Ignite Creation Date:
2024-05-05 @ 11:31 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00060853
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2003-05-14
Brief Title:
Magnetic Resonance Imaging of the Brain in Social and Emotional Reasoning
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Reasoning About Social and Economic Knowledge Identifying the Role of the Human Prefrontal Cortex Using Functional Neuroimaging
Status:
COMPLETED
Status Verified Date:
2005-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use magnetic resonance imaging MRI to identify brain regions involved in social and emotional reasoning It will identify differences in brain activity during task performance between people who have a nervous system illness and those who do not MRI is a diagnostic tool that uses a strong magnetic field and radio waves to produce images of structural and chemical changes in the brain
Healthy normal volunteers between 21 and 55 years of age who are right-handed and are native English speakers may be eligible for this study Candidates will be screened with a medical history including psychiatric and neurological information
Participants will be asked to perform social and emotional reasoning tasks such as sorting and judging rules and rule violations while undergoing MRI scanning Some tasks may simply involve viewing items on a screen Others may involve solving complex problems and responding by pressing buttons During the scan the subject lies on a table in a narrow cylinder the scanner containing a magnetic field The scan will last about 2 hours with subjects asked to lie still for up to 10 minutes at a time
Healthy normal volunteers between 21 and 55 years of age who are right-handed and are native English speakers may be eligible for this study Candidates will be screened with a medical history including psychiatric and neurological information
Participants will be asked to perform social and emotional reasoning tasks such as sorting and judging rules and rule violations while undergoing MRI scanning Some tasks may simply involve viewing items on a screen Others may involve solving complex problems and responding by pressing buttons During the scan the subject lies on a table in a narrow cylinder the scanner containing a magnetic field The scan will last about 2 hours with subjects asked to lie still for up to 10 minutes at a time
Detailed Description:
The purpose of the protocol is to localize the neural regions and systems mediating the forms of knowledge representations hypothesized by the principal investigator to be stored in the human prefrontal cortex Utilizing a variety of experimental neuropsychological tasks during functional MRI we will investigate hypotheses regarding the role of the dorsolateral prefrontal cortex in planning problem solving economic exchange and reasoning and the role of ventromedial prefrontal cortex in social cognition and emotional processing We will ascertain the relationship between so-called cold cognitive processes such as planning and hot social processes such as mate choice and specific brain regions within the prefrontal cortex We will also attempt to determine the relationship between non-frontal neural structures involved in emotional expression such as the amygdala and those frontal neural structures involved in executive functions that may modulate emotion In addition we will attempt to determine the requirements for frontal-parietal versus frontal-temporal network involvement in spatial landmark tasks The data that we collect in this protocol will be of value in identifying a set of neural regions and distributed networks mediating the forms of knowledge representation stored in the prefrontal cortex These questions will be addressed over seven separate studies with healthy normal adult volunteers The studies will employ within- and between-subject event-related fMRI designs The data collected will consist of behavioral measures of cognitive and emotional performancejudgment and corresponding fMRI images
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-N-0197 | None | None | None |