Ignite Creation Date:
2024-05-05 @ 11:31 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00061204
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2003-05-21
Brief Title:
Magnetic Resonance Imaging of the Brain in Emotional Processing
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Functional Neuroimaging of Social Cognitive and Emotional Processing Technical and Cognitive Issues
Status:
COMPLETED
Status Verified Date:
2006-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use magnetic resonance imaging MRI to identify brain regions involved in performing certain tasks especially those involving emotions MRI is a diagnostic tool that uses a strong magnetic field and radio waves to produce images of structural and chemical changes in the brain The study will also examine which MRI techniques are best to use when scanning brain areas involved in different emotions
Healthy normal volunteers between 18 and 40 years of age who are right-handed and are native English speakers may be eligible for this study Individuals with a history of neurological disease post-traumatic stress disorder or other psychiatric disorder or who have a history of physical or sexual abuse may not participate Candidates will be screened with a written questionnaire and a medical history including psychiatric and neurological information
Participants will perform tasks involving emotions while undergoing MRI scanning For this procedure the subject lies on a table in a narrow metal cylinder the scanner containing a magnetic field Scanning time varies from 20 minutes to 3 hours with most scans lasting between 45 and 90 minutes The subject is asked to lie still for up to 10 minutes at a time During the scan the subject performs simple tasks involving the viewing of pictures on a screen Other tasks involve viewing pictures and responding to them by pressing buttons Some pictures are violent or pornographic while others are pleasant to view Of a total of 162 pictures 30 percent are categorized as graphic and possibly disturbing
Healthy normal volunteers between 18 and 40 years of age who are right-handed and are native English speakers may be eligible for this study Individuals with a history of neurological disease post-traumatic stress disorder or other psychiatric disorder or who have a history of physical or sexual abuse may not participate Candidates will be screened with a written questionnaire and a medical history including psychiatric and neurological information
Participants will perform tasks involving emotions while undergoing MRI scanning For this procedure the subject lies on a table in a narrow metal cylinder the scanner containing a magnetic field Scanning time varies from 20 minutes to 3 hours with most scans lasting between 45 and 90 minutes The subject is asked to lie still for up to 10 minutes at a time During the scan the subject performs simple tasks involving the viewing of pictures on a screen Other tasks involve viewing pictures and responding to them by pressing buttons Some pictures are violent or pornographic while others are pleasant to view Of a total of 162 pictures 30 percent are categorized as graphic and possibly disturbing
Detailed Description:
The purpose of the protocol is to localize the neural regions and systems mediating the forms of knowledge representations hypothesized by the principal investigator to be stored in the human prefrontal cortex Utilizing experimental neuropsychological tasks during functional MRI on healthy adult volunteers we will investigate hypotheses regarding the role of the ventromedial prefrontal cortex in social cognition and emotional processing as opposed to the dorsolateral prefrontal cortex involved in nonsocial-events planning problem solving economic exchange and reasoning We will also attempt to determine the relationship between non-frontal neural structures involved in emotional expression such as the amygdala and those frontal neural structures involved in executive functions that may modulate emotion Another goal of our study is to test different fMRI sequences to determine which one gives us the best quality of signal in the amygdala and orbitofrontal cortex affected by signal drop-out due to magnetic susceptibility artifacts The data that we collect in this protocol will be of value in 1 identifying a set of neural regions and distributed networks mediating the forms of knowledge representation stored in the prefrontal cortex and 2 contributing to optimization of functional imaging of the amygdala and orbitofrontal cortex at high field strength 3 Tesla We will also use the data obtained in these studies to constrain theories of frontal lobe function and to provide evidence for the role of specific frontal cortex sectors in specific cognitive functions
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-N-0195 | None | None | None |