Ignite Creation Date:
2024-05-05 @ 11:31 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00066027
Status:
COMPLETED
Last Update Posted:
2023-09-06
First Post:
2003-08-01
Brief Title:
Effects of Low-Dose Doxycycline on Oral Bone Loss
Sponsor:
University of Nebraska
Organization:
University of Nebraska
Study Overview
Official Title:
Low-Dose Doxycycline Effects on Osteopenic Bone Loss
Status:
COMPLETED
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The primary purpose of this clinical trial is to determine whether low-dose doxycycline can reduce alveolar bone density loss in postmenopausal osteopenic women with periodontitis and not on hormone replacement therapy ie estrogen deficient
Detailed Description:
The primary purpose of this clinical trial is to determine whether low-dose doxycycline LDD can reduce alveolar bone density loss in postmenopausal osteopenic women with periodontitis and not on hormone replacement therapy ie estrogen deficient The effects of LDD on alveolar bone height loss progressive periodontal attachment loss systemic bone mineral density gingival crevicular fluid biochemical markers of collagen degradation and bone resorption and serum biomarkers of bone formation bone resorption and inflammation also will be assessed In addition another objective is to determine if the microbial effects obtained with LDD over two years are equivalent to a placebo control This clinical trial involves two clinical sites the University of Nebraska Medical Center College of Dentistry and Stony Brook University School of Dental Medicine A total of 128 postmenopausal osteopenic women with periodontitis between the ages of 45 and 70 at the time of telephone screening will be randomized to LDD or placebo groups and subjects will be followed for two years
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01DE012872 | NIH | None | httpsreporternihgovquickSearchR01DE012872 |