Ignite Creation Date:
2024-05-05 @ 11:04 PM
Last Modification Date:
2024-10-26 @ 10:28 AM
Study NCT ID:
NCT01244802
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2023-12-21
First Post:
2010-11-18
Brief Title:
Characterization of Human Memory Immune Responses to Prior Yellow Fever Vaccination
Sponsor:
Emory University
Organization:
Emory University
Study Overview
Official Title:
Characterization of Human Memory Immune Responses to Prior Yellow Fever Vaccination
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The objective of this study is to study immune memory generated against the yellow fever YFV vaccine in participants who have previously received the vaccine Volunteers will not receive vaccine shots only immune responses to previous yellow fever vaccination will be studied The study involves one or multiple blood draws
Detailed Description:
The goal of this study is to characterize immune memory in humans who have previously received yellow fever vaccine The project is designed to study the magnitude and persistence of both humoral and cell-mediated immune memory generated post-vaccination Since aging has an effect on the immune system eg decreased thymic output replacement of hematopoietic cells in the bone marrow with adipocytes the researchers will analyze the young adults aged 18-45 years and the older vaccinees 55 years or older in separate groups
The specific aims of the study are to
Determine the phenotypic and functional characterization of memory T cell responses to yellow fever vaccination
Determine neutralizing antibody titer after yellow fever vaccination
The specific aims of the study are to
Determine the phenotypic and functional characterization of memory T cell responses to yellow fever vaccination
Determine neutralizing antibody titer after yellow fever vaccination
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| U19AI057266 | NIH | None | httpsreporternihgovquickSearchU19AI057266 |