Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001522
Status:
COMPLETED
Last Update Posted:
2019-09-23
First Post:
1999-11-03
Brief Title:
Metabolic Differences of Overweight Children and Children of Overweight Parents
Sponsor:
Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Population Differences in the Insulin Sensitivity Resting Energy Expenditure and Body Composition of Overweight Children and Children of Overweight Parents
Status:
COMPLETED
Status Verified Date:
2018-04-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study focuses on the way weight is gained Individuals who gain weight primarily in their midsection visceral weight are at an increased risk for developing diabetes and high blood pressure
Research has shown that African Americans suffer more often from high blood pressure diabetes non-insulin dependent and heart disease than Caucasian Americans These conditions lead to significant numbers of deaths and diseases associated with and made worse by obesity
African American women in particular suffer from obesity and the associated conditions of obesity more than any other race or gender However it is unknown if the conditions seen in African American women are a result of the obesity or differences in their insulin sensitivity glucose disposal or fat metabolism
This study will compare body composition total and resting energy expenditure and glucose disposal of obese African American and Caucasian children and of non-obese children of obese African American and Caucasian parents to characterize the timing and nature of factors that may contribute to the prevalence of obesity and its complications
Patients participating in this study will be followed for 15 years and be evaluated every 5 years during the studyTAB
Research has shown that African Americans suffer more often from high blood pressure diabetes non-insulin dependent and heart disease than Caucasian Americans These conditions lead to significant numbers of deaths and diseases associated with and made worse by obesity
African American women in particular suffer from obesity and the associated conditions of obesity more than any other race or gender However it is unknown if the conditions seen in African American women are a result of the obesity or differences in their insulin sensitivity glucose disposal or fat metabolism
This study will compare body composition total and resting energy expenditure and glucose disposal of obese African American and Caucasian children and of non-obese children of obese African American and Caucasian parents to characterize the timing and nature of factors that may contribute to the prevalence of obesity and its complications
Patients participating in this study will be followed for 15 years and be evaluated every 5 years during the studyTAB
Detailed Description:
African Americans have a greater prevalence than Caucasian Americans of hypertension non-insulin-dependent diabetes mellitus and cardiovascular disease These conditions lead to substantial excess morbidity and mortality and are associated with and exacerbated by obesity the prevalence of which is strikingly elevated in African American women It is unknown if this increased prevalence of comorbid conditions is solely related to the greater prevalence of severe obesity among African American women or due to differences in insulin sensitivity glucose disposal body composition or fat cell metabolism Through this project we have verified that many of the physiological differences observed between African American and Caucasian adults are already present in obese children and in children at high risk for developing obesity However the roles that differences in energy expenditure glucose metabolism body composition and other factors play in determining which children develop obesity and its comorbid conditions in adulthood remain unclear In this study we compare body composition total and resting energy expenditure and glucose disposal of obese African American and Caucasian children and of non-obese children of obese African American and Caucasian parents to characterize the timing and nature of factors that may contribute to the prevalence of obesity and its complications We also relate serum levels of the body-fat related circulating factors such as leptin to these measures and obtain samples for genomic DNA isolation from participants and their parents to characterize the roles of genes felt important for the development of obesity We will follow these children for 15 years studying them intensively at 5 year intervals until adulthood
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 96-CH-0101 | None | None | None |