Ignite Creation Date:
2024-05-05 @ 11:31 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00060593
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2003-05-07
Brief Title:
MRI Study of Self-Perception of Postural Stability
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Self-Perception of Postural Stability Event-Related fMRI Study
Status:
COMPLETED
Status Verified Date:
2005-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use functional magnetic resonance imaging MRI to examine loss of balance in the elderly Falls due to balance problems are a major health issue in older people often resulting in bone fractures and other bodily injuries and in functional decline Risk factors for falling in the elderly include some standing positions in which older people usually experience balance problems such as leaning forwards or backwards Functional MRI records brain function while the subject performs a task such as moving a limb or speaking and detects changes in the brain regions involved in those tasks This study will look at different brain areas to see which areas might control what people see around them while they are standing
Healthy normal volunteers between 20 and 90 years of age may be eligible for this study Candidates must be in good health have no difficulties in performing activities of daily living and be able to walk for at least 400 meters 14 mile They will be screened with a medical history and physical examination
Participants will undergo functional MRI while performing visual recognition tasks in two experiments described below For the MRI procedure the subject lies in the MRI scanner a narrow metal cylinder containing a strong magnet for 20 minutes to 3 hours with most scans lasting between 45 and 90 minutes The experiments are as follows
Experiment 1
During MRI scanning the subject watches computer-generated movies of a person leaning forwards and backwards When the subject recognizes an unstable body position in the movements he or she presses a computer mouse
Experiment 2
During MRI scanning the subject watches still pictures of people leaning in stable and unstable postures and presses a button as soon as he or she recognizes that the posture is unstable
Healthy normal volunteers between 20 and 90 years of age may be eligible for this study Candidates must be in good health have no difficulties in performing activities of daily living and be able to walk for at least 400 meters 14 mile They will be screened with a medical history and physical examination
Participants will undergo functional MRI while performing visual recognition tasks in two experiments described below For the MRI procedure the subject lies in the MRI scanner a narrow metal cylinder containing a strong magnet for 20 minutes to 3 hours with most scans lasting between 45 and 90 minutes The experiments are as follows
Experiment 1
During MRI scanning the subject watches computer-generated movies of a person leaning forwards and backwards When the subject recognizes an unstable body position in the movements he or she presses a computer mouse
Experiment 2
During MRI scanning the subject watches still pictures of people leaning in stable and unstable postures and presses a button as soon as he or she recognizes that the posture is unstable
Detailed Description:
A number of studies have explored the role of visual vestibular and somatosensory systems in the control of upright posture However the cortical control of postural stability in general and the role of higher cognitive function in assessment of postural stability in specific has not been studied extensively It is well established that certain features of postural control change during the advancing years of life so that the stability of posture can be a problem in the elderly However neural mechanisms of postural stability that decline with age and make older adults more prone to falling have not been identified specifically To characterize specific causes of falling in the elderly is problematic because human posture is a product of an extremely complex dynamical system and like any other physical activity undergoes dramatic changes in organization throughout the life-span In our previous research we showed the neural activation patterns embodied in the electroencephalogram EEG were associated with recognition of unstable postures in young healthy subjects In another protocol we propose that these patterns will systematically change with aging and will result in difficulty to discriminate relevant from irrelevant information in the control of upright posture The present study focuses on the evaluation of neural activation patterns underlying recognition of unstable postures in 15 young controls and 15 elderly subjects using both the block and event-related functional MRI fMRI designs We will first analyze how the frontal-parieto-occipital circuits play a role in perception of postural stability in young subjects and then perform similar studies using elderly subjects After the fMRI measurements a detailed evaluation of the haemodynamic response BOLD signals will be performed Further analysis will look at the functional connectivity between the motion-selective cortical area V5 the posterior parietal cortex PP and the frontal cortex FC using correlation methods It is expected that from the study will uncover important insights in neural mechanisms as it relates to the self-perception of postural stability and its deterioration as a result of aging
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-N-0183 | None | None | None |