Ignite Creation Date:
2024-05-05 @ 11:01 PM
Last Modification Date:
2024-10-26 @ 10:27 AM
Study NCT ID:
NCT01239979
Status:
COMPLETED
Last Update Posted:
2010-12-22
First Post:
2010-11-12
Brief Title:
Plasma Myeloperoxidase Levels in Patients With Coronary Artery Disease
Sponsor:
Isfahan University of Medical Sciences
Organization:
Isfahan University of Medical Sciences
Study Overview
Official Title:
Evaluation of the Association Between Myeloperoxidase Levels and Cardiovascular Risk Factors in Patients With Coronary Artery Disease
Status:
COMPLETED
Status Verified Date:
2009-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators sought to assess whether plasma myeloperoxidase MPO levels differ among patients with stable and unstable CAD patients and control subjects and correlate with inflammatory and clinical risk factors such as ox-LDL NOleptin adiponectin sPLA2 Lp-PLA2 homocysteine and 3-nitrotyrosine in the patients
Detailed Description:
Elevation of the leukocyte enzyme myeloperoxidase MPO in stable coronary artery disease CAD patients in contrast to unstable CAD patients is controversial and its relationship with some inflammatory and noninflammatory markers such as oxidized LDL ox-LDL and nitric oxide NO in the CAD patients has not been evaluated yet Evaluation of these relationships is the aim of the studyAlso the relationships between MPO and some other inflammatory biomarker such as leptin adiponectin sPLA2 Lp-PLA2 homocysteine and 3-nitrotyrosine are examined This study includes 50 stable CAD 50 unstable CAD patients and 50 controls Plasma MPO ox-LDL leptin adiponectin sPLA2 levels are determined using enzyme immunoassayHomocysteine and 3-nitrotyrosine are measured using HPLC-fluorescence method Plasma total NO and other risk factors such as lipid profile hypertension smoking diabetes mellitus and familial history of CAD are also determined in the patients Results are statistically analysed and the association between all markers are assessed
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None