Ignite Creation Date:
2024-05-05 @ 11:31 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00068120
Status:
COMPLETED
Last Update Posted:
2010-01-14
First Post:
2003-09-08
Brief Title:
ORWHSCOR - SexGender Factors Affecting Womens Health
Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases NIDDK
Organization:
National Institute of Diabetes and Digestive and Kidney Diseases NIDDK
Study Overview
Official Title:
ORWHSCOR - SexGender Factors Affecting Womens Health
Status:
COMPLETED
Status Verified Date:
2010-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This project is the clinical project of a Specialized Center of Research SCOR proposal which is designed to further our understanding of urinary tract infection UTI in women Acute uncomplicated urinary tract infections UTIs occur in an estimated 7-11 million women each year and the annual costs of caring for these women are thought to approach 16 billion Approximately 20-30 of women suffer from frequent recurrent infections UTIs in young women result in substantial symptoms time lost from work and medical costs An improved understanding of the mechanisms underlying UTIs could result in new approaches to their prevention and reduced numbers of women with infections and the amount of antibiotics use
In this project we seek a better understanding of the causes of UTI Most experts believe that vaginal colonization with UTI-causing bacteria from the rectal flora precedes colonization of the urethra the tube from the bladder for urination and bladder and subsequent UTI but the relationships between these events has not been established Moreover recent information from studies in mice strongly suggest that persistent bladder infection follows an initial bladder infection
In this project we will prospectively follow a large group of women with recurrent UTI to determine 1 the relationships in time between vaginal colonization with a UTI-causing bacteriuria asymptomatic bacteriuria bacteria in the bladder but without any UTI symptoms and symptomatic UTI and 2 the presence of persistent bacteria in the bladder following the symptomatic UTI at entry into the study and whether such bacteria are related to later UTIs that are caused by the same bacteria that caused the UTI at entry into the study We will thus be able to determine the relative importance of vaginal colonization vs persistent infection of the bladder as the origin of the bacteria causing recurrent UTI
UTI-causing bacteria cultured from women with symptomatic UTI and asymptomatic bacteriuria will undergo studies by Dr Scott Hultgrens group at Washington University in Project 1 to identify unique genes that may help us understand why some bacteria cause symptoms and others do not The effect of bacteria causing UTI in these women on host response will also be determined by studies by Dr Jeff Gordons laboratory at Washington University in Project 3
A better understanding of the molecular and epidemiologic basis of UTI is critical in developing the best possible prevention and management strategies
In this project we seek a better understanding of the causes of UTI Most experts believe that vaginal colonization with UTI-causing bacteria from the rectal flora precedes colonization of the urethra the tube from the bladder for urination and bladder and subsequent UTI but the relationships between these events has not been established Moreover recent information from studies in mice strongly suggest that persistent bladder infection follows an initial bladder infection
In this project we will prospectively follow a large group of women with recurrent UTI to determine 1 the relationships in time between vaginal colonization with a UTI-causing bacteriuria asymptomatic bacteriuria bacteria in the bladder but without any UTI symptoms and symptomatic UTI and 2 the presence of persistent bacteria in the bladder following the symptomatic UTI at entry into the study and whether such bacteria are related to later UTIs that are caused by the same bacteria that caused the UTI at entry into the study We will thus be able to determine the relative importance of vaginal colonization vs persistent infection of the bladder as the origin of the bacteria causing recurrent UTI
UTI-causing bacteria cultured from women with symptomatic UTI and asymptomatic bacteriuria will undergo studies by Dr Scott Hultgrens group at Washington University in Project 1 to identify unique genes that may help us understand why some bacteria cause symptoms and others do not The effect of bacteria causing UTI in these women on host response will also be determined by studies by Dr Jeff Gordons laboratory at Washington University in Project 3
A better understanding of the molecular and epidemiologic basis of UTI is critical in developing the best possible prevention and management strategies
Detailed Description:
None
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?: