Viewing Study NCT01234870



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Last Modification Date: 2024-10-26 @ 10:27 AM
Study NCT ID: NCT01234870
Status: COMPLETED
Last Update Posted: 2014-09-26
First Post: 2010-10-05

Brief Title: Comprehensive Evaluation of Ischemic Heart Disease Using MRI
Sponsor: Northwestern University
Organization: Northwestern University

Study Overview

Official Title: Comprehensive Evaluation of Ischemic Heart Disease Using MRI
Status: COMPLETED
Status Verified Date: 2014-09
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: The purpose of the study is to assess the diagnostic performance of fully automated motion corrected MC first pass myocardial perfusion MRI compared to the original non-corrected first pass myocardial perfusion images in a cohort of patients with suspected ischemic heart disease using coronary angiography as the reference standard It is expected that this improved comprehensive protocol for cardiac MRI be accurate at detecting significant coronary artery disease and may obviate the need for other more expensive and invasive diagnostic tests currently used
Detailed Description: Coronary heart disease is the leading cause of death and disability in the US accounting for about one-third of all deaths in subjects over age 35

With the development of newer Magnetic Resonance Imaging MRI techniques such as faster pulse sequences and parallel imaging cardiac MRI has become a routine tool for the evaluation and detection of myocardial ischemic disease First pass myocardial perfusion FPMP using MRI is increasingly being used to assess ischemic heart disease MRI offers the advantages of spatial resolution sufficient to differentiate between subendocardial and subepicardial perfusion shorter examination time and also lack of ionizing radiation Left ventricle cine gradient echo imaging can be used to assess regional ventricular function Left ventricular myocardial viability can also be easily assessed at the same time in order to determine the amount of viable left ventricular myocardium and the percentage of irreversibly scarred myocardium by delayed enhanced images Viability imaging is usually added to the perfusion protocol to increase specificity by allowing detection of fixed perfusion defects which represent scar The ultimate cardiac MRI protocol would be to combine both of these imaging strategies with a reliable and accurate coronary Magnetic Resonance AngiographyMRA technique such that obstructive coronary artery disease could be evaluated comprehensively at the same time If all of these techniques can be combined together in a single study it may be feasible to finally achieve a one stop shop for cardiac Magnetic Resonance Imaging

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: None
Is a FDA Regulated Device?: None
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None
Secondary IDs
Secondary ID Type Domain Link
ASCA-9J02 OTHER_GRANT Astellas Pharma Global Development Inc None