvement in control of stepping speed
We aim to determine whether the development of a motor memory in the human spinal cord circuitry expressed as a down regulation of the monosynaptic soleus H reflex after a brief period of learning of a locomotor skill is intrinsically encoded at the spinal cord level or if it is determined by descending suprasegmental influences
The results of this study would be useful for designing new rehabilitation strategies based upon manipulation of peripheral inputs aimed at activating spinal cord circuitry for motor recovery independent of the higher centers
Study population
Seventy 70 healthy volunteers median age 21-65 will participate in the study
Design
Subjects will complete one training session using a recumbent cycle ergometer and will be tested physiologically and behaviorally once before training and four times after training through 14 to 16 days
Outcome measures
We will assess homosynaptic depression of the soleus H reflex an expression of the excitability of the alpha-motorneuron pool a phenomenon that is not susceptible to descending suprasegmental influences but depends on the history of information arriving to the alpha-motorneuron from the periphery Amount of homosynaptic depression will be correlated with the behavioral learning assessed by improvement in control of stepping speed
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 04-N-0054 | None | None | None |