Ignite Creation Date:
2024-05-05 @ 11:31 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00077038
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2004-02-09
Brief Title:
Brain Activity in Visual-Motor Behavior
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Modulation of the Visual Information Processing in the Human Parieto-Frontal Network as Studied by a Frequency Tagging Technique During Visuomotor Tracking
Status:
COMPLETED
Status Verified Date:
2007-03-31
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine how the brain works when people look at an object follow a moving object with their eyes and reach out their hand to an object Different areas of the brain work together in reaching out a hand to an object These areas are also important for concentrating on objects or following them with the eyes This study will use magnetoencephalography MEG to observe more precisely how discrete parts of the brain work during these movements MEG is a new technique for recording magnetic field changes produced by brain activity
Healthy normal volunteers 20 years of age and older who are right-handed and who have no history of brain or eye disease may be eligible for this study Candidates will be screened with a medical history and brief physical examination They will complete questionnaires for MEG screening and for determining handedness
Participants undergo MEG recording and magnetic resonance imaging MRI For MEG the subject sits comfortably in front of a computer screen and a cone containing magnetic field detectors is lowered onto the head Electrodes are placed on both sides of the outer part of the eyelids and just above and below the left eye to monitor eye movement During MEG subjects perform the following tasks
1 Eye fixation A small white cross and a white ring appear on the center of the computer screen Another white ring moves slowly around the screen in random fashion Subjects keep their eyes fixed on the central cross and concentrate on the ring at the center ignoring the moving ring
2 Ocular tracking The same cross and rings in task 1 appear on the screen but in this task the subjects follow the moving ring with their eyes and ignore the cross and ring in the center
3 Peripheral manual tracking task right hand In addition to the cross and rings in task 1 a small white disc-shaped cursor appears on the screen Using their right hand subjects use a joystick to move the cursor as precisely as possible to follow the moving ring while keeping their eyes fixed on the central cross
4 Peripheral manual tracking task left hand The same as task 3 except using the left hand
5 Central manual tracking The cross rings and joystick are the same as in task 3 Subjects move the cursor to follow the moving ring as precisely as possible while following the moving ring with their eyes and ignoring the cross and ring in the center of the screen
Subjects practice each task before MEG recording starts Then they perform each task twice in random order with a 1- or 2-minute break between tasks
Subjects who do not have previous MRI images filed in NINDSs database undergo MRI scanning MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues The scanner is a metal cylinder surrounded by a strong magnetic field Subjects lie still on a table that can slide in an out of the cylinder They can communicate with the MRI staff at all times during the procedure
Healthy normal volunteers 20 years of age and older who are right-handed and who have no history of brain or eye disease may be eligible for this study Candidates will be screened with a medical history and brief physical examination They will complete questionnaires for MEG screening and for determining handedness
Participants undergo MEG recording and magnetic resonance imaging MRI For MEG the subject sits comfortably in front of a computer screen and a cone containing magnetic field detectors is lowered onto the head Electrodes are placed on both sides of the outer part of the eyelids and just above and below the left eye to monitor eye movement During MEG subjects perform the following tasks
1 Eye fixation A small white cross and a white ring appear on the center of the computer screen Another white ring moves slowly around the screen in random fashion Subjects keep their eyes fixed on the central cross and concentrate on the ring at the center ignoring the moving ring
2 Ocular tracking The same cross and rings in task 1 appear on the screen but in this task the subjects follow the moving ring with their eyes and ignore the cross and ring in the center
3 Peripheral manual tracking task right hand In addition to the cross and rings in task 1 a small white disc-shaped cursor appears on the screen Using their right hand subjects use a joystick to move the cursor as precisely as possible to follow the moving ring while keeping their eyes fixed on the central cross
4 Peripheral manual tracking task left hand The same as task 3 except using the left hand
5 Central manual tracking The cross rings and joystick are the same as in task 3 Subjects move the cursor to follow the moving ring as precisely as possible while following the moving ring with their eyes and ignoring the cross and ring in the center of the screen
Subjects practice each task before MEG recording starts Then they perform each task twice in random order with a 1- or 2-minute break between tasks
Subjects who do not have previous MRI images filed in NINDSs database undergo MRI scanning MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues The scanner is a metal cylinder surrounded by a strong magnetic field Subjects lie still on a table that can slide in an out of the cylinder They can communicate with the MRI staff at all times during the procedure
Detailed Description:
HYPOTHESIS
The hypothesis of this study is that the parieto-frontal network is activated by visuomotor behavior in humans
OBJECTIVES
To detect frontal and parietal cortical activity during a visuomotor task with frequency modulated visual stimuli using magnetoencephalography MEG
To reveal how the parieto-frontal activities change according to different conditions of attention gaze and motor output
STUDY POPULATION
Right handed normal volunteers with no known history of neurological or ophthalmological diseases will be recruited to participate in this study
DESIGN
This study is a combination of a frequency tagging method and an MEG Visual stimuli are presented flickering in specific tagged frequencies The cortical distribution of the visual information is estimated from the tagged frequency response of the MEG signal We will use a visuomotor tracking task with a multifactorial task design attention target motion position in retinal coordinate and manual tracking to evaluate the effect of each factor separately
OUTCOME MEASURES
We will use the adaptive linear-filter technique known as synthetic aperture magnetometry SAM to estimate the source location and strength of the tagged frequencies The estimated cortical source activity power at the frontal and parietal cortices will be group analyzed with multiple logistic models and by analysis of variance ANOVA with correction for multiple comparisons
The hypothesis of this study is that the parieto-frontal network is activated by visuomotor behavior in humans
OBJECTIVES
To detect frontal and parietal cortical activity during a visuomotor task with frequency modulated visual stimuli using magnetoencephalography MEG
To reveal how the parieto-frontal activities change according to different conditions of attention gaze and motor output
STUDY POPULATION
Right handed normal volunteers with no known history of neurological or ophthalmological diseases will be recruited to participate in this study
DESIGN
This study is a combination of a frequency tagging method and an MEG Visual stimuli are presented flickering in specific tagged frequencies The cortical distribution of the visual information is estimated from the tagged frequency response of the MEG signal We will use a visuomotor tracking task with a multifactorial task design attention target motion position in retinal coordinate and manual tracking to evaluate the effect of each factor separately
OUTCOME MEASURES
We will use the adaptive linear-filter technique known as synthetic aperture magnetometry SAM to estimate the source location and strength of the tagged frequencies The estimated cortical source activity power at the frontal and parietal cortices will be group analyzed with multiple logistic models and by analysis of variance ANOVA with correction for multiple comparisons
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 04-N-0117 | None | None | None |