Ignite Creation Date:
2024-05-05 @ 11:05 PM
Last Modification Date:
2024-10-26 @ 10:28 AM
Study NCT ID:
NCT01256801
Status:
COMPLETED
Last Update Posted:
2015-07-29
First Post:
2010-12-01
Brief Title:
Gene Expression Profiling of Breast Cancer Cells Predict the Response of Malignant Pleural Effusion
Sponsor:
Peking University Cancer Hospital Institute
Organization:
Peking University Cancer Hospital Institute
Study Overview
Official Title:
Gene Expression Profiling of Breast Cancer Cells in Pleural Effusion Prodict the Response of Malignant Pleural Effusion to Immunotherapy
Status:
COMPLETED
Status Verified Date:
2015-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
GMPE
Brief Summary:
The investigators want to develop a gene expression profile for the prediction of immunotherapy response of patients with metastatic breast cancer presenting malignant pleural effusion
Detailed Description:
1 The patiets with malignant pleural effusion are randomizned to be treated with cytokinsinteleukin 2 or dendritic cellsDC plus cytokine induced killer cellsCIK locally
2 Malignant pleural effusion from metastatic breast cancer patient is obtained through thoracentesis and is centrifugalized to enrich cancer cells before the therapy
3 The enriched cancer cells are flash frozen and stored at -80 until processing
4 The gene expression in pleural effusion is detected by microarray to screen gene markers that are differently expressed between groups
5 Statistical analysis is performed using unsupervised hierarchical cluster
2 Malignant pleural effusion from metastatic breast cancer patient is obtained through thoracentesis and is centrifugalized to enrich cancer cells before the therapy
3 The enriched cancer cells are flash frozen and stored at -80 until processing
4 The gene expression in pleural effusion is detected by microarray to screen gene markers that are differently expressed between groups
5 Statistical analysis is performed using unsupervised hierarchical cluster
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None