Ignite Creation Date:
2024-05-05 @ 11:31 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00067899
Status:
COMPLETED
Last Update Posted:
2013-06-19
First Post:
2003-08-29
Brief Title:
Oxidative Stress and Vitamin E Requirements
Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases NIDDK
Organization:
National Institute of Diabetes and Digestive and Kidney Diseases NIDDK
Study Overview
Official Title:
Oxidative Stress and Vitamin E Requirements
Status:
COMPLETED
Status Verified Date:
2013-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine if oxidative stress derived from cigarette smoking increases vitamin E requirements The study will also assess the role of vitamin C in modulating vitamin E requirements Vitamin E requirements will be assessed by measuring vitamin E in plasma as well as by measuring the excreted vitamin E metabolite in the urine
Detailed Description:
We will be investigating the fractional disappearance rate of tocopherols in cigarette smokers compared to nonsmokers This will be accomplished by supplementing individuals with deuterium labeled alpha- and gamma-tocopherols Quantification of plasma tocopherols as well as urinary metabolites alpha- and gamma-carboxy ethyl hydroxychromanol will be determined using liquid chromatographymass spectrometry analysis In addition the role of vitamin C as it pertains to its influence on the fraction disappearance rate of vitamin E will also be evaluated
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None